Patents Assigned to HIROSAKI UNIVERSITY
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Publication number: 20170283778Abstract: The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial peritoneal tissue.Type: ApplicationFiled: August 25, 2015Publication date: October 5, 2017Applicants: HIROSAKI UNIVERSITY, OSAKA UNIVERSITYInventors: Hiroshi SHIMODA, Yoshiya ASANO, Mitsuru AKASHI, Michiya MATSUSAKI
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Patent number: 9756791Abstract: A grafting technique effective for crops such as soybean and plants of the Poaceae family including rice, wheat, corn, etc. and a method of grafting crops of the present invention comprising the steps of replacing a radicle of a dry dormant seed with a radicle of another dormant seed capable of achieving grafting, and thereafter, germinating the seed.Type: GrantFiled: November 7, 2013Date of Patent: September 12, 2017Assignee: HIROSAKI UNIVERSITYInventor: Takeo Harada
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Patent number: 9695263Abstract: Disclosed is a fluorine-containing oligomer comprising a copolymer of a fluoroalkyl alcohol (meth)acrylic acid derivative of the formula: CnF2n+1(CH2)dOCOCR?CH2 [I], wherein R is a hydrogen atom or a methyl group, n is an integer of 1 to 10, and d is an integer of 1 to 6; and a (meth)acrylic acid derivative of the formula: (CH2?CRCO)mR? [II], wherein R is a hydrogen atom or a methyl group, m is 1, 2, or 3; and when m is 1, R? is —OH group, NH2 group that is unsubstituted or mono- or di-substituted with an alkyl group having 1 to 6 carbon atoms, or a monovalent group derived from an alkylene glycol or polyalkylene glycol group containing an alkylene group having 2 or 3 carbon atoms; when m is 2 or 3, R? is a divalent or trivalent organic group derived from a diol or triol. The copolymerization reaction is performed using a hydrocarbon-based peroxide or azo compound polymerization initiator.Type: GrantFiled: March 6, 2014Date of Patent: July 4, 2017Assignees: Unimatec Co., Ltd., Hirosaki UniversityInventors: Katsuyuki Sato, Hideo Sawada
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Publication number: 20170122955Abstract: Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.Type: ApplicationFiled: April 6, 2015Publication date: May 4, 2017Applicant: HIROSAKI UNIVERSITYInventors: Katsuya YAMADA, Ayako SASAKI, Tadashi TESHIMA, Toshihiro YAMAMOTO, Yuji OTSUKA
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Publication number: 20170081610Abstract: [Problem] To provide a phospholipid ?-linolenic acid composition of consistent quality and having a stable supply of source material, with focus on Torula yeast, which is edible and recognized as safe, in order to resolve issues with omega 3 sources. [Means for Solving the Problem] As a result of intensive study to resolve the above-noted issues, the inventors of the present invention have discovered that a phospholipid ?-linolenic acid composition can be obtained using residue of yeast extract extracted from Torula yeast (Candida utilis), for example, which is currently produced in large quantities for application in foods, and so arrived at the present invention.Type: ApplicationFiled: March 9, 2015Publication date: March 23, 2017Applicants: KOHJIN LIFE SCIENCES CO., LTD., KOHJIN LIFE SCIENCES CO., LTD., HIROSAKI UNIVERSITY, HIROSAKI UNIVERSITYInventors: Naoto KAJI, Shiroh AIDA, Katsuhiro OSAKI, Masato OMAE, Tomohiro NAKAGAWA, Motoyuki TOKURIKI, Hayato MAEDA
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Patent number: 9585828Abstract: The present invention was made in view of an object to produce a novel proteoglycan-containing material, and find a novel use and/or a superior effect of the proteoglycan-containing material. The present invention provides a proteoglycan-containing material obtained from fish cartilage, wherein the proteoglycan-containing material comprises an acidic saccharide component having a molecular weight of not less than 2000 kDa. The proteoglycan-containing material provides advantageous effects for skin-moisturizing and skin anti-aging, including a superior skin fibroblast proliferation effect, an effect of enhancing and improving the skin barrier function, an effect of enhancing and improving the skin's capability to produce collagen, a dermis-thickening inhibition effect, and the like.Type: GrantFiled: October 4, 2013Date of Patent: March 7, 2017Assignees: SUNSTAR INC., HIROSAKI UNIVERSITYInventors: Masashi Goto, Kazushi Yamamoto, Youji Katou, Yohtaro Katagata, Seiko Itou
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Publication number: 20170015833Abstract: Fluorine-containing titanium oxide—nano-silica composite particles comprising a condensate of a fluorine-containing alcohol and an alkoxysilane, and titanium oxide and nano-silica particles, wherein the fluorine-containing alcohol is represented by the general formula: RF—A—OH??[I] (wherein RF is a perfluoroalkyl group having 6 or less carbon atoms, or a polyfluoroalkyl group, in which some of the fluorine atom or atoms of the perfluoroalkyl group are replaced by a hydrogen atom or atoms, and which contains a terminal perfluoroalkyl group having 6 or less carbon atoms and a perfluoroalkylene group having 6 or less carbon atoms; and A is an alkylene group having 1 to 6 carbon atoms).Type: ApplicationFiled: March 10, 2015Publication date: January 19, 2017Applicants: UNIMATEC CO., LTD., HIROSAKI UNIVERSITYInventors: Takeshi Fukushima, Katsuyuki Sato, Hideo Sawada
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Patent number: 9475826Abstract: Fluorine-containing nano composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF-A-OH??[I] wherein RF is a perfluoroalkyl group or a polyfluoroalkyl group in which some of the fluorine atoms of the perfluoroalkyl group are replaced by hydrogen atoms, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane, or fluorine-containing nano composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF?-A-OH??[Ia] or the general formula: HO-A-RF?-A-OH??[Ib] wherein RF? is a linear or branched perfluoroalkyl group containing an O, S, or N atom, RF? is a linear or branched perfluoroalkylene group containing an O, S, or N atom, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane.Type: GrantFiled: March 6, 2014Date of Patent: October 25, 2016Assignees: Unimatec Co., Ltd., Hirosaki UniversityInventors: Katsuyuki Sato, Hideo Sawada
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Publication number: 20160300998Abstract: A method for producing a magnetostrictive material and a method for increasing the value of magnetostriction can increase the value of magnetostriction of magnetostrictive materials used, for example, in vibration power generation and force sensors utilizing inverse magnetostriction phenomenon. A magnetostrictive material having a value of magnetostriction of 100 ppm or more is produced by melting and casting an alloy material in the composition of range of 67-87 wt % Co with the balance consisting of Fe and unavoidable impurities and then performing hot forging. Furthermore, a magnetostrictive material having a value of magnetostriction of 130 ppm or more can be produced by performing cold rolling after the hot forging. Heat treatment at 400-1000° C. may also be performed after hot working or cold working.Type: ApplicationFiled: December 5, 2014Publication date: October 13, 2016Applicants: HIROSAKI UNIVERSITY, TOHOKU UNIVERSITY, TOHOKU STEEL Co., Ltd.Inventors: Yasufumi FURUYA, Shinichi YAMAURA, Takashi NAKAJIMA, Takashi EBATA, Takenobu SATO
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Patent number: 9284359Abstract: An object of the present invention is to efficiently extract proteoglycan from aquatic animal tissues. The method of the present invention is a method for extracting proteoglycan from fish cartilage, comprising the step of (A) heating small pieces of frozen fish cartilage in water. This method of the present invention enables easy extraction of proteoglycan from fish cartilage with very high efficiency. In particular, the method of the present invention enables extraction of high-molecular-weight proteoglycan. Further, since in the method of the present invention, extraction is performed using only water, it ensures safety in the extraction and safety of the resulting proteoglycan product, compared with hitherto known extraction methods using organic solvents or acids/alkali. Furthermore, the cumbersome step of removing organic solvents is not necessary in the method of the present invention.Type: GrantFiled: January 19, 2012Date of Patent: March 15, 2016Assignee: Hirosaki UniversityInventor: Yoji Kato
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Publication number: 20150369797Abstract: The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule.Type: ApplicationFiled: October 1, 2013Publication date: December 24, 2015Applicant: HIROSAKI UNIVERSITYInventors: Katsuya YAMADA, Tadashi TESHIMA, Toshihiro YAMAMOTO
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Publication number: 20150260720Abstract: An object of the present invention is to provide a method for distinguishing between prostate carcinoma and benign prostatic hyperplasia with high sensitivity and good reproducibility using a small amount of an analyte sample.Type: ApplicationFiled: October 9, 2013Publication date: September 17, 2015Applicants: HIROSAKI UNIVERSITY, SHIZUOKA PREFECTURAL UNIVERSITY CORPORATIONInventors: Chikara Ohyama, Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Takashi Suzuki, Ilpal Jwa, Maho Yamaguchi
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Patent number: 9101894Abstract: There is provided a highly branched hydrocarbon based surfactant for stabilizing a water/supercritical carbon dioxide microemulsion. A surfactant comprising: a sulfate compound of Formula (1): R1—OSO3M??(1) (where R1 is a C6-30 hydrocarbon group having a branched chain; and M is a hydrogen atom, an alkali metal, ammonium, a basic amino acid residue, an alkanolamine residue having a C2-3 hydroxyalkyl group, or an aliphatic alkanolammonium) for stabilizing a water/supercritical carbon dioxide microemulsion.Type: GrantFiled: June 19, 2014Date of Patent: August 11, 2015Assignees: NISSAN CHEMICAL INDUSTRIES, LTD., HIROSAKI UNIVERSITYInventors: Masanobu Sagisaka, Kotaro Kudo, Masahiro Hida, Yasufumi Shikauchi
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Patent number: 8986656Abstract: An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.Type: GrantFiled: August 7, 2009Date of Patent: March 24, 2015Assignees: Hirosaki University, National University Corporation Tokyo Unversity of Agriculture and TechnologyInventors: Katsuya Yamada, Hideaki Matsuoka, Tadashi Teshima, Toshihiro Yamamoto
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Publication number: 20140303062Abstract: There is provided a highly branched hydrocarbon based surfactant for stabilizing a water/supercritical carbon dioxide microemulsion. A surfactant comprising: a sulfate compound of Formula (1): R1—OSO3M??(1) (where R1 is a C6-30 hydrocarbon group having a branched chain; and M is a hydrogen atom, an alkali metal, ammonium, a basic amino acid residue, an alkanolamine residue having a C2-3 hydroxyalkyl group, or an aliphatic alkanolammonium) for stabilizing a water/supercritical carbon dioxide microemulsion.Type: ApplicationFiled: June 19, 2014Publication date: October 9, 2014Applicants: NISSAN CHEMICAL INDUSTRIES, LTD., HIROSAKI UNIVERSITYInventors: Masanobu SAGISAKA, Kotaro KUDO, Masahiro HIDA, Yasufumi SHIKAUCHI
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Patent number: 8815957Abstract: A surfactant for water/supercritical carbon dioxide microemulsions that can achieve high water dispersion ability, water/supercritical carbon dioxide microemulsion forming ability under a moderate condition, and high water solubilization rate and that reduces burden on the environment and ecosystem. Provided are a surfactant for stabilizing a water/supercritical carbon dioxide microemulsion including a compound of Formula (I) and a water/supercritical carbon dioxide microemulsion including the surfactant.Type: GrantFiled: March 2, 2011Date of Patent: August 26, 2014Assignees: Nissan Chemical Industries, Ltd., Hirosaki UniversityInventors: Masanobu Sagisaka, Shuho Iwama, Masahiro Hida, Yasufumi Shikauchi
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Publication number: 20140154717Abstract: The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient.Type: ApplicationFiled: March 29, 2012Publication date: June 5, 2014Applicants: HIROSAKI UNIVERSITY, PEPTIDE INSTITUTE, INC., RIKENInventors: Katsuya Yamada, Hirotaka Onoe, Tadashi Teshima, Toshihiro Yamamoto
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Publication number: 20140080761Abstract: The present invention was made in view of an object to produce a novel proteoglycan-containing material, and find a novel use and/or a superior effect of the proteoglycan-containing material. The present invention provides a proteoglycan-containing material obtained from fish cartilage, wherein the proteoglycan-containing material comprises an acidic saccharide component having a molecular weight of not less than 2000 kDa. The proteoglycan-containing material provides advantageous effects for skin-moisturizing and skin anti-aging, including a superior skin fibroblast proliferation effect, an effect of enhancing and improving the skin barrier function, an effect of enhancing and improving the skin's capability to produce collagen, a dermis-thickening inhibition effect, and the like.Type: ApplicationFiled: October 4, 2013Publication date: March 20, 2014Applicants: HIROSAKI UNIVERSITY, SUNSTAR INC.Inventors: Masashi GOTO, Kazushi YAMAMOTO, Youji KATOU, Yohtaro KATAGATA, Seiko ITOU
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Publication number: 20130310540Abstract: An object of the present invention is to obtain a useful extract from aquatic animal tissues. The present invention provides a fish cartilage water extract containing a proteoglycan having a molecular weight of not less than 2,500,000 (250×104). The extract has a superior skin anti-aging effect (in particular, anti-inflammatory effect, skin barrier functionality improving effect, and skin water-retention ability improving effect). Moreover, the fish cartilage water extract of the present invention provides these effects not only through application to skin but also through oral administration.Type: ApplicationFiled: January 19, 2012Publication date: November 21, 2013Applicants: SUNSTAR INC., HIROSAKI UNIVERSITYInventors: Yoji Kato, Yohtaro Katagata, Masashi Goto, Kazushi Yamamoto, Mariko Maeda, Yukako Hanada, Motoko Takai, Yutaka Suekawa
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Publication number: 20130303736Abstract: An object of the present invention is to efficiently extract proteoglycan from aquatic animal tissues. The method of the present invention is a method for extracting proteoglycan from fish cartilage, comprising the step of (A) heating small pieces of frozen fish cartilage in water. This method of the present invention enables easy extraction of proteoglycan from fish cartilage with very high efficiency. In particular, the method of the present invention enables extraction of high-molecular-weight proteoglycan. Further, since in the method of the present invention, extraction is performed using only water, it ensures safety in the extraction and safety of the resulting proteoglycan product, compared with hitherto known extraction methods using organic solvents or acids/alkali. Furthermore, the cumbersome step of removing organic solvents is not necessary in the method of the present invention.Type: ApplicationFiled: January 19, 2012Publication date: November 14, 2013Applicant: HIROSAKI UNIVERSITYInventor: Yoji Kato