Abstract: New methods and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. The method includes administering to a subject in need thereof an effective amount of a small molecule compound inhibitor for EphA4 signaling. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.

Abstract: A switchable liquid crystal grating cell, and methods for manufacturing the above. The switchable liquid crystal grating cell comprises a pair of switchable liquid crystal grating parts, each switchable liquid crystal grating part comprises a substrate; a conductive layer on the substrate; and a photoalignment layer with an alignment pattern above the conductive layer on the substrate, the alignment pattern having first and second types of domains, the first type of domain having a first uniform alignment direction, the second type of domain having a second uniform alignment direction that is reoriented at a predetermined angle to the first uniform alignment direction, the predetermined angle is 85°-95°, and a liquid crystal layer sandwiched between the pair of switchable liquid crystal grating parts, wherein an alignment pattern on a top surface is arranged to be shifted relative to the other alignment pattern on a bottom surface.

Abstract: GaN vertical trench MOSFETs and methods of manufacturing the same are disclosed. One example embodiment is a vertical trench MOSFET. The MOSFET includes a semiconductor transistor that has a first surface and a second surface, and a trench that extends from the first surface into the semiconductor transistor along a first direction perpendicular to the first and second surfaces. The semiconductor transistor includes a body region having a channel region arranged along the first direction along at least a portion of a wall of the trench. The doping concentration of the channel region is non-uniform. As a non-limiting example, two-step doping is conducted for forming asymmetric or non-uniform channel of a GaN vertical trench MOSFET. In some embodiments, multiple-step doping other than the two-step doing (such as doping in three steps, four steps, or more), linearly scaled doping, other proper asymmetric doping can be used.

Abstract: An aspect of the present disclosure is related to a method for measuring and controlling linear chirp level of ultrafast laser pulse. The method includes steps as follows. A carrier-envelope phase-chirp (CEP-chirp) relation which serve as a chirp monitor is extracted, in which the CEP-chirp relation is generated from an ultrafast laser pulse. A linear chirp level of a target pulse is measured in response to the CEP-chirp relation. According to the measuring with respect to the linear chirp level of the target pulse, a dispersion element which the ultrafast laser pulse passes through is varied to control and stabilize the linear chirp level of the target pulse.

Abstract: A method for performing Building Information Modelling design collaboration via Confidentiality-Minded Framework using Interplanetary-File-System-Blockchain integrated network by a server is provided. The method includes: segregating one or more sensitive and non-sensitive BIM portions of a BIM object; uploading a target BIM component into an IPFS network to receive a target content identifier (CID) of the target BIM component from the IPFS network; if the target BIM component has one or more of the sensitive portions, encrypting the target CID to obtain a target encrypted CID (ECID), and adding the target ECID into a target blockchain ledger as a target transaction via a target smart contract; accessing the target transaction to download the target BIM component from the IPFS network; and performing a design coordination operation on the target BIM component, so as to distributing revised target BIM component to a receiver terminal.

Abstract: Provided herein is a method for identifying and correcting optical aberrations within a sample under optical microscopy. The method includes providing a plurality of optical beams including at least a first optical beam and a second optical beam; modulating at least one of the optical beams at one or more frequencies; providing a combined optical beam at least partially superimposed in time by the first optical beam and the second optical beam; focusing the combined optical beam into the sample; detecting a first signal excited by the combined optical beam in the sample; demodulating the first signal by at least one lock-in amplifier to obtain a second signal including performing a plurality of measurements of spatial positions of the first optical beam with respect to the second optical beam; identifying and correcting the optical aberrations by the second signal through obtaining the electric-field point spread function of the optical beams.

Abstract: The invention provides a low-power wide area network integrated sensing and communication method based on channel sensing and reinforcement learning, and the method comprises the steps: receiving an uplink signal transmitted by a terminal node through a gateway receiver, demodulating the uplink signal through employing a soft demodulation algorithm, and obtaining a bit log-likelihood ratio; the deep reinforcement learning model completes channel reconstruction of the corresponding link during communication according to the bit log-likelihood ratio; and calculating the current optimal network configuration according to the reconstructed channel so as to distribute the current optimal network configuration to each terminal node during next downlink transmission.

Abstract: An all-optical neural network that utilizes light beams and optical components to implement layers of the neural network is disclosed herein. The all-optical neural network includes an input layer, zero or more hidden layers, and an output layer. Each layer of the neural network is configured to simulate linear and nonlinear operations of a conventional artificial neural network neuron on an optical signal. In an embodiment, the optical linear operation is performed by a spatial light modulator and an optical lens. The optical lens performs a Fourier transformation on the set of light beams and sums light beams with similar propagation orientations. The optical nonlinear operation is implemented utilizing a nonlinear optical medium having an electromagnetically induced transparency characteristic whose transmission of a probe beam of light is controlled by the intermediate output of a coupling beam of light from the optical linear operation.

Abstract: The invention provides a low-power wide area network integrated sensing and communication method based on channel sensing and reinforcement learning, and the method comprises the steps: receiving an uplink signal transmitted by a terminal node through a gateway receiver, demodulating the uplink signal through employing a soft demodulation algorithm, and obtaining a bit log-likelihood ratio; the deep reinforcement learning model completes channel reconstruction of the corresponding link during communication according to the bit log-likelihood ratio; and calculating the current optimal network configuration according to the reconstructed channel so as to distribute the current optimal network configuration to each terminal node during next downlink transmission.

Abstract: One or more devices, systems, apparatuses, methods of manufacture and/or methods of use to facilitate thermal sensing in a field related to thermal radiation are envisioned. In one embodiment, an ionic thermoelectric thermal radiation sensor, comprises a substrate, an ionic thermoelectric sensing unit arranged on the substrate and comprising ionically conductive and electrically insulating material, wherein the ionic thermoelectric sensing unit is a voltage-producing unit having first and second surfaces spaced apart from and disposed opposite to one other, wherein the ionic thermoelectric sensing unit produces voltage via thermal diffusion of ions or via the Soret effect under a temperature difference between the first and second surfaces, a thermal radiation absorber that generates heat when exposed to thermal radiation, and one or more electrical connectors that connect the first and second surface.

Abstract: Methods are provided for producing a biaxially oriented nanoporous UHMWPE membrane. The method can include combining a petroleum jelly, an ultra-high-molecular-weight polyethylene (UHMWPE), and an antioxidant, forming a suspension, feeding the suspension into an extruder to produce a gel filament, pressing the gel filament to form a gel film, subjecting the gel film to an annealing temperature, and extracting the petroleum jelly from the gel film.

Abstract: A compound comprises a donor and an acceptor, wherein at least one donor (“D”) and at least one acceptor (“A”) may be arranged in an order of D-A; D-A-D; A-D-A; D-D-A-D-D; A-A-D-A-A; D-A-D-A-D; and A-D-A-D-A. The compound may be selected from the group consisting of: MTPE-TP, MTPE-TT, TPE-TP A-TT, PTZ-BT-TP A, NPB-TQ, TPE-TQ-A, MTPE-BTSe, DCDPP-2TP A, DCDPP-2TPA4M, DCDP-2TPA, DCDP-2TPA4M, TTS, ROpen-DTE-TPECM, and RClosed-DTE-TPECM. The compound may be used as a probe and may be functionalized with special targeted groups to image biological species. As non-limiting examples, the compound may be used in cellular cytoplasms or tissue imaging, blood vessel imaging, in vivo fluorescence imaging, brain vascular imaging, sentinel lymph node mapping, and tumor imaging, and the compound may be used as a photoacoustic agent.

Abstract: The present invention belongs to the field of nanomedicine, and provides a DC biomimetic membrane nanoparticle loaded with an NIR-II AIE dye, a preparation method therefor and use thereof. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye comprises a DC membrane and an NIR-II AIE dye loaded therein, wherein the NIR-II AIE dye has photothermal characteristics. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye provided by the present invention not only solves the problem that the NIR-II AIE dye is poor in water solubility and limited in fluorescence imaging, but also increases the enrichment efficiency of the NIR-II AIE dye coated by the DC membrane at a tumor site and successfully activates the activity of T cells in vivo.

Abstract: Rotational translation of an inertial mass rotor is used for providing damping of low frequency noise and vibration. An axial component is mounted so as to translate axial movement of an inertial linearly-displaceable member to rotational movement of an inertial mass rotor. The translation to rotational movement of the inertial mass rotor provides inertial amplification in the form of translational-rotational coupling. This enables the construction of a compact assembly, which allows light ultra-low frequency resonances to be concentrated, and which absorbs such low frequency noise energy.

Abstract: The present disclosure provides compositions and methods for controlled release of macromolecules (such as proteins and polypeptides). The present disclosure also provides method for preparing and using the same.

Abstract: A method for predicting student performance in interactive question pools, comprising: a data processing and feature extraction module for: extracting from historical score data records statistical student features reflecting the students' past performances on the questions; and statistical question features indicating a question popularity of each question and the average students' scores on each question; and extracting from the pointing device movement data records a plurality of interactive edge features representing the characteristics of the students' problem-solving behaviors; a network construction module for: performing an Edge2Node transformation to transform the interactive edge features into one or more interaction nodes; and constructing a heterogeneous student-interaction-question (SIQ) network; and a prediction module for processing the SIQ network using a residual relational graph neural network to predict a student's score on unattempt questions.

Abstract: The subject invention pertains to compositions and methods of coating objects using BOC-butenolide. The invention also relates to compositions and methods for enhancing the performance and longevity of the coated objects with BOC-butenolide, including inhibiting fouling often caused by marine organisms.

Abstract: The present disclosure provides a solution-processed selective solar absorption coating and a process for the preparation thereof.

Abstract: Provided is a post-treatment method and system for a core-shell catalyst, which relate to the field of fuel cell materials. The post-treatment method of the present disclosure includes the following steps: a core-shell catalyst is added into an electrolyte solution containing citric acid or ethylenediamine tetraacetic acid, a gas containing oxygen is introduced into the electrolyte solution followed by stirring for a predetermined reaction time, the open circuit potential of the reactor base is recorded during the reaction time, and the open circuit potential should stabilize at 0.90˜1.0 V vs. RHE when the reaction is completed. The molar ratio of citric acid or ethylenediamine tetraacetic acid to platinum of the core-shell catalyst is 10 to 1000:1. A percentage of oxygen in the gas is 10 to 100% by volume. The post-treatment method of the present disclosure can significantly improve the platinum mass activity and PGM mass activity and durability of core-shell catalyst.

Abstract: The present invention provides new, fully human EphA4 monoclonal antibodies with distinct binding characteristics. Also disclosed are antigen binding fragments of these antibodies, bispecific forms of these antibodies, and conjugates of these antibodies. In addition, nucleic acids encoding these antibodies, antigen binding fragments, bispecific antibodies and conjugates are disclosed. These monoclonal antibodies, antigen binding fragments, bispecific antibodies, conjugates, nucleic acids and vector are of use for identifying and treating a subject with a disease or condition involving abnormal EphA4-mediated signaling.