Abstract: Antibodies and antigen binding fragments that specifically bind to gp120 and neutralize HIV-1 are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

Abstract: A system and method for assessing global wellness and developing a maintenance/treatment program are provided, wherein a plurality of data sources are compiled, including, at minimum (a) a subject's medical, dental and family histories, and (b) a body fluid sample (e.g. an oral swab or saliva) for detecting and determining levels of one or more biomarkers, and wherein these data are used to assess the subject's global health and wellness landscape, which is then compared to a reference/ideal wellness landscape, and the comparison used to design a maintenance therapy/treatment plan.

Abstract: A method of testing a web-based application comprising: at a computing device: receiving a test procedure, the web-based application having an associated web-based application code, the test procedure including at least one testing step comprised of at least an action attribute and an element attribute; for each of the at least one testing steps: identifying an action handler based on the action attribute; generating at least one instruction, by the action handler, and in accordance with a determination that the testing step is an interaction testing step and that there is a value attribute associated with the interaction testing step, modifying the at least one instruction based on the value attribute associated with the interaction testing step; and causing the web-driver to execute the at least one instruction on an identified section of web-based application code corresponding to the element attribute to perform an operation on the web-based application.

Abstract: An endoscope distal end protector and method including a body having a plurality of interconnected spaced members forming a body interior. The body has a longitudinal axis and defines a plurality of openings into the body interior. A first cover is disposed on the body and includes a first aperture formed therein. The first aperture is deformable and adapted to permit an endoscope distal end to pass therethrough and into the body interior and adapted to resiliently engage the endoscope distal end to retain the body on the endoscope distal end.

Abstract: A method for identifying errors associated with subject positioning in a thermal image of a subject and determining, applying a positional adjustment for adaptive positioning of the subject for capturing a new adjusted thermal image. The method includes (i) receiving an initial thermal image of body of a subject, (ii) automatically segmenting breast region from the initial thermal image, (iii) computing a plurality of positions and a plurality of deviations in the plurality of positions using a thermal imaging protocol, (iv) determining a positional adjustment to be made to a position of thermal imaging camera or a position of the subject based on the plurality of deviations in the plurality of positions of the breast region and (v) applying the positional adjustment for adjusting a position of the thermal imaging camera or subject for capturing a new adjusted thermal image at the required position as per thermal imaging protocol.

Abstract: Multidimensional MRI-based methods permit identification and categorization of brain specimens to identify sub-voxel tissue components that are specific to traumatic axon injury or other lesions. Lower dimensional MR spectral data is acquired and processed to provide multidimensional MR data of higher dimensions. One or more spectral ranges are selected that define signatures for brain injury and evaluation of the multidimensional MR data in these ranges is used to locate voxels associated with brain injury. For example, partial one dimensional data sets such as T1, T2, and mean diffusion coefficient (MD) data sets can be combined to provide two dimensional data sets such as T1-T2, MD-T2, and MD-T1 data sets. Using the spectral signatures, a specimen image can be produced showing areas of lesser or greater injury.

Abstract: The invention relates to a tube with an application tip for liquid or pasty material, in particular pharmaceutical. The tube has a tube body with an end which can be closed or has already been closed and with an outlet end. The outlet end of the tube has a tube neck with an outlet opening. Furthermore, the tube according to the invention has an application tip which is elongated in the longitudinal direction of the tube, is connected to the outlet end of the tube, and has an inner channel which connects an inlet opening and an application opening. A closure which closes the application opening is moulded onto the application opening of the application tip. The application tip has a gripping means.

Abstract: The present embodiments relate generally to methods for providing viewing access to an ultrasound image feed generated at an ultrasound imaging machine. A multi-use display device may form a first link-layer connection with the ultrasound image machine for transmitting commands that control imaging parameters of the ultrasound image feed. The multi-use display device may then: determine link-layer connection parameters that allow the ultrasound imaging machine to form a second link-layer connection with a receiving device (the receiving device having no link-layer connection with the ultrasound imaging machine), and provide the connection parameters to the receiving device. The ultrasound imaging machine forms a second link-layer connection with the receiving device, based the connection parameters. The second link-layer connection is then used for receiving, at the receiving device, the ultrasound image feed controlled by the multi-use display device.

Abstract: The present disclosure describes devices for intranasal delivery. The devices may have a housing with a dispensing element, and a positioning or trigger element coupled to the housing that engages a columella region of the subject to position the dispensing element within the nasal channel and limit its depth of insertion. The devices can also include two insertable portions, each for insertion into a nasal channel of the subject, and an actuator that delivers the composition from either or both of the insertable portions. The devices can be transitioned from a first configuration to a second configuration. Devices of the present disclosure may provide a convenient and effective way to deliver compositions intranasally and to accomplish lateralized delivery to targeted regions of the brain.

Abstract: The present invention provides asymmetrical duplex RNA molecules that are capable of effecting sequence-specific gene silencing. The RNA molecule comprises a first strand and a second strand. The first strand is longer than the second strand. The RNA molecule comprises a double-stranded region formed by the first strand and the second strand, and two ends independently selected from the group consisting of 5?-overhang, 3?-overhang, and blunt end. The RNA molecules of the present invention can be used as research tools and/or therapeutics.

Abstract: A device is provided for preventing buckling of a flexible elongate member during insertion of the flexible elongate member. The device includes a support frame comprising a first end, a second end, and multiple pairs of support members. The support frame is configured to reversibly move from a collapsed configuration to an expanded configuration when the first and second ends are moved away from each other. The device also includes multiple open channels coupled to the multiple pairs of support members of the support frame. The multiple open channels are configured to allow the flexible elongate member to be top loaded into the multiple open channels. Also, the multiple open channels are maintained in an axial alignment as the support frame is moved between the expanded and collapsed configurations.

Abstract: The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

Abstract: Dental devices are described that include isolated, non-pathogenic, hydrogen peroxide-producing bacterial strains and genetically engineered LDH-deficient bacterial strains, which can be used to whiten teeth and treat periodontal disease.

Abstract: Methods, systems, and devices for cardiovascular health metric determination are described. A system may be configured to receive a photoplethysmogram (PPG) signal representative of a pulse waveform for a user. The pulse waveform may include a first local maximum, a downward slope following the first local maximum, and a curved feature representative of a transition from a systolic phase to a diastolic phase of a cardiac cycle. Additionally, the system may extract one or more morphological features from the pulse waveform and compare the one or more morphological features with one or more features from a plurality of baseline PPG signal morphologies associated with a plurality of chronological ages. The system may determine a cardiovascular health metric that indicates a cardiovascular health of the user relative to a chronological age of the user and cause a graphical user interface to display an indication of the cardiovascular health metric.

Abstract: A detection chip, a method for using a detection chip and a detection apparatus are provided the detection chip includes a chip substrate and the chip substrate includes a fluid channel and a plurality of liquid cells. The fluid channel is arranged on a surface if the chip substrate and includes a main path and a plurality of branch paths. The plurality of branch paths are respectively communicated to the plurality of liquid cells, the plurality of branch paths are all communicated to the main path, and communication points between the plurality of branch paths and the main path are different. The plurality of branch paths are configured to allow liquid in the plurality of branch paths to be capable of merging into the main path in a same direction.

Abstract: Methods and systems for a hybrid analog-digital stethoscope is herein provided. In one example, an electronic stethoscope comprises a chestpiece including a sound collecting interface and a plurality of electronic components, wherein the plurality of electronic components includes one or more microphones and one or more speakers; an output tube coupled to the chestpiece via a connector comprising a mode switching port, wherein the output tube, when the mode switching port is in a first position for digital mode, is in acoustic communication with the one or more speakers and, when the mode switching port is in a second position for analog mode, is in acoustic communication with the sound collecting interface.

Abstract: The presently disclosed subject matter relates generally to a device for cutting soft tissue, such as transverse carpal ligaments and annular ligaments of the finger, and methods of using the soft tissue cutting device. A soft tissue cutting device includes an inner tubular member extending between a distal end and a proximal end of the inner tube, an outer tubular member disposed over at least a portion of the inner tubular member and movable between an initial position and an extended position, an outer tubular member movement controller that controls movement of the outer tubular member between the initial position and the extended position, and an attachment mechanism for removably coupling the proximal end of the inner tubular member to a dispensing member. A distal end of the outer tubular member includes a cutting member.

Abstract: Methods, systems, and computer-readable media for generating a statistically covaried machine learning model for performance measurement of service providers. The method receives a configuration file that includes one or more parameters associated with a plurality of individuals and parses it to generate and executing the database query on input data to generate sets of tabulated data of individuals of the plurality of individuals. The method next determines one or more measures of service providers listed in the configuration file using two or more tabulated data of individuals from the sets of tabulated data of individuals. The method finally generates a covaried machine learning model by training a machine learning model by statistically covarying measures and using them as training data.

Abstract: Implantable ports used for intravenous administration and methods of using the same.