Patents Assigned to Gesellschaft fur Biotechnologische Forschung
  • Patent number: 4374735
    Abstract: Oil polluted water or solid adsorbents are treated with microbially produced glycolipids to separate the oil phase. The treatment may be carried out in an apparatus which can be taken to the site and which comprises a mixing vessel supported by an undercarriage and provided with a storage container to supply the glycolipids, filling means, overflow discharge means and outlet means at its base.
    Type: Grant
    Filed: June 11, 1980
    Date of Patent: February 22, 1983
    Assignees: Wintershall Aktiengesellschaft, Gesellschaft fur Biotechnologische Forschung
    Inventors: Walter Lindorfer, Walther Schulz, Fritz Wagner, Wilhelm Jahn-Held
  • Patent number: 4343735
    Abstract: The invention concerns a process for the purification of interferon, where interferon is purified by partitioning interferon in an aqueous multi-phase system in the presence of ion exchangers that are soluble in this system and that are derivatives of polyethers.
    Type: Grant
    Filed: October 23, 1980
    Date of Patent: August 10, 1982
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH (GBF)
    Inventors: Ulrich Menge, Michael Morr, Maria-Regina Kula, Kristin Anastassiadis
  • Patent number: 4311643
    Abstract: A process for producing red metal corrinoids comprising reacting yellow metal-free corrinoids having main absorptions .lambda..sub.max of 480 and 290 nm, in a liquid medium, with complex-forming metal ions to give yellow metal corrinoids, and alkalizing said metal corrinoids by treatment with an alkali.
    Type: Grant
    Filed: March 4, 1980
    Date of Patent: January 19, 1982
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Volker Koppenhagen, Gerhard Schlingmann, Bernd Dresow, Ortrud Ebelmann
  • Patent number: 4304863
    Abstract: The present invention is directed to a process for the production of hybrid bacteria, characterized in that(a) a hybrid plasmid having only one cos site of a lambda or a lambdoid phage is produced from (1) a bacterial plasmid of not more than 21 Megadaltons and having only one cos site of a lambda or a lambdoid phage and (2) a foreign DNA fragment,(b) the resulting hybrid plasmid is packaged with the lysate of a lambda or lambdoid phage and(c) the packaging product is transduced into Escherichia coli whereby hybrid bacteria are formed.
    Type: Grant
    Filed: March 30, 1979
    Date of Patent: December 8, 1981
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: John Collins, Barbara Hohn
  • Patent number: 4305036
    Abstract: A nuclear magnetic resonance line broadened by an inhomogeneous magnetic field can be narrowed by rotating the sample. This, however, produces rotational side bands having a frequency equal to the frequency of a main signal plus/minus integer multiples of the speed of rotation. The generation of such spurious rotational side bands is avoided by varying the speed of rotation of the sample within a predetermined range of speeds. The lower limit of said range should be high enough to provide for narrowing the nuclear magnetic resonance lines by rotating the sample.
    Type: Grant
    Filed: July 9, 1979
    Date of Patent: December 8, 1981
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Ludger Ernst, David N. Lincoln, Viktor Wray
  • Patent number: 4286660
    Abstract: A process and installation for the flooding of petroleum deposits and oil shale and, more particularly, through the use of dispersions of non-ionogenic, boundary surface-active materials in water as the flooding medium. For the flooding of petroleum-hydrocarbon materials from petroleum deposits and oil shale there can be utilized dispersions of non-ionogenic, boundary surface-active glycolipids, and such preferred structures can be employed which are produced from hydrocarbon mixtures as the C-source. This is effected in two stages with predetermined technological measures. In the first stage, there are initially produced glycolipids through microorganisms with alkane mixtures under predetermined parameters in semi- or continual process cycles and, in the second stage, separated from the cellular material through temperature, pH, osmotic shock. The formed glycolipids can also be separated from the cellular material with unpolarized, organic solvent media.
    Type: Grant
    Filed: March 23, 1979
    Date of Patent: September 1, 1981
    Assignees: Gesellschaft fur Biotechnologische Forschung GmbH, Wintershall Aktiengesellschaft
    Inventors: Fritz Wagner, Peter Rapp, Hans Bock, Walter Lindorfer, Walther Schulz, Wilhelm Gebetsberger
  • Patent number: 4284509
    Abstract: After physical removal of the majority of the oil on the surface of the water, the thin film remaining is treated with microbial metabolites which reduce the surface and interface tension and cause the formation of oil agglomerates. These agglomerates may be drawn off or left to be degraded by hydrocarbon-degrading microorganisms normally present in the sea water or added thereto.
    Type: Grant
    Filed: November 15, 1979
    Date of Patent: August 18, 1981
    Assignee: Gesellschaft fur Biotechnologische Forschung
    Inventors: Walter Lindorfer, Fritz Wagner, Wilhelm Jahn-Held, Walther Schulz
  • Patent number: 4248712
    Abstract: An electrode device having an electrolyte container separated from the test medium by a membrane member, a cathode within the electrolyte container having the shape of the end section of a precious metal conductor protruding from an insulating body and a reference electrode being provided within the electrolyte container characterized in that the electrolyte container is sealed as a pressure chamber during sterilization whereby the pressure on each side of the membrane member remains substantially the same during sterilization.
    Type: Grant
    Filed: January 8, 1979
    Date of Patent: February 3, 1981
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventor: Gerd D. Bauermeister
  • Patent number: 4191469
    Abstract: The specification describes an interference optical measuring or sensing device, comprising a light source, a beam splitter, two component light paths and a radiation sensor for a multiple hole centrifuge rotor. When the rotor is in motion sample cells and the counter-weight move successively through the component light paths and at a particular position have both light paths extending through them. There is furthermore an arrangement for producing a position signal indicating that a selected hole is in a certain position in which it has both component light paths extending through it. A control arrangement ensures that the measuring device is activated briefly in the predetermined position of the selected hole. The light source continuously supplies light between the periods of activation of the measuring device.
    Type: Grant
    Filed: December 28, 1977
    Date of Patent: March 4, 1980
    Assignee: Gesellschaft fur biotechnologische Forschung m.b.H.
    Inventors: Josef Flossdorf, Henning Schillig, Klaus-Peter Schindler
  • Patent number: 4144130
    Abstract: A process for the recovery of enzymes from intact cells and cell fragments by means of partition in a multiphase system without prior separation of the cell liquid, cell fragments or the cells is described.
    Type: Grant
    Filed: April 14, 1977
    Date of Patent: March 13, 1979
    Assignee: Gesellschaft fur Biotechnologische Forschung
    Inventors: Maria-Regina Kula, Karl-Heinz Kroner, Wolfgang Stach, Helmut Hustedt, Andija Durekovic, Stefica Grandja
  • Patent number: 4064011
    Abstract: ECoRI restriction endonuclease is produced with certain mutant strains of E.coli which are not antibiotic resistant and do produce the said enzyme which is obtained from the E.coli mutant cells without destroying the cells by extraction procedures.
    Type: Grant
    Filed: March 16, 1977
    Date of Patent: December 20, 1977
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH
    Inventors: Hubert Mayer, Horst Schutte
  • Patent number: 4060455
    Abstract: L-serine is produced by aerobic cultivation of Pseudomonas Sp. DSM 672, or mutants thereof, in a nutrient medium including methanol and glycine.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: November 29, 1977
    Assignee: Gesellschaft fur Biotechnologische Forschung mbH, (GBF)
    Inventors: Fritz Wagner, Hermann Sahm, Walter Hartmut Keune