Abstract: A method for manufacturing a composite semipermeable membrane is capable of forming, on a surface of a porous support in a highly reproducible manner, a separation layer that is extremely thin and that exhibits superior separability. It provides, on a surface of a porous support, a composite semipermeable membrane that has an organic/inorganic hybrid separation layer that is extremely thin and that exhibits superior separability. A method for manufacturing a composite semipermeable membrane includes forming, on a surface of a porous support, a separation layer containing a cross-linked condensate having a siloxane bond by bringing an organic solution that contains an organic silicon compound containing three or more reactive functional groups, each of which is at least one type selected from a hydrolyzable group and a hydroxyl group, into contact with water or an aqueous solution on the porous support, and by performing interfacial polycondensation of the organic silicon compound.

Abstract: The stent graft (10) comprises a cylinder comprising a graft material in the form of a film and a stent that supports the cylinder. Further, the stent graft (10) is inserted within a region from the ascending aorta to the sinus of valsalva, and the stent graft comprises cylindrical body section (11) arranged in the ascending aorta and the sinus of valsalva section (12) arranged in the sinus of valsalva and having an inner diameter larger than that of the body section (11).

Abstract: Novel and effective anti-fibrosis agents are obtained. An anti-fibrosis agent containing an antagonist for integrin ?8?1 is used. In addition, used is an antagonist containing an anti-integrin ?8?1 antibody that specifically binds to at least one amino acid in a cap subdomain of an integrin ?8 chain and a periphery thereof. Also, used is an anti-fibrosis agent containing an anti-integrin ?8?1 antibody that specifically binds to R120 of an integrin ?8 chain and a periphery thereof or S132 and a periphery thereof. Note that the above antagonists may each be an anti-integrin ?8?1 antibody capable of binding to any of integrins ?8?1 derived from a human, mouse, and rat.

Abstract: A system that assists in treatment includes circuitry configured to generate three-dimensional body data of a patient using data obtained from a three-dimensional measurement unit, obtain a tomographic image of the patient from a body tomographic measurement apparatus, execute an examination assist process, which aligns the three-dimensional body data with the tomographic image, execute a treatment plan assist process, which make a treatment plan that specifies a posture of the patient when treatment is performed using the tomographic image and the three-dimensional body data that are aligned with each other, and execute a treatment assist process, which outputs a treatment instruction based on the posture specified in the treatment plan.

Abstract: Disclosed is a method for assisting the detection of Alzheimer's disease or mild cognitive impairment, the method for assisting the highly accurate detection of Alzheimer's disease or mild cognitive impairment. In the method for assisting the detection of Alzheimer's disease or mild cognitive impairment, the amount of at least one miRNA selected from miR-122, miR-144, let-7f, miR-128-3p and miR-107 contained in a test sample separated from a living body is used as an indicator. A larger amount of miR-122 than that in a healthy individual, or a smaller amount of at least one miRNA selected from miR-144, let-7f, miR-128-3p and miR-107 than that in a healthy individual is indicative that the living body is more likely to have developed Alzheimer's disease or mild cognitive impairment.

Abstract: A pulse wave analyzing apparatus comprises an acquiring section (11) which acquires a pulse wave that is non-invasively measured, and an analyzer (12) which calculates data on the frequency axis by using the pulse wave, and which obtains the index value of the respiratory-induced variation based on the calculated data on the frequency axis.

Abstract: Ammonia removal equipment including a first ammonia removal apparatus that removes ammonia in a mixed gas containing hydrogen and ammonia, a second ammonia removal apparatus that is installed at a stage subsequent to the first ammonia removal apparatus and that treats a first treated gas treated by the first ammonia removal apparatus, and a first ammonia concentration measurement apparatus that measures the ammonia concentration in the first treated gas treated by the first ammonia removal apparatus.

Abstract: An ammonia removal material to be used for obtaining a mixed gas (B) having an ammonia concentration of 0.1 mol ppm or less from a mixed gas (A) including hydrogen, nitrogen, and ammonia and having an ammonia concentration exceeding 0.1 mol ppm, the ammonia removal material containing zeolite having a pore size of 0.5 nm or more and 2.0 nm or less, a method for removing ammonia from the mixed gas using the ammonia removal material, and a method for producing a hydrogen gas for a fuel cell automobile, the method including the method for removing ammonia.

Abstract: Disclosed is a method for assisting the detection of Alzheimer's disease or mild cognitive impairment, the method for assisting the highly accurate detection of Alzheimer's disease or mild cognitive impairment. In the method for assisting the detection of Alzheimer's disease or mild cognitive impairment, the amount of at least one miRNA selected from miR-122, miR-144, let-7f, miR-128-3p and miR-107 contained in a test sample separated from a living body is used as an indicator. A larger amount of miR-122 than that in a healthy individual, or a smaller amount of at least one miRNA selected from miR-144, let-7f, miR-128-3p and miR-107 than that in a healthy individual is indicative that the living body is more likely to have developed Alzheimer's disease or mild cognitive impairment.

Abstract: Multilineage-differentiating stress enduring (Muse) cells are stage-specific embryonic antigen-3 (SSEA-3) positive cells that exist in mesenchymal stem cell (MSC) populations. Muse cells have the pluripotency to differentiate into all germ layers as embryonic stem cells. The purpose of the present study is to investigate the efficacy of Muse cell transplantation for repairing osteochondral defects. Muse cells were isolated from human bone marrow MSCs. As osteochondral defects, the patellar grooves of immunodeficient rats were injured. Next, cells were injected into the mice so that the animals were divided into the following 3 groups: a control group to which PBS was injected; a non-Muse group to which 5×104 SSEA-3 negative non-Muse cells were injected; and a Muse group to which 5×104 SSEA-3 positive Muse cells were injected.

Abstract: In order to achieve a prediction approximating an actual change with time of a pixel value in a tissue with higher accuracy, provided is a simulator, which is configured to predict a change with time of a pixel value in a tissue of an object, including: an object information acquisition unit configured to acquire information on the object; a protocol acquisition unit configured to acquire an injection protocol for a contrast medium; a tissue information acquisition unit configured to acquire information on the tissue; and a prediction unit configured to predict, based on the information on the object, the injection protocol, and the information on the tissue, a change with time of a pixel value of each of a plurality of compartments obtained by dividing the tissue along a blood flow direction.

Abstract: An object is to provide a novel means for ameliorating mastitis or improving milk production. An ameliorating or therapeutic agent for mastitis that contains a biosurfactant, or a milk production promoting agent that contains a biosurfactant, is provided.

Abstract: The present invention provides a method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain of a protein and a peptide, and a method for determining amino acid sequences of protein and peptide. A method for specifically cleaving a C?-C bond of a peptide backbone and/or a side chain bond of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of at least one hydroxynitrobenzoic acid selected from the group consisting of 3-hydroxy-2-nitrobenzoic acid, 4-hydroxy-3-nitrobenzoic acid, 5-hydroxy-2-nitrobenzoic acid, 3-hydroxy-5-nitrobenzoic acid, and 4-hydroxy-2-nitrobenzoic acid. A method for determining an amino acid sequence of a protein or a peptide, comprising irradiating a protein or a peptide with laser light in the presence of the above specific hydroxynitrobenzoic acid to specifically cleave a C?-C bond of a peptide backbone and/or a side chain bond, and analyzing generated fragment ions by mass spectrometry.

Abstract: A device includes: a controller that converts a pressure value detected by a pressure detector into visual or aural lingual pressure information changed depending on a magnitude of the pressure value; and an information output unit, such as a buzzer and a color display LED, that outputs the lingual pressure information in response to a signal from the controller. The information output unit outputs lingual pressure information different depending on a pressing force applied on an elastic balloon by a tongue, allowing users such as patients and elderly people to continue a training without being bored.

Abstract: A data-oriented feedback controller disclosed herein allows the user to wear or use a device under control comfortably, and includes: a device under control for determining a controlled variable ?(t) with respect to a human being in accordance with an input manipulated variable u(t); a primary controller for determining the manipulated variable u(t) based on an input difference v(t) between an estimated target value w(t) and the controlled variable ?(t); a psychological evaluator for detecting biometric information bio(t) about the human being corresponding to the controlled variable ?(t), evaluating the human being's psychology based on the biometric information bio(t), and determining a psychological output value y(t) representing the psychology; and a secondary controller for receiving a difference ?(t) between a target value r(t) of the human being's psychology and the psychological output value y(t) and determining the estimated target value w(t) based on the difference ?(t).

Abstract: Disclosed herein is a probe 1 for measuring a lip closing force, the probe including: a hollow balloon 10 configured to be disposed between an upper lip 50 and lower lip 51 of a subject, and crushed and deformed by the lip closing force, and a base 20 which is connected to a pressure measurement device 100 for measuring an internal pressure of the balloon 10. The balloon 10 is provided with a fixable portion 13 configured to be sandwiched between teeth 52 and 53 or gums of the subject.

Abstract: In order to achieve a prediction approximating an actual change with time of a pixel value in a tissue with higher accuracy, provided is a simulator, which is configured to predict a change with time of a pixel value in a tissue of an object, including: an object information acquisition unit configured to acquire information on the object; a protocol acquisition unit configured to acquire an injection protocol for a contrast medium; a tissue information acquisition unit configured to acquire information on the tissue; and a prediction unit configured to predict, based on the information on the object, the injection protocol, and the information on the tissue, a change with time of a pixel value of each of a plurality of compartments obtained by dividing the tissue along a blood flow direction.

Abstract: An object of the present invention is to develop a therapeutic agent for an inflammatory disease such as an inflammatory bowel disease or NASH, which therapeutic agent shows less side effects and high effectiveness. The present invention provides a compound represented by Formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic agent or a prophylactic agent for an inflammatory disease, and a therapeutic agent or a prophylactic agent for colon cancer, containing the compound.

Abstract: [Problem to be Solved] It is intended to provide a fusion polypeptide that regulates the transcription of a target gene. [Solution] The present inventors have provided a fusion polypeptide comprising: a cell-penetrating peptide; a DNA-binding polypeptide; and a transcriptional regulator.

Abstract: A wind power generation system including a power generation unit having an elastically deformable base material in a shape of a longitudinal flat plate and a piezoelectric element disposed on the base material, and which generates electricity as the power generation unit is vibrated; the piezoelectric element is repeatedly bent and deformed by the vibration and stacked on the base material, the wind power generation system being configured to include a tension adjusting device that, when a wind speed is increased, moves the movable member to increase a tensile force that pulls the power generation unit in the longitudinal direction, and the tension adjusting device being a lift generating member that is formed integrally with the movable member so as to be extended and to have wing shape to both sides of the movable member and that moves the movable member based on lift generated according to the wind speed.