Abstract: An all-solid-state battery system having a solid-state electrolyte composite is provided. The solid-state electrolyte composite includes a porous framework providing support and mechanical strength for the solid-state electrolyte composite and a plurality of ionic conductors filling voids of the porous framework for maximizing ionic conductance of the solid-state electrolyte composite. The porous framework may be made of ultra-high-molecular-weight polyethylene (UHMWPE) polymers and the plurality of ionic conductors may be made of poly(ethylene oxide)-LiN(SO2CF3)2 (PEO-LiTFSI) polymers. The all-solid-state battery system includes battery cells each including a cathode current collector, a cathode disposed beneath and connected to the cathode current collector, the solid-state electrolyte composite disposed beneath and connected to the cathode, an anode disposed beneath and connected to the solid-state electrolyte composite, and an anode current collector disposed beneath and connected to the anode.
Type:
Grant
Filed:
April 8, 2021
Date of Patent:
June 25, 2024
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Ping Gao, Minhua Shao, Jiadong Li, Qiao Gu, Jin Li
Abstract: The invention relates to the systems and methods for isolating single cells, capturing selected prey biomolecules within said cells, and detecting said prey biomolecules using a sensitive assay method. Also described herein are functionalized substrates and compositions for enabling the low limit of detection of selected prey biomolecules of selected cells.
Type:
Grant
Filed:
August 21, 2020
Date of Patent:
June 11, 2024
Assignee:
The Hong Kong University of Science and Technology
Abstract: A multifunctional and modular geotechnical testing device for testing a soil sample is provided. The testing device includes a testing cell, a plurality of needle probes, and a plurality of lateral pressure-measuring sensors. The testing cell has an oedometer ring for accommodating the soil sample, with a plurality of holes located on and angularly distributed over an internal lateral surface of the oedometer ring forming a plurality of channels to access the soil sample from outside. The plurality of needle probes, each configured to house a pore water pressure-measuring sensor, is detachably mountable to the plurality of channels from outside for simultaneously measuring the pore water pressures. The plurality of lateral pressure-measuring sensors is removably attachable to an inner peripheral side of the testing cell for measuring lateral pressures of the soil sample.
Type:
Grant
Filed:
January 29, 2021
Date of Patent:
June 4, 2024
Assignee:
The Hong Kong University of Science and Technology
Abstract: Provided herein are aggregation-induced emission luminogens useful for imaging and/or detecting cancer cells and dynamically monitoring the viability of cancer cells and methods of use and preparation thereof.
Type:
Grant
Filed:
April 20, 2021
Date of Patent:
April 23, 2024
Assignee:
The Hong Kong University of Science and Technology
Abstract: The subject invention pertains to composition and methods of using said composition as an in vitro biosensor of small molecules in biological and/or environmental samples using enzyme-assisted nucleic acid reactions. The methods and compositions can be used to sense and/or transduce the signal of a sensing event mediated by allosteric proteins, endonucleases and nucleic acid reactions. This invention allows the rapid development and setup of one-pot assays to provide results in minutes. The methods and compositions may be used to generate an electrochemical, fluorescent, colorimetric, and/or luminescent output and the methods can be performed in different modalities, including a solution-based or paper-based assay.
Type:
Grant
Filed:
July 29, 2021
Date of Patent:
April 23, 2024
Assignee:
The Hong Kong University of Science and Technology
Inventors:
I-Ming Hsing, Alan Fernando Rodriguez Serrano
Abstract: Sound absorbers using distributed absorption units each having an extended neck are provided. The absorption units can be, for example, Helmholtz resonators with extended neck (HRENs). The absorption units can be distributed in a lateral fashion, for example, in a checkerboard fashion with laterally, non-diagonally adjacent units having a different extended neck length and/or diameter. Each absorption unit can be, for example, a cylinder-structure core sandwiched between a back wall and a perforated plate.
Type:
Grant
Filed:
September 3, 2020
Date of Patent:
March 12, 2024
Assignee:
The Hong Kong University of Science and Technology
Abstract: The present invention provides a radiative cooling structure that can be fabricated using solution-based processes and offer great IR-selectivity referring to low absorptivity within solar spectrum and high emissivity within the atmosphere transmission window (8-13 microns) for daytime radiative cooling. This structure includes a reflective layer, a ceramic IR-selectively emissive layer and a ceramic emission boosting layer, and the ceramic emission boosting layer is able to boost the overall emissivity of the radiative cooling structure within the atmosphere transmission windows and avoid infrared emission outside the atmosphere transmission window. The IR-selectivity contributes to larger temperature reduction, especially in high humidity area.
Type:
Grant
Filed:
March 31, 2021
Date of Patent:
January 16, 2024
Assignee:
The Hong Kong University of Science and Technology
Abstract: Provided herein are aggregation-induced emission luminogens useful as photodynamic therapy and imaging agents, compositions including two or more aggregation-induced emission luminogens, pharmaceutical compositions comprising the same, and methods of use and preparation thereof.
Type:
Grant
Filed:
January 21, 2021
Date of Patent:
January 9, 2024
Assignee:
The Hong Kong University of Science and Technology
Abstract: Provided herein are chiral compounds that exhibit circularly polarized photoluminescence and electroluminescence and electroluminescent devices and circularly polarized fluorescent probes comprising the same.
Type:
Grant
Filed:
February 14, 2019
Date of Patent:
January 9, 2024
Assignee:
The Hong Kong University of Science and Technology
Abstract: Three-dimensional (3D) hierarchical morphologies widely exist in natural and biomimetic materials, which impart preferential functions including liquid and mass transport, energy conversion, and signal transmission for various applications. While notable progress has been made in the design and manufacturing of various hierarchical materials, the state-of-the-art approaches suffer from limited materials selection, high costs, as well as low processing throughput. Herein, by harnessing the configurable elastic crack engineering-controlled formation and configuration of cracks in elastic materials, an effect normally avoided in various industrial processes, the present invention provides a facile and powerful technique to enable the faithful transfer of arbitrary hierarchical structures with broad material compatibility and structural and functional integrity.
Type:
Grant
Filed:
October 23, 2020
Date of Patent:
December 12, 2023
Assignees:
Hong Kong Baptist University, The Hong Kong University of Science and Technology, City University of Hong Kong
Abstract: Systems and methods related to centrifuge energy harvesting chambers (CEHCs) for gas production simulation are provided. Certain CEHCs may include a high-pressure chamber, high-pressure syringe pumps, cooling systems, an actuator and surcharge, backpressure control inside the wellbore, a heating element on the wellbore, water gas separation systems, and flow measurement systems. Certain CEHCs may also provide software operably connected to sensors and instrumentation, comprising a module to continuously, in real-time, periodically, or asynchronously, measure and monitor simulation variables.
Type:
Grant
Filed:
November 16, 2021
Date of Patent:
December 5, 2023
Assignee:
The Hong Kong University of Science and Technology
Inventors:
Charles Wang Wai Ng, Sina Baghbanrezvan
Abstract: The subject invention pertains to compositions and methods for treating neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), multiple sclerosis, epilepsy, stroke, alcohol withdrawal, progressive supranuclear palsy (PSP), Pick's disease (PiD), corticobasal degeneration (CBD), frontotemporal dementia or parkinsonism linked to chromosome 17 (FTDP-17). The methods of the subject invention further relate to methods of fermentation of bacterial cells and methods of tautomerization of the subject compounds.
Type:
Grant
Filed:
September 15, 2021
Date of Patent:
November 21, 2023
Assignees:
The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
Abstract: Compounds including triphenylamine and luminol moieties exhibiting near-infrared chemiluminescence useful as reactive oxygen sensors, pharmaceutical compositions including the same, and methods of preparation and use thereof.
Type:
Grant
Filed:
March 1, 2021
Date of Patent:
November 14, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: The subject invention pertains to compositions comprising albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo. The subject invention further pertains to methods of treating a subject with HIV using albofungin and/or derivatives thereof, including, chloroalbofungin, 477-albo, 492-albo, 505-albo, 506-1-albo, 506-2-albo, 519-albo, and 562-albo.
Type:
Grant
Filed:
June 1, 2022
Date of Patent:
October 17, 2023
Assignees:
The Hong Kong University of Science and Technology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
Abstract: Non-d0 rhenium(V) alkylidyne catalysts useful for catalyzing alkyne metathesis reactions, such as homo- and cross-metathesis of alkynes or diynes, ring closing metathesis and ring-opening metathesis, methods or use, and preparation thereof. The catalysts are stable to air and moisture and tolerate a variety of functional groups in substrates.
Type:
Grant
Filed:
July 5, 2022
Date of Patent:
October 10, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: Provided herein are multifunctional photoresponsive compositions that can undergo conversion from an aggregation-caused quenching (ACQ) state to an aggregation-induced emission (AIE) state and macroscopic actuation and systems comprising the same and methods of use thereof.
Type:
Grant
Filed:
July 28, 2020
Date of Patent:
September 26, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.
Type:
Application
Filed:
April 17, 2023
Publication date:
September 21, 2023
Applicants:
The Hong Kong University Of Science And Technology, Hong Kong Baptist University, Macau University Of Science And Technology
Inventors:
Chun LIANG, Zhihong JIANG, Ziyi Wang, Zhiling Yu, Jingrong Wang, Liping Bai
Abstract: The subject invention pertains to the rapid amplification and real-time monitoring of nucleic acid sequences at a constant temperature. Specifically, fluorescent or electroactive-labeled loop probes and primers are designed to be specific to identified regions of a target nucleic acid sequences and subsequently amplify and permit the identification of the presence of the target sequence. In this method, a DNA polymerase with no 5? to 3? exonuclease activity is added to extend the primers and probes, while a nicking endonuclease is added to specifically identify the amplified nucleic acid product and cleave the label from the loop probe-extended DNA duplex.
Type:
Grant
Filed:
May 28, 2021
Date of Patent:
September 19, 2023
Assignee:
The Hong Kong University of Science and Technology
Inventors:
I-Ming Hsing, Xiao Lu, Henson Lim Lee Yu
Abstract: A PAM-4 receiver with jitter compensation clock and data recovery is provided. The receiver includes a first-order delay-locked loop (DLL) which employs a bang-bang phase detector (BBPD) and a voltage-controlled delay line (VCDL) circuit supporting 40 MHz jitter tracking bandwidth and static phase skew elimination. A second-order wideband phase-locked loop (WBPLL) using the ΒΌ-rate reference clock provides multi-phase clock generation with low input-to-output latency. To suppress the consequent jitter transfer, a jitter compensation circuit (JCC) acquires the jitter transfer amplitude and frequency information by detecting the DLL loop filter voltage (VLF(s)) signal, and generates an inverted loop filter voltage signal, denoted as VLFINV(s). The VLFINV(s) modulates a group of complementary VCDLs (C-VCDLs) to attenuate the jitter transfer on both recovered clock and data. With the provided receiver, a jitter compensation ratio up to 60% can be supported from DC to 4 MHz, with a ?3-dB corner frequency of 40 MHz.
Type:
Grant
Filed:
May 16, 2022
Date of Patent:
September 12, 2023
Assignee:
The Hong Kong University of Science and Technology
Abstract: The present invention provides a signal fusion system that is a probabilistic system fusing an arbitrary combination of heterogeneous signals for determining the location of electronic devices. The system includes a signal sampling device for detecting one or more signals emitted by an electronic device to be located, including geolocation signals, WiFi signals, Bluetooth signals, 4G communication signals, 5G communication signals, geomagnetism signals, or inertial navigation system signals (INS). A likelihood processor cooperates with the signal sampling device to receive information about selected sampled signals, and creates a grid of reference points for an interested area in which the electronic device may be located. The likelihood processor independently computes, for each selected sampled signal, a location likelihood that is a probability of observing the sampled signal given that the electronic device is located at different reference points in the grid.
Type:
Grant
Filed:
June 11, 2021
Date of Patent:
August 29, 2023
Assignee:
The Hong Kong University of Science and Technology