Patents Assigned to Hiroshima University
  • Patent number: 9499822
    Abstract: A simple and inexpensive method for selectively culturing a microorganism which method makes it possible to selectively culture a microorganism of interest even without using a sterilization operation or an antibiotic substance is provided. The method according to the present invention selectively culturing a microorganism includes the step of culturing, in a culture medium containing phosphorous acid as a sole phosphorous source, a recombinant microorganism into which a phosphite dehydrogenase gene has been introduced.
    Type: Grant
    Filed: August 8, 2013
    Date of Patent: November 22, 2016
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Akio Kuroda, Ryuichi Hirota, Takenori Ishida
  • Publication number: 20160326246
    Abstract: The present invention provides a composition for regulating cell proliferation comprising a peptide having a partial amino acid sequence of BBF2H7 or an antibody capable of binding to the peptide. The problem has been solved by preparation of the peptide having a partial amino acid sequence of BBF2H7 which has a cell proliferation activity.
    Type: Application
    Filed: July 28, 2016
    Publication date: November 10, 2016
    Applicant: Hiroshima University
    Inventors: Kazunori Imaizumi, Atsushi Saito
  • Patent number: 9457071
    Abstract: Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: October 4, 2016
    Assignee: Hiroshima University
    Inventors: Michihiro Hide, Takaaki Hiragun, Kaori Ishii, Shoji Mihara, Makiko Hiragun, Jens-M Schroeder
  • Patent number: 9453846
    Abstract: The present invention provides a mass spectrometry method using a matrix that is capable of easily and efficiently improving ionization efficiency in mass spectrometry without modifying a molecule to be analyzed, and a matrix for mass spectrometry. A mass spectrometry method using, as a matrix, a 2,4,6-trihydroxyalkylphenone represented by the following general formula (I): where R is an alkyl group having 4 to 12 carbon atoms. The mass spectrometry method as described above, wherein an analysis object is a hydrophobic compound, particularly, a hydrophobic peptide.
    Type: Grant
    Filed: March 4, 2014
    Date of Patent: September 27, 2016
    Assignees: SHIMADZU CORPORATION, NATIONAL UNIVERSITY OF CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Yuko Fukuyama, Shunsuke Izumi
  • Patent number: 9456224
    Abstract: A motion image distribution system includes a server and a user terminal. The server generates a feature quantity table CHT1 representing a data structure of motion image encoded data VDE, and authenticates the motion image encoded data VDE by using the generated feature quantity table CHT1. Then, the server transmits the motion image encoded data VDE and the feature quantity table CHT1 to the user terminal. The user terminal generates a feature quantity table CHT2 representing a data structure of the received motion image encoded data VDE, and authenticates received motion image encoded data VDE by using the generated feature quantity table CHT2. Then, the user terminal plays back the motion image encoded data VDE and outputs motion image playback information.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: September 27, 2016
    Assignee: HIROSHIMA UNIVERSITY
    Inventor: Mei Kodama
  • Patent number: 9445727
    Abstract: An apparatus for evaluating a vascular endothelial function, includes: a cuff pressure controlling unit configured to perform continuous pressure stimulation on a part of a body of a subject for a predetermined time, by using a cuff adapted to be wrapped around the part of the body of the subject; a cuff pressure detecting unit configured to detect a cuff pressure from an output of a pressure sensor connected to the cuff; a pulse wave detecting unit configured to detect a pulse wave from the output of the pressure sensor; and an analyzing unit configured to evaluate the vascular endothelial function by comparing vessel viscoelastic indexes which are obtained from the pulse wave detected in two of zones before, during, and after the pressure stimulation, and which exclude an amplitude of the pulse wave.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: September 20, 2016
    Assignees: HIROSHIMA UNIVERSITY, NIHON KOHDEN CORPORATION
    Inventors: Toshio Tsuji, Masao Yoshizumi, Yukihito Higashi, Masashi Kawamoto, Hideo Ozawa, Teiji Ukawa, Tsuneo Takayanagi, Haruka Morimoto, Ryosuke Kubo
  • Patent number: 9445605
    Abstract: Provided herein is a method for disinfection or infection control against a non-enveloped virus using a composition including, as an active ingredient, a persimmon extract containing tannin from an astringent fruit of a plant of the genus Diospyros, such as the plant Diospyros kaki. The non-enveloped virus is a non-enveloped virus belonging to the genus Betanodavirus, Aquavirnavirus, Ranavirus, Enterovirus, Mastadenovirus, Vesivirus, or Rotavirus. In certain embodiments, the persimmon extract is prepared by heating a squeezed juice or an extract from an astringent fruit of a plant of the genus Diospyros, or obtained by treating a squeezed juice or an extract from an astringent fruit of the plant of the genus Diospyros with an alcohol, in order to inactivate an enzyme contained therein. The persimmon extract may also contain at least condensed tannin.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: September 20, 2016
    Assignees: Hiroshima University, Altan Co., Ltd.
    Inventors: Tadashi Shimamoto, Yasushi Okinaka, Takemasa Sakaguchi, Toru Tsuji, Yoshiaki Nakai
  • Publication number: 20160264995
    Abstract: The present invention provides the following: a vector for inserting a desired nucleic acid into a predetermined site of a nucleic acid comprising a region formed of a first nucleotide sequence, the predetermined site, and a region composed of a second nucleotide sequence, in the stated order in the 5?-to-3? direction, wherein the vector comprises a region formed of the first nucleotide sequence, the desired nucleic acid, and the second nucleotide sequence in the stated order in the 5?-to-3? direction; a kit that includes this vector; a method of inserting a nucleic acid comprising a step for introducing this vector into a cell; a cell acquired by this method; and an organism comprising this cell.
    Type: Application
    Filed: October 30, 2014
    Publication date: September 15, 2016
    Applicant: HIROSHIMA UNIVERSITY
    Inventors: Takashi Yamamoto, Kenichi Suzuki, Tetsushi Sakuma, Yuto Sakane
  • Patent number: 9439414
    Abstract: A sperm diluent of the present invention contains a chelating agent such as EDTA and/or, EGTA, which forms a complex with a calcium ion, in a base diluent. Further, the sperm diluent contains an immunosuppressive factor such as a steroid hormone and/or, a cytokine, which suppresses migration of leukocytes. By diluting frozen sperm with this sperm diluent followed by performing artificial insemination, death of the sperm before fertilization and phagocytosis of the sperm and embryos by leukocytes in the uterus can be suppressed, allowing enhancement of the conception rate and the implantation rate.
    Type: Grant
    Filed: June 17, 2010
    Date of Patent: September 13, 2016
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Masayuki Shimada, Tetsuji Okazaki
  • Patent number: 9434992
    Abstract: Provided are a diagnosis marker, a diagnosis method, and a therapeutic agent suitable for diagnosing and treating amyotrophic lateral sclerosis (ALS). Also provided are an animal model and a cell model suitable for developing a therapeutic agent and a treatment method for ALS. The diagnosis method for ALS includes: an isolation step in which a nucleic acid is isolated from a specimen taken from a subject; a detection step in which bases expressed in a human chromosome 10 optineurin (OPTN) gene region are detected from the isolated nucleic acid; and a determination step in which it is determined whether or not the detected bases are mutated.
    Type: Grant
    Filed: March 3, 2014
    Date of Patent: September 6, 2016
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Hideshi Kawakami, Hirofumi Maruyama, Hiroyuki Morino
  • Patent number: 9387228
    Abstract: To provide a pharmaceutical product or food which has an excellent fat-accumulation-inhibiting activity and/or fat-metabolism-improving activity and which is effective for inhibition or improvement of obesity, fatty liver, etc. The present invention provides an agent for preventing or ameliorating obesity containing, as an active ingredient, cells of a lactic acid bacterium belonging to the genus Pediococcus, a cell culture thereof, or an extract of any of these.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: July 12, 2016
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Masanori Sugiyama, Fumiko Higashikawa, Masafumi Noda
  • Patent number: 9381287
    Abstract: A blood supply flow rate controlling device (2), which is a device for controlling the blood supply flow rate in an extracorporeal circulation device connected to a living body (10), includes rotational frequency detecting means that detects the rotational frequency of the centrifugal pump (40) of the extracorporeal circulation device, inlet pressure detecting means and outlet pressure detecting means that detect the inlet pressure and the outlet pressure of the centrifugal pump (40), respectively, flow rate regulating means that regulates a flow rate of blood supplied to the living body by adjusting a flow path cross section area of the blood circulation circuit (20), and controlling means that controls the flow rate regulating means.
    Type: Grant
    Filed: January 29, 2013
    Date of Patent: July 5, 2016
    Assignees: Hiroshima University, Josho Gakuen Educational Foundation
    Inventors: Shinji Ninomiya, Taijiro Sueda, Tatsuya Kurosaki, Masaaki Kudo, Naoya Okamura
  • Patent number: 9380786
    Abstract: Provided are: an agent for preventing bacterial wilt disease, which agent can prevent the development of bacterial wilt disease caused by various different bacterial wilt disease strains, that is, the development of bacterial wilt disease in various different plant varieties; and a method for preventing bacterial wilt disease utilizing the agent for preventing bacterial wilt disease. The agent for preventing bacterial wilt disease comprises as an active ingredient a wilt bacterium (Ralstonia solanacearum) infected with the ?RSM1-type filamentous phage and/or the ?RSM3-type filamentous phage. The method for preventing bacterial wilt disease comprises the step of inoculating the agent for preventing bacterial wilt disease to a plant. The plant is preferably any one of tomato, potato, green pepper, eggplant, tobacco, capsicum, Japanese basil, Japanese radish, strawberry, banana, marguerite, chrysanthemum and sunflower.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: July 5, 2016
    Assignee: Hiroshima University
    Inventors: Takashi Yamada, Makoto Fujie, Takeru Kawasaki
  • Patent number: 9381504
    Abstract: A deodorizing material is a cured substance that is obtained by dissolving a photosensitizing colorant in an unsaturated polyester resin composition which contains unsaturated polyester and a monomer copolymerizable with the unsaturated polyester and which is in a liquid state at a room temperature, and by adding a curing agent to let the liquid cured. This deodorizing material changes from the base state to the singlet excitation state, and further to the triplet excitation state upon irradiation with light in a gas phase containing oxygen and odor components. This energy is given to the oxygen molecules to produce singlet oxygen. The oxidation action of the produced singlet oxygen decomposes the odor components.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: July 5, 2016
    Assignees: HIROSHIMA UNIVERSITY, YOKOTA TRADING CO., LTD.
    Inventors: Yoshikuni Masaoka, Masatake Tagawa, Toshihiko Ohara
  • Publication number: 20160186151
    Abstract: The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting of 35 to 55 amino acid residues wherein amino acid residues at two sites in a DNA-binding module contained in a DNA-binding domain exhibit a mode of repetition that is different for every four DNA-binding modules; a vector for expressing said artificial nuclease; a vector library for preparing said vector; and a vector set for preparing said vector library.
    Type: Application
    Filed: May 9, 2014
    Publication date: June 30, 2016
    Applicant: HIROSHIMA UNIVERSITY
    Inventors: Takashi Yamamoto, Tetsushi Sakuma, Hiroshi Ochiai, Shinya Matsuura, Tatsuo Miyamoto
  • Publication number: 20160152990
    Abstract: The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting of 35 to 55 amino acid residues wherein amino acid residues at two sites in a DNA-binding module contained in a DNA-binding domain exhibit a mode of repetition that is different for every four DNA-binding modules; a vector for expressing said artificial nuclease; a vector library for preparing said vector; and a vector set for preparing said vector library.
    Type: Application
    Filed: February 9, 2016
    Publication date: June 2, 2016
    Applicant: HIROSHIMA UNIVERSITY
    Inventors: Takashi Yamamoto, Tetsushi Sakuma, Hiroshi Ochiai, Shinya Matsuura, Tatsuo Miyamoto
  • Publication number: 20160144347
    Abstract: Provided is AEI zeolite having a uniform acid strength of an appropriate degree. AEI zeolite comprising phosphorus, preferably AEI zeolite comprising phosphorus in the pores, and a method for producing AEI zeolite comprising a crystallization step of crystallizing a raw material mixture containing a tetraethylphosphonium cation.
    Type: Application
    Filed: July 9, 2014
    Publication date: May 26, 2016
    Applicants: TOSOH CORPORATION, HIROSHIMA UNIVERSITY
    Inventors: Tsuneji SANO, Masahiro SADAKANE, Yasuyuki TAKAMITSU
  • Patent number: 9343576
    Abstract: The present invention provides a thin film forming method. The method includes the steps of: providing a first substrate, of which a surface is covered with a thin film; forming a plurality of openings through the thin film; forming a hollow portion between the first substrate and the thin film by etching the first substrate through the openings; bringing the thin film into contact with a second substrate with a liquid interposed between the thin film and the second substrate; and heating the first substrate and/or the second substrate. In the step of heating, the liquid interposed between the thin film and the second substrate evaporates off, which results in that the thin film is separated from the first substrate and transferred onto the second substrate.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: May 17, 2016
    Assignee: Hiroshima University
    Inventors: Seiichiro Higashi, Kohei Sakaike, Yoshitaka Kobayashi, Shogo Nakamura, Muneki Akazawa
  • Patent number: 9322822
    Abstract: In order to provide a method for more efficiently, easily, and accurately detecting asbestos without changing the asbestos detection criterion of the phase-contrast microscope/electron microscope method as compared with the phase-contrast microscope/electron microscope method, a phase-contrast microscope and a fluorescence microscope are used in combination to detect asbestos contained in a test sample after the test sample is made contact with an asbestos-binding protein having a fluorescent label.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: April 26, 2016
    Assignee: Hiroshima University
    Inventors: Akio Kuroda, Takenori Ishida, Tomoki Nishimura
  • Patent number: 9314498
    Abstract: Provided is a bacteriocin that is capable of being easily mass-produced, has high antimicrobial activity even at low concentration, has a wide antimicrobial spectrum, and is less likely to produce resistant microorganisms. The bacteriocin has the amino acid sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2 in SEQUENCE LISTING, or has the same amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID NO: 2 in SEQUENCE LISTING except that one or several amino acids are deleted, substituted, inserted and/or added, wherein the amino acid sequence provides antimicrobial activity and the isoelectric point is not less than 12.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: April 19, 2016
    Assignee: Hiroshima University
    Inventor: Hiroki Nikawa