Abstract: Compositions and methods for treating macular degeneration are disclosed. The methods utilize IL17 inhibitors, such as IL17 receptors, as well as fusion proteins including an IL17 receptor fused with a multimerization domain, and recombinant viral vectors encoding such fusions.

Abstract: A working wire of a continuous biological sensor is disclosed. The working wire includes a substrate for the sensor having a conductive surface. An enzyme layer is on the conductive surface and includes an enzyme, an immobilization matrix, and an enzyme immobilization network. The enzyme immobilization network is formed using a polymeric crosslinking agent and a non-polymeric crosslinking agent crosslinking the enzyme and the immobilization matrix. The polymeric crosslinking agent and the non-polymeric crosslinking agent are a combination of polyethylene glycol (PEG) dialdehyde and glutaraldehyde. A protective layer is over the enzyme layer.

Abstract: Washable absorbent male underwear including a textile pant and an absorbent assembly, the absorbent assembly including a liquid permeable layer, a liquid impermeable layer; and an absorbent structure being arranged in a front portion of the textile pant between the liquid permeable layer and the liquid impermeable layer and including a first layer of textile absorbent material, the first layer of textile absorbent material having a first absorbent area; wherein the first absorbent area defines an area of a first absorbent zone of the absorbent assembly, the absorbent assembly further comprising a leak protection zone having an area which is defined by the area of the liquid impermeable layer, the absorbent structure completely overlapping the leak protection zone, the area of the leak protection zone being greater than the area of the first absorbent zone.

Abstract: A normothermic machine perfusion method for a pancreas is provided. First, a perfusate contained in a venous reservoir may be oxygenated such that a ratio of oxygen to carbon dioxide in the oxygenated perfusate is approximately 90%/10%. A first portion of the oxygenated perfusate may be pumped from the venous reservoir, through a dialysis filter, and back to the venous reservoir. A dialysate comprising a salt and glucose may be infused into the first portion of the oxygenated perfusate as the first portion is pumped through the dialysis filter. A concentration of glucose in the dialysate may be less than 8 mmol/L. A second portion of the oxygenated perfusate may be pumped through an arterial filter and through a pancreas graft. Venous outflow from the pancreas graft may then be pumped to the venous reservoir.

Abstract: A device for fluorescence-based imaging and monitoring of a target is provided. The device includes a light source emitting light for illuminating the target, the emitted light including at least one wavelength or wavelength band causing at least one biomarker associated with the target to fluoresce, and a light detector for detecting the fluorescence.

Abstract: A system and method for sports mental health fitness tracker. The system and method determines the impact of mental well-being on sports performance. The system includes a questionnaire component, interpreting component, aggregating component, and first and second display screens. The method includes obtaining information regarding the habits, behaviors, stress and overall well-being of an athlete by the questionnaire component. The information is processed by the interpreting and aggregating components to transmit electrical signals to the first and second display screens. The first display screens provide information regarding the mental well-being of individual athletes. The second display screen provides information regarding the mental well-being of more than one athlete as a group.

Abstract: Disclosed hereing are methods of diagnosing, and treating and/or preventing CD55-deficiency, hyperactivation of complement, angiopathic thrombosis and protein-losing enteropathy (CHAPLE). The method of diagnosing includes: providing a sample from a patient; performing an assay detecting at least one of at least one mutation in a DNA sequence of a CD55 gene, at least one mutation in a RNA sequence of a CD55 transcript, at least one mutation in a DNA sequence of a CD55 complementary-DNA (cDNA), CD55 protein, CD55 protein binding, complement deposition or combination thereof, and diagnosing the patient with CHAPLE. The method of treating and/or preventing at least one symptom of CHAPLE includes: administering an effective amount of a composition comprising at least one complement inhibitor to a subject in need thereof, wherein the composition is effective in treating or preventing at least on symptom of CHAPLE. The disclosure further relates to compositions effective at treating and/or preventing CHAPLE.

Abstract: A washable absorbent undergarment includes one or more fabric panels and an integrated absorbent assembly including a wearer facing top layer of a textile material, a garment facing moisture barrier layer, and one or more optional intermediate layers between the top layer and the moisture barrier layer. The moisture barrier layer comprises a woven or knitted fabric comprising activated carbon.

Abstract: A portable, handheld system for outputting a representation of a target tissue is provided. The system includes a housing configured to removably receive at least a portion of a wireless communication device, at least one excitation light source, a power supply contained in the housing and configured to provide power to the at least one excitation light source, and a non-transitory computer-readable medium storing a program that, when executed by the wireless communication device, causes the wireless communication device to perform operations including detecting signals responsive to illumination of the target tissue, receiving the detected signals and outputting a representation of the target tissue based on the detected signals, and displaying the representation of the target surface output by the processor.

Abstract: Methods for producing a protective immune response to Porcine Epidemic Diarrhea Virus (PEDV) is provided wherein a fusion protein comprising the S1 Spike protein of the virus operably fused to the heat labile enterotoxin B subunit (LTB) peptide is expressed in a plant and the plant or plant product comprising the fusion protein is orally administered to an animal. The vaccine can be produced by introducing into a plant a construct comprising a promoter preferentially directing expression to seed of said plant, a nucleic acid encoding the S1-LTB fusion protein and a nucleic acid targeting expression to the endoplasmic reticulum of the plant. When orally administered to an animal, a protective response is observed, including a serum antibody response and mucosal immune response.

Abstract: A washable absorbent hygienic underwear includes an outer pant and an absorbent assembly, being permanently secured in the outer pant and including a liquid permeable layer, a liquid impermeable layer; and an absorbent member located between the liquid permeable layer and the liquid impermeable layer, the absorbent member including a liquid acquisition structure and a liquid retaining structure, the liquid acquisition structure including a spacer fabric, the liquid acquisition structure being arranged between the liquid permeable layer and the liquid retaining structure; and wherein the spacer fabric completely overlaps with the liquid retaining structure and has an area which is 65% or less of an area of the liquid retaining structure, the liquid retaining structure having a density being higher than the density of the spacer fabric.

Abstract: Methods, systems, and devices for calibrating a medical instrument are discussed herein. For example, a first instrument can be configured to access an anatomical site via a first access path and a second instrument can be configured to access the anatomical site via a second access path. The second instrument can include an imaging component configured to provide image data representative of the anatomical site and the first instrument. A difference can be identified between a first coordinate frame associated with the first instrument and a second coordinate frame associated with the second instrument. A control frame of reference associated with the first instrument can be updated based at least in part on the difference.

Abstract: A system and method are provided for migrating and/or validating schedules for mainframe systems and/or distributed systems. The method may include interfacing with a plurality of schedulers including a source scheduler and a target scheduler. Each scheduler may be configured to schedule jobs across one or more distributed systems and one or more mainframe systems. The method may include obtaining a source schedule generated by the source scheduler and a target schedule generated by the target scheduler for a same system of the one or more distributed systems and one or more mainframe systems. The method may include determining validity of migration of jobs between the source schedule and the target schedule. The method may include, in accordance with a determination that one or more jobs in the target schedule are not valid, transmitting an indication to the target scheduler causing the target scheduler to correct the schedule.

Abstract: Washable absorbent assembly which is adapted to being permanently or detachably secured in a textile pant. The absorbent assembly includes a liquid permeable layer, a liquid impermeable layer; and an absorbent member located between the liquid permeable layer and the liquid impermeable layer, the absorbent member including a liquid acquisition structure and a liquid retaining structure and being arranged between the liquid permeable layer and the liquid retaining structure. The liquid permeable layer has a basis weight of less than 300 g/m2; the liquid acquisition structure includes a spacer fabric including a top web, a bottom web and an intermediate section including pile filaments connecting the top web with the bottom web. The spacer fabric has a density of 0.1 g/cm3 or less and the liquid retaining structure has a density higher than the density of the liquid acquisition structure.

Abstract: Provided are androstane and dihydrotestosterone compounds functionalized with carbocyclic groups or heterocyclic groups that may be saturated or unsaturated. The compounds may be used in methods of inhibiting cell growth of malignant cells and/or hyperplastic cells and/or treating individuals having diseases associated with malignant cell growth (e.g., cancer, such as, for example, prostate cancer) and/or hyperplastic cell growth and/or molecular imaging of malignant cells and/or hyperplastic cells and/or inducing degradation of a target protein. Also provided are compositions.

Abstract: A system for dispensing pills may include a plurality of containers, a retrieval arm movable into the plurality of containers to retrieve contents from the plurality of containers, a carrier supporting the plurality of containers, the carrier movable to adjust positions of the plurality of containers relative to a predetermined position, and a weighing assembly. The weighing assembly may include an actuator and a weight sensor. The actuator may be actuatable to control mechanical communication between the weight sensor and one of the plurality of containers at the predetermined position, and the weight sensor may be operable to measure weight of the one of the plurality of containers in mechanical communication with the weight sensor at the predetermined position.

Abstract: Methods, systems, and devices for gesture recognition are described. A system may identify geographical location data associated with a user throughout a time interval and may identify a set of gesture profiles corresponding to a set of gestures associated with the geographical location data of the user. The system may additionally acquire physiological data, including motion data, associated with the user from a wearable device worn by the user and may identify a set of motion segments within the time interval based on the motion data. Additionally, the system may identify a gesture the user engaged in based on matching a motion segment of the set of motion segments to a gesture profile of the set of gesture profiles and may cause a graphical user interface (GUI) of a user device running the application to display an indication of the gesture.

Abstract: An exercise apparatus includes a motor, an operating member driven by the motor, a sensor operable to detect engagement of a user with the operating member, and a controller in communication with the operating member and the sensor. The controller is configured to generate exercise use data when the operating member is driven by the motor. A communication interface is in communication with the controller. In response to the controller determining that the user is engaged with the operating member, the controller is configured to report the exercise use data to the communication interface. In response to the controller determining that the user is not engaged with the operating member, the controller is configured to stop reporting the exercise use data to the communication interface. The communication interface is configured to communicate the reported exercise use data to a third party.

Abstract: Methods for treating a subject with cancer, including administering to the subject an effective amount of an inhibitor of DNAse1L3 and an effective amount of radiation therapy are provided. In some examples, the methods involve enhancing or inducing response of tumor-associated immune cells in the subject, including administering to the subject an effective amount of radiation therapy, and administering to the subject an effective amount of an inhibitor of DNAse1L3, thereby enhancing or inducing the response of tumor-associated immune cells in the subject. In some examples, the tumor-associated immune cells comprise dendritic cells or macrophages.