Patents Assigned to Hiroshima University
  • Patent number: 10461669
    Abstract: A wind power generation system including a power generation unit having an elastically deformable base material in a shape of a longitudinal flat plate and a piezoelectric element disposed on the base material, and which generates electricity as the power generation unit is vibrated; the piezoelectric element is repeatedly bent and deformed by the vibration and stacked on the base material, the wind power generation system being configured to include a tension adjusting device that, when a wind speed is increased, moves the movable member to increase a tensile force that pulls the power generation unit in the longitudinal direction, and the tension adjusting device being a lift generating member that is formed integrally with the movable member so as to be extended and to have wing shape to both sides of the movable member and that moves the movable member based on lift generated according to the wind speed.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: October 29, 2019
    Assignees: TOYODA IRON WORKS CO., LTD., NATIONAL UNIVERSITY CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Hidenobu Takao, Yasuhiro Sone, Hidemi Mutsuda, Yoshikazu Tanaka
  • Patent number: 10413691
    Abstract: Provided is a gas storing mask which, with a simple configuration, allows a reduction in feeling of discomfort given to a patient. An oxygen delivering mask (1a) includes a first sheet (2) and a second sheet (3), oxygen supplied from outside the oxygen delivering mask (1a) being stored in a gas storing part (4) formed between the first sheet (2) and the second sheet (3).
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: September 17, 2019
    Assignees: HIROSHIMA UNIVERSITY, JMS CO., LTD.
    Inventors: Yuma Hayashi, Atsushi Kimura, Noboru Saeki, Takashi Kondo, Masashi Kawamoto, Sachiko Otsuki, Kensuke Yanabe
  • Patent number: 10420209
    Abstract: The polyester sheet in accordance with an aspect of the present invention contains crystals of polyester which is a polycondensate of polyvalent carboxylic acid and polyalcohol. The polyester sheet contains nano-oriented crystals which contain crystals of polyester in each of which a polymer chain is highly oriented and each of which has a crystal size of 50 nm or less. A heatproof temperature of the polyester sheet is higher than a temperature that is lower than an equilibrium melting point of the polyester by 80° C., and a melting point of the polyester sheet is higher than a temperature that is lower than the equilibrium melting point of the polyester by 40° C.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: September 17, 2019
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Masamichi Hikosaka, Kiyoka Okada, Yoshitaka Tanaka
  • Patent number: 10322136
    Abstract: Provided are a composition for inhibiting growth or proliferation of chronic myelogenous leukemia (CML) cancer stem cells, a pharmaceutical composition for preventing or treating CML, a method for preventing or treating CML, and a method of screening for a growth or proliferation inhibitor of CML cancer stem cells by blocking nutrient signaling in CML cancer stem cells.
    Type: Grant
    Filed: March 25, 2016
    Date of Patent: June 18, 2019
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Seong Jin Kim, Kazuhito Naka
  • Publication number: 20190177745
    Abstract: The present invention provides the following: a vector for inserting a desired nucleic acid into a predetermined site of a nucleic acid comprising a region formed of a first nucleotide sequence, the predetermined site, and a region composed of a second nucleotide sequence, in the stated order in the 5?-to-3? direction, wherein the vector comprises a region formed of the first nucleotide sequence, the desired nucleic acid, and the second nucleotide sequence in the stated order in the 5?-to-3? direction; a kit that includes this vector; a method of inserting a nucleic acid comprising a step for introducing this vector into a cell; a cell acquired by this method; and an organism comprising this cell.
    Type: Application
    Filed: February 22, 2019
    Publication date: June 13, 2019
    Applicant: HIROSHIMA UNIVERSITY
    Inventors: Takashi Yamamoto, Kenichi Suzuki, Tetsushi Sakuma, Yuto Sakane
  • Publication number: 20190169240
    Abstract: The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteristic. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (?2) A.A.
    Type: Application
    Filed: December 11, 2018
    Publication date: June 6, 2019
    Applicants: KYUSHU UNIVERSITY, NAT'L UNIVERSITY CORPORATION, HIROSHIMA UNIVERSITY
    Inventors: Takashi Yamamoto, Tetsushi Sakuma, Takahiro Nakamura, Yusuke Yagi, Yasuyuki Okawa
  • Publication number: 20190115434
    Abstract: Semiconductor devices each include: a semiconductor substrate that contains beta-gallium oxide and has a first conductivity type; a first semiconductor region that contains beta-gallium oxide, has the first conductivity type, and is provided on an upper side of the semiconductor substrate; a second semiconductor region that contains beta-gallium oxide, has a second conductivity type, and is provided on an upper side of a part of the first semiconductor region; and a third semiconductor region that contains beta-gallium oxide, has the first conductivity type, and is provided on an upper side of a part of the second semiconductor region. When the first conductivity type is an n-type and the second conductivity type is a p-type, the second semiconductor region further contains a band gap control element. The band gap control element is selected from a group of boron, aluminum, and indium.
    Type: Application
    Filed: October 15, 2018
    Publication date: April 18, 2019
    Applicants: Yazaki Corporation, National University Corporation Hiroshima University
    Inventors: Naotake SAKUMOTO, Yoshinori MATSUSHITA, Hiroki ISHIHARA, Tatsuo SUNAYAMA, Misako AIDA, Yoriko TOMINAGA, Dai AKASE
  • Patent number: 10253064
    Abstract: The present invention provides a method for purifying an intended substance, a kit for purifying the intended substance, and a silicon oxide-binding tag for use in the method and the kit. In the present invention, a complex of a silicon oxide-binding tag and a substance is caused to specifically bind to silicon oxide in a solution for binding, to which solution no salt is added, and binding between the silicon oxide-binding tag and the silicon oxide is broken with use of arginine.
    Type: Grant
    Filed: October 21, 2015
    Date of Patent: April 9, 2019
    Assignee: Hiroshima University
    Inventors: Akio Kuroda, Takeshi Ikeda, Hisakage Funabashi
  • Patent number: 10196610
    Abstract: The invention provides an animal cell culture kit to be used favorably for culturing animal cells, a method for culturing animal cells, a method for culturing selectively animal cells, and a method for differentiating a cell. An animal cell culture kit according to the invention includes an incubator containing one or more types of functional groups selected from the group consisting of hydrophilic functional groups and hydrophobic functional groups at predetermined contents on a surface, and a serum-free culture medium. Since the animal cell culture kit includes an incubator having a functional group suitable for adhesion and proliferation of specific animal cells, proliferation of animal cells can be promoted even with a serum-free culture medium.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: February 5, 2019
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Yukio Kato, Isao Hirata, Masami Kanawa
  • Patent number: 10189879
    Abstract: The object of the present invention is to, by analyzing PPR proteins that act to bind to DNA with a prediction that RNA recognition rules of PPR motifs can also be used for recognition of DNA, find a PPR protein showing such a characteristic. According to the present invention, it was revealed that, with a protein that can bind in a DNA base-selective manner or a DNA base sequence-specific manner, which contains one or more, preferably 2 to 30, more preferably 5 to 25, most preferably 9 to 15, of PPR motifs having a structure of the following formula 1 (wherein, in the formula 1, Helix A is a part that can form an ?-helix structure; X does not exist, or is a part consisting of 1 to 9 amino acids; Helix B is a part that can form an ?-helix structure; and L is a part consisting of 2 to 7 amino acids), and having a specific combination of amino acids corresponding to a DNA base or DNA base sequence as amino acids of three positions of No. 1 A.A., No. 4 A.A., in Helix A of the formula 1 and No. “ii” (?2) A. A.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: January 29, 2019
    Assignees: KYUSHU UNIVERSITY, NAT'L UNIVERSITY CORPORATION, HIROSHIMA UNIVERSITY
    Inventors: Takashi Yamamoto, Tetsushi Sakuma, Takahiro Nakamura, Yusuke Yagi, Yasuyuki Okawa
  • Publication number: 20190012932
    Abstract: The simulator includes a chemical liquid information acquisition section configured to acquire an amount of contrast medium, a target value acquisition section configured to acquire a target duration for which a target pixel value is maintained, a protocol acquisition section configured to acquire a contrast medium injection protocol, and a prediction section for determining a predicted duration, the prediction section configured to simulate the time-dependent change in the pixel value in the tissue of the subject based on the injection protocol and the amount of the contrast medium, and the prediction section compares the predicted duration with the target duration to re-simulate, in a case where the predicted duration is shorter than the target duration, the time-dependent change in a condition where a greater amount of the contrast medium than the amount of the contrast medium used in the simulation is injected to redetermine the predicted duration, and in a case where the predicted duration is longer than
    Type: Application
    Filed: July 23, 2018
    Publication date: January 10, 2019
    Applicants: HIROSHIMA UNIVERSITY, NEMOTO KYORINDO CO., LTD.
    Inventors: Toru HIGAKI, Kazuo AWAI, Yuko NAKAMURA, Kazumasa MASUDA, Koji YUBA, Shigeru NEMOTO
  • Patent number: 10143712
    Abstract: To provide a novel lactic acid bacterium strain having a broad antibacterial spectrum against bacteria that cause oral diseases, from which a fermented product having good flavor and being excellent in palatability can be produced, and a prophylactic, ameliorating or therapeutic agent for oral diseases using the same. A prophylactic, ameliorating or therapeutic agent for an oral disease, which contains a lactic acid bacterial cell of one or more kinds selected from the group consisting of Lactobacillus rhamnosus strain KO3, Lactobacillus casei strain YU3 and Lactobacillus paracasei strain YU4 or a culture of the cell, or an extract thereof, as an active ingredient.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: December 4, 2018
    Assignee: HIROSHIMA UNIVERSITY
    Inventor: Hiroki Nikawa
  • Publication number: 20180327448
    Abstract: The present invention provides a method for purifying an intended substance, a kit for purifying the intended substance, and a silicon oxide-binding tag for use in the method and the kit. In the present invention, a complex of a silicon oxide-binding tag and a substance is caused to specifically bind to silicon oxide in a solution for binding, to which solution no salt is added, and binding between the silicon oxide-binding tag and the silicon oxide is broken with use of arginine.
    Type: Application
    Filed: October 21, 2015
    Publication date: November 15, 2018
    Applicant: Hiroshima University
    Inventors: Akio KURODA, Takeshi IKEDA, Hisakage FUNABASHI
  • Publication number: 20180323457
    Abstract: An ammonia removal material to be used for obtaining a mixed gas (B) having an ammonia concentration of 0.1 mol ppm or less from a mixed gas (A) including hydrogen, nitrogen, and ammonia and having an ammonia concentration exceeding 0.1 mol ppm, the ammonia removal material containing zeolite having a pore size of 0.5 nm or more and 2.0 nm or less, a method for removing ammonia from the mixed gas using the ammonia removal material, and a method for producing a hydrogen gas for a fuel cell automobile, the method including the method for removing ammonia.
    Type: Application
    Filed: December 7, 2016
    Publication date: November 8, 2018
    Applicants: HIROSHIMA UNIVERSITY, SHOWA DENKO K.K., TAIYO NIPPON SANSO CORPORATION, TOYOTA INDUSTRIES CORPORATION
    Inventors: Yoshitsugu KOJIMA, Takanori AOKI, Tadahiro FUJITANI, Takayoshi ADACHI, Hidehito KUBO
  • Publication number: 20180273921
    Abstract: The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting of 35 to 55 amino acid residues wherein amino acid residues at two sites in a DNA-binding module contained in a DNA-binding domain exhibit a mode of repetition that is different for every four DNA-binding modules; a vector for expressing said artificial nuclease; a vector library for preparing said vector; and a vector set for preparing said vector library.
    Type: Application
    Filed: June 6, 2018
    Publication date: September 27, 2018
    Applicant: Hiroshima University
    Inventors: Takashi Yamamoto, Tetsushi Sakuma, Hiroshi Ochiai, Shinya Matsuura, Tatsuo Miyamoto
  • Patent number: 10075103
    Abstract: A power generation device for a mobile body includes power generating units and a holding member. Each power generating unit includes an elastically deformable base member and a piezoelectric film, which are laminated alternately. The holding member holds the power generating units. Each power generating unit has an elongated flat-plate shape. Opposite ends of the power generating unit in a longitudinal direction are held by the holding member such that the power generating unit is in an orientation in which a longitudinal axis is substantially perpendicular to the flow direction of the external fluid. A fixing member is provided at each of the opposite ends in the longitudinal direction of each power generating unit. The power generating units are arranged in the holding member via the fixing members to pivot in accordance with the flow of the external fluid.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: September 11, 2018
    Assignees: TOYODA IRON WORKS CO., LTD., NATIONAL UNIVERSITY CORPORATION HIROSHIMA UNIVERSITY
    Inventors: Hidenobu Takao, Yasuhiro Sone, Hidemi Mutsuda, Yoshikazu Tanaka
  • Publication number: 20180254528
    Abstract: An alkaline secondary battery includes at least a positive electrode, a negative electrode, and an electrolytic solution. The positive electrode includes at least one of manganese oxyhydroxide and manganese dioxide. The negative electrode includes a hydrogen storage alloy.
    Type: Application
    Filed: March 1, 2018
    Publication date: September 6, 2018
    Applicants: TOYOTA JIDOSHA KABUSHIKI KAISHA, HIROSHIMA UNIVERSITY
    Inventors: Haruyuki NAKANISHI, Yukihisa KATAYAMA, Yoshitsugu KOJIMA
  • Patent number: 10062161
    Abstract: An endoscopic image diagnosis support system (100) includes: a memory (10) that stores learning images pre-classified into pathological types; and a processor (20) that, given an endoscopic image, performs feature value matching between an image of an identification target region in the endoscopic image and the learning images, to identify the pathological types in the identification target region.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: August 28, 2018
    Assignee: HIROSHIMA UNIVERSITY
    Inventors: Tetsushi Koide, HoangAnh Tuan, Shigeto Yoshida, Tsubasa Mishima, Satoshi Shigemi, Toru Tamaki, Tsubasa Hirakawa, Rie Miyaki, Kouki Sugi
  • Patent number: 10035141
    Abstract: Provided is AEI zeolite having a uniform acid strength of an appropriate degree. AEI zeolite comprising phosphorus, preferably AEI zeolite comprising phosphorus in the pores, and a method for producing AEI zeolite comprising a crystallization step of crystallizing a raw material mixture containing a tetraethylphosphonium cation.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: July 31, 2018
    Assignees: TOSOH CORPORATION, HIROSHIMA UNIVERSITY
    Inventors: Tsuneji Sano, Masahiro Sadakane, Yasuyuki Takamitsu
  • Patent number: 10030235
    Abstract: The present invention provides an artificial nuclease comprising a DNA-binding domain and a function domain linked to each other via a polypeptide consisting of 35 to 55 amino acid residues wherein amino acid residues at two sites in a DNA-binding module contained in a DNA-binding domain exhibit a mode of repetition that is different for every four DNA-binding modules; a vector for expressing said artificial nuclease; a vector library for preparing said vector; and a vector set for preparing said vector library.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: July 24, 2018
    Assignee: Hiroshima University
    Inventors: Takashi Yamamoto, Tetsushi Sakuma, Hiroshi Ochiai, Shinya Matsuura, Tatsuo Miyamoto