Patents Assigned to Institut National de la Recherche
  • Method of lyophilization of a sample of faecal microbiota
    Patent number: 10736849
    Abstract: Method for lyophilisation of a simple of fecal microbiota. The present invention relates to a method for lyophilisation of a sample of fecal microbiota from a donor subject, comprising the following steps: A) mixing of a sample of fecal microbiota from a donor subject with a diluent selected from polyols, disaccharides to pentasaccharides, maltodextrins and mixtures thereof, and B) freezing the mixture obtained in A) at a temperature of less than ?50° C., preferably of between ?70° C. and ?100° C., followed by the lyophilisation thereof.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: August 11, 2020
    Assignees: MAAT PHARMA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Hervé Affagard, Carole Schwintner, Catherine Juste, Joël Dore, Audrey Chapron, Fernanda Fonseca, Olivier David
  • Process for implementing in vitro spermatogenesis and associated device
    Patent number: 10723999
    Abstract: The present invention relates to a process for in vitro spermatogenesis from male germinal tissue comprising conducting maturation of testicular tissue comprising germ cells in a bioreactor which is made of a biomaterial and comprises at least one cavity wherein the germinal tissue is placed, and recovering elongated spermatids and/or spermatozoa.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: July 28, 2020
    Assignees: KALLISTEM, UNIVERSITÉ CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.), INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), ECOLE NORMALE SUPERIEURE DE LYON
    Inventors: Marie-Hélène Perrard, Philippe Durand, Laurent David
  • LUMINESCENT SOLAR CONCENTRATOR USING A METAL-FREE EMITTER
    Publication number: 20200235254
    Abstract: A luminescent solar concentrator (LSC) comprising a metal-free emitter. The emitter may for example be carbon-based. In particular, the emitter may comprise colloidal carbon quantum dots, also called C-dots or C-QDs or C-dots. In embodiments of the invention, the surface of the C-dots is modified.
    Type: Application
    Filed: February 16, 2018
    Publication date: July 23, 2020
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA
    Inventors: Yufeng ZHOU, Daniele BENETTI, Xin TONG, Lei JIN, Zhiming M. WANG, Dongling MA, Haiguang ZHAO, Federico ROSEI
  • Methods for detecting beta-lactamase-producing bacteria
    Patent number: 10718006
    Abstract: An electrochemical method is provided for in-vitro determination of the presence of bacteria producing lactamases, in a sample that may contain such bacteria.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: July 21, 2020
    Assignees: UNIVERSITE DE BOURGOGNE, CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE DIJON, INSTITUT NATIONAL DE LA RECHERCHE AGRONMIQUE
    Inventors: Murielle Dequaire-Rochelet, Alain Hartmann, Catherine Neuwirth, Benoit Chantemesse
  • Method and system for analysis of objects
    Patent number: 10705036
    Abstract: A spectroscopy method and system, the method comprising irradiating an object with a laser-accelerated particle beam and detecting photons emitted by the object as a result of the interaction between the laser-accelerated particle beam and the object. The system comprises a laser; a particle source, positioned at a distance from the object; and a spectrometer and a detector; wherein the particle source generates a laser-accelerated particle beam under irradiation by the laser; and the spectrometer and the detector detect photons emitted from the object under irradiation by the laser-accelerated particle beam.
    Type: Grant
    Filed: January 23, 2018
    Date of Patent: July 7, 2020
    Assignees: UNIVERSITÁ DELLA CALABRIA, INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Patrizio Antici, Marianna Barberio
  • Use of FGF19 to increase muscle fiber size
    Patent number: 10695403
    Abstract: The present invention relates to an FGF19 polypeptide for use in increasing muscle fiber size in the treatment of muscle atrophy in a mammal.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: June 30, 2020
    Assignees: Universite Claude Bernard Lyon, Institut National de la Recherche Agronomique (INRA), Institut National de la Santè et de la Recherche Médicale (INSERM), Bergen Teknologioverforing AS
    Inventors: Emmanuelle Fouilloux-Meugnier, Hubert Vidal, Jérome Ruzzin
  • DIET CONTROLLED EXPRESSION OF A NUCLEIC ACID ENCODING A PRO-APOPTOTIC PROTEIN
    Publication number: 20200188533
    Abstract: A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide.
    Type: Application
    Filed: December 26, 2019
    Publication date: June 18, 2020
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventor: Pierre FAFOURNOUX
  • Dominant mutation in the gene leading to diplogametes production in plants
    Patent number: 10674686
    Abstract: The invention relates to a dominant mutation in the TDM gene leading to the production of 2n gametes in plants, to the plants comprising said mutation, and to their use in plant breeding. The invention relates also to plants in which the dominant mutation in the TDM gene is combined with the inactivation of a gene involved in meiotic recombination in plants and a gene involved in the monopolar orientation of the kinetochores during meiosis. These plants which produce apomeiotic gametes are also useful in plant breeding.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: June 9, 2020
    Assignee: Institut National de la Recherche Agronomique
    Inventors: Raphaël Mercier, Marta Cifuentes, Laurence Cromer
  • Process for the production of bio-butanol by fermentation of glycosidic waste matter
    Patent number: 10662445
    Abstract: An efficient, rapid ex-situ detoxification has been developed to reduce inhibitor concentration and enhance acetone-butanol-ethanol (ABE) production from brewery industry liquid waste (BLW) and brewery spent grain (BSG). About 80±2.0% extraction of furan derivative and more than 95±2.0% extraction of phenolic compounds and almost no extraction of reducing sugar from simulated synthetic media as well as real waste hydrolysate have been obtained. Ex-situ extraction of microbial inhibitors from BLW and BSG hydrolysates using bis-(2-ethylhexyl) sebacate as solvent leads to high production of ABE of 12.67 g/L and 11.23 g/L respectively. Lower power consumption (0.081 W/L) and reuse of the extracting solvent made this detoxification technique extremely useful for improving production of bio-butanol from agro-industrial waste.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: May 26, 2020
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE DE RECHERCHE INDUSTRIELLE DU QUEBEC
    Inventors: Sampa Maiti, Satinder Kaur Brar, Yann LeBihan, Gorka Gallastegui Ruiz de Gordoa
  • METHODS OF DEFIBRILLATING CELLULOSIC SUBSTRATES AND PRODUCING CELLULOSES USING A NEW FAMILY OF FUNGAL LYTIC POLYSACCHARIDE MONOOXYGENASES (LPMO)
    Publication number: 20200157591
    Abstract: Celluloses, notably nanocelluloses, and more particularly processes for manufacturing cellulose fibers and for defibrillating cellulose-based substrates. Most particularly, processes for defibrillating cellulose-based substrates and manufacturing celluloses, in particular nanocelluloses (NC), using a new family of fungal lytic polysaccharide monooxygenases (LPMOs).
    Type: Application
    Filed: July 31, 2018
    Publication date: May 21, 2020
    Applicant: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA)
    Inventors: Bernard CATHALA, Jean-Guy BERRIN, Ana VILLARES, Céline MOREAU
  • ELECTRON IMAGING METHOD AND SYSTEM
    Publication number: 20200161084
    Abstract: A transmission electron microscopy system for imaging a sample, comprising: a pulse generator for generating an initial electron pulse towards the sample, the initial electron pulse to be propagated through the sample to obtain a transmitted electron pulse; an encoding device for encoding the transmitted electron pulse according to a predefined pattern to obtain an encoded electron pulse; a shearing device for temporally shearing the encoded electron pulse in a given direction to obtain a given electron pulse; a detector for detecting the given electron pulse to obtain a single image of the sample; and a datacube generator for determining a spatiotemporal datacube from the single image using the predefined pattern, and outputting the spatiotemporal datacube.
    Type: Application
    Filed: November 20, 2019
    Publication date: May 21, 2020
    Applicant: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (INRS)
    Inventors: Jinyang LIANG, Xianglei Liu, Aycan Yurtsever
  • Flavonoids O-A-glucosylated on the B cycle, method for the production thereof and uses
    Patent number: 10647739
    Abstract: The invention relates to a method for producing derivatives of O-?-glucosylated flavonoid, comprising at least one step of incubating a glucansucrase with a flavonoid and at least one sucrose, the flavonoid being a flavonoid which is monohydroxylated or hydroxylated in a non-vicinal manner on the B cycle. The invention also relates to novel O-?-glucosylated flavonoid derivatives, and to the use thereof.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 12, 2020
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUTE NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Sandrine Morel, Isabelle Andre, Yoan Brison, Emmanuelle Cambon, Yannick Malbert, Denis Pompon, Magali Remaud-Simeon, Philippe Urban
  • METHOD FOR DETERMINING THE POTENTIAL EFFICACY OF ANTICANCER TREATMENT
    Publication number: 20200129566
    Abstract: Embodiments of the present disclosure relate to methods for ex vivo determining whether a patient with metastatic melanoma is likely to benefit from a treatment with an anti CTLA-4 molecule, preferably ipilimumab, by analyzing the gut microbiota in a fecal sample from said patient.
    Type: Application
    Filed: March 22, 2018
    Publication date: April 30, 2020
    Applicants: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, UNIVERSITE PARIS-SUD, INSTITUT GUSTAVE ROUSSY
    Inventor: Franck Carbonnel
  • Gene signatures of inflammatory disorders that relate to the liver
    Patent number: 10626471
    Abstract: This invention is related to the area of characterization of inflammation in relation with the gut microbiota, in metabolic and autoimmune disorders. In particular, it relates to the identification of gene signatures which can be used as a marker predictive of inflammation associated diseases, such as liver-related metabolic disorders, in particular to the evolution of benign steatosis towards its most severe forms (steatohepatitis and cirrhosis) or autoimmune disorders, in particular inflammatory bowel diseases (Crohn's and Ulcerative Colitis). These gene signatures can therefore be used as a means of diagnosis, prognosis, stratification for drug studies, for monitoring patient and for assigning an appropriate treatment.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: April 21, 2020
    Assignees: ENTEROME, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
    Inventors: Matthieu Pichaud, Pierre Rimbaud, Stanislav Ehrlich
  • System and method for phase-readout and active stabilization of optical interferometers
    Patent number: 10578421
    Abstract: A system and method for phase-readout/control and active stabilization on arbitrary interferometric phase in the optical interferometer platform is disclosed. The method makes use of a bi-colored polarization-multiplexed reference laser scheme. The disclosed scheme is based on two phase-locked reference signals with different frequencies that together remove the phase ambiguity. The two signals are polarization-multiplexed (either in free-space or optical fiber implementations) to enable easy separation and combining of these two signals through the use of polarization beam-splitters. The disclosed scheme provides a one-to-one map between phase and feedback signal levels, and enables phase-readout and stabilization even when one of the feedback-signals is at a maximum/minimum.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: March 3, 2020
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Piotr Roztocki, Christian Reimer, Michael Kues, Robin Helsten, Yoann Jestin, Roberto Morandotti
  • Process for producing at least one metabolite of interest by conversion of a pentose in a microorganism
    Patent number: 10570423
    Abstract: Disclosed is a process for producing at least one metabolite of interest by conversion of a pentose in a microorganism. The process includes at least: (i) an operation of culturing a recombinant microorganism expressing a synthetic pathway for pentose assimilation which includes at least the following steps: a) phosphorylation in position 1 of a pentose chosen from (D)-xylulose and/or (L)-ribulose, b) cleavage of the pentose-1-phosphate obtained at the end of step a), in order to obtain glycolaldehyde and dihydroxyacetone phosphate (DHAP), and (ii) an operation of recovering the at least one metabolite of interest obtained at the end of the culturing operation (i). Also disclosed is an associated microorganism.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: February 25, 2020
    Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE—INRA, INSTITUT NATIONAL DES SCIENCES APPLIQUEES—INSA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Thomas Walther, Yvan Cam, Jean-Marie Francois, Ceren Alkim
  • Use of for promoting recovery of the intestinal microbiota diversity after dysbiosis
    Patent number: 10548928
    Abstract: The present invention provides the use of Lactobacillus paracasei, for maintaining or increasing the intestinal microbiota diversity in a subject having dysbiosis.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: February 4, 2020
    Assignees: COMPAGNIE GERVAIS DANONE, INSTITUT NATIONAL DE LA RECHERCHE AGRNOMIQUE
    Inventors: Gianfranco Grompone, Muriel Derrien, Johan Van Hylckama Vlieg, Pascale Serror, Lionel Rigottier-Gois, Laureen Crouzet, Claire Cherbuy
  • SEPARATION OF ENZYMES FROM TRICHODERMA REESEI BY FILTER PRESS AND TANGENTIAL FILTRATION ON A CERAMIC MEMBRANE
    Publication number: 20200031864
    Abstract: The invention relates to a method for separating, from a culture medium, an enzymatic cocktail and the fungus Trichoderma reesei, the culture medium resulting from enzyme production by the fungus, method in which: said culture medium is subjected, in a period of no longer than 30 h from the halting of production, to a separation on a filter press lined with a fabric having a porosity of 3-20 ?m, so as to obtain a filtrate having a corrected optical density OD at 600 nm of less than 2.5; and the liquid phase obtained is subjected to tangenital micro-filtration on a ceramic membrane having a cut-off limit of 0.5 to 1.4 ?m, so that the corrected OD at 600 nm does not exceed 0.1.
    Type: Application
    Filed: July 11, 2017
    Publication date: January 30, 2020
    Applicants: IFP Energies Nouvelles, Institut National De La Recherche Agronomique
    Inventors: Mohamed Fadhel BEN CHAABANE, Romain ROUSSET
  • MUTANT YEAST STRAIN CAPABLE OF PRODUCING MEDIUM CHAIN FATTY ACIDS
    Publication number: 20200017892
    Abstract: Embodiments of the present disclosure relate to mutant yeast strains, in particular mutant Yarrowia strains, capable of producing medium chain fatty acids compared to the parent oleaginous yeast strain from which said mutant oleaginous yeast strain derives. Embodiments of the present disclosure also relate to means and methods for obtaining these mutant yeast strains.
    Type: Application
    Filed: January 8, 2018
    Publication date: January 16, 2020
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Florence Bordes, Coraline Rigouin, Alain Marty, Marc Gueroult, Isabelle Andre, Sophie Barbe, Benjamin Percheron, Christian Croux, Fayza Daboussi
  • Humidity sensing system and method
    Patent number: 10527539
    Abstract: A humidity sensing method and system comprising a transmitter, comprising a fiber optic head and a light source comprising a single LED emitting a measuring light, a receiver, and a sensing assembly comprising a plurality of optical fibers each comprising a first end fed the measuring light, a transducer positioned along a length thereof, the transducer comprising a side-polished portion of the optical fiber, the side polished portion coated with a gold layer and a film of a hydrophilic material wherein the transducer modifies an intensity of the measuring light dependent on an ambient humidity, and a second end for feeding the modified measuring light to the receiver, wherein the receiver compares an intensity of the measuring light with an intensity of the modified measuring light deriving therefrom a corresponding humidity level and dew point temperature.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: January 7, 2020
    Assignee: Institut National de la Recherche Scientifique
    Inventors: Hamid E. Limodehi, François Légaré, Mohamed Chaker