Patents Assigned to Inscripta, Inc.
  • CRISPR enabled multiplexed genome engineering
    Patent number: 10240167
    Abstract: Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any segment of a chromosome in a cell or population of cells, in which various CRISPR systems are used.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: March 26, 2019
    Assignee: Inscripta, Inc.
    Inventors: Ryan T. Gill, Andrew Garst
  • Methods for generating barcoded combinatorial libraries
    Patent number: 10017760
    Abstract: Provided herein are methods and composition for trackable genetic variant libraries. Further provided herein are methods and compositions for recursive engineering. Further provided herein are methods and compositions for multiplex engineering. Further provided herein are methods and compositions for enriching for editing and trackable engineered sequences and cells using nucleic acid-guided nucleases.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 10, 2018
    Assignees: Inscripta, Inc., The Regents of the University of Colorado, a Body Corporate
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb, Marcelo Colika Bassalo, Ramsey Ibrahim Zeitoun
  • Nucleic acid-guided nucleases
    Patent number: 10011849
    Abstract: Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered non-naturally occurring nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Targetable nuclease systems can be used to edit genetic targets, including recursive genetic engineering and trackable genetic engineering methods.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: July 3, 2018
    Assignee: Inscripta, Inc.
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb
  • Nucleic acid-guided nucleases
    Patent number: 9982279
    Abstract: Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered non-naturally occurring nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Targetable nuclease systems can be used to edit genetic targets, including recursive genetic engineering and trackable genetic engineering methods.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: May 29, 2018
    Assignee: Inscripta, Inc.
    Inventors: Ryan T. Gill, Andrew Garst, Tanya Elizabeth Warnecke Lipscomb