Patents Assigned to GRÜNENTHAL GMBH
  • Crystalline, anhydrous forms of oxymorphone hydrochloride
    Patent number: 8969368
    Abstract: Crystalline, anhydrous hydrochloride salts of 4,5?-epoxy-3,14-dihydroxy-17-methylmorphinan-6-one (oxymorphone) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a method for the production of such salts, a pharmaceutical composition comprising an effective amount of such a salt and such a salt as a medicament and for the treatment and/or prevention of pain.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: March 3, 2015
    Assignee: Grünenthal GmbH
    Inventors: Andreas Fischer, Dagmar Peters-Groth, Dagmar Lischke
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20150056147
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: October 30, 2014
    Publication date: February 26, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMAEUS, HEINRICH KUGELMANN
  • Combination of selected opioids with muscarine antagonists for treating urinary incontinence
    Patent number: 8946290
    Abstract: Active compound combinations of compounds of group A, particularly opioids such as (+)-(2R,3R)-1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol or a salt thereof with a physiologically tolerated acid, and compounds of group B, particularly anti-muscarine agents such as oxybutynin or a salt thereof with a physiologically tolerated acid suitable for treatment of an increased urge to urinate or urinary incontinence. Related pharmaceutical formulations and methods of treatment of an increased urge to urinate or urinary incontinence are also provided.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: February 3, 2015
    Assignee: Gruenenthal GmbH
    Inventor: Thomas Christoph
  • Substituted phenylureas and phenylamides as vanilloid receptor ligands
    Patent number: 8946204
    Abstract: Substituted phenylureas and phenylamides, processes for their preparation, pharmaceutical compositions containing these compounds, and the use of these compounds for preparing pharmaceutical compositions.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: February 3, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Nils Damann, Sven Frormann, Bernhard Lesch, Derek John Saunders, Jeewoo Lee, Yong-Soo Kim, Myeong-Seop Kim, Hannelore Stockhausen
  • Method for the production of a form of administration of a medicament
    Patent number: 8939748
    Abstract: The present invention relates to a device for cutting a strand to a length with regard to a weight and to the use of such device in a method for producing a medicament dosage form of at least one piece composed of at least one medicament and at least one additive, the medicament and the additive being mixed and extruded from a die as a strand and the strand being cut into pieces of precise weight using the device.
    Type: Grant
    Filed: November 30, 2009
    Date of Patent: January 27, 2015
    Assignee: Grünenthal GmbH
    Inventors: Elisabeth Arkenau-Maric, Johannes Bartholomäus, Dieter Schateikis, Kai-Uwe Ustorf
  • Aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands
    Patent number: 8937092
    Abstract: The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
    Type: Grant
    Filed: September 25, 2012
    Date of Patent: January 20, 2015
    Assignee: Gruenenthal GmbH
    Inventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Bernhard Lesch, Jeewoo Lee
  • TAMPER-RESISTANT DOSAGE FORM CONTAINING ETHYLENE-VINYL ACETATE POLYMER
    Publication number: 20150017250
    Abstract: The invention relates to a tamper-resistant, oral pharmaceutical dosage form comprising a pharmacologically active ingredient having psychotropic action and an ethylene-vinyl acetate (EVA) polymer which provides resistance against solvent extraction, resistance against grinding, and resistance against dose-dumping in aqueous ethanol.
    Type: Application
    Filed: July 10, 2014
    Publication date: January 15, 2015
    Applicant: GRÜNENTHAL GMBH
    Inventors: KLAUS WENING, LUTZ BARNSCHEID, SEBASTIAN SCHWIER, ANJA GEIßLER
  • Substituted Phenylureas and Phenylamides as Vanilloid Receptor Ligands
    Publication number: 20150011592
    Abstract: The invention relates to substituted phenylureas and phenylamides, to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.
    Type: Application
    Filed: October 24, 2013
    Publication date: January 8, 2015
    Applicant: Gruenenthal GmbH
    Inventors: Robert FRANK, Gregor BAHRENBERG, Thomas CHRISTOPH, Klaus SCHIENE, Jean DE VRY, Nils DAMANN, Sven FRORMANN, Bernhard LESCH, Jeewoo LEE, Yong-Soo KIM, Myeong-Seop KIM, Derek SAUNDERS, Hannelore STOCKHAUSEN
  • Pharmaceutical composition comprising (1r,4r) -6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine and a NSAR
    Patent number: 8912226
    Abstract: The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient selected from (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient which is a non-steroidal anti-rheumatic drug selected from the group consisting of indometacin, diclofenac, sulindac, tolmetin, zomepirac, aclofenac, bumadizone, etodolac, lonazolac, fentiazac, acemetacin, difenpiramide, oxametacin, proglumetacin, ketorolac, aceclofenac, bufexamac, mefenamic acid, tolfenamic acid, flufenamic acid, meclofenamic acid, and the physiologically acceptable salts thereof.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: December 16, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Stefanie Frosch, Klaus Linz, Klaus Schiene
  • Solid forms of (1r,4r)-6?-fluoro-(N, N-dimethyl)-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano-[3,4,b]indol]-4-amine and sulfuric acid
    Patent number: 8912343
    Abstract: Solid forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]indol]-4-amine and sulfuric acid such as (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4b]indol]-4-amine sulfate or hemi-sulfate, particularly crystalline forms and/or amorphous forms thereof, pharmaceutical compositions and medicaments containing these solid forms, the use of these solid forms, and a process for obtaining such solid forms.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: December 16, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Stefan Kluge, Stefan Pruehs
  • DOSAGE THAT IS SAFEGUARDED FROM ABUSE
    Publication number: 20140356294
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: August 13, 2014
    Publication date: December 4, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: Elisabeth ARKENAU-MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • SUBSTITUTED 4-AMINOCYCLOHEXANE DERIVATIVES
    Publication number: 20140357634
    Abstract: The invention relates to compounds that have an affinity to the ?-opioid receptor and the ORL 1-receptor, methods for their production, medications containing these compounds and the use of these compounds for the treatment of pain and other conditions.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: BERT NOLTE, WOLFGANG SCHRÖDER, KLAUS LINZ, WERNER ENGLBERGER, HANS SCHICK, HEINZ GRAUBAUM, BIRGIT ROLOFF, SIGRID OZEGOWSKI, JÓZSEF BÁLINT, HELMUT SONNENSCHEIN
  • TAMPER-RESISTANT DOSAGE FORM CONTAINING ONE OR MORE PARTICLES
    Publication number: 20140356426
    Abstract: The invention relates to a tamper-resistant pharmaceutical dosage form comprising one or more particles, wherein each of said one or more particles comprises a pharmacologically active ingredient and a physiologically acceptable polymer; has a breaking strength of at least 300 N; has a weight of at least 2 mg; and optionally, comprises a film-coating; wherein the total weight of the pharmaceutical dosage form is greater than the total weight of said one or more particles.
    Type: Application
    Filed: May 27, 2014
    Publication date: December 4, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: LUTZ BARNSCHEID, ANJA GEIßLER, KLAUS WENING, JANA PÄTZ
  • TAMPER RESISTANT DOSAGE FORM WITH BIMODAL RELEASE PROFILE
    Publication number: 20140356428
    Abstract: The invention relates to a pharmaceutical dosage form comprising (i) at least one formed segment (S1), which contains a first pharmacologically active ingredient (A1) and provides prolonged release thereof, and (ii) at least one further segment (S2), which contains a second pharmacologically active ingredient (A2) and provides immediate release thereof, wherein the at least one formed segment (S1) exhibits a higher breaking strength than the at least one further segment (S2) and the at least one formed segment (S1) exhibits a breaking strength of more than 500 N.
    Type: Application
    Filed: May 27, 2014
    Publication date: December 4, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: LUTZ BARNSCHEID, ANJA GEIßLER, KLAUS WENING, STEFANIE STRAUCH, JANA PÄTZ, SEBASTIAN SCHWIER
  • Intrathecal or epidural administration of 3-[(1S,25)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol
    Patent number: 8895623
    Abstract: The present invention relates to a method of providing pain management in a subject wherein the administration of the composition does not result in any non-central nervous system mediated systemic effect in the subject. In particular, the present invention relates to a method of administering 3-[(1S,2S)-3-(dimethylamino)-1-ethyl-2-methyl-propyl]-phenol in a space that is void of thrombocytes.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: November 25, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Petra Bloms-Funke, Derek John Saunders, Eric Lang
  • Solid forms of (1r,4r)-6?-fluoro-N,N-dimethy1-4-phenyl-4?,9?-dihydro-3? H-spiro-[cyclohexane-1,1?-pyrano-[3,4,b]indol]-4-amine hydrochloride
    Patent number: 8895604
    Abstract: Solid forms of (1r,4r)-6?-fluoro-N,N-dimethyl-4-phenyl-4?,9?-dihydro-3?H-spiro[cyclohexane-1,1?-pyrano[3,4,b]indol]-4-amine hydrochloride, in particular crystalline forms and/or amorphous forms thereof, pharmaceutical compositions and medicaments containing these solid forms, the use of these solid forms, and a process for obtaining such solid forms.
    Type: Grant
    Filed: December 11, 2012
    Date of Patent: November 25, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Michael Gruss, Stefan Kluge, Andreas Sieber
  • Star distributor
    Patent number: 8894904
    Abstract: The present invention relates to a device for distributing tablet blanks to the dies of a tablet press. The present invention moreover relates to a system consisting of the device according to the invention and a tablet press and to a method for forming tablets from tablet blanks.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: November 25, 2014
    Assignee: Gruenenthal GmbH
    Inventors: Dieter Schateikis, Elisabeth Arkenau-Maric, Johannes Bartholomäus
  • Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropy1)-phenol
    Patent number: 8877974
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: November 4, 2014
    Assignee: Grünenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Helmut Heinrich Buschmann, Joerg Holenz, Stefan Gladow
  • CRUSH RESISTAN DELAYED-RELEASE DOSAGE FORM
    Publication number: 20140322311
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: July 7, 2014
    Publication date: October 30, 2014
    Applicant: Grünenthal GmbH
    Inventors: Judy Ashworth, Elisabeth Arkenau Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • PHARMACEUTICAL DOSAGE FORM
    Publication number: 20140322323
    Abstract: The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
    Type: Application
    Filed: April 25, 2014
    Publication date: October 30, 2014
    Applicant: GRÜNENTHAL GMBH
    Inventors: EUGEEN MARIE JOZEF JANS, FILIP RENÉ IRENA KIEKENS, JODY FIRMIN MARCELINE VOORSPOELS, ANNE FAURE, IRIS ZIEGLER, ELISABETH ARKENAU-MARIC, LUTZ BARNSCHEID, JOHANNES BARTHOLOMÄUS, MARC FREVEL, ERIC GALIA, ANDREA SCHÜESSELE