Patents Assigned to Gesellschaft fur Biotechnologische Forschung
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Patent number: 4987149Abstract: Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.Type: GrantFiled: February 23, 1990Date of Patent: January 22, 1991Assignees: Gesellschaft fur Biotechnologische Forschung mbH, Braunschweig, Ciba-Geigy CorporationInventors: Bettina Bohlendorf, Norbert Bedorf, Gerhard Hofle, Dietmar Schummer, Marius Sutter
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Patent number: 4954517Abstract: A macrocyclic compound of the formula I, ##STR1## in which the substituents have the following meaning: X is hydrogen or methyl, Y is hydrogen, --CHO, --COCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 NH.sub.2, benzyl, methyl or a silyl group, and A--B--C is the following C.sub.3 -chain members: ##STR2## in which R.sub.1, R.sub.2 and R.sub.3, independently of one another, are hydrogen, methyl, --CHO, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 OCH.sub.3, --COCH.sub.2 NH.sub.2 or a silyl group, and R.sub.4 and R.sub.5 are hydrogen, halogen or --COO(C.sub.1 --C.sub.3) alkyl, is suitable for controlling and preventing plant diseases. A compound of this type can be employed in a customary manner in the form of plant-protecting agents formulated with carrier substances and extenders.Type: GrantFiled: September 8, 1989Date of Patent: September 4, 1990Assignees: Gesellschaft fur Biotechnologische Forschung mbH, Ciba-Geigy CorporationInventors: Marius Sutter, Bettina Bohlendorf, Norbert Bedorf, Gerhard Hofle
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Patent number: 4940804Abstract: Derived macrocyclic compounds of the formula I ##STR1## where R is hydrogen, methyl or certain acyl groups, the dotted line in the 9,10-position is a saturated bond or, in the event that R is methyl, is also a double bond, and X is a keto group, or a substituted or unsubstituted oxime, hydrazone or semicarbazone, represent effective microbicides for controlling plant diseases. They can be employed in the customary formulation as agrochemical agents.Type: GrantFiled: September 8, 1989Date of Patent: July 10, 1990Assignees: Gesellschaft fur Biotechnologische Forschung mbH, Ciba-Geigy CorporationInventors: Bettina Bohlendorf, Norbert Bedorf, Gerhard Hofle, Dietmar Schummer, Marius Sutter
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Patent number: 4879234Abstract: The invention relates to a process for the purification and, if desired, recovery of formate-dehydrogenase (FDH) from Candida boidinii, in which FDH is subjected to a phase distribution in an aqueous 2-phase system that contains a triazine dyestuff that is bonded to an inert water-soluble polymer.Type: GrantFiled: July 30, 1986Date of Patent: November 7, 1989Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Arno Cordes, Maria-Regina Kula, Karl-Heinz Kroner, Wolfgang Stach
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Patent number: 4877734Abstract: A microbiologically produced .alpha.-acetylamino cinnamic acid acylase and a method for its production from Brevibacterium species NCIB 12246 or NCIB 12247. The new enzyme can be used as constituent of a coupled enzyme system for enzymatic conversions which run via the intermediary stage .alpha.-imino-.beta.-phenylpropionic acid or phenylpyruvic acid.Type: GrantFiled: June 26, 1987Date of Patent: October 31, 1989Assignee: Degussa Aktiengesellschaft and Gesellschaft fur biotechnologische Forschung-mit beschrankter Haftung GBFInventors: Maria-Regina Kula, Werner Hummel, Horst Schutte, Wolfgang Leuchtenberger
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Patent number: 4870018Abstract: In a process and an apparatus for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures, in which process and apparatus a gas exchange occurs across an immersed membrane sheet, to achieve simple, effective and as uniform as possible a distribution of the gas introduction and gas desorption without mechanical damage to the liquid constituents, a tubular membrane cage formed by hollow membrane filaments is suspended flexibly in the medium to be gassed and moved in a circular oscillating movement without true rotation. The gassing rate is controlled by altering the angular oscillating movement frequency and/or the radius of the circular path, or alternatively by altering the gas concentration and/or the pressure of the gas flowing into the membrane cage.Type: GrantFiled: March 17, 1986Date of Patent: September 26, 1989Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventor: Jurgen Lehmann
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Patent number: 4863848Abstract: The invention concerns a double-stranded recombinant DNA cloning vector comprising one single insertion site for foreign DNA and one or two labelling sites adjacent or approximate to said insertion site. In the instance of two labelling sites, said sites flank the insertion site. The labelling site(s) can be individually labelled in a fashion that results in the labelling of the 3' end of either strand. The use of the invention in a process affords the ability to individually label only one strand at the 3' end in a simplified method for base sequencing analysis.Type: GrantFiled: April 7, 1986Date of Patent: September 5, 1989Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Helmut Blocker, Ronald Frank, Guido Volckaert
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Patent number: 4845222Abstract: Pyocyanine compounds of the formula: ##STR1## wherein R.sup.1 represents one of the formula --C.sub.1-10 -alkylene-CO.sub.2 -C.sub.1-5 -alkyl;--C.sub.1-10 -alkylene-CO.sub.2 H; and ##STR2## R.sup.2 represents hydrogen or C.sub.1-2 -alkyl and R.sup.1 is attached to the 7 or 8 aromatic ring position. The compounds are useful antibiotics.Type: GrantFiled: July 29, 1987Date of Patent: July 4, 1989Assignee: Gesellschaft fur Biotechnologische Forschung mbh (GBF)Inventors: Michael Morr, Christel Kakoschke, Hsin Tsai, Rita Getzlaff
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Patent number: 4826764Abstract: The invention concerns the intercistronic DNA sequence of the atp operon of Escherichia coli for the subunit c of the ATP synthase, a DNA structure and an expression vector which are characterized by the said intercistronic DNA sequence, and a process for the production of proteins using the same. The DNA sequence enhances the rate of synthesis of the proteins.Type: GrantFiled: July 17, 1985Date of Patent: May 2, 1989Assignee: Gesellschaft fur Biotechnologische Forschung mbHInventor: Walter Sebald
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Patent number: 4689405Abstract: The present invention relates to a process for the simultaneous synthesis of several oligonucleotides on a solid phase by using supports of flat material. Finally, the present invention relates to an apparatus for carrying out said process.Type: GrantFiled: January 4, 1984Date of Patent: August 25, 1987Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Ronald Frank, Wiebke Heikens
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Patent number: 4689407Abstract: The invention relates to 2'-deoxy-3'-phosphonylmethyl nucleosides that are not substituted in the 2'-position.Type: GrantFiled: March 2, 1984Date of Patent: August 25, 1987Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Michael Morr, Christel Kakoschke, Hans-Joachim Fritz
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Patent number: 4686183Abstract: The invention relates to a process for the manufacture of p-menth-8-ene-1,2-diol by the microbiological conversion of limonene in the presence of various fungi.Type: GrantFiled: October 17, 1983Date of Patent: August 11, 1987Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Wolf-Rainer Abraham, Burkhard Stumpf, Klaus Kieslich
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Patent number: 4663039Abstract: Oil polluted water or solid adsorbents are treated with microbially produced glycolipids to separate the oil phase. The treatment may be carried out in an apparatus which can be taken to the site and which comprises a mixing vessel supported by an undercarriage and provided with a storage container to supply the glycolipids, filling means, overflow discharge means and outlet means at its base.Type: GrantFiled: March 8, 1982Date of Patent: May 5, 1987Assignees: Wintershall Aktiengesellschaft, Gesellschaft fur Biotechnologische ForschungInventors: Walter Lindorfer, Walther Schulz, Fritz Wagner, Wilhelm Jahn-Held
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Patent number: 4605620Abstract: The invention relates to a process for fermenting carbohydrate- and phosphate-containing liquid media with limitation of phosphate with bacteria capable of forming butanol, acetone and/or ethanol as fermentation products performed with a total phosphate content in the medium of 1.0 to 0.4 mmoles.Type: GrantFiled: November 16, 1982Date of Patent: August 12, 1986Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Wolfram Andersch, Hubert Bahl, Gerhard Gottschalk
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Patent number: 4443594Abstract: A process for the production of adenine ring system containing co-enzymes bound to a macro-molecular carrier comprising the steps of alkylating an adenine ring system containing co-enzyme in the 1 position with an alkylating agent containing a terminal group capable of reacting with said macro-molecular carrier selected from the group consisting of carboxyl, amine and vinyl, reacting said alkylated co-enzyme with a macro-molecular carrier having groups capable of reacting with said terminal groups, subjecting said alkylated co-enzyme bound to a macro-molecular carrier to a Dimroth rearrangement into the N.sup.6 -form of alkylation, and recovering said adenine ring system containing co-enzyme bound to a macro-molecular carrier.Type: GrantFiled: September 8, 1981Date of Patent: April 17, 1984Assignee: Gesellschaft fur biotechnologische forschung mbH (GBF)Inventor: Andreas Buckmann
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Patent number: 4437993Abstract: A method and process for preventing the penetration and/or adhesion of hydrocarbons such as crude oil or mineral oil-hydrocarbons into or respectively on objects. The natural and/or constructed objects are sprayed with an aqueous solution and/or dispersion of glycolipids resulting in a thin layer covering the object. A hydrocarbon composition can contact the sprayed object and the resulting hydrocarbon; containing mass can be removed with a pressurized water jet. Various ways exist for degrading or separating the hydrocarbons from the run-off. Preferably the aqueous solution and/or dispersion is treated with ultrasonics before being applied to the surfaces of the objects.Type: GrantFiled: September 21, 1981Date of Patent: March 20, 1984Assignees: Wintershall AG, Gesellschaft fur Biotechnologische Forschung mbHInventors: Walter Lindorfer, Fritz Wagner, Walther Schulz
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Patent number: 4432921Abstract: A process in which phenolic substances, particularly lignin sulfonate, are used to produce a binder for wood materials. The phenolic substance is activated by displacing it with enzymes. Phenolic groups of the phenolic substance become oxidatively polymerized by a radical mechanism, so that the phenolic substance is changed into an active binder.Type: GrantFiled: October 7, 1981Date of Patent: February 21, 1984Assignee: Gesellschaft fur Biotechnologische ForschungInventors: Annegret Haars, Aloys Huttermann
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Patent number: 4416830Abstract: This invention relates to phosphorus-containing compounds having the formula: ##STR1## wherein A=O or S, Z=O or S and X and Y=various substituents.Type: GrantFiled: March 3, 1981Date of Patent: November 22, 1983Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Michael Morr, Maria-Regina Kula
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Patent number: 4407947Abstract: A process for obtaining metal-free corrinoids consisting of inoculating a culture media free of added compounds of metals of the VIIIth group of the Periodic Table with a parent strain of Rhodopseudomonas, cultivating under illumination, repeating the steps of inoculating and cultivating employing said culture media and said illumination employing a part of the sequential culture from the preceding stage as an inoculum in each subsequent state, for a series of several pre-production culture stages, inoculating said culture media with the preceding sequential culture for the last time, cultivating under illumination, separating the microorganism from the culture media of the production culture stage and isolating metal-free corrinoids from the culture media of the production culture stage.Type: GrantFiled: September 14, 1981Date of Patent: October 4, 1983Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)Inventors: Volker Koppenhagen, Gerhard Schlingmann, Bernd Dresow, Ludwig Bischoff, Rosemarie Penkert, Eicke Siefert
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Patent number: 4392892Abstract: Oils or petroleum hydrocarbons are separated from solid or solid/liquid mixtures thereof with soil, sand or oil processing residues, by treating these oil-containing mixtures with an aqueous solution or dispersion of a crude extract of microbially produced glycolipids and separating the oil-containing phase from the aqueous phase.Type: GrantFiled: September 18, 1981Date of Patent: July 12, 1983Assignees: Wintershall Aktiengesellschaft, Gesellschaft fur Biotechnologische ForschungInventors: Fritz Wagner, Walter Lindorfer, Wilhelm Jahn-Held, Walther Schulz