Abstract: Devices including a substrate and a plurality of coil portions disposed on the substrate. The plurality of coil portions electrically coupled to form a coil structure.

Abstract: Systems and methods to selectively protect therapeutic cells by reducing CD33 expression in the therapeutic cells using base editors and targeting non-therapeutic cells with an anti-CD33 therapy are described. The selective protection results in the enrichment of the therapeutic cells while simultaneously targeting any diseased, malignant and/or non-therapeutic CD33 expressing cells within a subject.

Abstract: Anti-vibration mount comprising a first frame, a second frame, an elastomeric main body connecting the first frame and the second frame, the elastomeric main body allowing relative displacements of the second frame relative to the first frame in a first direction of vibration and in a second direction of vibration perpendicular to the first direction of vibration, the elastomeric main body also being suitable for mounting a weight in the first direction of vibration. An inertia body is connected to the first frame by an elastic suspension interposed between the inertia body and the first frame along the second direction of vibration. An elastomeric lateral abutment body is interposed between the first frame and the inertia body to limit the relative displacements of the second frame with respect to the first frame in the second direction of vibration. The inertia body has a natural frequency lower than 800 Hz.

Abstract: A suspension assembly is described. A suspension assembly including a support member configured to receive at least a first circuit member. The first circuit member including at least a trace. The first circuit member disposed on the support member.

Abstract: A window module (60) for a vehicle, in particular automobile, comprising: a fixed window (22) comprising an internal face (22c) and an external face (22d), a movable window (14) comprising an internal face (14c) and an external face (14d), edges (14b, 22a) of the windows facing one another and defining a clearance (J) between them, and the external faces (14d, 22d) of the windows being substantially aligned, an elongated guide (26) extending along said edges and attached to the internal face (14c) of the movable window (14), an elongated upright (62) extending along said edges and attached to the internal face (22c) of the fixed window (22), and a trim element (70) fitted and attached to the upright, this trim element comprising at least one member (72) for retaining the guide in a housing (L) of the upright.

Abstract: Provided herein are compositions and methods comprising mutated coronavirus “S” spike proteins or receptor binding domains thereof that have an increased expression level, yield and stability compared to its corresponding native or wild-type coronavirus spike protein under the same expression, culture or storage conditions. These mutated spike proteins can be used for generating a protein-based vaccine against one or more coronaviruses.

Abstract: The present disclosure provides compositions and methods for targeting a Ras antigen to, for example, treat or prevent cancer. Disclosed embodiments include binding proteins, such as a T cell receptor or a chimeric antigen receptor, that bind to a Ras antigen:HLA complex. Polynucleotides encoding such binding protein can introduced into a host cell, such as a T cell, and the cell can be used in immunotherapy for treating various cancers. Also provided are immunogenic polypeptides that can be useful to, for example, induce an immune response against a mutated Ras or to identify a binding protein that binds to a Ras antigen.

Abstract: An insert for a run slide for a vehicle window. The insert may be overmoulded to form a connecting wedge between two strands of the run slide. The insert may be formed in one piece and is configured to cooperate with a portion of a vehicle door frame. The insert is further configured to cooperate with a portion of a hubcap to be attached to one of the strands. The insert includes a protruding pin configured to be engaged in a recess of a rabbet of the vehicle door frame to index the insert along an axis X substantially parallel to an axis of elongation of the rabbet. The insert is configured to cooperate with the portion of the hubcap to ensure indexing the hubcap along the axis X and along an axis Z perpendicular to X and substantially parallel to an axis of elongation of the hubcap.

Abstract: SMA actuators and related methods are described. One embodiment of an actuator includes a base; a plurality of buckle arms; and at least a first shape memory alloy wire coupled with a pair of buckle arms of the plurality of buckle arms. Another embodiment of an actuator includes a base and at least one bimorph actuator including a shape memory alloy material. The bimorph actuator attached to the base.

Abstract: Systems and methods to increase the efficacy of vaccines that require or are rendered more effective with T cell mediated immunity are described. The systems and methods utilize polynucleotides that genetically modify T cells to express a T cell receptor specific for an administered vaccine antigen.

Abstract: The present invention relates to methods, kits and compositions for expansion of embryonic hematopoietic stem cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TGF? pathway. Also provided herein are methods for expanding embryonic hematopoietic stem cells using kits and compositions comprising a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TGF? pathway. The embryonic hematopoietic stem cells expanded using the disclosed kits, compositions and methods include cells derived from an embryo (e.g., aorta-gonad-mesonephros region of the embryo), embryonic stem cells, induced pluripotent stem cells, or reprogrammed cells of other types.

Abstract: An inspection system is described. The inspection system includes a camera and a housing. The housing contains a reflective dome. The reflective dome includes an apex and a viewport. The viewport is offset from the apex. The camera is mounted to capture light exiting the reflective dome through the viewport. And, a plurality of light sources are arranged about the reflective dome such that light output from the plurality of light sources enters the dome.

Abstract: A radiometer probe for matching a spectral sensitivity of a dry-film resist is provided. The radiometer probe includes a light probe and a filter-diffuser assembly connected to the light probe. The filter-diffuser assembly includes a filter housing configured to receive an optical diffuser positioned on a filter. The optical diffuser and the filter are separated by a spacer.

Abstract: The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.

Abstract: Mutated and/or truncated malarial circumsporozoite proteins (CSP) and associated nucleic acids that are more stable and highly expressed in mammalian cells are described. The mutated and/or truncated CSP and associated nucleic acids can be expressed to produce malaria vaccine antigens.

Abstract: The disclosure provides methods for inducing Notch signaling in a targeted manner within aggregations of cells. The methods include contacting the aggregation of cells with a bi-specific molecule that facilitates trans-binding of Notch receptor. The bi-specific molecule comprising a cell-targeting domain that specifically binds to a cell-specific antigen expressed in the aggregation of cells, and a Notch-binding domain that specifically binds to Notch receptor. In some aspects, the disclosed methods and reagents provide methods of promoting pro-inflammatory states in tumor micro-environments.

Abstract: The disclosure provides methods and compositions for microlumen targeting in the treatment of cancers characterized by solid tumors or cell clusters, such as circulating tumor cell (CTC) clusters and disseminated tumor cell (DTC) clusters. The methods and compositions specifically target epigen in microlumenal space between two or more cancer cells and reduce the expression, functionality and/or concentration of epigen within the microlumenal space. The methods and compositions can be part of methods of treating cancer in a subject wherein the cancer is characterized by a solid tumor, a circulating tumor cell (CTC) cluster, and/or a disseminated tumor cell (DTC) cluster. The reduced levels of functional epigen in the microlumen result in reduced incidence of metastasis and increased susceptibility of the tumor cells to additional therapeutic interventions.

Abstract: The present disclosure provides, among other things, helper-dependent adenoviral serotype 35 (Ad35) vectors. In various embodiments, helper-dependent Ad35 vectors can be used to deliver a therapeutic payload to a subject in need thereof. Exemplary payloads can encode replacement proteins, antibodies, CARs, TCRs, small RNAs, and genome editing systems. In certain embodiments, a helper-dependent Ad35 vector is engineered for integration of a payload into a host cell genome. The present disclosure further includes methods of gene therapy that include administration of a helper-dependent Ad35 vector to a subject in need thereof.

Abstract: An uncoupling pulley includes a wheel rim including a first area, intended for receiving a belt connecting the wheel rim to a first power-transmission element, and a second area extending from the first area; a hub rigidly connected to a second power-transmission element; a ring gear including a first portion located under the second area and a second portion presented in the shape of a resilient cylindrical skirt extending, from the first portion, along the longitudinal axis, the cylindrical skirt of the ring gear including a plurality of longitudinal slots and consequently a plurality of portions separated from each other by one of the slots, the ring gear being capable of rotating relative to the wheel rim; and a device for driving the ring gear; and a resiliently deformable element, one end of which is attached to the hub and another end of which is attached to the ring gear.

Abstract: A method of making a component includes applying a clamping force to the component, the component coupled to a carrier strip of a panel via a polymeric tab and separating a portion of the polymeric tab from a substrate of the component, thereby causing the component to be detached from the panel.