Abstract: A load handling device for operating in a storage system, a floor of the storage system including a network of tracks, or track network, based on a grid system, the tracks including a first set of track members extending in a first (x-) direction, and a second set of track members extending in a second (y-) direction, the second set of track members running transversely to the first set of track members in a substantially horizontal plane. The load handling device includes: a first set of wheels and a second set of wheels; and a support pad for receiving a storage container which support pad can be raised and or lowered in a vertical (z-) direction.

Abstract: An electronic payment system is for a merchant server to transfer funds from a purchaser account to a merchant account, the merchant server to send a merchant transaction identification (ID) and transaction information. The electronic payment system includes a mobile wireless communications device to send a purchaser transaction ID and purchaser account access information. A payment processor server is to receive the purchaser transaction ID and purchaser account access information, and is also to send the transaction information to the mobile wireless communications device if the merchant transaction ID matches the purchaser transaction ID. The mobile wireless communications device is also to send confirmation of the transaction information to the payment processor server. The payment processor server is also to effect a transfer of funds from the purchaser account to the merchant account based upon the confirmation of the transaction information and the purchaser account access information.

Abstract: The present invention relates to devices comprising metal halide perovskites and organic passivating agents. In particular, the invention relates to photovoltaic and optoelectronic devices comprising passivated metal halide perovskites. The device according to the invention comprises: (a) a metal halide perovskite; and (b) a passivating agent which is an organic compound; wherein molecules of the passivating agent are chemically bonded to anions or cations in the metal halide perovskite.

Abstract: A system and method for picking items is disclosed. The system includes a grid-based storage area and an order assembly area. The system includes an array of presentation positions, the presentation positions being configured and adapted so as to present storage containers delivered to the presentation positions so as to enable picking of items contained therein.

Abstract: Methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain are provided. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.

Abstract: This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I).

Abstract: A vehicle for use with an object handling system, the object handling system including two substantially perpendicular sets of rails forming a first grid, a plurality of first uprights supporting the first grid, a plurality of containers arranged in stacks, each stack being located underneath the first grid, one or more robotic load handling devices configured to drive on top of the rails of the first grid, the one or more load handling devices including means for removing or replacing at least one container from the stacks. The vehicle includes two substantially perpendicular sets of rails forming a second grid substantially at the top of the vehicle above a storage space for carrying containers. The second grid interfaces with the first grid to allow the one or more load handling devices to drive from the rails of the first grid onto the rails of the second grid.

Abstract: A swivel (100) is described comprising a first swivel member (112) comprising a first load shoulder (116) and a second swivel member (115) comprising a second load shoulder (118). The first and second swivel members are rotatable relative to each other. A deformable bearing component (142) is provided within a cavity (140) defined between the first and second load shoulder (116, 118). The deformable bearing component (142) facilitates load transmission between the first and second load shoulders (116, 118) and is deformable to accommodate variations in alignment between the first and second load shoulders (116, 118).

Abstract: This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.

Abstract: A system for tracking selected wave parameters from a received sinusoidal wave with noise and methods for making and using the same. The method includes performing a multi-track double integral analysis of the sinusoidal wave with noise and creating time dependent outputs. These time dependent outputs may be analyzed mathematically to determine the amplitude, frequency and/or phase of the wave with reduced noise. In one embodiment, the method may employ multiple passes through double integral analysis. The method advantageously can measure output sinusoidal wave parameters with reduced noise, measurements that are close to theoretical noise reduction limits.

Abstract: The present disclosure relates to an apparatus for mounting on a guide member for insertion into an anatomical cavity, the apparatus comprising a body defining a cavity for receiving a guide member therethrough, a drive arrangement for moving the body along a guide member disposed through the body, a probe secured to the body for, in use, obtaining a measurement from, taking a sample of, applying a substance to, or applying a therapy to, an environment of the body, and a measurement arrangement for measuring a position relative to the guide member disposed through the body.

Abstract: A computer-implemented method of determining a location of a mobile device is provided. The method can include receiving inertial data generated at the mobile device, the inertial data including a plurality of samples taken at different times, segmenting the inertial data into pseudo-independent windows, wherein each pseudo-independent window can include a plurality of the samples and wherein one or more initial states for each pseudo-independent window are treated as unknown, estimating a change in navigation state over each pseudo-independent window using the samples of inertial data, and summing the changes in the navigation states over the pseudo-independent windows so as to determine the location of the mobile device.

Abstract: A control device is provided to reliably locate objects and calculate appropriate grasp points for each object to thereby effectively control a robot system. grasp point calculation is based on, at least, properties of a surface of the object to be grasped by the robot system to more effectively calculate a grasp point for the surface of the object. An organised point cloud generator and a robot system having a suction cup end are arranged to generate an organised point cloud of a storage. The robot system can grasp the object from the storage means. Normals of the organised point cloud and principal curvatures of the organised point cloud can be calculated. A grasp point can be calculated for the suction cup end effector of the robot system to grasp an object based on the organised point cloud, the calculated normal, the calculated principal curvatures, and a normal of a lower surface of the storage.

Abstract: A fire extinguishing robotic service device is described for use on a robotic picking system grid. The fire extinguishing robotic service device is capable of driving to any location on the grid in order to extinguish a fire. The service device may also be provided with a camera or a sensor to locate the fire.

Abstract: A system for picking items from a containerised storage system is described. The items are stored in storage bins in stacks within a framework comprising a grid system disposed above the stacks of bins. Robotic devices are disposed on the grid, the devices acting so as to pick containers from the stacks of bins. The storage system is provided with at least one picking device for picking items from bins and depositing them directly in delivery containers DT.

Abstract: This disclosure presents a manipulator for lifting objects and an upwards open container within which the objects are at least partly arranged. The manipulator includes a first object engaging device for engaging a first object, a second object engaging device for engaging a second object. The manipulation is configured for forcing the first and second objects apart when engaged by the first and second object engaging devices, such that the objects exert an internal force on the container. The disclosure also presents a method for lifting objects and an upwards open container.

Abstract: A robotic picking device for picking items from a containerised storage system wherein items are stored in storage bins in stacks within a framework having a grid system disposed above the stacks of bins. Robotic picking devices are disposed on the grid, the devices acting to pick containers from the stacks of bins. The storage system is provided with at least one picking device for picking items from bins and depositing them directly in delivery containers DT.

Abstract: A grid framework structure configured to support one or more load handling devices thereupon includes i) a grid structure including a plurality of grid cells; and ii) a load bearing framework, wherein the grid structure is suspended from the load bearing framework by three or more tension elements connected to a respective number of suspension points on the grid structure, each of the three or more tension elements having a length configured to suspend the grid structure in a substantially horizontal plane.

Abstract: Robotic systems, methods of operation of robotic systems, and storage media including processor-executable instructions are disclosed herein. The system may include a robot, at least one processor in communication with the robot, and an operator interface in communication with the robot and the at least one processor. The method may include executing a first set of autonomous robot control instructions which causes a robot to autonomously perform the at least one task in an autonomous mode, and generating a second set of autonomous robot control instructions from the first set of autonomous robot control instructions and a first set of environmental sensor data received from a senor. Execution of the second set of autonomous robot control instructions causes the robot to autonomously perform the at least one task. The method may include producing at least one signal that represents the second set of autonomous robot control instructions.

Abstract: In a handheld communication device capable of a plurality of wireless communication modes, a method of communication begins by receiving, at the handheld communication device, a notification of an available one of the wireless communication modes. Then, in a data communication window of the communication device, a user-indication of an active one of the available wireless communication modes is provided in accordance with the received communication mode indication. The data communication window is configured to facilitate data communication via the plurality of wireless communication modes, and facilitates the data communication via the active wireless communication mode.