Patents Assigned to HIROSAKI UNIVERSITY
  • Patent number: 9695263
    Abstract: Disclosed is a fluorine-containing oligomer comprising a copolymer of a fluoroalkyl alcohol (meth)acrylic acid derivative of the formula: CnF2n+1(CH2)dOCOCR?CH2 [I], wherein R is a hydrogen atom or a methyl group, n is an integer of 1 to 10, and d is an integer of 1 to 6; and a (meth)acrylic acid derivative of the formula: (CH2?CRCO)mR? [II], wherein R is a hydrogen atom or a methyl group, m is 1, 2, or 3; and when m is 1, R? is —OH group, NH2 group that is unsubstituted or mono- or di-substituted with an alkyl group having 1 to 6 carbon atoms, or a monovalent group derived from an alkylene glycol or polyalkylene glycol group containing an alkylene group having 2 or 3 carbon atoms; when m is 2 or 3, R? is a divalent or trivalent organic group derived from a diol or triol. The copolymerization reaction is performed using a hydrocarbon-based peroxide or azo compound polymerization initiator.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: July 4, 2017
    Assignees: Unimatec Co., Ltd., Hirosaki University
    Inventors: Katsuyuki Sato, Hideo Sawada
  • Publication number: 20170122955
    Abstract: Provided is a glucose derivative, which is taken into cells via a membrane sugar transport system and is represented by formula (1). Also provided are an imaging agent and an imaging method for a cell or intracellular molecule using said glucose derivative. Further provided are a method for detecting cancer cells with good accuracy using said glucose derivative and an imaging agent to be used in said method. More specifically provided are D-glucose derivatives and L-glucose derivatives in which glucose is bound to the 7-position of a fluorescent molecular group with a coumarin backbone or a quinolone backbone. Also provided are a cell imaging agent and imaging method using the derivative. A cancer cell imaging agent and imaging method using the L-glucose derivative is also provided. G is a group selected from formulas (G1)-(G4) below.
    Type: Application
    Filed: April 6, 2015
    Publication date: May 4, 2017
    Applicant: HIROSAKI UNIVERSITY
    Inventors: Katsuya YAMADA, Ayako SASAKI, Tadashi TESHIMA, Toshihiro YAMAMOTO, Yuji OTSUKA
  • Publication number: 20170081610
    Abstract: [Problem] To provide a phospholipid ?-linolenic acid composition of consistent quality and having a stable supply of source material, with focus on Torula yeast, which is edible and recognized as safe, in order to resolve issues with omega 3 sources. [Means for Solving the Problem] As a result of intensive study to resolve the above-noted issues, the inventors of the present invention have discovered that a phospholipid ?-linolenic acid composition can be obtained using residue of yeast extract extracted from Torula yeast (Candida utilis), for example, which is currently produced in large quantities for application in foods, and so arrived at the present invention.
    Type: Application
    Filed: March 9, 2015
    Publication date: March 23, 2017
    Applicants: KOHJIN LIFE SCIENCES CO., LTD., KOHJIN LIFE SCIENCES CO., LTD., HIROSAKI UNIVERSITY, HIROSAKI UNIVERSITY
    Inventors: Naoto KAJI, Shiroh AIDA, Katsuhiro OSAKI, Masato OMAE, Tomohiro NAKAGAWA, Motoyuki TOKURIKI, Hayato MAEDA
  • Patent number: 9585828
    Abstract: The present invention was made in view of an object to produce a novel proteoglycan-containing material, and find a novel use and/or a superior effect of the proteoglycan-containing material. The present invention provides a proteoglycan-containing material obtained from fish cartilage, wherein the proteoglycan-containing material comprises an acidic saccharide component having a molecular weight of not less than 2000 kDa. The proteoglycan-containing material provides advantageous effects for skin-moisturizing and skin anti-aging, including a superior skin fibroblast proliferation effect, an effect of enhancing and improving the skin barrier function, an effect of enhancing and improving the skin's capability to produce collagen, a dermis-thickening inhibition effect, and the like.
    Type: Grant
    Filed: October 4, 2013
    Date of Patent: March 7, 2017
    Assignees: SUNSTAR INC., HIROSAKI UNIVERSITY
    Inventors: Masashi Goto, Kazushi Yamamoto, Youji Katou, Yohtaro Katagata, Seiko Itou
  • Publication number: 20170015833
    Abstract: Fluorine-containing titanium oxide—nano-silica composite particles comprising a condensate of a fluorine-containing alcohol and an alkoxysilane, and titanium oxide and nano-silica particles, wherein the fluorine-containing alcohol is represented by the general formula: RF—A—OH??[I] (wherein RF is a perfluoroalkyl group having 6 or less carbon atoms, or a polyfluoroalkyl group, in which some of the fluorine atom or atoms of the perfluoroalkyl group are replaced by a hydrogen atom or atoms, and which contains a terminal perfluoroalkyl group having 6 or less carbon atoms and a perfluoroalkylene group having 6 or less carbon atoms; and A is an alkylene group having 1 to 6 carbon atoms).
    Type: Application
    Filed: March 10, 2015
    Publication date: January 19, 2017
    Applicants: UNIMATEC CO., LTD., HIROSAKI UNIVERSITY
    Inventors: Takeshi Fukushima, Katsuyuki Sato, Hideo Sawada
  • Patent number: 9475826
    Abstract: Fluorine-containing nano composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF-A-OH??[I] wherein RF is a perfluoroalkyl group or a polyfluoroalkyl group in which some of the fluorine atoms of the perfluoroalkyl group are replaced by hydrogen atoms, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane, or fluorine-containing nano composite particles comprising a condensate of a fluorine-containing alcohol represented by the general formula: RF?-A-OH??[Ia] or the general formula: HO-A-RF?-A-OH??[Ib] wherein RF? is a linear or branched perfluoroalkyl group containing an O, S, or N atom, RF? is a linear or branched perfluoroalkylene group containing an O, S, or N atom, and A is an alkylene group having 1 to 6 carbon atoms; and an alkoxysilane.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: October 25, 2016
    Assignees: Unimatec Co., Ltd., Hirosaki University
    Inventors: Katsuyuki Sato, Hideo Sawada
  • Publication number: 20160300998
    Abstract: A method for producing a magnetostrictive material and a method for increasing the value of magnetostriction can increase the value of magnetostriction of magnetostrictive materials used, for example, in vibration power generation and force sensors utilizing inverse magnetostriction phenomenon. A magnetostrictive material having a value of magnetostriction of 100 ppm or more is produced by melting and casting an alloy material in the composition of range of 67-87 wt % Co with the balance consisting of Fe and unavoidable impurities and then performing hot forging. Furthermore, a magnetostrictive material having a value of magnetostriction of 130 ppm or more can be produced by performing cold rolling after the hot forging. Heat treatment at 400-1000° C. may also be performed after hot working or cold working.
    Type: Application
    Filed: December 5, 2014
    Publication date: October 13, 2016
    Applicants: HIROSAKI UNIVERSITY, TOHOKU UNIVERSITY, TOHOKU STEEL Co., Ltd.
    Inventors: Yasufumi FURUYA, Shinichi YAMAURA, Takashi NAKAJIMA, Takashi EBATA, Takenobu SATO
  • Patent number: 9284359
    Abstract: An object of the present invention is to efficiently extract proteoglycan from aquatic animal tissues. The method of the present invention is a method for extracting proteoglycan from fish cartilage, comprising the step of (A) heating small pieces of frozen fish cartilage in water. This method of the present invention enables easy extraction of proteoglycan from fish cartilage with very high efficiency. In particular, the method of the present invention enables extraction of high-molecular-weight proteoglycan. Further, since in the method of the present invention, extraction is performed using only water, it ensures safety in the extraction and safety of the resulting proteoglycan product, compared with hitherto known extraction methods using organic solvents or acids/alkali. Furthermore, the cumbersome step of removing organic solvents is not necessary in the method of the present invention.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: March 15, 2016
    Assignee: Hirosaki University
    Inventor: Yoji Kato
  • Publication number: 20150369797
    Abstract: The present invention has an object of providing a sugar derivative emitting blue fluorescence color which can be used for imaging of cells or intracellular molecules and a method for imaging cells using the derivative. Further, the present invention has an object of providing a method for detecting cancer cells at high accuracy by imaging, and an imaging agent used for this method. The present invention provides a fluorescently labeled sugar derivative having 3-carboxy-6,8-difluoro-7-hydroxycoumarin or 3-carboxymethyl-6,8-difluoro-7-hydroxy-4-methylcoumarin as a fluorescent molecular group in its molecule, and a cell imaging agent and an imaging method using the derivative. Further, the present invention provides an imaging agent and an imaging method for cancer cells using an L-glucose derivative having the above-described fluorescent molecular group in its molecule.
    Type: Application
    Filed: October 1, 2013
    Publication date: December 24, 2015
    Applicant: HIROSAKI UNIVERSITY
    Inventors: Katsuya YAMADA, Tadashi TESHIMA, Toshihiro YAMAMOTO
  • Publication number: 20150260720
    Abstract: An object of the present invention is to provide a method for distinguishing between prostate carcinoma and benign prostatic hyperplasia with high sensitivity and good reproducibility using a small amount of an analyte sample.
    Type: Application
    Filed: October 9, 2013
    Publication date: September 17, 2015
    Applicants: HIROSAKI UNIVERSITY, SHIZUOKA PREFECTURAL UNIVERSITY CORPORATION
    Inventors: Chikara Ohyama, Tohru Yoneyama, Yuki Tobisawa, Shingo Hatakeyama, Takashi Suzuki, Ilpal Jwa, Maho Yamaguchi
  • Patent number: 9101894
    Abstract: There is provided a highly branched hydrocarbon based surfactant for stabilizing a water/supercritical carbon dioxide microemulsion. A surfactant comprising: a sulfate compound of Formula (1): R1—OSO3M??(1) (where R1 is a C6-30 hydrocarbon group having a branched chain; and M is a hydrogen atom, an alkali metal, ammonium, a basic amino acid residue, an alkanolamine residue having a C2-3 hydroxyalkyl group, or an aliphatic alkanolammonium) for stabilizing a water/supercritical carbon dioxide microemulsion.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: August 11, 2015
    Assignees: NISSAN CHEMICAL INDUSTRIES, LTD., HIROSAKI UNIVERSITY
    Inventors: Masanobu Sagisaka, Kotaro Kudo, Masahiro Hida, Yasufumi Shikauchi
  • Patent number: 8986656
    Abstract: An object of the present invention is to provide a method for accurately evaluating the specific incorporation of D-glucose into cells. The present invention as a means for achieving the object is characterized by comprising contacting a D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells and an L-glucose derivative that has a fluorescent chromophore in the molecule with different cells in the same cell strain to be evaluated, respectively, comparing the fluorescence emitted by the D-glucose derivative that has a fluorescent chromophore in the molecule and is specifically incorporated into cells with the fluorescence emitted by the L-glucose derivative that has a fluorescent chromophore in the molecule, and evaluating the specific incorporation of D-glucose into cells relative to L-glucose by taking the difference between the two kinds of fluorescence intensities.
    Type: Grant
    Filed: August 7, 2009
    Date of Patent: March 24, 2015
    Assignees: Hirosaki University, National University Corporation Tokyo Unversity of Agriculture and Technology
    Inventors: Katsuya Yamada, Hideaki Matsuoka, Tadashi Teshima, Toshihiro Yamamoto
  • Publication number: 20140303062
    Abstract: There is provided a highly branched hydrocarbon based surfactant for stabilizing a water/supercritical carbon dioxide microemulsion. A surfactant comprising: a sulfate compound of Formula (1): R1—OSO3M??(1) (where R1 is a C6-30 hydrocarbon group having a branched chain; and M is a hydrogen atom, an alkali metal, ammonium, a basic amino acid residue, an alkanolamine residue having a C2-3 hydroxyalkyl group, or an aliphatic alkanolammonium) for stabilizing a water/supercritical carbon dioxide microemulsion.
    Type: Application
    Filed: June 19, 2014
    Publication date: October 9, 2014
    Applicants: NISSAN CHEMICAL INDUSTRIES, LTD., HIROSAKI UNIVERSITY
    Inventors: Masanobu SAGISAKA, Kotaro KUDO, Masahiro HIDA, Yasufumi SHIKAUCHI
  • Patent number: 8815957
    Abstract: A surfactant for water/supercritical carbon dioxide microemulsions that can achieve high water dispersion ability, water/supercritical carbon dioxide microemulsion forming ability under a moderate condition, and high water solubilization rate and that reduces burden on the environment and ecosystem. Provided are a surfactant for stabilizing a water/supercritical carbon dioxide microemulsion including a compound of Formula (I) and a water/supercritical carbon dioxide microemulsion including the surfactant.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: August 26, 2014
    Assignees: Nissan Chemical Industries, Ltd., Hirosaki University
    Inventors: Masanobu Sagisaka, Shuho Iwama, Masahiro Hida, Yasufumi Shikauchi
  • Publication number: 20140154717
    Abstract: The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient.
    Type: Application
    Filed: March 29, 2012
    Publication date: June 5, 2014
    Applicants: HIROSAKI UNIVERSITY, PEPTIDE INSTITUTE, INC., RIKEN
    Inventors: Katsuya Yamada, Hirotaka Onoe, Tadashi Teshima, Toshihiro Yamamoto
  • Publication number: 20140080761
    Abstract: The present invention was made in view of an object to produce a novel proteoglycan-containing material, and find a novel use and/or a superior effect of the proteoglycan-containing material. The present invention provides a proteoglycan-containing material obtained from fish cartilage, wherein the proteoglycan-containing material comprises an acidic saccharide component having a molecular weight of not less than 2000 kDa. The proteoglycan-containing material provides advantageous effects for skin-moisturizing and skin anti-aging, including a superior skin fibroblast proliferation effect, an effect of enhancing and improving the skin barrier function, an effect of enhancing and improving the skin's capability to produce collagen, a dermis-thickening inhibition effect, and the like.
    Type: Application
    Filed: October 4, 2013
    Publication date: March 20, 2014
    Applicants: HIROSAKI UNIVERSITY, SUNSTAR INC.
    Inventors: Masashi GOTO, Kazushi YAMAMOTO, Youji KATOU, Yohtaro KATAGATA, Seiko ITOU
  • Publication number: 20130310540
    Abstract: An object of the present invention is to obtain a useful extract from aquatic animal tissues. The present invention provides a fish cartilage water extract containing a proteoglycan having a molecular weight of not less than 2,500,000 (250×104). The extract has a superior skin anti-aging effect (in particular, anti-inflammatory effect, skin barrier functionality improving effect, and skin water-retention ability improving effect). Moreover, the fish cartilage water extract of the present invention provides these effects not only through application to skin but also through oral administration.
    Type: Application
    Filed: January 19, 2012
    Publication date: November 21, 2013
    Applicants: SUNSTAR INC., HIROSAKI UNIVERSITY
    Inventors: Yoji Kato, Yohtaro Katagata, Masashi Goto, Kazushi Yamamoto, Mariko Maeda, Yukako Hanada, Motoko Takai, Yutaka Suekawa
  • Publication number: 20130303736
    Abstract: An object of the present invention is to efficiently extract proteoglycan from aquatic animal tissues. The method of the present invention is a method for extracting proteoglycan from fish cartilage, comprising the step of (A) heating small pieces of frozen fish cartilage in water. This method of the present invention enables easy extraction of proteoglycan from fish cartilage with very high efficiency. In particular, the method of the present invention enables extraction of high-molecular-weight proteoglycan. Further, since in the method of the present invention, extraction is performed using only water, it ensures safety in the extraction and safety of the resulting proteoglycan product, compared with hitherto known extraction methods using organic solvents or acids/alkali. Furthermore, the cumbersome step of removing organic solvents is not necessary in the method of the present invention.
    Type: Application
    Filed: January 19, 2012
    Publication date: November 14, 2013
    Applicant: HIROSAKI UNIVERSITY
    Inventor: Yoji Kato
  • Publication number: 20130254939
    Abstract: An object of the present invention is to provide a method for transforming a plant by grafting of a rootstock and a scion, and using siRNA for initiating transcriptional gene silencing. The method for transforming a plant by grafting of a rootstock and a scion of the present invention as a means for resolution is characterized in that siRNA for initiating transcriptional gene silencing is produced in a scion, the siRNA produced in the scion is transported to a rootstock by grafting, and the rootstock is transformed by initiating transcriptional gene silencing therein.
    Type: Application
    Filed: December 6, 2011
    Publication date: September 26, 2013
    Applicant: HIROSAKI UNIVERSITY
    Inventors: Takeo Harada, Atsushi Kasai, Kaori Yamada, Songling Bai
  • Publication number: 20130023687
    Abstract: There is provided a highly branched hydrocarbon based surfactant for stabilizing a water/supercritical carbon dioxide microemulsion. A surfactant comprising: a sulfate compound of Formula (1): R1—OSO3M ??(1) (where R1 is a C6-30 hydrocarbon group having a branched chain; and M is a hydrogen atom, an alkali metal, ammonium, a basic amino acid residue, an alkanolamine residue having a C2-3 hydroxyalkyl group, or an aliphatic alkanolammonium) for stabilizing a water/supercritical carbon dioxide microemulsion.
    Type: Application
    Filed: March 1, 2011
    Publication date: January 24, 2013
    Applicants: HIROSAKI UNIVERSITY, NISSAN CHEMICAL INDUSTRIES, LTD.
    Inventors: Masanobu Sagisaka, Kotaro Kudo, Masahiro Hida, Yasufumi Shikauchi