Abstract: The disclosure relates to a valve (20) for use with breathing assistance apparatus.

Abstract: The present invention relates to an anti-CRISPR construct useful to counteract the spread of a gene-drive in an arthropod population. The invention is also concerned with a system comprising the anti-CRISPR construct and a crispr-based gene-drive construct, a method of producing a genetically modified arthropod, a genetically modified arthropod, and a method for counteracting a CRISPR-based gene-drive in an arthropod population.

Abstract: A method for generating a spatially transformed optical output from a laser system, the method comprising: disposing a laser gain medium within a laser cavity structure; arranging an interferometric device to complete the laser cavity structure, wherein the interferometric device receives an input beam from laser oscillation in the laser cavity structure, splits the input beam into two sub-beams, and recombines the two sub-beams to provide an optical feedback beam to sustain laser oscillation; configuring the optical components that comprise the interferometric device to provide relative misalignment of the two sub-beams that are produced internally to the interferometric device; using at least a first output port of the interferometric device to provide an output beam of the laser system that due to the misalignment is a spatial transformation of the internal mode structure of the laser; and using at least a second output port of the interferometric device to provide the optical feedback beam to the laser ca

Abstract: A method comprising applying an object recognition pipeline to frames of video data. The object recognition pipeline provides a mask output of objects detected in the frames. The method includes fusing the mask output of the object recognition pipeline with depth data associated with the frames of video data to generate a map of object instances, including projecting the mask output to a model space for the map of object instances using a camera pose estimate and the depth data. An object instance in the map of object instances is defined using surface-distance metric values within a three-dimensional object volume, and has an object pose estimate indicating a transformation of the object instance to the model space. The object pose estimate and the camera pose estimate form nodes of a pose graph for the map of model instances.

Abstract: The present invention is directed to an RNAi-inducing agent capable of reducing and/or inhibiting the expression of proteins associated with the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Specifically, the RNAi-inducing agent is capable of reducing and/or inhibiting the expression of proteins expressed in the tight junction complex or supporting the tight junction complex joining Schlemm's canal endothelial cells (SCEC) in the eye of a subject for use in the prevention and/or treatment of glaucoma. Methods using this RNAi-inducing agent are also contemplated.

Abstract: A control system for a robotic device comprising a task embedding network to receive one or more demonstrations of a task and to generate a task embedding. The task embedding comprises a representation of the task, and each demonstration comprises one or more observations of a performance of the task. The control system includes a control network to receive the task embedding from the task embedding network and to apply a policy to map a plurality of successive observations of the robotic device to respective control instructions for the robotic device. The policy applied by the control network is modulated across the plurality of successive observations of the robotic device using the task embedding from the task embedding network.

Abstract: The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to anti-T-cell receptor (TCR) V-beta CARs, and to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention extends to genetic constructs per se, and to their use in generating the CAR-MAIT cells, and to transduced CAR-MAIT cells per se. The invention also extends to various medical uses of the constructs and transduced CAR-MAIT cells, and to pharmaceutical compositions comprising these constructs and CAR-MAIT cells.

Abstract: The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating, and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention is also concerned with methods for expansion of MAIT cells in vitro.

Abstract: An antibody or antigen-binding fragment thereof is described which binds to the spike protein S2 domain of severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV) and/or severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). The antibodies can be used in the diagnosis and treatment of coronavirus infection. The invention extends to compositions comprising the antibodies, including pharmaceutical compositions, diagnostic compositions, and kits. The invention also extends to methods of making and using the antibodies, for example in the diagnosis and therapy of coronavirus infections.

Abstract: The present disclosure relates to a device, comprising a base and a plurality of microneedles attached to the base, wherein each microneedle has an outer surface; the outer surface of at least one microneedle being coated with a composition comprising at least one polymer and least one Peptide Nucleic Acid (PNA). The present disclosure additionally relates to a method of detecting an analyte in interstitial fluid (ISF), comprising contacting the device to a subject, for example, to human skin.

Abstract: A method for ultrasound data processing includes transmitting an ultrasound excitation signal from each element of a transducer array and receiving a response signal from each element of a transducer array. Each response signal corresponds to a respective channel. Each response signal is sampled at one or more time points in the response signal to create a plurality of samples, each sample corresponding to a channel and a time point. The samples are divided into at least two groups. Response signals from the first group are beamformed and response signals from the second group are beamformed separately. The process is repeated over multiple data frames. The beamformed signals of each group are correlated over the multiple data frames and beamformed signals having a lower degree of correlation or negative correlation are selectively attenuated. An image output is generated from the correlation output.

Abstract: The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to anti-CD4 CARs, and to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention extends to genetic constructs per se, and to their use in generating the CAR-MAIT cells, and to transduced CAR-MAIT cells per se. The invention also extends to various medical uses of the constructs and transduced CAR-MAIT cells, and to pharmaceutical compositions comprising these constructs and CAR-MAIT cells.

Abstract: A method of supporting a body part (16), comprising providing a device (100) comprising: a first portion (105) configured to support a body part, wherein, in use, the body part applies a first pressure to the first portion in a first direction; means for detecting the first pressure; and a second portion (115) having means (212) for applying a second pressure to the body part in a second direction substantially perpendicular to the first direction; detecting the first pressure; determining the second pressure based on a user parameter; and applying the second pressure to the body part in the second direction at a pre-determined ratio relative to the first pressure using said means for applying the second pressure.

Abstract: The invention relates to compounds of Formula (I): and related aspects.

Abstract: An attachment for use with a device to scan a surface, for example a bony surface, the attachment comprising: a first housing portion configured to releasably secure a device comprising a camera, a second housing portion connected to the first housing portion and having a wall defining an internal region of the second housing portion and an external region of the second housing portion, and a plurality of pins slidably secured to the wall, each of the plurality of pins having a proximal end disposed in the internal region and a distal end disposed in the external region. Upon abutment of the distal end of each of the pins against a surface, the proximal end of each of the pins is configured to translate relative to the wall. When the device is secured to the first housing portion, the proximal ends of the plurality of pins are viewable by the camera.

Abstract: The present invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: A computer-implemented method is disclosed. The method comprises classifying an arterial Doppler ultrasound waveform using the arterial Doppler ultrasound waveform and/or a set of features extracted from the arterial Doppler ultrasound waveform using one or more trained machine learning models to identify whether a peripheral arterial disease condition is present and/or to predict a medical outcome related to peripheral arterial disease. The method comprises, upon identifying the presence of the peripheral arterial disease condition and/or predicting the medical outcome, signalling the presence of the peripheral arterial disease condition and/or the medical outcome.

Abstract: The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.

Abstract: The invention relates to polymeric compositions, nanoparticles and vaccines comprising polymeric compositions. The invention extends to medical uses of the polymeric compositions, nanoparticles and vaccines. The invention further extends to methods of producing the polymeric compositions and nanoparticles.

Abstract: Method of forming a cement-based material pad (3) comprising a plurality of drainage holes and forms for use in such a method.