Abstract: A molecular complex comprising a therapeutic agent and a controlled release construct, the controlled release construct comprising a primary matrix conjugation site which is linked to an cell adhesive site, via a binding region and optionally via one or more spacer elements, wherein the binding region has a folded configuration in which it is bound to the therapeutic agent, wherein the construct is configured such that when mechanical tension is applied between the primary matrix conjugation site and the cell adhesive site, the binding region adopts a less folded configuration in which bound therapeutic agent is released. Related controlled release constructs for loading with the therapeutic agent, pharmaceutical compositions and methods of manufacture and use.

Abstract: A vehicle suspension system is disclosed. The suspension system comprises: a control arm (2) having a first end connectable to a wheel carrier and a second end connectable to an inboard component of the vehicle (5); a rotary actuator (6); and a linkage (17) connecting the rotary actuator to the control arm, so that torque applied to the linkage by the rotary actuator (6) is translated into force which acts on the control arm (2).

Abstract: The present invention relates to a process for producing a carbon nanotube-grafted substrate, the process comprising: providing a substrate having catalytic material deposited thereon; and synthesising carbon nanotubes on the substrate by a chemical vapour deposition process in a reaction chamber; characterised in that the process comprises providing a counter electrode, applying a potential difference to the substrate in relation to the counter electrode and maintaining the potential difference of the substrate in relation to the counter electrode during the chemical vapour deposition process.

Abstract: A method of image processing includes receiving a set of images of an object, the set of images including images corresponding to binary spherical gradient illumination along first, second and third mutually orthogonal axes and images corresponding to complementary binary spherical gradient illumination along the first, second and third axes. The method also includes determining a specular reflectance map of the object and a diffuse reflectance map of the object based on the set of images, and/or determining a diffuse photometric normal map and a specular photometric normal map of the object based on the set of images.

Abstract: The present invention pertains to antigen recognizing constructs against tumor specific proteasome splicing variants. The invention in particular provides novel T cell receptor (TCR) based molecules which are selective and specific for tumor cells carrying antigenic epitopes generated by proteasome peptide splicing of tumor specific antigens. The TCRs of the invention, and antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of proliferative diseases, preferably for the treatment of cancer. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.

Abstract: Certain examples described herein enable semantically-labelled representations of a three-dimensional (3D) space to be generated from video data. In described examples, a 3D representation is a surface element or ‘surfel’ representation, where the geometry of the space is modelled using a plurality of surfaces that are defined within a 3D co-ordinate system. Object-label probability values for spatial elements of frames of video data may be determined using a two-dimensional image classifier. Surface elements that correspond to the spatial elements are identified based on a projection of the surface element representation using an estimated pose for a frame. Object-label probability values for the surface elements are then updated based on the object-label probability values for corresponding spatial elements. This results in a semantically-labelled 3D surface element representation of objects present in the video data.

Abstract: A method of image processing includes receiving a set of images of an object, the set of images including images corresponding to binary spherical gradient illumination along first, second and third mutually orthogonal axes and images corresponding to complementary binary spherical gradient illumination along the first, second and third axes. The method also includes determining a specular reflectance map of the object and a diffuse reflectance map of the object based on the set of images, and/or determining a diffuse photometric normal map and a specular photometric normal map of the object based on the set of images.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: The present technique provides an apparatus comprising receiver circuitry to receive a signal formed from a plurality of multipath signal components, including a first set of multipath signal components that have been subjected to modulation by interaction with at least one moving part of a target machine. The first set of multipath signal components have time varying signal paths due to the interaction with said at least one moving part. Evaluation circuitry is used to generate, for at least one property of the received signal, an evaluation signal, and modification circuitry then produces a modified evaluation signal by applying a removal operation to at least partially remove from said evaluation signal a contribution to that evaluation signal from the multipath signal components whose associated signal paths are non-time-varying.

Abstract: The invention provides a recombinant targeted bacteriophage for expressing a transgene in a target cell transduced with the bacteriophage. The bacteriophage comprises a first nucleic acid sequence encoding a pill capsid minor coat protein that is configured to display a cell-targeting ligand for enabling delivery of the bacteriophage to a target cell, a second nucleic acid sequence encoding at least one pVIII capsid major coat protein that is configured to display a foreign peptide thereon, and a transgene which encodes a protein which exerts a biological effect on the target cell.

Abstract: Apparatus for monitoring activation in a heart comprises a probe (100), a plurality of electrodes (101, 102) supported on the probe and each arranged to detect electrical potential at a respective position in the heart during a series of activations, and processing means (104) arranged to analyse the detected electrical potentials to identify a propagation direction of the activation, and to generate an output indicative of that direction.

Abstract: The invention relates to inorganic-organic hybrid materials comprising interpenetrated organic and inorganic components, wherein the organic component comprises polymer chains formed at least in part by ring-opening polymerization of a cyclic monomer, and processes for the production thereof.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: A method of forming a part from sheet metal and a part formed by said method. The method comprising the steps of: (a) heating a metal sheet to a temperature T; and (b) forming the sheet into the part between dies while applying cooling means to the sheet, where in step a) the metal sheet is heated at a rate of at least 50° C.s?1, and temperature T is above a critical forming temperature and does not exceed a critical microstructure change temperature of said metal sheet.

Abstract: A method of measuring Gadd45? expression comprising the step of measuring Gadd45? expression levels in a sample of cells, for example CD 138 expressing cells, obtained from a subject known to have or suspected of having a haematological malignancy. Expression levels may be used in diagnosis, for example of multiple myeloma, in providing a prognosis, for example in a patient having multiple myeloma or in guiding selection of an appropriate treatment agent, especially a treatment agent comprising Gadd45? and or MKK7 inhibitors. Also datasets comprising measured expression levels from multiple subjects.

Abstract: Methods of treatment of disorders of the knee, such as medial osteoarthritis and knee instability due to anterior cruciate ligament deficiency, are provided herein.

Abstract: An oxidant production apparatus comprises an electrochemical reactant reservoir, an electrolysis compartment, a porous first electrode and a second electrode. The porous first electrode defines a boundary between the reservoir and the electrolysis compartment and is configured to allow an electrochemical reactant to pass from the reservoir, through the first electrode and into the electrolysis compartment. The second electrode disposed at least substantially in the electrolysis compartment and spaced apart from the first electrode. The apparatus is configured to produce an oxidant in an electrochemical reaction when a voltage is applied across the first and second electrodes and a current is passed through the first and second electrodes and an electrolyte disposed in the electrolysis compartment.

Abstract: Example embodiments described herein are directed towards dynamic state estimation of an operating state of a generator in a power system. Such estimation is performed for an individual generator in real time with improved accuracy and without the use of Global Position System (GPS) synchronization.

Abstract: A robotic vehicle has legs and propellers to enable it to walk, fly, and or swim.

Abstract: There is provided a method of using a device capable of controlled flight in a surrounding environment, the device comprising: lifting means for providing lift to the device; object-retaining means for holding an object to be affixed to a target site; and a dispensing assembly for dispensing an adhesive, wherein the method comprises: controlling the lifting means so as to controllably fly the device in the surrounding environment; and using the device to affix an object held by the object-retaining means to a target site in the surrounding environment by dispensing an adhesive from the dispensing assembly. Thus, an aerial device, for example a robotic device, may be used to fly to a desired location and affix an object at the desired location, by dispensing, ejecting or otherwise applying an adhesive.