Abstract: Reversibly and irreversibly-linking amino-polysiloxanes, methods of making such amino-polysiloxanes, and systems and methods of using such amino-polysiloxanes for the containment and/or remediation of a release and/or spill of a crude oil, a petroleum product and/or a chemical is described. Gels and/or emulsions formed from the combination and/or contacting of such an amino-polysiloxane with these materials can be used to recover these oils or chemicals while allowing the amino-polysiloxane to be recovered and reused to clean up or contain additional materials. Such amino-polysiloxanes can be used as well for the selective uptake of one component of liquid mixtures when such mixtures contain more and less lipophilic components. Methods of making and using adhesive and sealants containing such amino-polysiloxanes are described.

Abstract: A combination treatment taking advantage of the synergistic effect of inhibiting ?-synuclein expression and chemotherapeutic agents to provide improved treatment of cancers, preferably stage III/IV cancers. A method for identifying improved cancer treatments.

Abstract: Disclosed are molecules and their synthesis, for use in blocking gated ion channels such as voltage-gated sodium channels (VGSCs) and prostate voltage sodium channels (PVSCs). These inhibitors have superior blocking efficacy, for instance in displacing the radioligand [3H]-Batrachotoxin-B ([3H]-BTX-B) that binds to site 2 of a VGSC. The molecules of the invention comprise a moiety which increases the binding affinity of molecules for the protein binding site in prostate cancer cells (PCs), and which is also fluorescent. In one embodiment the invention molecules are an inhibition system that can be used to target over-abundant or hyperactive VGSCs selectively in pain, epilepsy or prostate cancer, inhibiting the proliferation of PCs. The fluorescent moiety also facilitates screening, tracking, and pharmacodynamic studies of the drug in a biological system both in vitro and in vivo.

Abstract: A system and method for protecting information on a mobile device. The method and apparatus obtain a predetermined portion of asymmetric information upon an input of the asymmetric information in the mobile device; generate an identifier by using a first generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate an encryption key by using a second generating algorithm that uses the predetermined portion of the asymmetric information as an algorithm input; generate ciphered information by using an encryption algorithm that uses the encryption key and the information as algorithm inputs; associate the identifier with the ciphered information; and store the ciphered information as associated with the identifier.

Abstract: Cadherin-11 inhibitors, including 4-(2-phenylpyridin-3-yl)phenol, and methods for the prevention and treatment of cadherin-11 related diseases are described herein. Cadherin-11 related diseases include cancer and rheumatoid arthritis.

Abstract: Methods of treating exposure to Giardia lamblia and/or giardiasis and methods of antagonizing Giardia lamblia attachment to the intestinal wall of a subject are described herein.

Abstract: Devices, systems and techniques for directly coupling an optical slot waveguide to another optical waveguide without a taper waveguide region between the two optical waveguides.

Abstract: Devices incorporating a single to a few-layer MoS2 channels in combination with optimized substrate, dielectric, contact and electrode materials and configurations thereof, exhibit light emission, photoelectric effect, and superconductivity, respectively.

Abstract: The present invention is in the fields of drug delivery, cancer treatment and diagnosis and pharmaceuticals. This invention provides a method of making antibody- or antibody fragment-targeted immunoliposomes for the systemic delivery of molecules to treat and image diseases, including cancerous tumors. The invention also provides immunoliposomes and compositions, as well as methods of imaging various tissues. The liposome complexes are useful for encapsulation of imaging agents, for example, for use in magnetic resonance imaging. The specificity of the delivery system is derived from the targeting antibodies or antibody fragments.

Abstract: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.

Abstract: One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of the invention for modulation of a mammalian nicotinic acetylcholine receptor.

Abstract: A dental arch bar system includes upper and lower dental arch bars having movable transverse arms and ligature connectors. Fasteners secure the transverse arms to a subject's maxilla and mandible. Ligatures are secured around upper and lower ligature connectors to achieve intermaxillary fixation. A method is also disclosed for using the arch bar system to achieve intermaxillary fixation by securing the arch bars against opposing dental arches with ligature connectors of the upper and lower arch bar generally aligned. In some embodiments, a single dental arch bar is utilized and one or more ligature connectors (such as screws) are fixed directly in the bone of the opposite jaw. Ligatures then are secured to arch bar ligature connectors and the opposing ligature connectors.

Abstract: The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.

Abstract: The present invention is in the field of drug delivery, and specifically, cationic liposome-based drug delivery. In embodiments, this invention provides methods of making ligand-targeted (e.g., antibody- or antibody fragment-targeted) liposomes useful for the delivery of liposomes to tumors, including brain tumors. In embodiments, the liposomes deliver temozolomide across the blood-brain barrier for treatment of primary or metastatic brain tumors. Additional cancers that can be treated with the liposomes include neuroendocrine tumors, melanoma, prostate, head and neck, ovarian, lung, liver, kidney, breast, urogenital, gastric, colorectal, cervical, vaginal, angiosarcoma, liposarcoma, rhabdomyosarcoma, choriocarcinoma, pancreatic, retinoblastoma and other types of cancer. In another embodiment the liposomes deliver melphalan for the treatment of multiple myeloma, other tumors of the blood or other solid tumors.

Abstract: A device contains individually controllable sites for electrochemically monitoring an analyte in interstitial fluid of a user. The sites include a conductive pattern attached at a first and second ends thereof to electrode material in a closed-circuit configuration for receiving a first predetermined voltage applied thereto in order to thermally ablate a stratum corneum of a user's skin to access the interstitial fluid and form an open-circuit configuration including first and second portions of the electrode material that are electrically isolated from each other; a sensing area deposited on at least one of the first and second portions of the electrode material; and a measuring component for receiving individual measurement data from the sensing area in response to a second predetermined voltage applied to the open circuit configuration. The individual measurement data is indicative of an amount of the analyte in the interstitial fluid.

Abstract: One aspect of the present invention relates to salts that are room-temperature ionic liquids (RTILs), methods of making them, and methods of using them in connection with temporary or permanent gas sequestration. Another aspect of the present invention relates to a class of solvents which can be transformed into RTILs by exposure to a gas, and methods of using them in connection with temporary or permanent gas sequestration.

Abstract: Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.

Abstract: Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

Abstract: Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.

Abstract: A dental arch bar system includes upper and lower dental arch bars having movable transverse arms and ligature connectors. Fasteners secure the transverse arms to a subject's maxilla and mandible. Ligatures are secured around upper and lower ligature connectors to achieve intermaxillary fixation. A method is also disclosed for using the arch bar system to achieve intermaxillary fixation by securing the arch bars against opposing dental arches with ligature connectors of the upper and lower arch bar generally aligned. In some embodiments, a single dental arch bar is utilized and one or more ligature connectors (such as screws) are fixed directly in the bone of the opposite jaw. Ligatures then are secured to arch bar ligature connectors and the opposing ligature connectors.