Patents Assigned to Institut National de la Recherche
  • Patent number: 11021508
    Abstract: The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R1 is chosen from the group constituted of —CH(CH3)2, —CH(CH3)CH2CH3, or cyclohexyl, (ii) X represents —CH2—CH2—, or —CH?CH—, (iii) R2 is chosen from or an OH group, (iv) R3 is OH or NOH, (v) represents a single bond when R3 is OH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: June 1, 2021
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARN
    Inventors: Anne Lespine, Roger Prichard, Cecile Menez
  • Patent number: 11013498
    Abstract: A sampling method using a sampling device (2) comprising a container (5) comprising a body (6) consisting of a soft pouch, and a lid (30), in which at least one among the container (5) and the lid (30) is provided with a discharging member (40) suitable for, in an open state, discharging at least one part of the gases contained in the internal space (7) of the body (6) of the container (5), wherein the sampling method comprises the steps consisting in: —collecting a biological material in the body (6) of the container (5), and assembling the lid (30) on the neck (10) of the container (5), —and placing an internal space (7) of the body (6) of the container (5) under anaerobic conditions by placing the discharging member (40) in the open state, by compressing the body (6) of the container (5) and by placing the discharging member (40) in a closed state.
    Type: Grant
    Filed: April 22, 2016
    Date of Patent: May 25, 2021
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Carole Schwintner, Hervé Affagard, Joël Dore
  • Publication number: 20210109219
    Abstract: There is provided a dual-frequency LIDAR system for determining a distance and velocity of a target and a method of operating the same. The system includes tunable lasers operable to generate a first signal, a second signal, and a third signal having a phase noise below the phase of the first signal. The system includes at least one coupler operable to: couple the first and second signal for directing a transmission signal on the target, couple a backscattered signal and the third signal to obtain a received signal, and couple the transmission signal and the third signal to obtain a reference signal. Digital processing techniques are used to determine the distance of the target by estimating a time delay between the transmission and reference signals via cross-correlation. The velocity is obtained by estimating a Doppler-frequency shift based on the time delay, the received signal and the transmission signal.
    Type: Application
    Filed: October 9, 2019
    Publication date: April 15, 2021
    Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (INRS)
    Inventors: Daniel ONORI, Jose AZANA
  • Patent number: 10978271
    Abstract: A transmission electron microscopy system for imaging a sample, comprising: a pulse generator for generating an initial electron pulse towards the sample, the initial electron pulse to be propagated through the sample to obtain a transmitted electron pulse; an encoding device for encoding the transmitted electron pulse according to a predefined pattern to obtain an encoded electron pulse; a shearing device for temporally shearing the encoded electron pulse in a given direction to obtain a given electron pulse; a detector for detecting the given electron pulse to obtain a single image of the sample; and a datacube generator for determining a spatiotemporal datacube from the single image using the predefined pattern, and outputting the spatiotemporal datacube.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: April 13, 2021
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (INRS)
    Inventors: Jinyang Liang, Xianglei Liu, Aycan Yurtsever
  • Publication number: 20210096026
    Abstract: A method and a system for generating a time-frequency representation of an aperiodic continuous input signal comprising generating a periodic train of short pulses having a repetition frequency, and sampling the signal temporally using the periodic train of short pulses to obtain a temporally sampled signal, the temporally sampled signal comprising a plurality of sampled copies of the input signal, each sampled copy being spaced in function of the repetition frequency of the periodic train of short pulses. The temporally sampled signal is delayed based on the repetition frequency to obtain a delayed temporally sampled signal comprising a plurality of delayed sampled copies, a spectral representation of a given delayed sampled copy being delayed in function of the repetition frequency. The delayed temporally sampled signal is evaluated over consecutive time slots to obtain, for each consecutive time slot, a respective output signal in the time-frequency domain.
    Type: Application
    Filed: September 26, 2019
    Publication date: April 1, 2021
    Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (INRS)
    Inventors: Jose AZANA, Konatham Saikrishna REDDY, Reza MARAM, Hugues Guillet DE CHATELLUS
  • Publication number: 20210077574
    Abstract: The present invention relates to a phycocyanin composition for use in inhibiting bone resorption in humans or animals.
    Type: Application
    Filed: June 5, 2018
    Publication date: March 18, 2021
    Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
    Inventors: Véronique COXAM, Marie-Jeanne DAVICCO, Laurent LEOTOING, Fabien WAUQUIER
  • Patent number: 10920237
    Abstract: The invention relates to a method for increasing the frequency of meiotic recombination in plants, by inhibiting the RECQ4 or TOP3A protein, especially by mutagenesis or extinction of the RECQ4 or TOP3A gene coding for said protein. The invention can be used especially in the field of plant breeding and genetic mapping.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: February 16, 2021
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Raphaël Mercier, Mathilde Seguela-Arnaud, Wayne Crismani
  • Patent number: 10918678
    Abstract: The invention relates to a bacterial strain of species Faecalibacterium prausnitzii deposited at the CNCM under access number CNCM I-4573, for use in the treatment and/or prevention of an inflammatory gastrointestinal illness in an individual.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: February 16, 2021
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: Philippe Langella, Rebeca Martin Rosique, Luis Bermudez Humaran, Florian Chain, Harry Sokol
  • Patent number: 10850231
    Abstract: Techniques are described for chemical sequestration of carbon dioxide and production of precipitated magnesium carbonate. The process can include contacting carbon dioxide from industrial emissions with water and magnesium-containing particulate material, such as serpentinite, which is thermally pre-treated and has a particle size of at most 75 microns. The process can also include separation of the loaded aqueous stream from the solids, followed by precipitation of magnesium carbonate material that includes carbon and oxygen from industrial emissions and magnesium from serpentinite or chrysotile mining residue, for example.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: December 1, 2020
    Assignee: Institut National de la Recherche Scientifique
    Inventors: Guy Mercier, Jean-Francois Blais, Emmanuelle Cecchi, Sanoopkumar Puthiya Veetil, Louis-Cesar Pasquier, Sandra Kentish
  • Patent number: 10840667
    Abstract: A method and a system for laser pulse wavefront correction and focusing optimization for laser Wakefield interaction to accelerate electrons to high energy, and more generally for laser matter interaction where both far field and intermediate field optimization are important, allowing a robust wavefront correction and focusing optimization with a high-power laser system at its nominal laser pulse energy and laser pulse duration. The method comprises, after laser beam focusing by focusing optics, coupling an imaging unit to a wavefront sensor, thereby measuring the laser beam wavefront, and adjusting the measured laser beam wavefront to converge to a reference wavefront of the imaging unit using a spatial phase-modifying device.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: November 17, 2020
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Sylvain Fourmaux, Stéphane Payeur, Jean-Claude Kieffer
  • Patent number: 10837030
    Abstract: The invention relates to a method for propagating yeast, for use in the production of a fermentation product from lignocellulosic biomass, including the steps that consist of: a. providing a reactor; b. placing in contact in said reactor: a population of yeasts capable of metabolising pentoses and hexoses, with 0.2 to 2.0 g of yeast solids per kg of prepared complete medium, raw marc from the pretreatment of the lignocellulosic biomass, with a solids content (MS) of 8% to 15%, nutrients, and cellulases, with 5 to 15 mg of proteins per gram of MS; and c. incubating the mixture at a temperature of 25° C. to 38° C., preferably 28° C. to 33° C., in microaerobiosis, in which the saccharification of the raw marc and the growth of the yeast are carried out simultaneously.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: November 17, 2020
    Assignees: LESAFFRE ET COMPAGNIE, AGRO INDUSTRIE RECHERCHES ET DEVELOPPEMENTS A.R.D., INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA
    Inventor: Flora Ghisoni
  • Patent number: 10822600
    Abstract: The invention relates to a process for producing cellulolytic or hemicellulolytic enzymes comprising A growth phase a) of a cellulolytic microorganism in a closed reactor, in the presence of at least one carbonaceous growth substrate in a concentration between 10 and 90 g/L, at a temperature of 25-30° C. and a pH of 4-5.5 An enzyme production phase b) in which at least one inducer carbonaceous substrate is added, at a temperature of 25-27° C. and a pH of 4-5, process in which the said inducer substrate is a pretreated pomace obtained from a pretreatment process of lignocellulosic material that has not undergone enzymatic hydrolysis and that is added in fed-batch or continuous mode, and which has particular characteristics: a hydrolysis yield greater than 80% in a test and an apparent viscosity, measured in the test, of less than 1 Pa·s for a shear rate of 10 s?1.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: November 3, 2020
    Assignees: IFP Energies nouvelles, AGRO INDUSTRIES RECHERCHE ET DEVELOPPEMENT, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Mohamed Fadhel Ben Chaabane, Celine Cohen
  • Publication number: 20200323237
    Abstract: A meat analogue may include a set protein emulsion, the protein emulsion having a protein and at least one insoluble particle. In some embodiments, at least a portion of the particle can include at least one mineral material selected from the group consisting of silicium, and calcium, such as one or more of rhombohedral calcite, scalenohedral calcite, silicon dioxide, and magnesium oxide; at least one organic material selected from the group consisting of a bone meal, a cartilage meal, a ground crustacean shell, a ground sea fish shell, and a ground egg shell; and/or a gelled vegetable gum, a gelled hydrocolloid, a polymerized vegetable gum, a polymerized hydrocolloid, or a mixture thereof. The meat analogue can be made by extruding the protein emulsion and cooling the extruded emulsion. The meat analogue can be cut into chunks and/or added to another comestible composition such as a gravy or broth.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 15, 2020
    Applicants: Université de Montpellier, Institut National de la Recherche Agronomique
    Inventors: Patrick Pibarot, Christian Sanchez, Marie-Héléne Morel
  • Publication number: 20200323238
    Abstract: A meat analogue may include a macrostructure of connected sheared fibers oriented parallel to one another and gaps positioned between the sheared fibers. The macrostructure may include meat and may include a vegetable protein. An extrusion system may include an extruder and a die. The extrusion system may produce a meat analogue. A meat analogue may include an animal protein. The extruder may be connectable to the die. The extrusion system may be configured to direct a material including an animal protein from the extruder to the die and through a fluid path extending through the die. The die may be configured to inject a fat or a fat analogue into the material such that the fat or the fat analogue is embedded but visually distinct from the material including the animal protein when the fat or the fat analogue and the material exit the die.
    Type: Application
    Filed: April 8, 2020
    Publication date: October 15, 2020
    Applicants: Université de Montpellier, Institut National de la Recherche Agronomique
    Inventors: Patrick Pibarot, Christophe Joseph Etienne Schmitt, Christian Sanchez, Marie-Héléne Morel
  • Patent number: 10801043
    Abstract: The present document describes a process for production of hydrogen gas (H2) from fermentation of crude glycerol with a hydrogen producing microorganism in a bioreactor. The process comprises the step of introducing a volume of crude glycerol in a fermentation mixture which comprises a fermentation medium comprised of crude glycerol and hydrogen producing microorganisms under a fermentative hydrogen production condition, and then removing a volume of the fermentation mixture equal to the second volume of the crude glycerol, to maintain constant the total volume of the fermentation mixture.
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: October 13, 2020
    Assignees: CENTRE DE RECHERCHE INDUSTRIELLE DU QUEBEC (CRIQ), INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE CENTRE EAU TERRE ENVIRONNEMENT
    Inventors: Vinayak Pachapur, Saurabh Jyoti Sarma, Sampa Maiti, Satinder Kaur Brar, Yann Lebihan, Gerardo Buelna, Mausam Verma, Ratul Kumar Das
  • Patent number: 10787655
    Abstract: A process for producing oligosaccharides from lignocellulosic biomass, having the following steps: a) pre-treating the biomass in a pre-treatment reactor (1) in order to provide an effluent containing a pre-treated substrate; b) enzymatic hydrolysis of the pre-treated substrate contained in the effluent from step a) in a reactor, in the presence of cellulases such that a hydrolysate containing glucose, cellulases and water is produced; c) removing at least a portion of the hydrolysate from step b) comprising a liquid fraction; d) reducing the water content of said portion of the hydrolysate in step c) such that the liquid fraction of the hydrolysate has a water content of less than 65% by weight with respect to the total weight of the liquid fraction; e) incubating the hydrolysate from step d) at a temperature in the range 40° C. to 70° C. for the time necessary to produce an effluent enriched in oligosaccharides.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: September 29, 2020
    Assignees: IFP ENERGIES NOUVELLES, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, ARGO INDUSTRIES RECHERCHE ET DEVELOPPEMENT
    Inventors: Etienne Jourdier, Caroline Aymard, Fadhel Ben Chaabane
  • Patent number: 10779769
    Abstract: There is described a method for evaluating a level of noise in a biosignal, the method comprising: receiving a time signal representative of a biological activity, the time signal comprising a biological activity component and a noise component; determining a modulation spectrum for the time signal, the modulation spectrum representing a signal frequency as a function of a modulation frequency; from the modulation spectrum determining a first amount of modulation energy corresponding to the biological activity component and a second amount of modulation energy corresponding to the noise component determining an indication of the level of noise using the first and second amounts of modulation energy; and outputting the indication of the level of noise.
    Type: Grant
    Filed: February 17, 2015
    Date of Patent: September 22, 2020
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Tiago Henrique Falk, Diana Patricia Tobon Vallejo, Martin Maier
  • Publication number: 20200277556
    Abstract: The present disclosure relates to an additive for treating beverages made from plant musts, particularly wine, beer, cider or fruit juices, and more particularly for improving the quality of such beverages, namely, for example, protein stability and for avoiding the cloudiness of such beverages. In its broadest application, such an additive includes a cysteine protease and a cofactor.
    Type: Application
    Filed: September 26, 2018
    Publication date: September 3, 2020
    Applicants: OENOTROPIC INNOVATION, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL D'ETUDES SUPERIEURES AGRONOMIQUES DE MONTPELLIER
    Inventors: François-Xavier SAUVAGE, Sacha BAUDOIN, Aude VERNET, Amélie BREYSSE, Julie RETTMAN
  • Patent number: 10760100
    Abstract: The present invention relates to a novel polypeptide having the enzymatic activity of reduction of NADP+ using electrons from reduced ferredoxin (Ferredoxin-NADP+ reductase activity), a polynucleotide having a nucleotide sequence encoding such polypeptide and uses thereof. The invention relates to the modulation of the Ferredoxin NADP+ reductase activity in a microorganism by varying the expression level of the polynucleotide coding for such polypeptide. The invention also relates to the production of commodity chemicals, especially ethanol, n-butanol, 1,3-propanediol, 1,2-propanediol, isopropanol and acetone by fermenting microorganisms wherein their Ferredoxin NADP+ reductase activity is modulated.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: September 1, 2020
    Assignees: Institut National des Sciences Appliquees, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique
    Inventors: Philippe Soucaille, Isabelle Meynial-Salles, Céline Foulquier, Antoine Riviere
  • Patent number: 10736925
    Abstract: The present invention relates to a method of selecting or identifying probiotic strains capable of acting on the absorption of water in the colon, and use thereof as medicinal products in the treatment and/or prevention of diarrhea. The invention relates in particular to the strain of Bacillus subtilis CU1 for use in the treatment and/or prevention of diarrhea.
    Type: Grant
    Filed: October 10, 2018
    Date of Patent: August 11, 2020
    Assignees: LESAFFRE ET COMPAGNIE, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA, ECOLE NATIONALE SUPERIEURE DES SCIENCES AGRONOMIQUES DE BORDEAUX AQUITAINE (BORDEAUX SCIENCES AGRO)
    Inventors: Marie Khuong Huu, Jean Fioramonti, Maria Urdaci