Patents Assigned to Georgetown University
  • Isoform selective HDAC inhibitors
    Patent number: 8653278
    Abstract: One aspect of the invention relates to isoform-selective HDAC inhibitors. Also provided are methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy. The invention also provides methods for treating cancer, methods for treating neurological diseases and methods for treating malaria. Additionally, the invention provides pharmaceutical compositions comprising an HDAC inhibitor of the invention; and kits comprising an HDAC inhibitor of the invention.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: February 18, 2014
    Assignees: Georgetown University, The Board of Trustees of the University of Illinois
    Inventors: Alan P. Kozikowski, Mira Jung, Anatoly Dritschilo, Arsen Gaysin, Pavel A. Petukhov, Werner Tueckmantel, Hongbin Yuan, Yufeng Chen
  • Flavivirus Inhibitors and Methods of Their Use
    Publication number: 20140038962
    Abstract: Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
    Type: Application
    Filed: September 20, 2013
    Publication date: February 6, 2014
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Radhakrishnan Padmanabhan, Nagarajan Pattabiraman, Niklaus Mueller, Kuppuswamy Nagarajan
  • Linked Myc-max small molecule inhibitors
    Patent number: 8637556
    Abstract: Provided herein are compounds and compositions for interfering with the association of Myc and Max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell. Methods of inhibiting growth or proliferation of a cell comprise contacting the cell with an amount of a compound that interferes with Myc and Max association effective to inhibit growth or proliferation of the cell.
    Type: Grant
    Filed: January 15, 2010
    Date of Patent: January 28, 2014
    Assignees: University of Pittsburgh—Of the Commonwealth System of Higher Education, Georgetown University
    Inventors: Steven J. Metallo, Edward V. Prochownik, Ariele Viacava Follis
  • Systems and Methods For Monitoring Health and Delivering Drugs Transdermally
    Publication number: 20140025000
    Abstract: The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicants: Science Applications International Corporation, Georgetown University
    Inventors: John F. Currie, Makarand Paranjape, Carl C. Peck, Robert White, Thomas W. Schneider
  • SYSTEM AND METHOD OF APPLYING STATE OF BEING TO HEALTH CARE DELIVERY
    Publication number: 20140019468
    Abstract: A system for assisting a subject to select a proper form of treatment. The system comprises: a monitoring section that remotely monitors a health status of the subject; an inference section that infers medical information about the subject based on information subject posted on social networks; a subject database that stores subject's information; and a symptom engine that stores symptoms of medical situations. The inference section applies the health status and the medical information against symptoms stored in the symptom engine to determine a proper form of treatment.
    Type: Application
    Filed: July 16, 2012
    Publication date: January 16, 2014
    Applicant: Georgetown University
    Inventors: Howard Federoff, Ophir Frieder, Eric Burger
  • Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
    Patent number: 8617514
    Abstract: The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted immunoliposomes for the systemic delivery of molecules to treat and image diseases, including cancerous tumors. The invention also provides immunoliposomes and compositions, as well as methods of imaging various tissues. The liposome complexes are useful for encapsulation of imaging agents, for example, for use in magnetic resonance imaging. The specificity of the delivery system is derived from the targeting antibodies or antibody fragments.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: December 31, 2013
    Assignee: Georgetown University
    Inventors: Esther H. Chang, Kathleen F. Pirollo
  • Methods and compositions for the inhibition of Stat5 in prostate cancer cells
    Patent number: 8609624
    Abstract: The present invention relates to compositions and methods for the treatment of prostate cancer. In certain embodiments, the invention relates to compositions and methods for the inhibition of prostate cancer cell growth, comprising inhibiting the activity of Stat5 in prostate cancer cells.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: December 17, 2013
    Assignee: Georgetown University
    Inventor: Marja T. Nevalainen
  • Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
    Patent number: 8609721
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: December 17, 2013
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan
  • SMALL MOLECULE INHIBITORS OF AGBL2
    Publication number: 20130331328
    Abstract: Small molecule inhibitors of AGBL2 are provided, as well as methods of using the inhibitors to treat or prevent cancer and neurologic disorders.
    Type: Application
    Filed: February 14, 2012
    Publication date: December 12, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Stephen W. Byers, Sivanesan Dakshanamurthy, Ziad Sahab
  • REVERSAL OF HIGH BREAST CANCER RISK IN MAMMALS EXPOSED TO ESTROGENIC CHEMICALS IN UTERO BY ADULT EXPOSURE TO HDAC AND DNMT INHIBITORS
    Publication number: 20130324543
    Abstract: Methods of reducing breast cancer risk in an individual exposed in utero to an elevated estrogenic environment, where the individuals are identified by obtaining a measurement of at least one of: (a) DNMT1 expression; (b) methylation of normally unmethylated CpG islands of tumor suppressor genes; and (c) polycomb target genes, in cells obtained from the individual and comparing the measurement to a statistical level of a population not exposed in utero to an elevated estrogenic environment. Methods of reducing breast cancer risk in such an individual can be reduced by administering at least one DNA methyltransferase (DNMT) and/or histone deacetylase (HDAC) inhibitor. The administration of these inhibitors may be part of a treatment regime which may include the administration of at least one anti-cancer agent.
    Type: Application
    Filed: April 5, 2013
    Publication date: December 5, 2013
    Applicant: Georgetown University
    Inventors: Leena Hilakivi-Clarke, Anni Warri, Dominic Kim
  • Immortalization of Epithelial Cells and Methods of Use
    Publication number: 20130309681
    Abstract: The present invention is directed towards methods of culturing non-keratinocyte epithelial cells, with the methods comprising culturing non-keratinocyte epithelial cells in the presence of feeder cells and a calcium-containing medium while inhibiting the activity of Rho kinase (ROCK) in the feeder cell, the non-keratinocyte epithelial cells or both during culturing.
    Type: Application
    Filed: November 11, 2011
    Publication date: November 21, 2013
    Applicant: Georgetown University
    Inventors: Richard Schlegel, Xuefeng Liu
  • Reversible room-temperature ionic liquids
    Patent number: 8574453
    Abstract: One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.
    Type: Grant
    Filed: January 28, 2008
    Date of Patent: November 5, 2013
    Assignee: Georgetown University
    Inventors: Tao Yu, Richard G. Weiss, Taisuke Yamada, Mathew George
  • COMPOSITIONS AND METHODS FOR DETECTING ACETYLATED SUMO PROTEINS
    Publication number: 20130288275
    Abstract: The invention is directed to methods of using antibodies or antibody fragments that specifically bind to an acetylation domain of a small ubiquitin-like modifier protein (SUMO protein) when the acetylation domain is at least partially acetylated. The invention is also directed towards antibodies or antibody fragments that specifically bind to an acetylation domain of a small ubiquitin-like modifier protein (SUMO protein) when the acetylation domain is at least partially acetylated.
    Type: Application
    Filed: May 6, 2011
    Publication date: October 31, 2013
    Applicant: Georgetown University
    Inventor: Maria Laura Avantaggiati
  • Systems and methods for monitoring health and delivering drugs transdermally
    Patent number: 8568315
    Abstract: The present invention pertains to a system and method for transdermal sampling, comprising: at least one sampler for retrieving and transferring at least one analyte obtained transdermally from the skin of a subject; at least one detector system for identifying and quantifying said at least one analyte; and at least one logic module for (i) receiving and storing input data from said at least one detector, (ii) relating the input data to other data obtained from the subject, (iii) displaying output information, (iv) transmitting the output information to another system, and (v) controlling the operation of said at least one sampler and at least one detector.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: October 29, 2013
    Assignees: Georgetown University, Science Applications International Corporation
    Inventors: John F. Currie, Makarand Paranjape, Carl C. Peck, Robert White, Thomas W. Schneider
  • inhibitors and methods for their use
    Patent number: 8563580
    Abstract: Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor, e.g., a Flavivirus serine protease inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivurs infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: October 22, 2013
    Assignee: Georgetown University
    Inventors: Radhakrishnan Padmanabhan, Nagarajan Pattabiraman, Niklaus Mueller, Kuppuswamy Nagarajan
  • SYSTEM AND METHOD FOR DETECTING, COLLECTING, ANALYZING, AND COMMUNICATING EMERGING EVENT- RELATED INFORMATION
    Publication number: 20130238356
    Abstract: A system and method involves detecting operational social disruptive events on a global scale, modeling data in conjunction with linguistics analysis to establish responsive actions, and generating visualization and executing models for communicating information.
    Type: Application
    Filed: November 7, 2011
    Publication date: September 12, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Manabu Torii, David M. Hartley, Noele P. Nelson
  • COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISEASES
    Publication number: 20130236532
    Abstract: The present application discloses compositions and methods useful for treating and preventing inflammation associated with inflammatory diseases and disorders.
    Type: Application
    Filed: August 4, 2011
    Publication date: September 12, 2013
    Applicants: UNIVERSITY OF VIRGINIA PATENT FOUNDATION, GEORGETOWN UNIVERSITY
    Inventors: Yun Michael Shim, Mikell Paige
  • AUTOMATED FORENSIC DOCUMENT SIGNATURES
    Publication number: 20130227604
    Abstract: Methods and systems are provided for a proactive approach for computer forensic investigations. The invention allows organizations anticipating the need for forensic analysis to prepare in advance. Forensic signatures are created including a digital fingerprint and other information associated with a file. In one aspect, informational signatures are created, which may assist in determining what information is included in a file. In another aspect, the digital fingerprint may represent contents of the file and is resistant to minor modification of the file. In another aspect, fingerprints can be compared in parallel on different computers.
    Type: Application
    Filed: April 8, 2013
    Publication date: August 29, 2013
    Applicant: Georgetown University
    Inventor: Georgetown University
  • Mass Spectrometric Methods for Quantifying NPY 1-36 and NPY 3-36
    Publication number: 20130214151
    Abstract: Provided are methods of detecting the presence or amount of NPY 1-36 or NPY 3-36 in a sample using mass spectrometry. Importantly, by methods of the invention, both NPY 1-36 and NPY 3-36 can be quantified simultaneously, separately, and independently in a sample that contains both peptides. The methods provide enhanced specificity, and excellent sensitivity with limits of quantitation (LOQ) of about 0.1 ng/mL, and are accomplished in less time and with less sample preparation than required in other assays for NPY. In certain embodiments, because the methods of the invention are specific for both NPY 1-36 and NPY 3-36, the methods provide a major advantage over existing immunoassays. Therefore, the methods may be used to obtain reliable concentration data in several important patient populations, such as patients with hypertension, heart disease, or cancer.
    Type: Application
    Filed: July 22, 2011
    Publication date: August 22, 2013
    Applicant: Georgetown University
    Inventor: Steven J. Soldin
  • Stromal Antigen 2 (STAG2) Compositions and Methods
    Publication number: 20130216559
    Abstract: Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 22, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: TODD WALDMAN, DAVID SOLOMON, JUNG-SIK KIM