Abstract: A method of analysing changes in the electrical activity of a patient's heart between a reference state and a test state, the method using a reference data set of electrophysiological data captured from the patient in the reference state and at least one test data set of electrophysiological data captured from the patient in the test state, each data set defining a plurality of electrograms for a respective plurality of spatial locations relative to the heart, the method comprising processing the electrophysiological data by, matching each electrogram in the reference data set to a corresponding electrogram in the at least one test data set to create a pair of electrograms for each of the plurality of spatial locations, and deriving a time delay for each spatial location by calculating the time delay between the electrograms of the pair of matched electrograms for that spatial location.

Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: A method of image processing includes receiving a first image of human skin. The first image corresponds to a first, uniform broadband illumination condition. The method also includes receiving a second image which has the same field of view and contents as the first image. The second image corresponds to a second illumination condition which comprises a uniform narrowband illumination condition. The method also includes processing the first and second images to fit parameter maps for a spectral bidirectional scattering surface reflectance distribution function skin model. The parameter maps include a modelled melanin concentration, a modelled haemoglobin concentration, a modelled melanin blend-type fraction and a modelled epidermal haemoglobin fraction. At least three of the parameter maps are independent.

Abstract: The disclosure provides compositions and methods for growing programmable enzyme-functionalized and sense-and-response bacterial cellulose living materials with engineered microbial co-cultures.

Abstract: An apparatus comprising an actuator for moving an actuator rod and a bioreactor vessel is disclosed herein. The bioreactor vessel comprises a container for holding a liquid, a mounting for mounting a tissue sample in the container, and, an actuator coupling to enable the actuator rod to be connected for applying mechanical force to the tissue sample. The apparatus also comprises a seat, fixed with respect to the actuator and configured for locating the reactor vessel in a location selected so that the actuator can be connected for applying said force via the actuator coupling. The reactor vessel is removable from the apparatus.

Abstract: A method for forming a component to a target shape from an aluminium blank workpiece is disclosed, the method comprising: (a) cold forming an aluminium blank workpiece between a set of dies, thereby producing a component fully or partially formed to a target shape; (b) solution heat treating the fully or partially formed component by heating to or above a solution heat treatment (SHT) temperature and substantially maintaining that temperature until SHT has been completed, thereby producing a solution heat treated fully or partially formed component; and (c) quenching the solution heat treated fully or partially formed component whilst held between a set of dies, wherein holding between the dies may provide additional forming at the same time as quenching, to produce a component fully formed to the target shape.

Abstract: An apparatus for providing electrostimulation of a biological tissue, the apparatus comprising: a first electrical signal provider for providing a first alternating electric field in the biological tissue, the first alternating electric field having a first frequency; a second electrical signal provider for providing a second alternating electric field in the biological tissue the second alternating electric field having a second frequency; wherein the first alternating electric field and the second alternating electric field provide a combined field in the biological tissue, and the apparatus comprises a controller configured to provide variations of at least one of the first frequency and the second frequency so that the combined field provides a pulsed interferential stimulation signal.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: The present invention provides a method of prophylaxis or treatment of a senescence-associated disease or disorder by administering to a subject in need thereof, a therapeutically effective amount of a NMT inhibitor.

Abstract: This invention relates to a process for obtaining lead (Pb) and/or tin (Sn) from a lead- and/or tin-based material using a deep eutectic solvent.

Abstract: The invention relates to RNA constructs encoding (i) at least one therapeutic biomolecule; and (ii) at least one innate inhibitor protein (IIP). The constructs are RNA replicons and saRNA molecules, and the invention includes genetic constructs or vectors encoding such RNA replicons. The invention extends to the use of such RNA constructs and replicons in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: A method of measuring states of qubits of a quantum processor, the method includes providing, to the qubits, a control signal to control states of n qubits in the quantum processor, where n is a natural number; performing a bit-flip to invert a state of at least one qubit of the qubits; reading out output qubit values of bit-flipped qubits based on the performing of the bit-flip; and generating an error model indicating a probability of occurrence of measurement errors in the output qubit values based on a result of the reading-out of the output qubit values.

Abstract: A method of image processing is described. The method comprises receiving a set of at least three images of an object including at least two linearly-polarized images and at least one color image, wherein the three images have the same view of the object and are acquired under the same illumination condition in which either diffuse polarization or specular polarization dominates in surface reflectance, and wherein a set of Stokes parameters s0, s1 and s2 is determinable from the at least three images.

Abstract: A method for monitoring the production of a material such as graphene in a liquid dispersion in real time, comprises supplying the liquid dispersion to a fluid gap defined between a first layer and an opposed second layer, wherein the first layer is light-transmissive and wherein the second layer has a diffusely reflective surface facing the first layer. The diffusely reflective surface is illuminated with light from a light source and light reflected from the diffusely reflective surface is detected at an associated photodetector. A light path from the light source to the photodetector comprises the light passing through the transmissive layer towards the diffusely reflective surface through the fluid gap, reflecting off the diffusely reflective surface and passing back through the fluid gap towards and onwards through the transmissive layer. The concentration of the material in the liquid dispersion can be determined from the detected reflected light.

Abstract: The present invention relates to a method of measuring the rate of reaction between a target molecule and a ligand candidate, ligands of interest identified according to this method and drugs developed from such ligands. The present invention also relates to a method of measuring the rate of reaction between a thiol and a molecule capable of reacting with said thiol.

Abstract: A method of image processing is described. The method comprises receiving a set of at least three images of an object including at least two linearly-polarized images and at least one color image, wherein the three images have the same view of the object and are acquired under the same illumination condition in which either diffuse polarization or specular polarization dominates in surface reflectance, and wherein a set of Stokes parameters s0, s1 and s2 is determinable from the at least three images.

Abstract: Disclosed herein is a rectifier circuit for receiving an AC signal from a receiver coil in an inductive power transfer system. The circuit is configured to operate at an operating frequency. The circuit comprises a Class-E rectifier; an AC signal supplier configured to supply an AC signal to the rectifier circuit; and a resonant network having an inductor and a capacitor. The resonant network has a resonant frequency, and the ratio of the resonant frequency to the operating frequency is within the range of 1.75 to 3.

Abstract: Provided are a thermoelectric material, and a thermoelectric element and a thermoelectric module, each including the thermoelectric material. The thermoelectric material, according to some embodiments includes an n-doped metal halide compound having a zero-dimensional (0D) electronic system. The thermoelectric material has a significantly low electrical thermal conductivity and improved electron conductivity and thus may enhance thermoelectrical performance.

Abstract: Herein is disclosed, a rechargeable flow battery, wherein the flow battery comprises: first and second electrodes, separated such that ions are allowed to flow between them, wherein a first reservoir comprising or for holding a first fluid electrolyte is fluidly connected to the first electrode, to allow circulation of the first fluid electrolyte from the first reservoir to the first electrode and from the first electrode to the first reservoir; and a first current collector comprising a layer of electrically conductive material having opposing first and second sides, wherein the first electrode is disposed on the first side of the first current collector, such that electrons can flow from the electrode to the first current collector, and a first layer of dielectric material is disposed on the second side of the first current collector.