Abstract: Compounds having useful cannabinoid receptor modulating properties. The compounds may be useful in treating complications arising from metabolic, inflammatory and fibrotic disorders.

Abstract: The present invention relates to a method of differentiating an induced pluripotent stem cell into a retinal pigment epithelial cell. Additionally, the present invention relates to a retinal pigment epithelial cell culture obtainable by the differentiation method and a retinal pigment epithelial cell culture obtained by the differentiation method. In addition, the present invention concerns a retinal pigment epithelium consisting of or comprising a retinal pigment epithelial cell culture obtainable or obtained by the differentiation method. The present invention also relates to a pharmaceutical composition comprising a retinal pigment epithelial cell culture obtained by the differentiation method. The present invention concerns a method of treating a retinal degenerative disease in a subject, comprising administering to a subject a retinal pigment epithelial cell differentiated from the induced pluripotent stem cell by the method.

Abstract: A method for a plurality of administration engines on remote processing devices coupled to an anonymization engine operable to replace personally identifiable information (PII) with a unique identifier, further coupling the administration engines to a server and transmitting queries to the administration engines and receiving results in response to the querying. Then associating the contextual information in response to the unique identifiers, and formatting the contextual information to ensure data compatibility. Certain embodiments may include academic and health information.

Abstract: Provided herein are methods of producing an RPE cell population from a starting cell suspension, such as a single cell suspension, of pluripotent stem cells (PSCs). Such a method may comprise culturing the starting single cell suspension of PSCs in differentiation media to produce human RPE cells.

Abstract: Immunogens comprising a soluble HIV-1 Env ectodomain trimer stabilized in a prefusion closed conformation and comprising modifications to introduce N-linked glycan sequons at the membrane-proximal base of the trimer, as well as methods of their use and production are disclosed. In several implementations, the immunogen can be used to elicit an immune response to HIV-1 in a subject.

Abstract: Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.

Abstract: Bispecific antibodies that specifically bind to HIV-1 Env and neutralize HIV-1 are disclosed. Nucleic acids encoding these bispecific antibodies, vectors and host cells are also provided. In addition, the use of these bispecific antibodies, nucleic acid molecules, and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: Antibodies and antigen binding fragments that specifically bind to HIV-1 Env and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: The present disclosure discloses an ?-herpesvirus insensitive monoclonal cell strain, and a preparation method therefor and use thereof, belonging to the technical field of biomedicine. In order to perform targeted research of intercellular transmission of an ?-herpesvirus and an action mechanism thereof, the present disclosure discloses the ?-herpesvirus insensitive monoclonal cell strain. The cell strain is named as a human liver cancer continuous cell line Huh7-C10 and has a potential of being applied to developing a new generation of enhanced oncolytic herpesvirus and single-round infection attenuated live vaccine.

Abstract: Introduced here are computer programs that are able to generate computer vision data through local analysis of image data (also referred to as “raw data” or “input data”). The image data may be representative of one or more digital images that are generated by an image sensor. Also introduced here are apparatuses for generating and handling the image data and computer vision data.

Abstract: The present invention is directed to systems for data integration and analysis using artificial intelligence networks to generate predictive outputs based on one or more inputs. The present invention incorporates healthcare data from a variety of sources and databases into a single system for predictive analysis using artificial intelligence. The present invention incorporates multifaceted authorization to access data from a variety of databases and integrate the data into a single data warehouse. The system of the present invention is further configured to analyze the integrated data to identify predictors, and subsequently uses the predictors to determine a predictive output based on an input.

Abstract: Compositions, systems and methods of improving the health of the microbiome of an individual's skin relate to the provision of skin contacting formulations containing beneficial bacteria and other microbe components to foster the growth and maintenance of a healthy skin microbiome. Certain embodiments include methods of treatment for acne and other skin disorders involving the use of probiotics, as well as the use of bacteria engineered via CRISPR systems for the treatment of specific skin disorders.

Abstract: An emergency response system (ERS) configured to acquire equipment location data, target terminal location data, and emergency responder terminal location data; determine a horizontal distance measure between the emergency responder terminal and a select unit of equipment, determine a vertical distance measure between the emergency responder terminal and a select unit of equipment, engage a camera component of the emergency responder terminal to capture images of at least a portion of the surrounding real-world scene, providing such images for display on the touchscreen display of the emergency responder terminal, and/or providing an equipment display object for display on the touchscreen of the emergency responder terminal such that, when an image provided for display spans a region of the real-world scene within which the equipment is located, the equipment display object dynamically overlays a segment of the image associated with the acquired equipment location data.

Abstract: Disclosed are apparatuses and methods for irradiating a perfusate. The apparatus includes a tank which defines a first chamber. A separator is located inside the first chamber. The separator defines a second chamber. The first chamber and the second chamber are concentric and have substantially annular cross sections, each having at least one diameter and a substantially common longitudinal axis. A perfusate is introduced into the first chamber by an inlet. A UV radiation-emitting device is disposed inside the second chamber for providing irradiation to the perfusate. Irradiated perfusate is removed from the tank by an outlet. Other apparatuses and systems are described and methods for inactivating micro organisms by performing EVP and irradiating the perfusate.

Abstract: Methods and devices are disclosed for intra-operative viewing of pre- and intra-operative 3D patient images.

Abstract: The present disclosure relates to a method for establishing the suitability for printing of a thermoplastic film for use in a packaging of absorbent hygienic articles, said thermoplastic film comprising at least 30% recycled polymer material. The method comprises scanning a sample of said film for Gel Spots, defining an Amount of Gel spots and a Relative Gel Spot Coverage area, and, determining that if the Amount of Gel Spots is less than or equal to a first threshold and the Relative Gel Spot Coverage Area is less than or equal to a second threshold, determining that said thermoplastic film is suitable for printing. The disclosure also relates to a method of forming a package from a thermoplastic film, and to a package comprising a thermoplastic film.

Abstract: A device for ablating target tissue of a patient with electrical energy is provided. An elongate shaft includes a proximal portion and a distal portion, and a radially expandable element is attached to the distal portion. An ablation element for delivering electrical energy to target tissue is mounted to the radially expandable element. The device can be constructed and arranged to ablate the duodenal mucosa of a patient while avoiding damage to the duodenal adventitial tissue. Systems and methods of treating target tissue are also provided.

Abstract: A composition for weight reduction and body fat reduction, its preparation method and application are disclosed, which relates to the technical field of health food. The composition includes the following components: 10-30 parts of concentrated milk protein, 10-30 parts of soybean isolated protein powder, 10-30 parts of concentrated whey protein powder, 5-15 parts of skim milk powder, 0.5-15 parts of collagen peptide, 0.1-3 parts of Agaricus bisporus extract, 0.1-3 parts of Flammulina velutipes extract, 0.1-5 parts of okra powder, 0.1-2 parts of Opuntia ficus-indica extract, 1-10 parts of medium chain triglyceride microcapsule powder, 0.1-5 parts of mango concentrated powder, 0.1-2 parts of ginger oil microcapsule powder, 0.1-2 parts of citrus powder, 0.1-5 parts of guarana extract and 0.5-2 parts of compound vitamin.

Abstract: Aspects include a system and method of automatic data segmentation to optimize a client's collection efforts against individuals serviced by the client. At least accounts receivables data, historical payment data, and credit related data associated with an individual may be provided to a model as input data to predict a recovery value for the individual. The recovery value may be a weighted average of a unit yield and recovery rate. Based on the predicted recovery value and client-provided segmentation boundaries that define segments as a range of recovery values, the individual may be assigned to a segment. The segment may inform the client of a particular collection strategy for the individual to optimize collection efforts. Additionally, recovery values for the individuals serviced by the client may be provided to a comparison system and utilized to directly compare collection efforts across a plurality of clients nationally and/or demographically.