Patents Assigned to Hutchinson
  • STABLE CORONAVIRUS PROTEINS AND VACCINE COMPOSITIONS THEREOF
    Publication number: 20220325279
    Abstract: Provided herein are compositions and methods comprising mutated coronavirus “S” spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.
    Type: Application
    Filed: December 28, 2021
    Publication date: October 13, 2022
    Applicants: UNIVERSITY OF WASHINGTON, FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Daniel ELLIS, Neil KING, Jesse BLOOM, Tyler STARR, Allison GREANEY
  • Binding proteins specific for RAS neoantigens and uses thereof
    Patent number: 11458191
    Abstract: The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.
    Type: Grant
    Filed: December 8, 2021
    Date of Patent: October 4, 2022
    Assignee: FRED HUTCHINSON CANCER CENTER
    Inventors: Rachel Perret, Philip D. Greenberg, Thomas M. Schmitt, Aude G. Chapuis, Ingunn M. Stromnes, Tijana Martinov
  • Insert for a run slide for a vehicle window
    Patent number: 11453280
    Abstract: An insert for a run slide for a vehicle window. The insert may be overmoulded to form a connecting wedge between two strands of the run slide. The insert may be formed in one piece and is configured to cooperate with a portion of a vehicle door frame. The insert is further configured to cooperate with a portion of a hubcap to be attached to one of the strands. The insert includes a protruding pin configured to be engaged in a recess of a rabbet of the vehicle door frame to index the insert along an axis X substantially parallel to an axis of elongation of the rabbet. The insert is configured to cooperate with the portion of the hubcap to ensure indexing the hubcap along the axis X and along an axis Z perpendicular to X and substantially parallel to an axis of elongation of the hubcap.
    Type: Grant
    Filed: September 3, 2018
    Date of Patent: September 27, 2022
    Assignee: HUTCHINSON
    Inventors: Emmanuel Petit, Benoît Prochasson, Pierre David
  • Shape memory alloy actuators and methods thereof
    Patent number: 11448853
    Abstract: SMA actuators and related methods are described. One embodiment of an actuator includes a base; a plurality of buckle arms; and at least a first shape memory alloy wire coupled with a pair of buckle arms of the plurality of buckle arms. Another embodiment of an actuator includes a base and at least one bimorph actuator including a shape memory alloy material. The bimorph actuator attached to the base.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: September 20, 2022
    Assignee: Hutchinson Technology Incorporated
    Inventors: Mark A. Miller, Nathaniel K. Behning, Dean E. Myers, Michael W. Davis, Ryan N. Ruzicka
  • Systems and methods to improve vaccine efficacy
    Patent number: 11440945
    Abstract: Systems and methods to increase the efficacy of vaccines that require or are rendered more effective with T cell mediated immunity are described. The systems and methods utilize polynucleotides that genetically modify T cells to express a T cell receptor specific for an administered vaccine antigen.
    Type: Grant
    Filed: January 5, 2018
    Date of Patent: September 13, 2022
    Assignee: Fred Hutchinson Cancer Center
    Inventor: Matthias Stephan
  • Compositions and methods for expansion of embryonic hematopoietic stem cells
    Patent number: 11439667
    Abstract: The present invention relates to methods, kits and compositions for expansion of embryonic hematopoietic stem cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TGF? pathway. Also provided herein are methods for expanding embryonic hematopoietic stem cells using kits and compositions comprising a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TGF? pathway. The embryonic hematopoietic stem cells expanded using the disclosed kits, compositions and methods include cells derived from an embryo (e.g., aorta-gonad-mesonephros region of the embryo), embryonic stem cells, induced pluripotent stem cells, or reprogrammed cells of other types.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: September 13, 2022
    Assignee: FRED HUTCHINSON CANCER CENTER
    Inventors: Irwin D. Bernstein, Brandon K. Hadland
  • On-axis and diffuse illumination for inspection systems
    Patent number: 11442020
    Abstract: An inspection system is described. The inspection system includes a camera and a housing. The housing contains a reflective dome. The reflective dome includes an apex and a viewport. The viewport is offset from the apex. The camera is mounted to capture light exiting the reflective dome through the viewport. And, a plurality of light sources are arranged about the reflective dome such that light output from the plurality of light sources enters the dome.
    Type: Grant
    Filed: October 6, 2017
    Date of Patent: September 13, 2022
    Assignee: Hutchinson Technology Incorporated
    Inventors: Matthew S. Lang, Timothy J. Maday, Dennis R. Johnson
  • Photoresist spectral sensitivity matching radiometer for trace/space width variation improvement
    Patent number: 11441942
    Abstract: A radiometer probe for matching a spectral sensitivity of a dry-film resist is provided. The radiometer probe includes a light probe and a filter-diffuser assembly connected to the light probe. The filter-diffuser assembly includes a filter housing configured to receive an optical diffuser positioned on a filter. The optical diffuser and the filter are separated by a spacer.
    Type: Grant
    Filed: June 19, 2019
    Date of Patent: September 13, 2022
    Assignee: Hutchinson Technology Incorporated
    Inventors: Matthew S. Lang, Lawrence E. LaLonde, Kyle T. Tobias
  • Compositions and methods for accurately identifying mutations
    Patent number: 11441180
    Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
    Type: Grant
    Filed: November 6, 2020
    Date of Patent: September 13, 2022
    Assignee: Fred Hutchinson Cancer Center
    Inventor: Jason H. Bielas
  • CIRCUMSPOROZOITE PROTEINS WITH INCREASED EXPRESSION IN MAMMALIAN CELLS
    Publication number: 20220280626
    Abstract: Mutated and/or truncated malarial circumsporozoite proteins (CSP) and associated nucleic acids that are more stable and highly expressed in mammalian cells are described. The mutated and/or truncated CSP and associated nucleic acids can be expressed to produce malaria vaccine antigens.
    Type: Application
    Filed: March 18, 2020
    Publication date: September 8, 2022
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Marie Pancera, Connor Weidle
  • METHODS AND COMPOSITIONS FOR INDUCING NOTCH SIGNALING IN TUMOR MICROENVIRONMENTS
    Publication number: 20220267437
    Abstract: The disclosure provides methods for inducing Notch signaling in a targeted manner within aggregations of cells. The methods include contacting the aggregation of cells with a bi-specific molecule that facilitates trans-binding of Notch receptor. The bi-specific molecule comprising a cell-targeting domain that specifically binds to a cell-specific antigen expressed in the aggregation of cells, and a Notch-binding domain that specifically binds to Notch receptor. In some aspects, the disclosed methods and reagents provide methods of promoting pro-inflammatory states in tumor micro-environments.
    Type: Application
    Filed: July 28, 2020
    Publication date: August 25, 2022
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Irwin D. Bernstein, Suzanne Furuyama
  • MICROLUMENAL TARGETING OF CANCER CELLS
    Publication number: 20220257632
    Abstract: The disclosure provides methods and compositions for microlumen targeting in the treatment of cancers characterized by solid tumors or cell clusters, such as circulating tumor cell (CTC) clusters and disseminated tumor cell (DTC) clusters. The methods and compositions specifically target epigen in microlumenal space between two or more cancer cells and reduce the expression, functionality and/or concentration of epigen within the microlumenal space. The methods and compositions can be part of methods of treating cancer in a subject wherein the cancer is characterized by a solid tumor, a circulating tumor cell (CTC) cluster, and/or a disseminated tumor cell (DTC) cluster. The reduced levels of functional epigen in the microlumen result in reduced incidence of metastasis and increased susceptibility of the tumor cells to additional therapeutic interventions.
    Type: Application
    Filed: June 19, 2020
    Publication date: August 18, 2022
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Kevin J. Cheung, Emma D. Wrenn
  • RECOMBINANT AD35 VECTORS AND RELATED GENE THERAPY IMPROVEMENTS
    Publication number: 20220257796
    Abstract: The present disclosure provides, among other things, helper-dependent adenoviral serotype 35 (Ad35) vectors. In various embodiments, helper-dependent Ad35 vectors can be used to deliver a therapeutic payload to a subject in need thereof. Exemplary payloads can encode replacement proteins, antibodies, CARs, TCRs, small RNAs, and genome editing systems. In certain embodiments, a helper-dependent Ad35 vector is engineered for integration of a payload into a host cell genome. The present disclosure further includes methods of gene therapy that include administration of a helper-dependent Ad35 vector to a subject in need thereof.
    Type: Application
    Filed: July 2, 2020
    Publication date: August 18, 2022
    Applicants: Fred Hutchinson Cancer Research Center, University of Washington
    Inventors: Hans-Peter Kiem, Andre Lieber, Chang Li, Hongjie Wang
  • Uncoupling pulley
    Patent number: 11415211
    Abstract: An uncoupling pulley includes a wheel rim including a first area, intended for receiving a belt connecting the wheel rim to a first power-transmission element, and a second area extending from the first area; a hub rigidly connected to a second power-transmission element; a ring gear including a first portion located under the second area and a second portion presented in the shape of a resilient cylindrical skirt extending, from the first portion, along the longitudinal axis, the cylindrical skirt of the ring gear including a plurality of longitudinal slots and consequently a plurality of portions separated from each other by one of the slots, the ring gear being capable of rotating relative to the wheel rim; and a device for driving the ring gear; and a resiliently deformable element, one end of which is attached to the hub and another end of which is attached to the ring gear.
    Type: Grant
    Filed: November 15, 2017
    Date of Patent: August 16, 2022
    Assignee: HUTCHINSON
    Inventor: Hervé Varin
  • Removable tabs and methods of making and using the same
    Patent number: 11414226
    Abstract: A method of making a component includes applying a clamping force to the component, the component coupled to a carrier strip of a panel via a polymeric tab and separating a portion of the polymeric tab from a substrate of the component, thereby causing the component to be detached from the panel.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: August 16, 2022
    Assignee: Hutchinson Technology Incorporated
    Inventors: Erich W. Bierbrauer, Scott J. Cray, Peter F. Ladwig, Clark T. Olsen, Zachary A. Pokornowski
  • METHODS AND COMPOSITIONS FOR TREATING ANDROGEN RECEPTOR DEFICIENT, ANDROGEN RECEPTOR LOW, AND CASTRATION-RESISTANT PROSTATE CANCERS
    Publication number: 20220249439
    Abstract: Methods and compositions for treatment of prostate cancers, such as androgen receptor (AR) deficient and androgen receptor (AR) low cancers, are disclosed. The methods include administration of an agent that inhibits activity of eIF4F or an agent that disrupts the eIF4F translation-initiation complex (composed of eIF4E, eIF4A, and eIF4G).
    Type: Application
    Filed: July 23, 2020
    Publication date: August 11, 2022
    Applicant: Fred Hutchinson Cancer Research Center
    Inventor: Andrew Hsieh
  • Installation for the thermal conditioning of a passenger compartment and/or at least one component of a motor vehicle
    Patent number: 11407282
    Abstract: The invention concerns an installation for the thermal conditioning of a passenger compartment and/or at least one component of a motor vehicle, comprising a first circuit (1) for circulating a heat transfer fluid, a second circuit (2) for circulating a refrigerant fluid, capable of forming a heat pump type circuit, the heat transfer fluid circuit comprising heating and/or cooling means (M1, M2, M3) for at least one component of a motor vehicle, means (S1, S2) for storing calories and/or frigories, a first exchanger (E1) forming an evaporator and capable of exchanging heat with the refrigerant circuit, and means for circulating the heat transfer fluid capable of drawing the frigories and/or calories from the storage means (S1, S2) or the first exchanger (E1), so as to transfer them to the heating and/or cooling means (M1, M2, M3).
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: August 9, 2022
    Assignee: Hutchinson
    Inventors: Fabrice Chopard, Hélder Filipe De Campos Garcia, Mathieu Leborgne
  • Shape memory alloy wire attachment structures with adhesive for a suspension assembly
    Patent number: 11409070
    Abstract: Embodiments of the disclosure include a suspension assembly having a support member, a moving member movably coupled to the support member, and shape metal alloy wires coupled between the support and moving members by attachment structures. According to various embodiments, the attachment structures include at least one of: an adhesive disposed proximate to a side of the attachment structures and between the attachment structures.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: August 9, 2022
    Assignee: Hutchinson Technology Incorporated
    Inventors: Bryan J. Scheele, Dean E. Myers, Michael W. Davis, Erich W. Bierbrauer, Mark A. Miller
  • Block and unit for storing thermal energy
    Patent number: 11408685
    Abstract: A modular block for storing thermal energy having a bottom wall and lateral walls defining a chamber. The lateral walls are made from a mouldable material. First thermal management elements are disposed in the chamber, which has at least one communication passage to the outside environment to allow a refrigerating fluid or a heat-transfer fluid a in heat exchange relationship with the first thermal management elements to pass into and out of the chamber. The modular block has second thermal management elements arranged laterally around the lateral walls or included in the mouldable material of the lateral walls for the thermal management of the chamber. The first thermal management elements are separated from the second thermal management elements by a part of the mouldable material of the lateral walls.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: August 9, 2022
    Assignee: Hutchinson
    Inventors: Fabrice Chopard, Paul Bline, Boris Chauvet, Christophe Dominiak
  • HIGH TOLERANCE QUICK CONNECT COUPLING
    Publication number: 20220243849
    Abstract: A fitting for use in a manifold or other tubular assembly includes a core and at least one tubular coupling sleeve slidably and sealingly fitted over a distal end of the core to accommodate predetermined tolerances in the relative positions of fluid ports connected with the tubular assembly. Features are provided to limit the range of motion to the predetermined tolerances and to prevent disassembly of the coupling sleeve from the core of the fitting.
    Type: Application
    Filed: January 29, 2021
    Publication date: August 4, 2022
    Applicant: Hutchinson Fluid Management Systems, Inc.
    Inventors: Chethan Kumar Hanumanthappa Tembad, Aaron Ritzrow, Steve Todt, Luc Milanini