Patents Assigned to HIROSAKI UNIVERSITY
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Publication number: 20240149219Abstract: A lithium recovery device equipped with a processing tank partitioned into a supply tank and a recovery tank by a lithium ion-conducting electrolyte film, and which, in order to selectively move Li+ to an aqueous solution in the recovery tank from an aqueous solution in the supply tank containing Li+ and metal ions Mn+ which are different therefrom, is also equipped with a first power supply connected between porous-structure electrodes provided so as to respectively contact both surfaces of the electrolyte film with the electrode on the supply tank side as the positive electrode, and a second power supply which connects in series to the negative electrode of the first power supply and in which said negative electrode is connected to a sub-electrode provided at a distance from the electrolyte film inside the recovery tank, wherein the second power supply applies a voltage so as to cause a current to flow from the positive electrode to the electrode.Type: ApplicationFiled: May 13, 2022Publication date: May 9, 2024Applicant: HIROSAKI UNIVERSITYInventors: Kazuya SASAKI, Kiyoto SHINMURA
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Publication number: 20240068884Abstract: A thermosensitive part sensing temperature; a temperature sensor for measurement provided in the unit and measuring temperature by contacting the unit with a body to be measured; a temperature detecting part detecting, from when the unit contacts the body, the time when the sensor senses a difference from an initial temperature of the sensor, and a measured temperature of the sensor at that time, and detecting, from when the difference is sensed, a time after a certain length of time and a measured temperature of the sensor at that time; an estimating part estimating, from the time when the difference is sensed and a time after a certain length of time, the time when the thermosensitive part contacts the body, and the measured temperature at that time; and a heat conduction analyzing part estimating the measured temperature based on output information from the temperature detecting part and the estimating part.Type: ApplicationFiled: January 12, 2022Publication date: February 29, 2024Applicants: SEMITEC Corporation, National Institute of Technology, HIROSAKI UNIVERSITYInventors: Shigenao MARUYAMA, Yuya ISEKI, Takuma KOGAWA, Takashi NONAKA, Yasushi HOSOKAWA, Takahiro OKABE, Yutaro TABATA, Tadashi MATSUDATE, Toshinori NAKAJIMA, Masaya HIGASHI, Manabu ORITO
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Patent number: 11845972Abstract: The objective of the present invention is to provide a microorganism that makes it possible to produce muconic acid from a lignin-derived aromatic compound with sufficient economic efficiency and without depending on the type of lignin, and a method of producing muconic acid using the microorganism. The objective can be achieved by a transformed microorganism wherein the host microorganism is a microorganism of the genus Pseudomonas that has pcaH gene, pcaG gene, catA gene, and catB gene on its chromosome, and that can assimilate an aromatic compound derived from syringyl lignin; and wherein the transformed microorganism lacks at least one gene selected from the group consisting of pcaH gene and pcaG gene on its chromosome, lacks catB gene on its chromosome, and expresses aroY gene inserted; and a method of producing muconic acid using the transformed microorganism and the like.Type: GrantFiled: October 17, 2019Date of Patent: December 19, 2023Assignee: HIROSAKI UNIVERSITYInventors: Tomonori Sonoki, Eiji Masai, Naofumi Kamimura
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Publication number: 20230395221Abstract: A health improvement path search device including: a first model generating unit configured to generate a first model predicting a value of a health index; a second model generating unit configured to generate a second model deriving a presence probability; and a path searching unit configured to derive the value of the health index and the presence probability corresponding to each measurement target value specify a plurality of paths transitioning to each of the measurement target values from the current values as start points, specify paths in which the value of the health index at an end point is improved from the current value of the health index among the plurality of paths as candidate paths, and specify a path for which a product of the presence probabilities of the measurement target values included in the candidate path is a maximum as a health improvement path.Type: ApplicationFiled: October 22, 2021Publication date: December 7, 2023Applicants: KYOWA HAKKO BIO CO., LTD., Kyoto University, HIROSAKI UNIVERSITYInventors: Kazuki NAKAMURA, Yasushi OKUNO, Ryosuke KOJIMA, Eiichiro UCHINO, Koichi MURASHITA, Ken ITOH, Shigeyuki NAKAJI
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Patent number: 11834608Abstract: An aqueous sol used in CO2 foam flooding, one of EOR flooding methods for recovering crude oil by injection into the oil reservoir of an onshore or offshore oil field, the aqueous sol increasing foam stability even over a substantial period of time, at high temperatures and pressures, and in salt water, thus improving crude oil recovery rate. The aqueous sol for increasing stability of froth or emulsion in a mixture containing carbon dioxide, water, and oil in CO2 foam flooding of EOR, the sol including silica particles having an average particle diameter of 1 to 100 nm as measured by dynamic light scattering and having surfaces at least partially coated with a silane compound having a hydrolyzable group, the silica particles serving as a dispersoid and dispersed in an aqueous solvent having a pH of 1.0 to 6.0 serving as a dispersion medium.Type: GrantFiled: November 26, 2020Date of Patent: December 5, 2023Assignees: INPEX CORPORATION, HIROSAKI UNIVERSITY, NISSAN CHEMICAL CORPORATIONInventors: Takashi Hiraoka, Hideharu Yonebayashi, Yoshihiro Miyagawa, Masanobu Sagisaka, Masashi Abe
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Publication number: 20230374372Abstract: An aqueous sol used in CO2 foam flooding, one of EOR flooding methods for recovering crude oil by injection into the oil reservoir of an onshore or offshore oil field, the aqueous sol increasing foam stability even over a substantial period of time, at high temperatures and pressures, and in salt water, thus improving crude oil recovery rate. The aqueous sol for increasing stability of froth or emulsion in a mixture containing carbon dioxide, water, and oil in CO2 foam flooding of EOR, the sol including silica particles having an average particle diameter of 1 to 100 nm as measured by dynamic light scattering and having surfaces at least partially coated with a silane compound having a hydrolyzable group, the silica particles serving as a dispersoid and dispersed in an aqueous solvent having a pH of 1.0 to 6.0 serving as a dispersion medium.Type: ApplicationFiled: July 31, 2023Publication date: November 23, 2023Applicants: INPEX CORPORATION, HIROSAKI UNIVERSITY, NISSAN CHEMICAL CORPORATIONInventors: Takashi HIRAOKA, Hideharu YONEBAYASHI, Yoshihiro MIYAGAWA, Masanobu SAGISAKA, Masashi ABE
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Publication number: 20230296447Abstract: A temperature measurement device (10) comprises: a thermosensitive unit (41) that senses temperature; a thin film thermosensitive element (1) for measurement capable of measuring the temperature by bringing the thermosensitive unit (41) into contact with a subject; a thin film thermosensitive element (2) for protective heating disposed to enable heat exchange with the thin film thermosensitive element (1) via an insulating layer (S1), and controlled so that the temperature thereof is equal to the temperature of the thin film thermosensitive element (1); a temperature control element (3) capable of causing the thin film thermosensitive element (1) to be in a temperature state in which the temperature thereof is a certain degree lower than the temperature of the subject; and a control processing unit (5) controlling the thin film thermosensitive element (1), the thin film thermosensitive element (2), and the temperature control element (3).Type: ApplicationFiled: June 15, 2021Publication date: September 21, 2023Applicants: SEMITEC Corporation, National Institute of Technology, HIROSAKI UNIVERSITYInventors: Shigenao MARUYAMA, Takahiro OKABE, Yuya ISEKI, Takashi NONAKA, Takuma KOGAWA, Yasushi HOSOKAWA, Yutaro TABATA, Tadashi MATSUDATE, Toshinori NAKAJIMA, Masaya HIGASHI, Manabu ORITO
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Publication number: 20230256390Abstract: A lithium isotope concentration device includes a treatment tank partitioned in a supply tank and a recovery tank by an electrolyte membrane having a lithium-ion conductivity. The electrolyte membrane is cooled by a cooling device via an Li-containing aqueous solution in the supply tank to have a low temperature at which the Li isotope separation coefficient is larger. A power supply device, connected between electrodes provided on opposite surfaces of the electrolyte membrane, applies a positive voltage to an electrode on a supply tank side.Type: ApplicationFiled: July 6, 2021Publication date: August 17, 2023Applicant: Hirosaki UniversityInventors: Kazuya SASAKI, Kiyoto SHINMURA
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Patent number: 11688525Abstract: A radioactive fine particle manufacturing system and method to manufacture physically stable radioactive fine particles, and which enables performance evaluation of a radioactivity measuring instrument employing a physical indicator, by controlling radioactivity concentration, and facilitating performance evaluation of the overall radioactivity measuring instrument. The radioactive fine particle manufacturing system includes a radioactive gas generating system, a specific particle-sized aerosol generating system and a mixing chamber, to manufacture radioactive fine particles employing natural radioactive nuclides, and uses. 220Rn to manufacture radioactive fine particles using physically stable progeny nuclides. In the mixing chamber, the progeny nuclides are caused to attach only to an aerosol having a specific particle size, to generate radioactive fine particles having a specific particle size.Type: GrantFiled: March 9, 2018Date of Patent: June 27, 2023Assignee: HIROSAKI UNIVERSITYInventor: Shinji Tokonami
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Publication number: 20230093691Abstract: A fluorine-containing alcohol composite comprising a condensate of a fluorine-containing alcohol represented by the general formula: HO-A-RF-A-OH [I] (wherein RF is a group containing a perfluoroalkylene group or a polyfluoroalkylene group having 6 or less carbon atoms and an ether bond, and A is an alkylene group having 1 to 3 carbon atoms), a hydroxyl group-containing polymer, and a zirconium compound. The fluorine-containing alcohol composite, using a fluorine-containing alcohol, does not produce perfluorooctanoic acid and the like when released into the environment and that has a unit easily decomposed into short chain compounds. And also, it exhibits hydrophilic oil repellency.Type: ApplicationFiled: December 15, 2020Publication date: March 23, 2023Applicants: UNIMATEC CO., LTD., HIROSAKI UNIVERSITYInventors: Tetsushi KIJIMA, Yasuhiko AKATSU, Hideo SAWADA
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Publication number: 20230002669Abstract: An aqueous sol used in CO2 foam flooding, one of EOR flooding methods for recovering crude oil by injection into the oil reservoir of an onshore or offshore oil field, the aqueous sol increasing foam stability even over a substantial period of time, at high temperatures and pressures, and in salt water, thus improving crude oil recovery rate. The aqueous sol for increasing stability of froth or emulsion in a mixture containing carbon dioxide, water, and oil in CO2 foam flooding of EOR, the sol including silica particles having an average particle diameter of 1 to 100 nm as measured by dynamic light scattering and having surfaces at least partially coated with a silane compound having a hydrolyzable group, the silica particles serving as a dispersoid and dispersed in an aqueous solvent having a pH of 1.0 to 6.0 serving as a dispersion medium.Type: ApplicationFiled: November 26, 2020Publication date: January 5, 2023Applicants: INPEX CORPORATION, HIROSAKI UNIVERSITY, NISSAN CHEMICAL CORPORATIONInventors: Takashi HIRAOKA, Hideharu YONEBAYASHI, Yoshihiro MIYAGAWA, Masanobu SAGISAKA, Masashi ABE
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Patent number: 11471981Abstract: A fabrication method of transparent material is a method of processing a thermosetting transparent material including a disposing step of disposing an uncured thermosetting transparent material, a laser beam irradiation step of irradiating the disposed uncured thermosetting transparent material with a laser beam so that cavitation bubbles are generated in the uncured thermosetting transparent material, and a curing step of performing a curing process on the uncured thermosetting transparent material in which the cavitation bubbles are generated.Type: GrantFiled: December 20, 2018Date of Patent: October 18, 2022Assignee: HIROSAKI UNIVERSITYInventor: Yasutaka Hanada
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Patent number: 11349131Abstract: Provided is a catalyst for fuel cells including an oxygen atom, a nitrogen atom, a pentavalent phosphorus atom, and a transition metal atom, in which when the transition metal atom is represented by M, the catalyst for fuel cells is represented by a chemical formula MOxNyPz, and the transition metal atom is at least one selected from the group consisting of a titanium atom, a tantalum atom, a niobium atom, and a zirconium atom.Type: GrantFiled: October 28, 2020Date of Patent: May 31, 2022Assignees: TOPPAN PRINTING CO., LTD., HIROSAKI UNIVERSITYInventors: Hiroyuki Morioka, Madoka Ozawa, Mitsuharu Chisaka
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Publication number: 20220112490Abstract: There is provided a method for suppressing protein expression, including using an oligomer for RNA having first, second, third, and fourth guanine repeat sequences (referred to as “first G sequence,” “second G sequence,” “third G sequence,” and “fourth G sequence,” respectively), the oligomer hybridizing with regions proximal to the guanine repeat sequences, so as to bring the guanine repeat sequences closer together, thereby forming a guanine-quadruplex structure.Type: ApplicationFiled: October 25, 2019Publication date: April 14, 2022Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY, HIROSAKI UNIVERSITYInventors: Yosuke KATSUDA, Shinichi SATO, Masaki HAGIHARA, Toshihiro IHARA, Yusuke KITAMURA
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Publication number: 20220080116Abstract: A drug administration device according to the present invention is a drug administration device for subcutaneously administering a drug, and includes a main body portion configured to be arranged on skin of a patient, and a movable portion to which at least one needle member protruding toward the skin is attached. The movable portion is configured to be capable of being moved between a first position that is spaced apart from the skin and a second position that is near the skin. The leading end portion of the needle member is to be inserted into the skin when the movable portion is located at the second position. The drug is to be discharged from a hole provided in the needle member.Type: ApplicationFiled: December 25, 2019Publication date: March 17, 2022Applicants: HIROSAKI UNIVERSITY, OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Tadashi KOBAYASHI, Hiroki MAITA, Hiroyuki KATO, Takashi AKIMOTO, Hidetoshi MISAWA, Takehito HAYASHI, Koichi TAKEDA, Toshimitsu TERAO, Tomoki MORITA, Shinichiro ITO
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Publication number: 20210371885Abstract: The objective of the present invention is to provide a microorganism that makes it possible to produce muconic acid from a lignin-derived aromatic compound with sufficient economic efficiency and without depending on the type of lignin, and a method of producing muconic acid using the microorganism. The objective can be achieved by a transformed microorganism wherein the host microorganism is a microorganism of the genus Pseudomonas that has pcaH gene, pcaG gene, catA gene, and catB gene on its chromosome, and that can assimilate an aromatic compound derived from syringyl lignin; and wherein the transformed microorganism lacks at least one gene selected from the group consisting of pcaH gene and pcaG gene on its chromosome, lacks catB gene on its chromosome, and expresses aroY gene inserted; and a method of producing muconic acid using the transformed microorganism and the like.Type: ApplicationFiled: October 17, 2019Publication date: December 2, 2021Applicant: HIROSAKI UNIVERSITYInventors: Tomonori SONOKI, Eiji MASAI, Naofumi KAMIMURA
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Patent number: 11137403Abstract: The present invention provides methods that are for acquiring various types of supplementary information used for diagnosis or treatment of prostate cancer, and that can be implemented in a less-invasive manner at a low cost. Provided are, by measuring the content of prostate specific antigen (PSA) having a ?-N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a specimen, and comparing the measured value with a threshold value, (1) a method for estimating whether a Gleason score (primary pattern and secondary pattern) is not less than or less than a prescribed value, (2) a method for estimating whether the pathological stage (pT) is not less than or less than a prescribed value, and (3) a method for acquiring information for assessment indicating diagnosis or treatment should be actively conducted because a GS at gross total removal is expected to be higher than a GS at biopsy.Type: GrantFiled: November 29, 2017Date of Patent: October 5, 2021Assignees: Konica Minolta, Inc., HIROSAKI UNIVERSITYInventors: Tomonori Kaneko, Takatoshi Kaya, Chikara Ohyama, Tohru Yoneyama, Yuki Tobisawa
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Publication number: 20210215699Abstract: The present invention relates to a method for determining prostate carcinoma, including obtaining a ratio 1 between an amount of a free prostate specific antigen and an amount of a free PSA having an ?(2,3) glycan, the free PSA having an ?(2,3) glycan being a free prostate specific antigen having a glycan in which a terminal sialic acid residue of the glycan is ?(2,3)-linked to a second galactose residue from a terminal of the glycan, in a sample derived from a subject; obtaining a ratio 2 between the ratio 1 and a volume of the prostate of the subject; and determining prostate carcinoma based on the obtained ratio 2.Type: ApplicationFiled: May 17, 2019Publication date: July 15, 2021Applicants: FUJIFILM WAKO PURE CHEMICAL CORPORATION, HIROSAKI UNIVERSITYInventors: Chikara OHYAMA, Tohru YONEYAMA, Yuki TOBISAWA, Tomokazu ISHIKAWA, Mutsuhiro DATE, Kenji NAKAMURA
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Publication number: 20210138274Abstract: The purpose of the present invention is to provide a 10B medicine that can be selectively accumulated in tumor tissues at a low dose in a short time, and can be applied to BNCT. The 10B medicine comprises a compound containing: a peptide capable of selectively binding to tumor vascular endothelial cells; and 10B, wherein the 10B medicine is administered to a subject suffering from cancer at a dose of 300-600 mg per administration, and is accumulated after the administration such that the concentration of 10B in the cancer tissue of the subject becomes 1 ppm or higher.Type: ApplicationFiled: June 19, 2019Publication date: May 13, 2021Applicant: HIROSAKI UNIVERSITYInventors: Chikara OHYAMA, Tohru YONEYAMA, Shingo HATAKEYAMA, Shintaro ISHIYAMA
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Patent number: D975845Type: GrantFiled: December 29, 2020Date of Patent: January 17, 2023Assignees: HIROSAKI UNIVERSITY, OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Tadashi Kobayashi, Hiroki Maita, Hiroyuki Kato, Takashi Akimoto, Takehito Hayashi, Koichi Takeda, Toshimitsu Terao, Tomoki Morita, Shinichiro Ito, Tadashi Komuro, Teruyuki Iwama