Abstract: An absorbent article comprising an absorbent core comprising absorbent material. The absorbent core is sandwiched between a liquid-permeable upper core cover layer and a lower core cover layer. The absorbent core has one or more elongated areas arranged therein, each elongated area being an absorbent material free area having a length as measured along the elongated area and a width. The upper core cover layer and the lower core cover layer in each of the one or more elongated absorbent material free areas are attached to each other within at least 2 attachment zones and at most 12 attachment zones, the attachment zones being spaced-apart in the longitudinal direction (Y) within each of the one or more absorbent material free areas.

Abstract: The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.

Abstract: The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications, and antidotes.

Abstract: Compositions containing a protease inhibitor for treating viral infections and methods for treating a patient before, during, or after exposure to an infectious agent by administering such compositions are described herein.

Abstract: Methods for decellularizing organs and tissues in vitro and in vivo are provided, as are methods of maintaining organ and tissue frameworks and methods of recellularizing organs and tissues, thereby providing an approach to needed organs or tissues.

Abstract: The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.

Abstract: The present embodiments relate generally to ultrasound imaging systems and methods that provide a user interface on the touchscreen display. The user interface includes an ultrasound image feed and a single control for modifying imaging depth of the ultrasound image feed. When input via the single control is received to modify the imaging depth, the system: adjusts frequency of ultrasound signals being used to acquire the ultrasound image feed; adjusts a beamformer parameter of the ultrasound signals being used to acquire the ultrasound image feed; receives first image data of the ultrasound image feed based on the adjusted frequency and the adjusted beamformer parameter; based on the first image data, adjusts Time Gain Compensation (TGC) of the ultrasound image feed; and receives second image data of the ultrasound image feed based on the adjusted frequency, beamformer parameter and TGC. Display of the second image data on the touchscreen display is then optimized without receipt of additional user input.

Abstract: Methods of using a soft tissue cutting device are disclosed. The methods include providing the soft tissue cutting device, positioning the soft tissue cutting device in a priming slot of a tray configured for receiving and holding the soft tissue cutting device, attaching a priming syringe to the soft tissue cutting device, priming a balloon disposed on a distal end of the soft tissue cutting device by equalizing a first pressure inside the balloon to a second pressure inside the priming syringe, removing the soft tissue cutting device from the priming slot, and positioning the distal end of the soft tissue cutting device on a safety slot included in the tray to determine whether the tissue cutting device has been properly primed.

Abstract: A method of displaying a GUI including a multidimensional array of axes includes constructing a multidimensional array of axes, each axis comprising a plurality of entities located therealong, each entity configured to contain data for display on the axis; for a particular axis of the axes of the array, determining an entity first encountered in a first direction along the particular axis which contains data for display on the particular axis; displaying a view of the array of axes, which view comprises at least a portion of the particular axis that precedes the first encountered data-containing entity in the first direction; and, in conjunction with the displaying of the view of the array of axes, providing an indicator of an absence of data for display being contained in each entity of the particular axis preceding the first data-containing entity encountered in the first direction.

Abstract: A medical dressing is provided. The dressing has a central portion and a border portion, and comprises a backing layer, an adhesive body contact layer and a pad arranged in the central portion between the backing layer and the adhesive body contact layer. The pad is symmetric about a longitudinal center line and the dressing comprises a lobed portion on each side of the center line. The central portion of the dressing has a tensile strength in the longitudinal (y) direction of at least 60 N, preferably at least 70 N at an elongation of 25%, as measured by the test method ASTM D 882-12. The medical dressing may be used for pressure ulcer prevention, such as at the sacrum region of a human body.

Abstract: Described is a negative wound therapy (NPWT) dressing that includes a backing layer and an adhesive skin contact layer, the adhesive skin contact layer being configured to detachably adhere the dressing to a dermal surface, wherein the backing layer includes a coupling member. The coupling member includes a tubing configured to connect the dressing to a negative pressure source and to a remote fluid collector.

Abstract: A method of training an artificial neural network to predict gene expression for a patient having a pathological condition is provided. The method comprises obtaining a set of histopathological images from a database of patients having the pathological condition, collecting from the database a set of gene expression profiles corresponding to the histopathological images, identifying in the set of gene expression profiles a set of considered genes, selecting a training subset of the considered genes comprising genes characterized by similar median gene expression values, and training the neural network to predict a gene expression value of an input histopathological image, using gene expression profiles of the genes in the training subset simultaneously.

Abstract: Disclosed are a method for synthesizing nuciferine or a derivative thereof, a derivative of nuciferine and use thereof. A compound having a structure shown in formula IV and R—X are subjected to Schotten-Baumann reaction, followed by carbon-hydrogen bond activation, to obtain the nuciferine or the derivative thereof, which has a structure shown in formula VI. The compound having the structure shown in formula IV is prepared through acyl chlorination reaction, nucleophilic substitution reaction, Bischler-Napieralski reaction, and reduction reaction, with 2-bromophenylacetic acid as a starting material. The derivative of nuciferine could be used in preparation of a lipid-lowering drug.

Abstract: A cover for a urinary catheter may include at least one cover sheath, the at least one cover sheath including a longitudinal slit extending from a first end of the at least one cover sheath to a second end of the at least one cover sheath. The catheter cover may also include and a spring mechanically coupled to the at least one cover sheath and configured to retain the slit in a closed state, where the at least one cover sheath substantially surrounds an outer diameter surface of a urinary catheter when the cover sheath is in the closed state.

Abstract: Systems and methods for monitoring of biometric and contextual variables to assist in screening for, quantification of, and prediction of smoking behavior, and for assisting in smoking cessation are described.

Abstract: Disclosed herein are immunotherapeutic constructs comprising a delivery particle, at least one adjuvant, and one or more therapeutic agents/compounds that cause antigen release and/or modulate immunosuppressive tumor microenvironment. These immunotherapeutic constructs create adaptive immunity or anti-cancer immune response(s) that can be used, for instance, to prevent and treat broad types of cancer. Further disclosed are uses of the immunotherapeutic constructs, including to prevent and treat cancer in humans and animals.

Abstract: The present technology provides for a remote continuous monitoring system that monitors a patient's vital signs and generates an alarm in response to detecting a likely onset of an adverse event. The monitoring system advantageously allows patients recovering from clinical treatments to do so at home, outside of a hospital. Furthermore, the monitoring system provides continuous monitoring of patient vital signs, which advantageously provides more information than intermittent manual measurements of patient vital signs typical in a hospital. The monitoring system, therefore, may more readily and more timely detect a likely onset of an adverse event.

Abstract: A system includes an imaging device configured to rotate axially about a rotational axis and to capture a plurality of images associated with a sinogram at a plurality of angles, respectively, along the rotational axis, one or more processors, and a memory storing instructions that, when executed by the one or more processors, cause the system to: detect an object in each image of the plurality of images, determine a moment of inertia associated with the object based on the plurality of images, simulate one or more images for the sinogram based at least in part on the moment of inertia, generate a reconstruction of the object based on the sinogram; and determine one or more properties of the object based on the reconstruction.