Patents Assigned to Hutchinson
  • Systems for electroplating and methods of use thereof
    Patent number: 11713514
    Abstract: A system for electroplating a web of conductive material with a source material comprises a transport mechanism, an electrical contact, a plating bath, and at least one nozzle. The transport mechanism transports the web through the system. The electrical contact electrically engages the web to cause current to flow into the web. The plating bath contains a volume of an electrically conductive liquid contain ions of the source material. The nozzle is configured to flow a low electrical conductivity fluid onto the web. A portion of the web is immersed in the electrically conductive liquid. The current flowing in the web causes the ions of the source material in the electrically conductive liquid to attach to a surface of the portion of the web.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: August 1, 2023
    Assignee: Hutchinson Technology Incorporated
    Inventors: Douglas P. Riemer, Stephen P. Toperzer, Donovan D. Turvold, Christopher R. Rosenau, Dylan S. Johnson
  • CHIMERIC ANTIGEN RECEPTORS TARGETING CD33
    Publication number: 20230220103
    Abstract: Chimeric antigen receptors (CARs) with binding domains derived from a novel suite of human CD33-binding antibodies are described. The CARs include optimized short and intermediate spacer regions. The current disclosure also provides methods of cell expansion/activation processes utilizing IL-2, IL-7, IL-15, and/or IL-21 that improve cellular proliferation and cell lysis of the CARs as described.
    Type: Application
    Filed: March 31, 2021
    Publication date: July 13, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Cameron J. Turtle, Roland B. Walter, George S. Laszlo, Salvatore Fiorenza
  • AUGMENTING ANTIGEN-NEGATIVE CELL DEATH IN ANTIGEN-TARGETED IMMUNOTHERAPIES
    Publication number: 20230218669
    Abstract: Combination therapies that include (i) an immune cell that expresses a chimeric antigen receptor (CAR) or similar molecule and (ii) a compound that preserves or potentiates the in vivo actions of tumor necrosis factor alpha (TNF?) against cancer cells are described. The combination therapies result in the killing of antigen-negative cells in the vicinity of immunotherapy targeted-antigen-positive cells reducing the survivability of escape variants and providing other benefits.
    Type: Application
    Filed: March 31, 2021
    Publication date: July 13, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Cameron J. Turtle, Salvatore Fiorenza
  • NEUTRALIZING MONOCLONAL ANTIBODIES AGAINST COVID19
    Publication number: 20230212266
    Abstract: The disclosure provides antibodies, antibody fragments, and antibody derivatives that bind to the viral envelope spike protein (S2P) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), and related compositions, and methods. In some embodiments, the antibodies, antibody fragments, and antibody derivatives bind to an epitope of the receptor binding domain (RBD) of SARS-CoV-2.
    Type: Application
    Filed: April 26, 2021
    Publication date: July 6, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Leonidas Stamatatos, Andrew McGuire, Marie Pancera
  • BIOMARKERS FOR DETECTION OF LUNG CANCER
    Publication number: 20230213521
    Abstract: The application discloses in vitro methods for diagnosing lung cancer in a subject, wherein the method comprises detecting at least one biomarker selected from the group consisting of Rho GDP dissociation inhibitor beta (ARHGDIB), alpha-tubulin 4A (TUBA4A), glutathione S-transferase omega 1 (GSTO1), filamin A (FLNA), peroxiredoxin 6 (PRDX6) and cadherin 13 (CDH13) in a biological sample from the subject, and kits for measuring said at least one biomarker.
    Type: Application
    Filed: April 28, 2021
    Publication date: July 6, 2023
    Applicants: Luxembourg Institute of Health (LIH), Fred Hutchinson Cancer Center, The Translational Genomics Research Institute (TGEN)
    Inventors: Victoria EL KHOURY, Anna Elisabeth SCHRITZ, Yeoun Jin KIM, Guy BERCHEM, Amanda PAULOVICH, Jeffrey WHITEAKER, Konstantinos PETRITIS, Patrick PIRROTTE, Tony TEGELER
  • Vortex separation device for a fluid transfer circuit
    Patent number: 11691477
    Abstract: The invention relates to a vortex degassing device (1) for a fluid transfer circuit (F1, F2), in particular of a motor vehicle, this device (1) comprising: a first internal chamber (10) connected to a first inlet (11) for a fluid (F1) as well as to a first outlet (12) for a liquid fraction and to a second outlet (13) for a gaseous fraction, a second internal chamber (20) connected to a second inlet (21) for a fluid (F2) as well as to a third outlet (22) for a liquid fraction and to a fourth outlet (23) for a gaseous fraction, the second chamber (20) being located above the first chamber (10) and the second outlet (13) extending through the second chamber (20) to the level of the fourth outlet (23). The invention also relates to a fluid transfer circuit comprising at least one such device (1) as well as a method for using such a device (1).
    Type: Grant
    Filed: August 26, 2021
    Date of Patent: July 4, 2023
    Assignee: HUTCHINSON
    Inventors: Philippe Grouillet, Bastien Rouprich
  • MYELOMA-SPECIFIC IMMUNITY REQUIRES THE DIFFERENTIATION OF STEM-LIKE MEMORY T CELLS IN THE BONE MARROW
    Publication number: 20230201262
    Abstract: Methods for treating malignancies such as hematological malignancies, including myeloma, that are resistant to tissue transplant treatments and that can be characterized by an increased risk of relapse or graft-versus-host disease (GVHD). A method for treatment includes transplanting a tissue that includes T cells to a subject, enriching for a stem-like memory T cell phenotype in the T cells, and stimulating the T cells to enhance a graft-versus-tumor (GVT) response of the T cells. The enriching for the stem-like memory T cell phenotype can include depletion of exhausted alloreactive T cells with a post-transplant cyclophosphamide (PT-Cy) treatment and the stimulating the T cells can include an agonist immunotherapy, such as a decoy-resistant IL-18 (DR-18) treatment, to enhance the GVT response.
    Type: Application
    Filed: December 6, 2022
    Publication date: June 29, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Simone Minnie, Geoffrey Hill
  • Shape memory alloy actuators and methods thereof
    Patent number: 11686294
    Abstract: SMA actuators and related methods are described. One embodiment of an actuator includes a base; a plurality of buckle arms; and at least a first shape memory alloy wire coupled with a pair of buckle arms of the plurality of buckle arms. Another embodiment of an actuator includes a base and at least one bimorph actuator including a shape memory alloy material. The bimorph actuator attached to the base.
    Type: Grant
    Filed: April 26, 2022
    Date of Patent: June 27, 2023
    Assignee: Hutchinson Technology Incorporated
    Inventors: Mark A. Miller, Nathaniel K. Behning, Dean E. Myers, Michael W. Davis, Ryan N. Ruzicka, Zachary A. Pokornowski, Yasushi Sakamoto
  • ANTI-CD33 ANTIBODIES AND USES THEREOF
    Publication number: 20230190810
    Abstract: A suite of novel anti-CD33 antibodies is described. The provided antibodies are pan-binders, binding the C2-set Ig-like domain in the presence or absence of the V-set Ig-like domain of CD33; are C2-set specific binders, binding the C2-set Ig-like domain only in the absence of the V-set Ig-like domain of CD33; or are V-set binders, binding the V-set Ig-like domain of CD33. The antibodies provide novel therapeutic and diagnostic tools against CD33-related disorders, such as acute myeloid leukemia (AML).
    Type: Application
    Filed: March 31, 2021
    Publication date: June 22, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Roland B. Walter, George S. Laszlo
  • COMPOSITIONS AND METHODS FOR ENHANCING CANCER IMMUNOTHERAPY
    Publication number: 20230190707
    Abstract: The disclosure provides methods of enhancing susceptibility of neoplastic, transformed, and/or cancer cells (“cancer cells”) to immunotherapeutic agents. The methods comprise contacting the cancer cell with an agent that modulates RNA splicing. In some embodiments, the method further comprise contacting the cancer cell with the immunotherapeutic agent, such as an immune checkpoint inhibitor. The disclosure also provides compositions and/or methods for treating a subject with cancer. In some embodiments, the disclosure provides compositions and methods for combination therapy that comprises administering to a subject with cancer an effective amount of an agent that modulates RNA splicing and a therapeutically effective amount of an immunotherapeutic agent, such as an immune checkpoint inhibitor.
    Type: Application
    Filed: May 14, 2021
    Publication date: June 22, 2023
    Applicants: Fred Hutchinson Cancer Center, Memorial Sloan Kettering Cancer Center
    Inventors: Robert K. Bradley, Omar Abdel-Wahab, Sydney Lu
  • Wire feeding and attaching system for camera lens suspensions
    Patent number: 11682876
    Abstract: A wire feeding and bonding tool and method for attaching wires to a component having first and second spaced-apart wire attach structures. Wire from a supply is fed through a capillary having at least a linear end portion with a feed opening. The capillary is positioned with respect to the component to locate a first portion of the wire extending from the feed opening adjacent to the first wire attach structure, and the wire is attached to the first attach structure. The capillary is moved with respect to the component along a wire feed path to feed the wire from the first wire attach structure to the second wire attach structure and to locate a second portion of the wire extending from the feed opening adjacent to the second attach structure. The wire is attached to the second wire attach structure, and cut from the supply.
    Type: Grant
    Filed: November 16, 2020
    Date of Patent: June 20, 2023
    Assignee: Hutchinson Technology Incorporated
    Inventors: Michael W. Davis, Bryan J. Scheele, Daniel W. Scheele, Andrew H. Ashwill, Matthew D. Crane
  • CONNECTION FOR FLUID WITH TWO WELDS
    Publication number: 20230184365
    Abstract: A connection for a fluid includes a pipe; a connector in which a fluid is flows, and a housing in which the pipe is at least partially inserted. The pipe and the connector are in fluidic communication. A gasket is arranged in the housing and radially interposed between the pipe and the connector to prevent any leakage of fluid between the pipe and the connector. A closing element in which the pipe is inserted, is mounted both to the pipe (2) and to the connector by two respective welds ensuring fluid tightness.
    Type: Application
    Filed: December 7, 2022
    Publication date: June 15, 2023
    Applicant: HUTCHINSON S.R.L.
    Inventors: Nicola MORETTI, Roberto BERTALMIO, Stéphane ULLY, Fabrizio ROCCA
  • Plating method to reduce or eliminate voids in solder applied without flux
    Patent number: 11674235
    Abstract: A method of plating a copper substrate with gold that reduces or eliminates the presence of microvoids at the interface of the gold/copper substrate is described. Suitably, live entry of the substrate into the plating bath is performed with application of external current to the bath such that no portion of the substrate is exposed to the bath for more than one second without the application of the external current. Increase of the applied current for gold strike to the mass-transfer-limit for gold reduction accomplishes the full measure of improvement in eliminating microvoids.
    Type: Grant
    Filed: March 27, 2019
    Date of Patent: June 13, 2023
    Assignee: Hutchinson Technology Incorporated
    Inventors: Douglas P. Riemer, Peter F. Ladwig
  • Shape memory alloy actuators and methods thereof
    Patent number: 11668288
    Abstract: SMA actuators and related methods are described. One embodiment of an actuator includes a base; a plurality of buckle arms; and at least a first shape memory alloy wire coupled with a pair of buckle arms of the plurality of buckle arms. Another embodiment of an actuator includes a base and at least one bimorph actuator including a shape memory alloy material. The bimorph actuator attached to the base.
    Type: Grant
    Filed: April 5, 2022
    Date of Patent: June 6, 2023
    Assignee: Hutchinson Technology Incorporated
    Inventors: Ryan N. Ruzicka, Yasushi Sakamoto
  • STRATEGIES TO ASSESS AND/OR PRODUCE CELL POPULATIONS WITH PREDICTIVE ENGRAFTMENT POTENTIAL
    Publication number: 20230159895
    Abstract: Strategies to assess and/or produce cell populations with predictive engraftment potential are described. The cell populations can be used for a variety of therapeutic and research purposes.
    Type: Application
    Filed: November 18, 2022
    Publication date: May 25, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Stefan Radtke, Hans-Peter Kiem, Jennifer E. Adair
  • METHODS AND COMPOSITIONS COMPRISING BRD9 ACTIVATING THERAPIES FOR TREATING CANCERS AND RELATED DISORDERS
    Publication number: 20230159920
    Abstract: The current disclosure relates to methods and compositions for increasing functional expression of BRD9 in a cell. The methods and compositions can be incorporated into methods for treating cancer through the administration of BRD9 activating therapies. Accordingly, aspects of the disclosure relate to compositions and methods for treating cancer, a pre-malignant disease, or a dysplastic disease in a subject. The method can comprise administering a BRD9 activating therapy to the subject.
    Type: Application
    Filed: June 25, 2020
    Publication date: May 25, 2023
    Applicants: Fred Hutchinson Cancer Research Center, Memorial Sloan Kettering Cancer Center
    Inventors: Robert K. Bradley, Omar Abdel-Wahab, Daichi Inoue
  • METHODS AND COMPOSITIONS TO ENHANCE HUMORAL IMMUNITY TO REDUCE CYTOMEGALOVIRUS INFECTION AND REACTIVATION BY IL-6 INHIBITION
    Publication number: 20230151101
    Abstract: Embodiments of the present disclosure are directed to methods and compositions for inhibiting cytomegalovirus (CMV) in a transplant recipient. In some embodiments, the methods are directed to inhibiting CMV reactivation in a transplant recipient with a CMV-seropositive serological status, the method comprising administering an effective amount of a compound to block IL-6 function. In some embodiments, the methods are directed to preventing CMV infection in a transplant recipient, wherein a transplant donor has a CMV-seropositive serological status, the method comprising administering an effective amount of a compound to block IL-6 function. In still other embodiments, a composition comprising a compound to block IL-6 function is administered to a transplant recipient with a CMV-seropositive serological status to prevent CMV reactivation.
    Type: Application
    Filed: January 11, 2022
    Publication date: May 18, 2023
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Geoffrey Hill, Siok Tey, Mariapia Degli-Esposti
  • CHIMERIC ANTIGEN RECEPTORS TARGETING CD33
    Publication number: 20230151094
    Abstract: Chimeric antigen receptors (CARs) with binding domains derived from a novel suite of CD33-binding antibodies are described. The CARs include optimized short and intermediate spacer regions. The current disclosure also provides methods of cell expansion/activation processes utilizing IL-2, IL-7, IL-15, and/or IL-21 that improve cellular proliferation and cell lysis of the CARs as described.
    Type: Application
    Filed: March 31, 2021
    Publication date: May 18, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Cameron J. Turtle, Roland B. Walter, George S. Laszlo, Salvatore Fiorenza
  • Cartilage-homing peptides
    Patent number: 11648290
    Abstract: Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in and/or binds to the cartilage of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide-active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of a drug to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide-active agent complexes to target regions, tissues, structures or cells targeted by the peptide.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: May 16, 2023
    Assignees: FRED HUTCHINSON CANCER CENTER, BLAZE BIOSCIENCE, INC.
    Inventors: James Olson, Andrew David Strand, Emily June Girard, Roland Strong, Christopher Mehlin, Colin Correnti, Natalie Nairn
  • HUMAN ANTI-CD33 ANTIBODIES AND USES THEREOF
    Publication number: 20230144405
    Abstract: A suite of novel human anti-CD33 antibodies is described. The provided antibodies are pan-binders, binding the C2-set Ig-like domain in the presence or absence of the V-set Ig-like domain of CD33 or are V-set binders, binding the V-set Ig-like domain of CD33. The antibodies provide novel therapeutic and diagnostic tools against CD33-related disorders, such as acute myeloid leukemia (AML).
    Type: Application
    Filed: March 31, 2021
    Publication date: May 11, 2023
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Roland B. Walter, George S. Laszlo