Abstract: A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object.

Abstract: A method and system for auto-focusing is disclosed where the number of the fractal pixels having a fractal dimension within a predetermined range is determined. The focused image is determined by adjusting the image to maximize the fractal pixel count. Alternatively, the focused image may be selected from a set of images, the image having the largest fractal pixel count selected as the focused image.

Abstract: The present invention provides devices and methods for detection of particles, such as biological cells, in samples using a photosensitive waveguide. The photosensitive waveguide changes its transmissivity in a detectable manner in response to controlling radiation emitted from the particles. In preferred embodiments, the waveguide is two-dimensional and the position of the particles as well as their presence is obtained by scanning the waveguide in two non-parallel directions. The provided devices are preferably used to locate labeled cells. The present invention also includes control systems and methods for detecting and locating cells using the devices provided.

Abstract: A light-tight enclosure system, displaceable along a surface, for housing an automated microscope, having electronically controllable components and an image capturing device. The enclosure system may include device for displacement, a shelf for placement of the automated microscope, an externally viewable monitor, and a plurality of electrical power receptacles.

Abstract: An automated cassette and slide handling system is disclosed which organizes microscope slides in cassettes, automatically and sequentially removes individual slides from their respective cassettes, positioned each slide under the microscope as provided by the protocol, and after examination returns the slide to its proper cassette.

Abstract: A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object.

Abstract: A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins.

Abstract: A method for detecting and quantitating multiple and unique fluorescent signals from a cell sample is provided. The method combines immunohistochemistry and a fluorescent-labeled in situ hybridization techniques. The method is useful for identifying specific subcellular components of cells such as chromosomes and proteins.

Abstract: A system for automatically locating positions on an object and uniquely identifying the object employing an electronic tag positioned in or on the object. The system utilizes a plurality of sensors to locate the electronic tag and identify the object, and triangulation techniques to locate positions on the object where the object may be manipulated according to instructions coded with respect to the positions. Advantageously, the present invention may be used for automatically locating specimens on a microscope slide without regards to their positions on the slide, and for uniquely labeling a microscope slide.

Abstract: A mechanism is disclosed for incorporation into automatic microscope which permits the interchanging of optical path components such as objective lens assemblies, filters, and imaging devices. The mechanism features good placement accuracy and repeatability to permit the maintenance of system calibrations.

Abstract: A method and system for auto-focusing is disclosed where the number of the fractal pixels having a fractal dimension within a predetermined range is determined. The focused image is determined by adjusting the image to maximize the fractal pixel count. Alternatively, the focused image may be selected from a set of images, the image having the largest fractal pixel count selected as the focused image.

Abstract: Automated methods for detecting cancer and related hyperplasias in biological samples.

Abstract: An embodiment is disclosed for performing the image processing for analyzing the results of a fluorescence in situ hybridization (FISH) microscopic automated sample analysis to determine specific chromosomal characteristics.

Abstract: An embodiment is disclosed for performing the image processing for analyzing the results of a fluorescence in situ hybridization (FISH) microscopic automated sample analysis to determine specific chromosomal characteristics.

Abstract: Improvements in FISH staining employing a microscope slide holder which allows for batch processing of slides in the hybridization process.

Abstract: A method for recognizing an object in an image is disclosed wherein a fractal map of the image is generated by estimating the fractal dimension of each pixel in the image. The fractal map may be segmented by thresholding and locations of candidate objects are determined. The pixel value of the image pixel corresponding to the same location where the candidate object is found in the fractal map may be compared to a threshold value. If the pixel value is greater than the threshold value, the candidate object is recognized as a valid object.

Abstract: A microscope slide mount capable of z-axis movement.

Abstract: An apparatus for the feeding of microscope slides from a storage device to a slide stage.

Abstract: A light-tight enclosure system for housing an automated microscope.

Abstract: Automated methods for detecting cancer and related hyperplasias in biological samples.