Patents Assigned to Imperial College Innovations
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Publication number: 20230330145Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.Type: ApplicationFiled: January 10, 2023Publication date: October 19, 2023Applicant: Imperial College Innovation LimitedInventors: Hugh J.M. BRADY, Matthew FUCHTER
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Patent number: 11786111Abstract: The present disclosure relates to an apparatus for mounting on a guide member for insertion into an anatomical cavity, the apparatus comprising a body defining a cavity for receiving a guide member therethrough, a drive arrangement for moving the body along a guide member disposed through the body, a probe secured to the body for, in use, obtaining a measurement from, taking a sample of, applying a substance to, or applying a therapy to, an environment of the body, and a measurement arrangement for measuring a position relative to the guide member disposed through the body.Type: GrantFiled: March 6, 2015Date of Patent: October 17, 2023Assignee: Imperial College Innovations LimitedInventors: Fernando Basilio Avila Rencoret, Daniel Stuart Elson, George Mylonas
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Publication number: 20230282351Abstract: A computer implemented method by which digital images of the human brain can be used to diagnose or to predict cognitive impairment, such as Alzheimer's disease and other forms of cognitive impairment such as so-called prodromal Alzheimer's disease. Methods of classifying or stratifying cohorts of human subjects such as for the purpose of clinical trials and/or to assess the impact of therapies are included. In some embodiments the images comprise T1 weighted MRI images.Type: ApplicationFiled: February 15, 2021Publication date: September 7, 2023Applicant: Imperial College Innovations LimitedInventors: Eric Aboagye, Marianna Inglese
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Publication number: 20230270841Abstract: The invention relates to vaccines, and in particular, to vaccines for preventing, treating or ameliorating coronavirus infections, such as severe acute respiratory syndrome coronavirus (SARS), SARS-CoV-2 and Middle East respiratory syndrome-related coronavirus (MERS). The invention is especially concerned with self-amplifying RNA replicons and genetic constructs or vectors encoding such RNA replicons, and their use in vaccine delivery for preventing infections of coronavirus. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.Type: ApplicationFiled: March 26, 2021Publication date: August 31, 2023Applicant: Imperial College Innovations LimitedInventors: Robin Shattock, Paul McKay, Anna Blakney
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Publication number: 20230265452Abstract: The invention provides hybrid and recombinant phagemid vectors for expressing a transgene in a target cell transduced with the vector. A recombinant phagemid particle comprises at least one transgene expression cassette which encodes an agent which exerts a biological effect on the target cell, characterised in that the phagemid particle comprises a genome which lacks at least 50% of its bacteriophage genome. The invention extends to the use of such phagemid expression systems as a research tool, and for the delivery of transgenes in a variety of gene therapy applications, DNA and/or peptide vaccine delivery and imaging techniques. The invention extends to in vitro, in vivo or in situ methods for producing viral vectors, such as recombinant adeno-associated viruses (rAAV) or lentivirus vectors (rLV), and to genetic constructs used in such methods.Type: ApplicationFiled: September 29, 2022Publication date: August 24, 2023Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Amin Hajitou, Paladd Asavarut, Teerapong Yata
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Patent number: 11732029Abstract: The methods and compositions described herein address the need in the art by providing peptides and polypeptides comprising a growth factor binding domain. In some embodiments, the peptides have an amino acid sequence that is at least 80% identical to one of SEQ ID NOS:1-7, 13-15, 49-50, or 66-70, or a fragment thereof; wherein the peptide is less than 300 amino acids in length.Type: GrantFiled: November 13, 2018Date of Patent: August 22, 2023Assignees: The University Chicago, Imperial College Innovations LimitedInventors: Jeffrey A. Hubbell, Anna M. Randi, Jun Ishihara, Ako Ishihara, Priscilla Briquez, Richard Starke
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Patent number: 11702470Abstract: Provided herein are methods for promoting axonal regeneration of sensory neurons and functional recovery of neurons following peripheral nerve injury in a subject experiencing aging-dependent nerve regenerative decline, the method comprising administering to a subject in need thereof an effective amount of an isolated binding molecule which specifically binds to CXCL13.Type: GrantFiled: June 8, 2021Date of Patent: July 18, 2023Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Simone Di Giovanni, Luming Zhou
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Publication number: 20230165499Abstract: A neural interface arrangement comprising: a plurality of probes for subdural implantation into or onto a human brain, each probe including at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the sensing electrode(s), and means for wirelessly transmitting data-carrying signals arising from the sensing electrode(s); an array of coils for implantation above the dura, beneath the skull, the array of coils being for inductively coupling with the coil of each of the plurality of probes, for transmitting power to the probes; and a primary (e.g.Type: ApplicationFiled: January 26, 2023Publication date: June 1, 2023Applicant: Imperial College Innovations LimitedInventors: Timothy CONSTANDINOU, Andrew JACKSON
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Patent number: 11655610Abstract: A seismic wave shield for protecting an area from seismic vibrations and a method of shielding an area from seismic waves by installing a seismic wave shield. The seismic wave shield comprises a set of columns embedded in regolith and in contact with bedrock. There is a material contrast between a material forming the columns and the regolith.Type: GrantFiled: October 20, 2017Date of Patent: May 23, 2023Assignees: Imperial College Innovations Limited, Universite D'Aix Marseille, Centre National de la Recherche Scientifique, Ecole Centrale de MarseilleInventors: Tryfon Antonakakis, Richard Craster, Younes Achaoui, Stefan Enoch, Sebastien Guenneau, Stephane Brule
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Publication number: 20230135821Abstract: The invention provides a method for identifying a subject suitable for receiving a lung transplant, the method comprising: subjecting a sample to mass spectrometry analysis (in the negative ion mode or positive ion mode; preferably in the positive ion mode) and generating a mass spectrum output; wherein said sample is an isolated sample obtained from a subject that is a candidate for receiving a lung transplant; detecting one or more peak set in said mass spectrum output; wherein the presence of said one or more peak set indicates that the subject is not a suitable candidate for receiving a lung transplant; or wherein the absence of said one or more peak set indicates that the subject is a suitable candidate for receiving a lung transplant. The invention relies on the detection of peak sets specific to the membrane of pathogens, in particular mycobacteria.Type: ApplicationFiled: October 2, 2020Publication date: May 4, 2023Applicant: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Gerald Larrouy-Maumus, Francis Drobniewski
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Patent number: 11633142Abstract: The disclosure relates to a device and method of obtaining an electrocardiogram for a subject. The method comprises receiving electrical signals from at least two head-mounted sensors; and analysing said electrical signals to resolve shape and timing information for each of the P-, Q-, R-, S-, and T-waves available for the subject over a number of cardiac cycles, to derive a composite electrocardiogram, ECG, in which the composite electrocardiogram is derived using signals only from said head-mounted sensors.Type: GrantFiled: October 18, 2018Date of Patent: April 25, 2023Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Wilhelm Von Rosenberg, Valentin Goverdovsky, Theerasak Chanwimalueang, Danilo Mandic
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Publication number: 20230125052Abstract: The invention relates to red blood cell-derived vesicles comprising encapsulated active agents, their use in therapy and methods of production thereof.Type: ApplicationFiled: December 18, 2020Publication date: April 20, 2023Applicant: Imperial College Innovations LimitedInventors: Rongjun CHEN, Yu HUANG, Xiao Yun XU, Simon THOM
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Publication number: 20230107442Abstract: A computer-implemented method of processing 1H-NMR spectral data is disclosed. The method comprises receiving 1H-NMR spectral data for a sample or set of samples, performing a Fourier transform of the 1H-NMR spectral data to obtain Fourier-transformed spectral data, first differentiating the imaginary part of the Fourier-transformed spectral data or processed Fourier-transformed spectral data obtained from the Fourier-transformed spectral data to obtain a first derivative and storing the first derivative in storage.Type: ApplicationFiled: December 15, 2020Publication date: April 6, 2023Applicant: Imperial College Innovations LimitedInventors: Panteleimon G. TAKIS, Matthew R. LEWIS
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Patent number: 11618042Abstract: The disclosure relates to a dielectrophoretic tweezer, and associated methods of fabrication and use. The tweezer comprises a first end and a second end, in which the first end has a lateral dimension of less than 10 microns; a structure, extending in a longitudinal direction between the first and second ends, comprising an electrically insulating barrier defining a first chamber and a second chamber within the structure, in which the first and second chambers are insulated from each other by the electrically insulating barrier; a first electrode in the first chamber at the first end; and a second electrode in the second chamber at the first end, in which a width of the electrically insulating barrier separating the first electrode from the second electrode is 50 nm or less.Type: GrantFiled: September 25, 2018Date of Patent: April 4, 2023Assignee: Imperial College Innovations LimitedInventors: Joshua Edel, Aleksandar Ivanov, Binoy Paulose Nadappuram, Paolo Cadinu
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Patent number: 11603540Abstract: The invention provides hybrid and recombinant phagemid vectors for expressing a transgene in a target cell transduced with the vector. A recombinant phagemid particle comprises at least one transgene expression cassette which encodes an agent which exerts a biological effect on the target cell, characterised in that the phagemid particle comprises a genome which lacks at least 50% of its bacteriophage genome. The invention extends to the use of such phagemid expression systems as a research tool, and for the delivery of transgenes in a variety of gene therapy applications, DNA and/or peptide vaccine delivery and imaging techniques. The invention extends to in vitro, in vivo or in situ methods for producing viral vectors, such as recombinant adeno-associated viruses (rAAV) or lentivirus vectors (rLV), and to genetic constructs used in such methods.Type: GrantFiled: October 31, 2016Date of Patent: March 14, 2023Assignee: Imperial College Innovations LimitedInventors: Amin Hajitou, Paladd Asavarut, Teerapong Yata
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Patent number: 11589790Abstract: A neural interface arrangement has multiple probes for subdural implantation into or onto a human brain. Each probe has at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the electrode(s), and a transmitter for wirelessly transmitting data signals arising from the electrode(s). An array of coils is implanted above the dura beneath the skull, for inductively coupling with the coil of each probe, and for transmitting power to the probes. A primary coil is connected to the coil array, for inductively coupling with an external transmitter device, and for receiving power from the external transmitter device. In use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the coil array to transmit power to the probes by inductive coupling, and the probes wirelessly transmit data signals arising from the electrodes.Type: GrantFiled: May 19, 2017Date of Patent: February 28, 2023Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Timothy Constandinou, Andrew Jackson
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Patent number: 11579067Abstract: The disclosure relates to an apparatus and associated method for concentration of polarizable molecules within a fluid medium. The apparatus comprising a structure defining a cavity, having a cross-sectional dimension of 200 nm or less; at least two translocation electrodes positioned relative to the structure to enable generation of a DC electric field passing through the cavity; and at least two trapping electrodes positioned relative to the structure to enable generation of a time-varying electric field proximal to the cavity inlet.Type: GrantFiled: June 10, 2016Date of Patent: February 14, 2023Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Joshua Benno Edel, Kevin Joseph Freedman
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Patent number: 11566226Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.Type: GrantFiled: March 28, 2018Date of Patent: January 31, 2023Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Hugh J. M. Brady, Matthew Fuchter, Tomasz Kostrzewski
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Patent number: 11559547Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.Type: GrantFiled: March 2, 2018Date of Patent: January 24, 2023Assignee: IMPERIAL COLLEGE INNOVATIONS LIMITEDInventors: Hugh J. M. Brady, Matthew Fuchter
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Patent number: 11547783Abstract: A blood filter device having an iron-chelating molecule, a haem-binding molecule and a haemoglobin-binding molecule bound to a support. Use of the device in a vessel containing blood, for example a blood bag or a flow line, removes haemolysis-derived components from the blood.Type: GrantFiled: December 2, 2015Date of Patent: January 10, 2023Assignees: IMPERIAL COLLEGE INNOVATIONS LIMITED, UCL BUSINESS LTDInventors: Alan Christopher Spivey, Gregory John Quinlan, Nathan Davies