Patents Assigned to Gesellschaft fur Biotechnologische Forschung
  • Patent number: 4987149
    Abstract: Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
    Type: Grant
    Filed: February 23, 1990
    Date of Patent: January 22, 1991
    Assignees: Gesellschaft fur Biotechnologische Forschung mbH, Braunschweig, Ciba-Geigy Corporation
    Inventors: Bettina Bohlendorf, Norbert Bedorf, Gerhard Hofle, Dietmar Schummer, Marius Sutter
  • Patent number: 4954517
    Abstract: A macrocyclic compound of the formula I, ##STR1## in which the substituents have the following meaning: X is hydrogen or methyl, Y is hydrogen, --CHO, --COCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 NH.sub.2, benzyl, methyl or a silyl group, and A--B--C is the following C.sub.3 -chain members: ##STR2## in which R.sub.1, R.sub.2 and R.sub.3, independently of one another, are hydrogen, methyl, --CHO, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 NH.sub.2 or a silyl group, and R.sub.4 and R.sub.5 are hydrogen, halogen or --COO(C.sub.1 --C.sub.3) alkyl, is suitable for controlling and preventing plant diseases. A compound of this type can be employed in a customary manner in the form of plant-protecting agents formulated with carrier substances and extenders.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: September 4, 1990
    Assignees: Gesellschaft fur Biotechnologische Forschung mbH, Ciba-Geigy Corporation
    Inventors: Marius Sutter, Bettina Bohlendorf, Norbert Bedorf, Gerhard Hofle
  • Patent number: 4940804
    Abstract: Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.
    Type: Grant
    Filed: September 8, 1989
    Date of Patent: July 10, 1990
    Assignees: Gesellschaft fur Biotechnologische Forschung mbH, Ciba-Geigy Corporation
    Inventors: Bettina Bohlendorf, Norbert Bedorf, Gerhard Hofle, Dietmar Schummer, Marius Sutter
  • Patent number: 4879234
    Abstract: The invention relates to a process for the purification and, if desired, recovery of formate-dehydrogenase (FDH) from Candida boidinii, in which FDH is subjected to a phase distribution in an aqueous 2-phase system that contains a triazine dyestuff that is bonded to an inert water-soluble polymer.
    Type: Grant
    Filed: July 30, 1986
    Date of Patent: November 7, 1989
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Arno Cordes, Maria-Regina Kula, Karl-Heinz Kroner, Wolfgang Stach
  • Patent number: 4877734
    Abstract: A microbiologically produced .alpha.-acetylamino cinnamic acid acylase and a method for its production from Brevibacterium species NCIB 12246 or NCIB 12247. The new enzyme can be used as constituent of a coupled enzyme system for enzymatic conversions which run via the intermediary stage .alpha.-imino-.beta.-phenylpropionic acid or phenylpyruvic acid.
    Type: Grant
    Filed: June 26, 1987
    Date of Patent: October 31, 1989
    Assignee: Degussa Aktiengesellschaft and Gesellschaft fur biotechnologische Forschung-mit beschrankter Haftung GBF
    Inventors: Maria-Regina Kula, Werner Hummel, Horst Schutte, Wolfgang Leuchtenberger
  • Patent number: 4870018
    Abstract: In a process and an apparatus for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures, in which process and apparatus a gas exchange occurs across an immersed membrane sheet, to achieve simple, effective and as uniform as possible a distribution of the gas introduction and gas desorption without mechanical damage to the liquid constituents, a tubular membrane cage formed by hollow membrane filaments is suspended flexibly in the medium to be gassed and moved in a circular oscillating movement without true rotation. The gassing rate is controlled by altering the angular oscillating movement frequency and/or the radius of the circular path, or alternatively by altering the gas concentration and/or the pressure of the gas flowing into the membrane cage.
    Type: Grant
    Filed: March 17, 1986
    Date of Patent: September 26, 1989
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventor: Jurgen Lehmann
  • Patent number: 4863848
    Abstract: The invention concerns a double-stranded recombinant DNA cloning vector comprising one single insertion site for foreign DNA and one or two labelling sites adjacent or approximate to said insertion site. In the instance of two labelling sites, said sites flank the insertion site. The labelling site(s) can be individually labelled in a fashion that results in the labelling of the 3' end of either strand. The use of the invention in a process affords the ability to individually label only one strand at the 3' end in a simplified method for base sequencing analysis.
    Type: Grant
    Filed: April 7, 1986
    Date of Patent: September 5, 1989
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Helmut Blocker, Ronald Frank, Guido Volckaert
  • Patent number: 4845222
    Abstract: Pyocyanine compounds of the formula: ##STR1## wherein R.sup.1 represents one of the formula --C.sub.1-10 -alkylene-CO.sub.2 -C.sub.1-5 -alkyl;--C.sub.1-10 -alkylene-CO.sub.2 H; and ##STR2## R.sup.2 represents hydrogen or C.sub.1-2 -alkyl and R.sup.1 is attached to the 7 or 8 aromatic ring position. The compounds are useful antibiotics.
    Type: Grant
    Filed: July 29, 1987
    Date of Patent: July 4, 1989
    Assignee: Gesellschaft fur Biotechnologische Forschung mbh (GBF)
    Inventors: Michael Morr, Christel Kakoschke, Hsin Tsai, Rita Getzlaff
  • Patent number: 4826764
    Abstract: The invention concerns the intercistronic DNA sequence of the atp operon of Escherichia coli for the subunit c of the ATP synthase, a DNA structure and an expression vector which are characterized by the said intercistronic DNA sequence, and a process for the production of proteins using the same. The DNA sequence enhances the rate of synthesis of the proteins.
    Type: Grant
    Filed: July 17, 1985
    Date of Patent: May 2, 1989
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventor: Walter Sebald
  • Patent number: 4689405
    Abstract: The present invention relates to a process for the simultaneous synthesis of several oligonucleotides on a solid phase by using supports of flat material. Finally, the present invention relates to an apparatus for carrying out said process.
    Type: Grant
    Filed: January 4, 1984
    Date of Patent: August 25, 1987
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Ronald Frank, Wiebke Heikens
  • Patent number: 4689407
    Abstract: The invention relates to 2'-deoxy-3'-phosphonylmethyl nucleosides that are not substituted in the 2'-position.
    Type: Grant
    Filed: March 2, 1984
    Date of Patent: August 25, 1987
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Michael Morr, Christel Kakoschke, Hans-Joachim Fritz
  • Patent number: 4686183
    Abstract: The invention relates to a process for the manufacture of p-menth-8-ene-1,2-diol by the microbiological conversion of limonene in the presence of various fungi.
    Type: Grant
    Filed: October 17, 1983
    Date of Patent: August 11, 1987
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Wolf-Rainer Abraham, Burkhard Stumpf, Klaus Kieslich
  • Patent number: 4663039
    Abstract: Oil polluted water or solid adsorbents are treated with microbially produced glycolipids to separate the oil phase. The treatment may be carried out in an apparatus which can be taken to the site and which comprises a mixing vessel supported by an undercarriage and provided with a storage container to supply the glycolipids, filling means, overflow discharge means and outlet means at its base.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: May 5, 1987
    Assignees: Wintershall Aktiengesellschaft, Gesellschaft fur Biotechnologische Forschung
    Inventors: Walter Lindorfer, Walther Schulz, Fritz Wagner, Wilhelm Jahn-Held
  • Patent number: 4605620
    Abstract: The invention relates to a process for fermenting carbohydrate- and phosphate-containing liquid media with limitation of phosphate with bacteria capable of forming butanol, acetone and/or ethanol as fermentation products performed with a total phosphate content in the medium of 1.0 to 0.4 mmoles.
    Type: Grant
    Filed: November 16, 1982
    Date of Patent: August 12, 1986
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Wolfram Andersch, Hubert Bahl, Gerhard Gottschalk
  • Patent number: 4443594
    Abstract: A process for the production of adenine ring system containing co-enzymes bound to a macro-molecular carrier comprising the steps of alkylating an adenine ring system containing co-enzyme in the 1 position with an alkylating agent containing a terminal group capable of reacting with said macro-molecular carrier selected from the group consisting of carboxyl, amine and vinyl, reacting said alkylated co-enzyme with a macro-molecular carrier having groups capable of reacting with said terminal groups, subjecting said alkylated co-enzyme bound to a macro-molecular carrier to a Dimroth rearrangement into the N.sup.6 -form of alkylation, and recovering said adenine ring system containing co-enzyme bound to a macro-molecular carrier.
    Type: Grant
    Filed: September 8, 1981
    Date of Patent: April 17, 1984
    Assignee: Gesellschaft fur biotechnologische forschung mbH (GBF)
    Inventor: Andreas Buckmann
  • Patent number: 4437993
    Abstract: A method and process for preventing the penetration and/or adhesion of hydrocarbons such as crude oil or mineral oil-hydrocarbons into or respectively on objects. The natural and/or constructed objects are sprayed with an aqueous solution and/or dispersion of glycolipids resulting in a thin layer covering the object. A hydrocarbon composition can contact the sprayed object and the resulting hydrocarbon; containing mass can be removed with a pressurized water jet. Various ways exist for degrading or separating the hydrocarbons from the run-off. Preferably the aqueous solution and/or dispersion is treated with ultrasonics before being applied to the surfaces of the objects.
    Type: Grant
    Filed: September 21, 1981
    Date of Patent: March 20, 1984
    Assignees: Wintershall AG, Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Walter Lindorfer, Fritz Wagner, Walther Schulz
  • Patent number: 4432921
    Abstract: A process in which phenolic substances, particularly lignin sulfonate, are used to produce a binder for wood materials. The phenolic substance is activated by displacing it with enzymes. Phenolic groups of the phenolic substance become oxidatively polymerized by a radical mechanism, so that the phenolic substance is changed into an active binder.
    Type: Grant
    Filed: October 7, 1981
    Date of Patent: February 21, 1984
    Assignee: Gesellschaft fur Biotechnologische Forschung
    Inventors: Annegret Haars, Aloys Huttermann
  • Patent number: 4416830
    Abstract: This invention relates to phosphorus-containing compounds having the formula: ##STR1## wherein A=O or S, Z=O or S and X and Y=various substituents.
    Type: Grant
    Filed: March 3, 1981
    Date of Patent: November 22, 1983
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Michael Morr, Maria-Regina Kula
  • Patent number: 4407947
    Abstract: A process for obtaining metal-free corrinoids consisting of inoculating a culture media free of added compounds of metals of the VIIIth group of the Periodic Table with a parent strain of Rhodopseudomonas, cultivating under illumination, repeating the steps of inoculating and cultivating employing said culture media and said illumination employing a part of the sequential culture from the preceding stage as an inoculum in each subsequent state, for a series of several pre-production culture stages, inoculating said culture media with the preceding sequential culture for the last time, cultivating under illumination, separating the microorganism from the culture media of the production culture stage and isolating metal-free corrinoids from the culture media of the production culture stage.
    Type: Grant
    Filed: September 14, 1981
    Date of Patent: October 4, 1983
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Volker Koppenhagen, Gerhard Schlingmann, Bernd Dresow, Ludwig Bischoff, Rosemarie Penkert, Eicke Siefert
  • Patent number: 4392892
    Abstract: Oils or petroleum hydrocarbons are separated from solid or solid/liquid mixtures thereof with soil, sand or oil processing residues, by treating these oil-containing mixtures with an aqueous solution or dispersion of a crude extract of microbially produced glycolipids and separating the oil-containing phase from the aqueous phase.
    Type: Grant
    Filed: September 18, 1981
    Date of Patent: July 12, 1983
    Assignees: Wintershall Aktiengesellschaft, Gesellschaft fur Biotechnologische Forschung
    Inventors: Fritz Wagner, Walter Lindorfer, Wilhelm Jahn-Held, Walther Schulz