Abstract: The present invention relates to humanized antibodies that specifically bind to human BTN3A and their use in treating cancer and infectious disorders.

Abstract: A method for 3D surface imaging of an object, comprising generating a sinusoidal pattern from an input beam; projecting the sinusoidal pattern onto the object; acquiring deformed structured images from the object; reconstructing and displaying the surface of the object in real-time. A system comprises an device encoding an input beam with a structured pattern; a filter configured to spatially filter the encoded beam; a projector lens projecting the structured pattern onto the object; a high speed camera acquiring a structured pattern deformed by the 3D surface of the object; a graphic processing unit; and a CoaXPress interface transferring data acquired by the camera to the graphic processing unit; the graphic processing unit reconstructing and displaying the 3D surface of the object in real-time.

Abstract: A method and a system, the system, comprising a laser source, a ionization and acceleration unit, a separation unit, and a collecting unit, wherein the laser source comprises a large bandwidth laser delivering successive pulses of fixed central wavelength and bandwidth to a surface of a target positioned inside the ionization and acceleration unit, surface atoms of the target being ionized by the pulses, accelerated from the surface of the target to a kinetic energy in the range between 100 eV and 10 KeV, and focused to the separation unit, the separation unit separating received atoms into different ions species, and the collecting unit separately collecting the different ion species.

Abstract: Disclosed is a multi-axis atom interferometer system, including a source of cold atoms, a laser source generating a first light pulse configured in such a way as to spatially split the source of cold atoms into a first cloud of atoms propagating along a first trajectory along a first axis and a second cloud of atoms propagating along a second trajectory along a second axis, a second light pulse adapted to spatially deflect the first trajectory along the second axis and simultaneously the second trajectory along the first axis towards a first point and a last light pulse adapted to recombine the at least one part of the first cloud of atoms and the at least one part of the second cloud of atoms at the first point, and a detection system measuring an interferometric phase-shift accumulated between the first light pulse and the last light pulse.

Abstract: The invention relates to recombinant measles virus expressing Lassa virus polypeptides, and concerns in particular immunogenic LASV particles expressed by a measles virus and/or virus like particles (VLPs) that contain proteins of a Lassa virus. These particles are recombinant infectious particles able to replicate in a host after an administration. The invention provides means, in particular nucleic acid constructs, vectors, cells and rescue systems to produce these recombinant infectious particles. The invention also relates to the use of these recombinant infectious particles, in particular under the form of a composition, more particularly in a vaccine formulation, for the treatment or prevention of an infection by Lassa virus.

Abstract: The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as drug for inhibiting ferroptosis.

Abstract: The present invention relates to a device (40) for generating a control signal for an electrical system (S), comprising: an analog block (46) connected to the input (42) and to the output (44) of the generation device (40), the analog block (46) comprising an electrical circuit comprising a passive analog component, a measuring component and a generator, a digital block (50) comprising at least one digitally controllable component (70), the passive analog component of the electrical circuit being configured so as to generate the first component of the control signal and the generator of the electrical circuit being configured so as to generate the second component of the control signal, the electrical circuit being configured so as to sum the first and the second component that are generated in order to obtain the control signal.

Abstract: The present invention relates to humanized antibodies that specifically bind to human BTN3A and their use in treating cancer and infectious disorders.

Abstract: Silicone material obtained by a reaction between:—at least one organopolysiloxane (A) that has a molar mass of less than 70,000 g/mol, preferably less than 50,000 g/mol, and contains siloxyl units I.1 and I.2; and—at least one organic compound (B) carrying at least two carboxylic acid groups and having no unsaturation. Y a ? Z b 1 ? SiO 4 - ( a + b ) 2 ( I ? .1 ) Z c 2 ? SiO 4 - c 2 ( I ? .

Abstract: Collimation device for an X-ray detection system, the collimation device comprising: a collimator comprising a substantially planar support made of a material with partial or zero radiotransparency, the support being rotatably movable about an axis of rotation (?) which passes through the support and which is perpendicular to a first face of the support which acts as an X-ray plane of incidence referred to as the main plane of the support (P), the support (D) being provided on the first face with a slit which is completely transparent to X-rays and which is configured to generate an X-ray flow when the collimator is exposed to an X-ray source, the slit extending longitudinally in the main plane of the support along an axis located at a non-zero distance (d) from the axis of rotation (?), the slit extending through the entire thickness of the support.

Abstract: A method for monitoring a hadron beam during hadron-therapy treatment of a subject including tumour cells labelled with a radiopharmaceutical product, in which the hadron beam includes a plurality of discrete hadron bursts, the method including the following steps: when a burst impacts on the subject, detecting the prompt gamma generated by the interaction of the hadrons of the burst with the tissues of the subject using a Compton telescope and reconstructing an image of the interaction volume; when no burst impacts on the subject, extracting the position of the tumour cells labelled with the radiopharmaceutical product using the Compton telescope and reconstructing an image of the total volume of the tumour; comparing the image of the interaction volume and the image of the total volume of the tumour so as to locate the measured interaction volume relative to the measured total volume of the tumour.

Abstract: The present invention is in the field of bioluminescence in biology and/or medicine. In particular, the invention provides imidazopyrazine derivatives, processes for preparation thereof, and their uses as luciferins.

Abstract: The present invention relates to an expression cassette allowing expression of a functional LRIT3 protein in mammal eyes; said expression cassette is inserted in an expression vector, preferably an adeno-associated virus (AAV); accordingly, the present invention further relates to a recombinant adeno-associated virus (AAV) vector carrying a nucleic acid sequence encoding a normal LRIT3 gene, or fragment thereof, under the control of regulatory sequences which express the product of the gene in the ocular cells, a pharmaceutically acceptable composition comprising such a recombinant AAV vector and to its use for the treatment of congenital stationary night blindness

Abstract: There is provided a system for generating a spectrogram signal representative of a spectrogram of an initial signal, the system comprising: a temporal phase modulator for receiving the initial signal and quadratically modulating a temporal phase of the initial signal in a periodic series of consecutive quadratic time lenses in order to obtain a temporal phase modulated signal; a spectral phase modulator for quadratically modulating a spectral phase of the temporal phase modulated signal to obtain a given signal representative of a series of consecutive spectra; and a sensor for detecting the given signal in a temporal domain in order to obtained a sensed signal and outputting the sensed signal, the sensed signal being representative of the spectrogram of the initial signal.

Abstract: The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R? is an -A1-Cy1 group, or R is an -A1-Cy1 group and R? is an R1 group, R1 particularly being H or (C1-C6)alkyl group; A1 being an —NH— radical or —NH—CH2— radical; Cy1 particularly being a phenyl group, A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.

Abstract: The present invention relates to a polynucleotide comprising a gene encoding a hook protein and a gene encoding a protein of interest, said protein of interest being either a secretory protein or a cell membrane-anchored protein, wherein: said gene encoding the hook protein is under the control of a first transcription-activating signal, said gene encoding the protein of interest is under the control of a second transcription-activating signal, said second transcription-activating signal allowing a lower rate or frequency of transcription initiation than the first transcription-activating signal, said hook protein is fused to a cellular compartment-retention peptide, and said protein of interest is fused to a hook protein-binding domain It also related to vectors comprising the polynucleotide, cells comprising the polynucleotide or the vector and compositions comprising the same.

Abstract: Monocytopoiesis is a hematological process that supplies the periphery with monocytes and subsequently with macrophages and monocyte-derived dendritic cells. Typically, monocytes circulate in the bloodstream for a very short time before undergoing apoptosis, however, stimulatory signals can trigger monocyte survival by inhibiting the apoptotic pathway, and thus contribute to the maintenance of the inflammatory response. Accordingly, there is a need for methods and pharmaceutical compositions for modulating monocytopoiesis. Now, the inventors show that type I interferons signaling promote the differentiation of monocyte-derived phagocytes at the level of their progenitors. Importantly, IFN-alpha and -beta were found to efficiently generate the development of monocyte-derived antigen-presenting cells while having no impact on the precursor activity of conventional dendritic cells. Accordingly, modulators of type I interferon (e.g.

Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.

Abstract: This dosimeter comprises: a transducer material capable, when it is excited by a secondary ionizing radiation, of generating photons or electric charges, an amplifying layer capable, in response to its excitation by the primary ionizing radiation, of generating the secondary ionizing radiation. This amplifying layer comprises a first and a second amplifying sublayer stacked on top of one another. The first and the second amplifying sublayers are composed of at least 70%, by weight, respectively, of at least one first and one second material, the atomic numbers of which are greater than or equal to 29. The atomic number of the first material being less than the atomic number of the second material. The first sublayer is interposed between the second sublayer and the transducer material.

Abstract: The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.