Patents Assigned to Hoechst Aktiengesellschaft
  • Patent number: 5996784
    Abstract: A cigarette pack is described which is made from a thermoplastic film. In addition, an opening device for opening cigarette film packs made from thermoplastics and a process for the production of an opening device are described.
    Type: Grant
    Filed: March 23, 1995
    Date of Patent: December 7, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus Thoeren, Horst Kromer, Ruth Aey
  • Patent number: 5998447
    Abstract: Compounds of the formula I ##STR1## in which B, D, E, R, W, Y, Z, b, c, d, e, f, g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antagonists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention relates to the use of compounds of the formula I, and of pharmaceutical preparations which contain such compounds, for the treatment and prophylaxis of diseases which are caused by an un desired extent of leucocyte adhesion and/or leucocyte migration or which are associated therewith or in which cell--cell or cell-matrix interactions play a part which are based on interactions of VLA-4 receptors with their ligands, for example of inflammatory processes, rheumatoid arthritis or allergic disorders, and it also relates to the use of compounds of the formula I for the production of pharmaceuticals for use in such diseases. It further relates to novel compounds of the formula I.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: December 7, 1999
    Assignee: Hoechst Aktiengesellschaft AG
    Inventors: Hans Ulrich Stilz, Volkmar Wehner, Christoph Huels, Dirk Seiffge
  • Patent number: 5994307
    Abstract: This invention relates to the antibiotic feglymycin, as well as processes for its preparation and use. Feglymycin is represented by the structural formula (SEQ. ID. NO.
    Type: Grant
    Filed: December 2, 1998
    Date of Patent: November 30, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Martin Knauf, Joachim Wink, Dieter Isert, Wilhelm Stahl, Gunther Riess, Jozsef Aszodi, Dominique Le Beller
  • Patent number: 5990145
    Abstract: The present invention relates to compounds of the formula I,A--B--D--E--F--G (I)in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: December 22, 1997
    Date of Patent: November 23, 1999
    Assignees: Hoechst Aktiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Karlheinz Scheunemann, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Patent number: 5986089
    Abstract: Moenomycin A can be prepared by fermentation of a moenomycin-producing microorganism and subsequent separation of moenomycin A from the other components of the culture filtrate by chromatography, using an anion exchanger as chromatography material.
    Type: Grant
    Filed: April 16, 1998
    Date of Patent: November 16, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Andreas Stark, Eberhard Ehlers
  • Patent number: 5985180
    Abstract: A coating agent for plastic films which contains an intrinsically electrically conducting polymer and one or more additives which have an anti-adhesion action with respect to a metal coating to be applied to the plastic film can be used to coat plastic films. The plastic films so coated can be used to transfer a coated metal to another substrate.
    Type: Grant
    Filed: February 5, 1993
    Date of Patent: November 16, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ekkehard Beer, Karl-Heinz Kochem, Michael Schmidt
  • Patent number: 5981492
    Abstract: The present invention pertains to 5-ring heterocycles of general formula (I), wherein W, Y, Z, B, D, E and R as well as b, c, d, e, f, g, and h are as indicated in the description; to methods for preparing them, and to their use as inhibitors of platelet aggregation, metastasizing of carcinomatous cells and the attachment of osteoclasts to the bone surface.
    Type: Grant
    Filed: July 19, 1996
    Date of Patent: November 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Zoller, Otmar Klingler, Bernd Jablonka, Melitta Just, Gerhard Breipohl, Jochen Knolle, Wolfgang Konig, Hans-Ulrich Stilz
  • Patent number: 5981536
    Abstract: Compounds of the formula I ##STR1## where one of the radicals R.sup.1 and R.sup.3 is a radical of the formula II --(CH.sub.2).sub.n --A--CH.sub.3 (II) in which A is a covalent bond,--C(O)-- or --C(R.sup.4)(OH)--, are suitable for the production of pharmaceuticals for the modulation of apoptosis. A combination preparation comprising a compound of the formula I and a compound of the formula IV and/or V ##STR2## is suitable for the production of pharmaceuticals for the modulation of apoptosis.
    Type: Grant
    Filed: October 20, 1998
    Date of Patent: November 9, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Claudia Dax
  • Patent number: 5977177
    Abstract: This invention relates to substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them.Substituted benzenesulfonylureas and -thioureas of the formula I ##STR1## exhibit effects on the cardiovascular system.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Heinrich Englert, Uwe Gerlach, Dieter Mania, Heinz Gogelein, Joachim Kaiser
  • Patent number: 5975165
    Abstract: This invention relates to a refueling nozzle that can be inserted easily into a filler opening in such a manner as to seal up the filler opening, securely engaging the nozzle and opening, and thereby prevent erroneous operation. Additionally, the refueling nozzle can automatically stop or start the refueling. The fuel discharge unit 3 comprises a fitting member 9 in the shape of a truncated cone such that the cross-sectional diameter gradually becomes smaller from a value larger than the inside diameter of the filler opening of a fuel tank. In the fitting member 9, a vapor passage 11 is formed to recover or discharge fuel vapor in the fuel tank. A fuel sensor 14 detects the presence of fuel and kind of fuel vapor present in the fuel tank through contact with the fuel vapor flowing through the vapor passage 11. A liquid level sensor 15 determines the surface level of fuel in the tank and whether the level of the fuel in the fuel tank has reached a predetermined level.
    Type: Grant
    Filed: December 28, 1995
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Kenji Motosugi, Zenjiro Odera
  • Patent number: 5977297
    Abstract: A process for isolating insulin which entails performing high-pressure liquid chromatography with pressure-stable acidic cation exchange material under a pressure of from 1.1 MPa to 40 MPa.
    Type: Grant
    Filed: December 17, 1997
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rainer Obermeier, Jurgen Ludwig, Walter Sabel
  • Patent number: 5977266
    Abstract: The novel molding made from a combination of polyacetal with directly molded-on function elements is distinguished by the fact that the function elements comprise one or more elastomers. Such elastomers comprise partially or fully hydrogenated nitrile rubbers, one- or multi-component silicone rubbers or sulfur-containing rubbers.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Frank Reil, Frank Reuter, Ulrich Haack, Gerhard Reuschel
  • Patent number: 5977229
    Abstract: Hydrophilically modified high and/or ultra-high molecular weight polyethylene (HMW-PE or UHMW-PE) coated with a mixture comprising 1-99.9% by weight of at least one water-soluble additive and 0.1 to 99% by weight of at least one water-insoluble additive, the content of the mixture being 0.1 to 10% by weight, based on the total weight of hydrophilically modified HMW-PE and/or UHMW-PE and a process for the preparation of the hydrophilically modified HMW-PE and/or UHMW-PE and its use for the production of porous moldings.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Christiane Barth, Jens Ehlers, Stanislaw Haftka
  • Patent number: 5977151
    Abstract: A compound of the formula ##STR1## where R.sup.1 is the radical of the formula II or III ##STR2## is suitable for the production of a pharmaceutical for the treatment of inflammations, carcinomatous diseases, or autoimmune diseases. A compound of the formula IV ##STR3## is suitable for the production of specific antibodies against a compound of the formula I for the discovery of specific-binding proteins from cell extracts, serum, blood, or synovial fluids, for the purification of proteins, for the modification of microtiter plates, or for the preparation of chromatography material, in particular of affinity chromatography material, and for use in diagnostics.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: November 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Stefan Mullner, Bernd Kirschbaum, Wilfried Schwab
  • Patent number: 5969166
    Abstract: Catalysts for the selective epoxidization of olefins with atmospheric oxygen, processes for their preparation and processes for the preparation of epoxides by oxidation of olefins with air or oxygen.Compounds of the formula (1) as catalysts for the selective epoxidization of alkenesM.sub.x O.sub.y (L).sub.z (1)in whichthe indices x, y and z have the following meaning:x is a whole number from 1 to 3, y is a whole number from 1 to 2x+1, y being selected so that the sum of x+z gives a metal oxidation number of +5 (vanadium) or +6 (molybdenum, ruthenium); z is a whole number in the range from 2 to 2x;M is molybdenum, ruthenium or vanadium andL is an N, 0 or S donor ligand.
    Type: Grant
    Filed: September 12, 1997
    Date of Patent: October 19, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Bernd Scharbert, Gerhard Lobmaier, Wolfgang Anton Herrmann
  • Patent number: 5965555
    Abstract: Compounds of the formula I, ##STR1## in which one of the radicals R.sup.1 and R.sup.3 is an alkynol residue of the formula Ia or Ib ##STR2## are suitable for producing pharmaceuticals having a neuroprotective effect.
    Type: Grant
    Filed: May 30, 1997
    Date of Patent: October 12, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Ulrich Gebert, Elisabeth Defossa, Uwe Heinelt, Karl Rudolphi, John J. Grome
  • Patent number: 5962595
    Abstract: The invention relates to a high-molecular-weight reactor blend comprising a high-molecular weight polypropylene and a high-molecular weight ethylene-propylene copolymer and having an ethylene content in the range from 0.1 to 2% by weight based on the total amount of blend, a melt flow index MFR (230/5) of .ltoreq.5 dg/min and a molecular weight distribution M.sub.w /M.sub.n in the range from 6 to 20.
    Type: Grant
    Filed: May 22, 1997
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Volker Dolle, Thomas Bohm
  • Patent number: 5962471
    Abstract: Compounds of the formula I ##STR1## are suitable for the preparation of pharmaceuticals for the prophylaxis and therapy of disorders involving increased activity of matrix-degrading metalloproteinases.
    Type: Grant
    Filed: May 11, 1998
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventor: Manfred Schudok
  • Patent number: 5962281
    Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Klaus Bartsch, Hans-Matthias Deger, Susanne Grabley, Rudiger Marquardt
  • Patent number: 5962275
    Abstract: The invention relates to an improved process for enzymically galactosylating monosaccharides and oligosaccharides, with in-situ regeneration of the nucleotide sugar (or of the nucleoside diphosphate sugar), in the presence of sucrose synthase, .beta.-1-4-galactosyl transferase and uridine diphosphate-glucose 4'-epimerase, (UDP-glucose 4'-epimerase), in which process the uridine diphosphate-glucose 4'-epimerase is reactivated with a ketosugar derivative.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Brigitte Horsch, Andreas Seiffert-Storiko, Rudiger Marquardt, Astrid Zervosen, Lothar Elling, Maria Regina Kula