Abstract: A method for forming a component to a target shape from an aluminium blank workpiece is disclosed, the method comprising: (a) cold forming an aluminium blank workpiece between a set of dies, thereby producing a component fully or partially formed to a target shape; (b) solution heat treating the fully or partially formed component by heating to or above a solution heat treatment (SHT) temperature and substantially maintaining that temperature until SHT has been completed, thereby producing a solution heat treated fully or partially formed component; and (c) quenching the solution heat treated fully or partially formed component whilst held between a set of dies, wherein holding between the dies may provide additional forming at the same time as quenching, to produce a component fully formed to the target shape.

Abstract: An apparatus for providing electrostimulation of a biological tissue, the apparatus comprising: a first electrical signal provider for providing a first alternating electric field in the biological tissue, the first alternating electric field having a first frequency; a second electrical signal provider for providing a second alternating electric field in the biological tissue the second alternating electric field having a second frequency; wherein the first alternating electric field and the second alternating electric field provide a combined field in the biological tissue, and the apparatus comprises a controller configured to provide variations of at least one of the first frequency and the second frequency so that the combined field provides a pulsed interferential stimulation signal.

Abstract: This invention provides compounds of formula (I) and salts thereof, which have activity as inhibitors of N-myristoyl transferase (NMT). The invention also relates to uses of such compounds as medicaments, in particular in the treatment of a disease or disorder in which inhibition of N-myristoyl transferase provides a therapeutic or prophylactic effect, including protozoan infections (such as malaria and leishmaniasis), viral infections (such as human rhinovirus and HIV), and hyperproliferative disorders (such as B-cell lymphoma).

Abstract: The present invention provides a method of prophylaxis or treatment of a senescence-associated disease or disorder by administering to a subject in need thereof, a therapeutically effective amount of a NMT inhibitor.

Abstract: This invention relates to a process for obtaining lead (Pb) and/or tin (Sn) from a lead- and/or tin-based material using a deep eutectic solvent.

Abstract: A method of image processing is described. The method comprises receiving a set of at least three images of an object including at least two linearly-polarized images and at least one color image, wherein the three images have the same view of the object and are acquired under the same illumination condition in which either diffuse polarization or specular polarization dominates in surface reflectance, and wherein a set of Stokes parameters s0, s1 and s2 is determinable from the at least three images.

Abstract: A method of measuring states of qubits of a quantum processor, the method includes providing, to the qubits, a control signal to control states of n qubits in the quantum processor, where n is a natural number; performing a bit-flip to invert a state of at least one qubit of the qubits; reading out output qubit values of bit-flipped qubits based on the performing of the bit-flip; and generating an error model indicating a probability of occurrence of measurement errors in the output qubit values based on a result of the reading-out of the output qubit values.

Abstract: The invention relates to RNA constructs encoding (i) at least one therapeutic biomolecule; and (ii) at least one innate inhibitor protein (IIP). The constructs are RNA replicons and saRNA molecules, and the invention includes genetic constructs or vectors encoding such RNA replicons. The invention extends to the use of such RNA constructs and replicons in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.

Abstract: A method for monitoring the production of a material such as graphene in a liquid dispersion in real time, comprises supplying the liquid dispersion to a fluid gap defined between a first layer and an opposed second layer, wherein the first layer is light-transmissive and wherein the second layer has a diffusely reflective surface facing the first layer. The diffusely reflective surface is illuminated with light from a light source and light reflected from the diffusely reflective surface is detected at an associated photodetector. A light path from the light source to the photodetector comprises the light passing through the transmissive layer towards the diffusely reflective surface through the fluid gap, reflecting off the diffusely reflective surface and passing back through the fluid gap towards and onwards through the transmissive layer. The concentration of the material in the liquid dispersion can be determined from the detected reflected light.

Abstract: The present invention relates to a method of measuring the rate of reaction between a target molecule and a ligand candidate, ligands of interest identified according to this method and drugs developed from such ligands. The present invention also relates to a method of measuring the rate of reaction between a thiol and a molecule capable of reacting with said thiol.

Abstract: A method of image processing is described. The method comprises receiving a set of at least three images of an object including at least two linearly-polarized images and at least one color image, wherein the three images have the same view of the object and are acquired under the same illumination condition in which either diffuse polarization or specular polarization dominates in surface reflectance, and wherein a set of Stokes parameters s0, s1 and s2 is determinable from the at least three images.

Abstract: Disclosed herein is a rectifier circuit for receiving an AC signal from a receiver coil in an inductive power transfer system. The circuit is configured to operate at an operating frequency. The circuit comprises a Class-E rectifier; an AC signal supplier configured to supply an AC signal to the rectifier circuit; and a resonant network having an inductor and a capacitor. The resonant network has a resonant frequency, and the ratio of the resonant frequency to the operating frequency is within the range of 1.75 to 3.

Abstract: Provided are a thermoelectric material, and a thermoelectric element and a thermoelectric module, each including the thermoelectric material. The thermoelectric material, according to some embodiments includes an n-doped metal halide compound having a zero-dimensional (0D) electronic system. The thermoelectric material has a significantly low electrical thermal conductivity and improved electron conductivity and thus may enhance thermoelectrical performance.

Abstract: Herein is disclosed, a rechargeable flow battery, wherein the flow battery comprises: first and second electrodes, separated such that ions are allowed to flow between them, wherein a first reservoir comprising or for holding a first fluid electrolyte is fluidly connected to the first electrode, to allow circulation of the first fluid electrolyte from the first reservoir to the first electrode and from the first electrode to the first reservoir; and a first current collector comprising a layer of electrically conductive material having opposing first and second sides, wherein the first electrode is disposed on the first side of the first current collector, such that electrons can flow from the electrode to the first current collector, and a first layer of dielectric material is disposed on the second side of the first current collector.

Abstract: The invention relates to parasites, and to methods for purifying a metabolically active obligate parasite of vertebrates and arthropods. The invention is especially concerned with methods of purifying Plasmodium and Theileria parasites, such as P. falciparum and T. parva, and highly motile parasite forms thereof, called sporozoites. The invention also relates to obligate parasites of vertebrates and arthropods purified by the methods of the invention and their use thereof.

Abstract: The present invention relates to novel truncated fragments of von Willebrand factor (VWF) and the use of such fragments and nucleic acids encoding such fragments in the treatment of von Willebrand disease (VWD) and haemophilia.

Abstract: A method of manufacturing a component for a stretchable electronic device comprises providing a silicon wafer comprising a first surface and a second surface; applying a layer of a conductive metal onto at least a portion of the first surface of the silicon wafer; providing a stretchable silicone substrate having a first surface and a second surface; and plasma bonding at least a portion of the second surface of the silicon wafer to at least a portion of the first surface of the stretchable silicone substrate.

Abstract: A method of forming a part from sheet metal and a part formed by said method. The method comprising the steps of: (a) heating a metal sheet to a temperature T; and (b) forming the sheet into the part between dies while applying cooling means to the sheet, where in step a) the metal sheet is heated at a rate of at least 50° C.·s?1, and temperature T is above a critical forming temperature and does not exceed a critical microstructure change temperature of said metal sheet.

Abstract: A method of determining a measure of wave speed or intensity in a fluid conduit uses ultrasound measurements to determine the conduit diameter and fluid velocity in a volume element, each as a function of time, and each at a same longitudinal position of the conduit. The ultrasound measurement to determine fluid velocity is effected by tracking objects within the fluid flow in successive frames sampling the volume element, and obtaining displacement vectors for the objects. A wave speed may be determined from a ratio of the change in fluid velocity at the longitudinal position as a function of time and the change in a logarithmic function of the conduit diameter as a function of time. A measure of wave intensity may be determined as a function of change in determined conduit diameter and corresponding change in fluid velocity.

Abstract: A medical device for assisting the break-up, disruption or disintegration of calcified or other hardened material within vessels of the human or animal body which material otherwise prevents or inhibits stenting procedures or passage of guidewires, catheters and other devices through the vessels. The device includes a catheter having a lumen extending between a distal end and a proximal end of the catheter and a displaceable element at the distal end of the catheter configured for axial and/or radial displacement relative to the catheter when driven by pressure fluctuations within the lumen. A pressure pump is coupled to a proximal end of the catheter and is configured for application of a baseline pressure to the catheter lumen. A pressure modulation source is also coupled to the proximal end of the catheter, configured to modulate the baseline pressure in the catheter lumen with one or more pressure impulses, and preferably with a series of pressure pulses.