Patents Assigned to Governors of the University of Alberta
  • Patent number: 9261423
    Abstract: A three-axis load sensor utilizing four piezoresistive devices on a flexible silicon membrane is provided. The load sensor further includes a mesa disposed on the membrane substantially equidistant from the piezoresistive devices. A six-axis load cell is provided by placing a plurality of load sensors disposed on a substrate, the substrate configured to attach to an object wherein forces applied to the object can be measured and/or determined. The load sensors can be manufactured using bulk microfabrication techniques on a single crystal silicon wafer, and can detect normal and shear loading applied to the membrane.
    Type: Grant
    Filed: February 7, 2012
    Date of Patent: February 16, 2016
    Assignee: The Governors of the University of Alberta
    Inventors: David Benfield, Walied Ahmed Mohamed Moussa
  • Publication number: 20160039902
    Abstract: CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.
    Type: Application
    Filed: August 4, 2015
    Publication date: February 11, 2016
    Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Nathan Klapoetke, Brian Yichiun Chow, Edward Boyden, Gane Ka-Shu Wong, Yongku Peter Cho
  • Patent number: 9249266
    Abstract: Micro- and nano-sized particles, agglomerates and fibers are generated from high molecular weight water-soluble biopolymers applying supercritical fluid technology. A method of producing micro- or nanoparticles from an aqueous solution of a high molecular weight biopolymer includes the step of spraying the aqueous solution together with a mixture of a compressible gas and a water-soluble co-solvent/antisolvent into a pressurized chamber. The method may be adapted to impregnate the micro- or nanoparticles with a bioactive material. A method for microencapsulating a bioactive material with a biopolymer is also provided.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: February 2, 2016
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Feral Temelli, Bernhard Seifried
  • Patent number: 9250119
    Abstract: An apparatus and method is provided for characterizing adhesive bonding using an acoustic wave MEMS sensor. The sensor can consist of a silicon substrate, a thin aluminum nitride film on top of the substrate and a thin gold film above the aluminum nitride layer. An adhesive layer is added on top of the sensor and the dispersion property of acoustic waves in the layered configuration can be utilized for bonding integrity characterization. A wave dispersion model is developed to study the effect of changing the interface stiffness on the wave dispersion profile and to investigate the sensitivity of different sensor configurations. The results of the model illustrate that the dispersion profile shifts in the direction of decreasing wave velocity as the interface stiffness decreases.
    Type: Grant
    Filed: May 31, 2013
    Date of Patent: February 2, 2016
    Assignees: The Governors of the University of Alberta, Alberta Health Services
    Inventors: Mohamed Mahmoud Taher El Gowini, Walied Ahmed Mohamed Moussa, Edmond Hok Ming Lou
  • Publication number: 20160024394
    Abstract: Described herein are methods for producing branched alkanes and branched alkenes from the pyrolysis of radical precursors in the presence of one or more alkenes. The branched alkanes and branched alkene have numerous applications as fuels, plat form chemicals, and solvents.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventor: David BRESSLER
  • Patent number: 9238830
    Abstract: Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA comprising a gene that produces a protein to be O-glycosylated are used. The PglL-like oligosaccharyltransferase facilitates the covalent attachment of the glycan to the protein to produce the O-glycosylated protein. The methods and systems described herein provide an approach for the design and production of new vaccines and therapeutic agents for the treatment of various diseases.
    Type: Grant
    Filed: December 13, 2007
    Date of Patent: January 19, 2016
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Mario Feldman, Amirreza Faridmoayer
  • Patent number: 9239226
    Abstract: An apparatus for measuring the quantity and optical parameters of a liquid in a container using the principle of optical low coherence reflectometry is provided, the apparatus having: a source arm with a low coherence light source; a reference arm including a reference lens, a mirror, means for adjusting the distance between the reference lens and the mirror and means for measuring the distance between the reference lens and the mirror; a test arm with a test lens; means for dividing the output of the source arm between the test arm and the reference arm; means for combining light reflected back into the reference arm and the test arm to create an interference signal; and means for detecting and analyzing the interference signal.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: January 19, 2016
    Assignee: The Governors of the University of Alberta
    Inventors: Robert Fedosejevs, Ilya Utkin, Sunita Sindhu, Ying Yin Tsui
  • Publication number: 20150379724
    Abstract: A time series of image frames in an anatomical scan is segmented. An image frame k in the time series of image frames is manually segmented. A non-rigid registration is then performed between the image frame k and a next image frame k+1 in the time series of image frames. A segmentation on the image frame k+1 is computed based on the non-rigid registration. Each subsequent image frame k+n in the time series of image frames is iteratively segmented using non-rigid registration with the segmented previous image frame k+(n?1) in the time series of image frames.
    Type: Application
    Filed: June 26, 2015
    Publication date: December 31, 2015
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Michelle Noga, Kumaradevan Punithakumar
  • Patent number: 9221898
    Abstract: An isolated or purified compound is provided, comprising A-GlcNAc[GlcNAc]-GalNAc-GalNAc-QuiNAc4NAc, wherein A is GlcNAc or Glc. There is further provided a vaccine based on such compound, having particular use to treat or prevent an infection caused by a Campylobacter organism. There is also provided an antibody or antisera against the compound, having particular use to diagnose the presence of an infection caused by a Campylobacter organism.
    Type: Grant
    Filed: February 11, 2011
    Date of Patent: December 29, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Christine Szymanski, Harald Nothaft
  • Publication number: 20150369740
    Abstract: Provided herein are variants of an archaerhodopsin useful for application such as optical measurement of membrane potential. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, cells comprising the polynucleotides, and cells comprising the polypeptides; and methods of using the variants.
    Type: Application
    Filed: June 17, 2015
    Publication date: December 24, 2015
    Applicants: President and Fellows of Harvard College, The Governors of the University of Alberta
    Inventors: Adam E. Cohen, Daniel Hochbaum, Peng Zou, Samouil Leon Farhi, Robert Earl Campbell, Yongxin Zhao, Daniel Jed Harrison
  • Patent number: 9216940
    Abstract: A method for preparing polyols from fatty acid substrates such as free fatty acids, alkyl esters of fatty acids, mono-glycerides, diglycerides, and triglycerides. The method comprises the steps of (a) epoxidizing an unsaturated fatty acid substrate and (b) hydroxylating the epoxidized fatty acid substrate with at least one diol to produce a polyol or a blend of polyols. The method may be varied to produce polyols with desired functionality, molecular weights, or viscosity.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: December 22, 2015
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Jonathan Curtis, Guoguang Liu, Tolibjon Omonov, Ereddad Kharraz
  • Publication number: 20150365033
    Abstract: A method and system for controlling the power factor of induction machines connected to power distribution grids are provided. In some embodiments, the method can comprise inserting an adjustable voltage source in series with one or more windings of a grid-connected induction machine such that the adjustable voltage source can be adjusted to manipulate the phase angle of the current flowing through the one or more windings relative to the phase angle of the grid voltage. The system can comprise an adjustable voltage source in series with one or more windings of a grid-connected induction machine such that the adjustable voltage source can be adjusted to manipulate the phase angle of the current flowing through the one or more windings relative to the phase angle of the grid voltage.
    Type: Application
    Filed: January 14, 2014
    Publication date: December 17, 2015
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: John Salmon, Andrew Knight
  • Patent number: 9213945
    Abstract: A quantum device is provided that includes controllably quantum mechanically coupled dangling bonds extending from a surface of a semiconductor material. Each of the controllably quantum mechanically coupled dangling bonds has a separation of at least one atom of the semiconductor material. At least one electrode is provided for selectively modifying an electronic state of the controllably quantum mechanically coupled dangling bonds. By providing at least one additional electron within the controllably quantum mechanically coupled dangling bonds with the proviso that there exists at least one unoccupied dangling bond for each one additional electron present, the inventive device is operable at least to 293 degrees Kelvin and is largely immune to stray electrostatic perturbations. Room temperature operable quantum cellular automata and qubits are constructed thereform.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: December 15, 2015
    Assignees: National Research Council of Canada, The Governors of The University of Alberta
    Inventors: Gino A. Dilabio, Robert A. Wolkow, Jason L. Pitters, Paul G. Piva
  • Publication number: 20150348662
    Abstract: Systems and methods for separation or isolation of technetium radioisotopes from aqueous solutions of radioactive or non-radioactive molybdate salts using a polyalkyl glycol-based cross-linked polyether polymer. Some embodiments can be used for the effective purification of radio-active technetium-99m produced from low specific activity 99Mo.
    Type: Application
    Filed: December 20, 2013
    Publication date: December 3, 2015
    Applicant: The Governors of the University of Alberta, The University of British Columbia, Carleton Unive
    Inventors: Francois BENARD, Kuo-Shyan LIN, Stefan ZEISLER, Milan VUCKOVIC, Paul SCHAFFER
  • Publication number: 20150329686
    Abstract: Biocomposite materials are derived from animal proteins, and, in particular, animal proteins derived from byproducts such as specified risk material. The composite materials are created by embedding a fibrous material with a polymer matrix comprising a hydrolysate from the animal protein and a crosslinking reagent such as an epoxy.
    Type: Application
    Filed: November 6, 2013
    Publication date: November 19, 2015
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: David BRESSLER, Phillip CHOI
  • Patent number: 9176123
    Abstract: This application relates to a binding-induced hairpin detection system comprising: a. a first probe comprising a targeting molecule and an oligonucleotide that has a free end and an end attached to the targeting molecule; and b. a second probe comprising a targeting molecule and an oligonucleotide that has an end attached to the targeting molecule and a free end comprising a nucleotide sequence that is complementary to a nucleotide sequence at or near the free end of the oligonucleotide of the first probe; wherein upon binding of the targeting molecule to a target molecule, the free end of the oligonucleotide of the second probe hybridizes at or near the free end of the oligonucleotide of the first probe forming a hairpin stem, the non-hybridized portions of the first and second probes together with the target molecule bound thereto forming a hairpin loop, thereby providing a binding-induced hairpin.
    Type: Grant
    Filed: August 30, 2010
    Date of Patent: November 3, 2015
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Xiaochun Le, Hongquan Zhang, Xing-Fang Li
  • Patent number: 9150866
    Abstract: A method for single-cycle selection of aptamers is provided. More specifically, a method comprising single-cycle selection of aptamers for proteins blotted on a membrane is provided. In some embodiments, the present methods can comprise a deoxyribonuclease I (DNase I) mediated aptamers selection strategy that may be capable of isolating strong binding aptamers for target proteins from a crude protein extract. Aptamers selected using the present method are further provided. More specifically, the presently selected aptamers may be thermally stable, modifiable and easily produced through single-cycle synthesis process. The present aptamers may provide unique affinity reagents for use in diagnosing and detecting infectious disease (for example Hepatitis B), for research and biochemical studies (e.g. into molecular mechanisms). Further, the present aptamers may be utilized to develop unique assays or kits for clinical application, such as monitoring disease treatment and outcome.
    Type: Grant
    Filed: August 28, 2013
    Date of Patent: October 6, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Xing-Fang Li, X. Chris Le, Yanming Liu
  • Patent number: 9145443
    Abstract: The present invention provides non-naturally occurring polypeptides that specifically bind hepatitis B virus (HBV) DNA; and polynucleotides encoding the polypeptides. The present invention further provides methods of detecting HBV DNA; methods of detecting a covalently closed circular DNA (cccDNA) form of HBV; and methods for treating HBV infection.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: September 29, 2015
    Assignee: The Governors of the University of Alberta
    Inventors: Kimberley Zimmerman, Michael A. Joyce, Karl Fischer, D. Lorne Tyrrell
  • Patent number: 9139553
    Abstract: The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: September 22, 2015
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Afsaneh Lavasanifar, Abdullah Mahmud
  • Publication number: 20150246957
    Abstract: Described herein is insulin, an insulin-like growth factor, parathyroid hormone, a fragment of parathyroid hormone, or a parathyroid hormone related protein that includes at least one bone targeting moiety, wherein the bone targeting moiety is covalently bonded to the peptide. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and preventing bone fractures, and/or the inability to initiate de novo bone turnover and stimulate bone fracture repair.
    Type: Application
    Filed: August 28, 2013
    Publication date: September 3, 2015
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Michael Doschak, Yang Yang, Krishna Hari Bhandari