Abstract: A system and method may allow displaying a plurality of image streams, where the image streams may be divided, for example into a number of selected subset couplet images which follow predetermined criteria. According to some embodiments, each couplet may be displayed simultaneously or substantially simultaneously. A workstation may accept the images acquired by, for example a capsule and may display the images on a monitor as a moving image.

Abstract: An in vivo device for sensing a lumen such as the GI tract, such as an in vivo imaging device or other sensing device, may include a substantially spherical housing and an oblong appendage attached to the housing. The appendage may be detached in vivo, for example in the stomach. The in vivo device may then roll and glide along a stomach wall to provide, for example, a smooth sampled image stream.

Abstract: A system and method may display an image stream, where an original image stream may be divided into two or more subset images streams, each subset image stream being displayed simultaneously or substantially simultaneously. Post processing may be used to fuse images shown simultaneously or substantially simultaneously. The images may be collected from an ingestible capsule traversing the GI tract.

Abstract: Provided are a system and method for in vivo and in situ detection of body lumen conditions. The system comprises at least one interaction chamber for containing an endo-luminal sample, the interaction chamber comprising at least one indicator; at least one light source for illuminating the interaction chamber; and at least one optical detector for detecting in vivo optical changes occurring in the interaction chamber. The reaction between the indicator and sample may result in an optical change, which is detected and possibly imaged by the optical detector.

Abstract: An in vivo device and a method for collecting and measuring oximetry data in a body lumen, such as using a swallowable capsule. The in vivo device may include instruments for collecting oximetry data, for example an illuminator and an oximetry data detector.

Abstract: The present invention provides an optical system for illuminating and viewing a target in which an illumination element and a receiving means are disposed behind a single optical window, and which obtains data essentially free of backscatter and stray light. The optical window of the optical system is configured such that it defines a shape having at least one focal curve, i.e., an ellipsoid shaped dome. The illumination element and the receiving means are geometrically positioned on the focal curve plane or in proximity of the focal curve plane, such that, when illuminating, rays from the illumination elements, that are internally reflected from the optical window, will not be incident on the receiving means.

Abstract: Devices, systems and method for in vivo analysis. For example, an in vivo device includes: a reaction chamber to store a detecting reagent able to react with a sample collected in vivo; and optionally a labeled-substance chamber to store a labeled substance able to bind to at least a portion of a compound resulting from a reaction of the detecting reagent and the sample.

Abstract: An autonomous in vivo sensing device may include a polarizing filter to polarize light emitted by an illumination unit, and to block light specularly reflected from a turbid media from reaching an imager of such device. An autonomous in vivo sensing device with monochromatic illumination units to alternatingly illuminate a target area with light of different wavelengths, and to subtract an image illuminated by light in a first wavelength from an image illuminated by light in a second wavelength, to produce an image of a sub-surface layer of such target area.

Abstract: A device, system and method of in-vivo analysis. An in-vivo device may include a chromatography unit to interact in-vivo with a body lumen substance, and a sensor to sense in-vivo a property of the chromatography unit.

Abstract: A device, system, and method for reducing image data using spatially varying reduction are described. Images may be captured from an in-vivo device, while the reduced images may be transmitted via wireless communications. Reduction may be achieved by selecting a spatial area of interest on an image frame, dividing the spatial area of interest into one or more sub-regions, reducing each sub-region by a defined reduction ratio according to the spatial properties of said sub-region, and transmitting image data from spatial area of interest.

Abstract: The present invention provides an optical system for illuminating and viewing a target in which an illumination element and a receiving means are disposed behind a single optical window, and which obtains data essentially free of backscatter and stray light. The optical window of the optical system is configured such that it defines a shape having at least one focal curve, i.e., an ellipsoid shaped dome. The illumination element and the receiving means are geometrically positioned on the focal curve plane or in proximity of the focal curve plane, such that, when illuminating, rays from the illumination elements, that are internally reflected from the optical window, will not be incident on the receiving means.

Abstract: The present invention is a method for activating an image collecting process (step 34), comprising the steps of releasing the power source of a component essential to the image collecting process from an inhibition imposed by an external magnet, wherein the invention also provides suitable packaging for storing the imaging system having a magnet, designed for the inside of a body lumen.

Abstract: A device and method for operating an in vivo imaging device (10A) wherein the illumination produced by the device may be varied in intensity and/or duration, and/or the gain level or other parameters may be varied, according to, for example, the amount of illumination produced by the device which is reflected back to the device. In addition, a method is provided for detecting problematic pixels in an imaging device. This method may define and exclude non-functional pixels, based on for example an initial short exposure that enables a threshold saturation level to be reached only for problematic pixels. Moreover, a method is described for determining when an in vivo device enters the body, for example by calculating the progress of a dark frame, based on the light saturation threshold of the dark frame.

Abstract: There is provided an imager with, for example, a fiber plate cover capable of transferring to a sensor element an image of a sample that may be close to or in contact with such fiber plate cover, and imaging such sample. An imager may include a fiber plate cover capable of capturing images from a microarray analysis device. There is also provided a method of capturing images with an imager of a sample that is for example in contact with a fiber plate cover on such imager.

Abstract: A device, system and method for in-vivo sensing (e.g., pH sensing, pressure sensing, or other sensing) may include more than one sensor receiving in-vivo data. The sensed data may be analyzed to, for example, determine a gradient or fluid flow. A device including multiple sensors may be held or immobilized in-vivo, and may detect a fluid flow or gradient moving past the sensors.

Abstract: An in-vivo sensing system and a method for creating a summarized graphical presentation of a data stream captured in-vivo. The graphical presentation may be in the form of for example a color bar. The color bar may be a fixed display along side a streaming display of the data stream. A cursor or other indicator may move along the fixed color bar as the data stream is displayed and/or streamed so as to indicate to a health professional what part of the data stream may be currently displayed. The color content in the color bar may map out the data stream and give indication of the location of anatomical sites as well as possible locations of pathology.

Abstract: The present invention relates to a method and system for the in vivo determination of the presence and/or concentration of biological and/or chemical substances in body lumens. The system of the invention comprises a solid support, the support being inserted into a body lumen and having immobilized thereon at least one reactant capable of reacting with the substance resulting in an optical change; and a detecting unit, in communication with the support, capable of detecting a reaction resulting in an optical change between the reactant and the substance.

Abstract: A system and method for measuring and analyzing motility within a body lumen such as the gastrointestinal (GI) tract, where an in vivo imaging device such as a capsule captures images and transmits the images to a processor, which calculates the motility of the device based on comparison of the images. Preferably, the processor compares the intensity of pairs of images or of elements of pairs of images, generates a variance for the compared images, and calculates the motility of the imaging device from the variances. The motility data may be presented to a user in various manners; for example, a plot of motility over time may be generated, or indications of low motility may be presented to the user of the system.

Abstract: The invention relates to an in vivo sensing device having a specific gravity of about 1 or a volume to weight ratio that enables it essentially to float. In one embodiment the in vivo sensing device consists of an image sensor system and a buoyant body. The buoyant body, which is attached to the sensor system or which can optionally house one or more elements of the sensor system, keeps the sensor system essentially floating in a body lumen liquid.