Abstract: A system and method may detect a transition in an image stream captured within a body lumen. One or more parameters may be computed at points corresponding to a time scale of the image stream. Transition in the values of the parameters may be identified and may indicate a location along the body lumen. The image stream may be segmented at the transition points identified.

Abstract: An in vivo imaging device and method, the device including at least one illumination source; at least one image sensor; and at least two optical systems. The optical systems have different depths of focus. A first and second image are focused onto the image sensor.

Abstract: The present invention provides a system and method for obtaining in vivo images. The system contains an imaging system and a transmitter for transmitting signals from a camera to a receiving system located outside a patient.

Abstract: A system for transfer of a signal, such as an energizing signal, to a transmitting in vivo sensing device. The in vivo device includes at least one signal transmitter and at least one signal receiving unit. The system includes an external phased array antenna. The phased array antenna receives a signal from the sensing device and then transmits a signal to the device phased in the reverse order to that of receipt the signal from the sensing device.

Abstract: A system and method for determining the path length through a body lumen, for example to a specified location, is described. A location detection system may identify the location in space of an in-vivo device over time. A path-length detection unit may use data from the location detection system to determine a path traveled by an in-vivo device. A site of interest along that path may be identified. The distance of the site of interest from at least one end point of a body lumen may be determined.

Abstract: A substantially spherical in vivo imaging device may be used for imaging body lumens in the GI tract. The imaging device may include for example a ballast weight for setting a preferred orientation of the device within the body lumen. The substantially spherical shape of the in vivo imaging device may facilitate capturing steady streams of imaging data in large body lumens. A method of manufacture is presented.

Abstract: A lens holder assembly for aligning an optical system over an image sensor is described. The image sensor may be lying on a substrate. The assembly may include a lens holder aperture and at least one centering leg or protrusion which may be detached from the substrate and wherein the centering legs or protrusions may tightly abut or surround the image sensor in order to center the lens holder assembly with respect to the image sensor and to the optical system.

Abstract: An autonomous device that may include for example a camera, a transmitter for transmitting a signal from the camera and a storage compartment for retaining a substance in the device. A method of delivering a medicament to a patient including imaging a gastro intestinal tract with an autonomous device, identifying a target location in such tract, and releasing a medicament from the device at the target location.

Abstract: The present invention relates to a system and method for displaying an image stream captured by an in vivo imaging device and for displaying an image stream in a consolidated manner.

Abstract: An in-vivo device may include an optical system, and a method for viewing in-vivo sites. A dome or cover may cover an end of the device, protecting optical elements such as illumination devices or imagers, which may be behind the dome. The dome may be forward projecting and may have a convex shape. The field of view of the imager may be for example forward looking. Illumination element(s) and a receiving unit or imager may be disposed behind a single optical window, which for example may enable obtaining of images free of backscatter and stray light. The convex shape of the dome may be defined such that it may have a shape having an isolated area. At least one illumination element and at least one receiving unit may be geometrically positioned (for example in the isolated area) such that rays from the illumination elements, some of which are internally reflected from the internal and/or external surface of the optical window, will not be incident on the receiving unit.

Abstract: The present invention discloses a system comprising an in vivo imaging device able to transmit in vivo data via a wireless medium, a receiver to receive in vivo data via the wireless medium, input means for entering to the receiver indications by a user, an indication storage unit to store the indications and to store data representing entering time at which the indications was entered by the user and information identifying in vivo data portions corresponding to that entering time, and a display unit to display the indications concurrently with the in vivo data portions corresponding to the entering time at which the indications was entered. The indications entered by the user may be indicative of activities of the user, condition of the user, environmental conditions next to the user and the like.

Abstract: The invention provides a device, and method for in vivo imaging, for example, using an in vivo imaging device including a circuit board having rigid sections and flexible sections. The circuit board may include one or more layers and an antenna may be embedded into one or more layers.

Abstract: An in vivo imaging device with a curved reflective element and for example a concave portion of an outer shell of such device. Such curved reflective element may for example reflect onto an image sensor light rays from an object where such light rays before reflection are substantially parallel to the plane of the image sensor. An in vivo imaging device with a reflective surface situated at an angle to an image sensor of such imaging device. Such an angle may be for example a 45 degree angle so that light rays that are substantially parallel to a plain of an image sensor of an imaging device may for example be reflected by the reflective surface onto the image sensor.

Abstract: A system and method for in vivo diagnosis are provided. A composition including for example a radioactive marking agent and a pharmaceutically acceptable carrier is administered to a patient and an autonomous in vivo device, which may include for example an illumination source an image sensor and a radiation and/or light detector, is used to for example facilitate the difference between. normal and pathological cells in a body lumen.

Abstract: A modulator including a direct modulation synthesizer circuit, a reference frequency oscillator for providing an input reference signal to the direct modulation synthesizer circuit for locking a carrier frequency to a stable frequency and a pre-emphasis unit for data bits and for producing a modulating signal for direct modulation of the direct modulation synthesizer circuit, the modulating signal having data bit dependent voltage levels.

Abstract: The present invention relates to a method for activating an image collecting process, comprising the step of releasing the power source of a component essential to the image collecting process from an inhibition imposed by an external magnet. In an embodiment of the invention the image collecting process is designed to image the insides of a body lumen. The present invention further relates to a packaging suitable for storing therein an imaging system, said package comprising a magnet. The imaging system comprises components essential to an image collecting process, said components operable in accordance with the invention.

Abstract: A system and method to model a tracking curve of an in-vivo device capturing in-vivo data of the colon is provided. Data analysis is performed on a raw tracking curve to identify one or more milestone data points that correspond to defined locations in the colon. A modeled path may be defined between and along the selected milestone data points. Raw tracking curve data may be translated to modeled data along the modeled path. The modeled tracking curve may be displayed alongside a streaming display of captured in-vivo image frames of the colon.

Abstract: An in vivo imaging device may include a capsule shaped housing and an image sensor. The capsule shaped housing may have a longitudinal axis and a window. The image sensor (e.g., a CMOS sensor) may include a pixel array portion and a circuitry portion. The circuitry portion may be segregated, for example longitudinally, from the pixel array portion. The pixel array portion may be disposed within said housing substantially parallel to said longitudinal axis. A light deflecting element disposed at an angle smaller than 45 degrees with respect to the pixel array portion introduces image distortion which is compensated by a distortion compensation mechanism.

Abstract: A moveable in vivo device comprises a device body and at least one moveable appendage that is moveably coupled the device body such that movement of the moveable appendage causes the device body to move in a body lumen.