Patents Assigned to Institut National de la Recherche
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Patent number: 11932638Abstract: The present invention concerns a compound of following general formula (I): where: either R is an R1 group and R? is an -A1-Cy1 group, or R is an -A1-Cy1 group and R? is an R1 group, R1 particularly being H or (C1-C6)alkyl group; A1 being an —NH— radical or —NH—CH2— radical; Cy1 particularly being a phenyl group, A is a fused (hetero)aromatic ring having 5 to 7 atoms, for use for treating cancer.Type: GrantFiled: May 23, 2018Date of Patent: March 19, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE, UNIVERSITE D'ORLEANS, UNIVERSITE DE TOURS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE (INSERM), CHU NANTESInventors: Sylvain Routier, Frédéric Buron, Nuno Rodrigues, Gaëlle Fourriere-Grandclaude, Christophe Vandier, Aurélie Chantome, Marie Potier-Cartereau, Maxime Gueguinou, Séverine Marionneau-Lambot
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Publication number: 20240084354Abstract: The present invention relates to a polynucleotide comprising a gene encoding a hook protein and a gene encoding a protein of interest, said protein of interest being either a secretory protein or a cell membrane-anchored protein, wherein: said gene encoding the hook protein is under the control of a first transcription-activating signal, said gene encoding the protein of interest is under the control of a second transcription-activating signal, said second transcription-activating signal allowing a lower rate or frequency of transcription initiation than the first transcription-activating signal, said hook protein is fused to a cellular compartment-retention peptide, and said protein of interest is fused to a hook protein-binding domain It also related to vectors comprising the polynucleotide, cells comprising the polynucleotide or the vector and compositions comprising the same.Type: ApplicationFiled: November 15, 2021Publication date: March 14, 2024Applicants: HONING BIOSCIENCES, INSTITUT CURIE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Franck PEREZ, Zelia GOUVEIA
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Patent number: 11926664Abstract: Monocytopoiesis is a hematological process that supplies the periphery with monocytes and subsequently with macrophages and monocyte-derived dendritic cells. Typically, monocytes circulate in the bloodstream for a very short time before undergoing apoptosis, however, stimulatory signals can trigger monocyte survival by inhibiting the apoptotic pathway, and thus contribute to the maintenance of the inflammatory response. Accordingly, there is a need for methods and pharmaceutical compositions for modulating monocytopoiesis. Now, the inventors show that type I interferons signaling promote the differentiation of monocyte-derived phagocytes at the level of their progenitors. Importantly, IFN-alpha and -beta were found to efficiently generate the development of monocyte-derived antigen-presenting cells while having no impact on the precursor activity of conventional dendritic cells. Accordingly, modulators of type I interferon (e.g.Type: GrantFiled: July 24, 2018Date of Patent: March 12, 2024Assignees: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE), INSTITUT PASTEUR DE LILLE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITÉ DE LILLEInventors: Lionel Poulin, Corentin Lasseaux, Mathias Chamaillard
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Patent number: 11919854Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.Type: GrantFiled: March 29, 2019Date of Patent: March 5, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CHRU DE LILLE, UNIVERSITE COTE D'AZUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), UNIVERSITE DE LILLE, JUNIAInventors: Valérie Vouret, Laetitia Douguet, Alina Ghinet, Germain Homerin, Benoît Guy Marie Rigo, Davy Jérémy Baudelet, Xavier Dezitter, Régis Millet, Christophe Furman
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Patent number: 11914083Abstract: This dosimeter comprises: a transducer material capable, when it is excited by a secondary ionizing radiation, of generating photons or electric charges, an amplifying layer capable, in response to its excitation by the primary ionizing radiation, of generating the secondary ionizing radiation. This amplifying layer comprises a first and a second amplifying sublayer stacked on top of one another. The first and the second amplifying sublayers are composed of at least 70%, by weight, respectively, of at least one first and one second material, the atomic numbers of which are greater than or equal to 29. The atomic number of the first material being less than the atomic number of the second material. The first sublayer is interposed between the second sublayer and the transducer material.Type: GrantFiled: September 1, 2020Date of Patent: February 27, 2024Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITÉ D'AIX-MARSEILLE, INSTITUT JEAN PAOLI & IRENE CALMETTES CENTRE REGIONAL DE LUTTE CONTRE LE CANCERInventors: Sree Bash Chandra Debnath, Julien Darreon, Carole Fauquet, Didier Tonneau, Agnès Tallet
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Patent number: 11834468Abstract: The present invention provides protected tetrasaccharides, their process of preparation and their use in the synthesis of oligosaccharides, in particular fragments of O-antigens from Shigella flexneri, for example of serotype 1a, 1b, 2a, 2b, 3a, X, 4a, 4b, 5a, 5b, 7a or 7b.Type: GrantFiled: July 3, 2018Date of Patent: December 5, 2023Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Laurence Mulard, Guillaume Le Heiget, Zhaohu Hu, Louis-Antoine Barel, Isabelle Andre, Claire Moulis, Magali Remaud-Simeon, Sophie Barbe, Mounir Benkoulouche, Akli Ben Imeddourene
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Publication number: 20230340546Abstract: The use of UV-activated Copper Radical Oxidase (CRO) enzymes in the implementation of oxidation reactions. Also, a process for oxidizing organic compounds using enzymes which are activated by UV light. The process also leads to concomitant formation of hydrogen peroxide, that can optionally be used in hydrogen peroxide mediated processes. Further, the process relates to the oxidation of alcohols in aldehydes.Type: ApplicationFiled: July 21, 2021Publication date: October 26, 2023Applicants: INSTITUT NATIONAL DE LA RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE D'AIX MARSEILLE, ECOLE CENTRALE DE MARSEILLEInventors: Bastien BISSARO, Jean-Guy BERRIN, Michael LAFOND
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Patent number: 11742629Abstract: A method and a system for controlling an output of an optical system, the method comprising generating a plurality of optical signal components having different optical properties and passing the generated optical signal components as input to an optical system comprising an optical device and/or an optical medium; an output of the optical system being based on interactions of the signal components within the optical device and/or the optical medium; and relative proportions of the optical signal components that are generated and individual optical properties thereof being selected to control the output of the optical system.Type: GrantFiled: February 5, 2019Date of Patent: August 29, 2023Assignees: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE, THE UNIVERSITY OF SUSSEX, THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOWInventors: Benjamin Wetzel, Michael Kues, Christian Reimer, Robin Helsten, Piotr Roztocki, Yoann Jestin, Roberto Morandotti
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Patent number: 11735719Abstract: A reduced graphene oxide/manganese(IV) oxide nanocomposite is provided. This nanocomposite comprises reduced graphene oxide flakes and manganese oxide nanoparticles distributed on the surface of the flakes. Electrodes comprising this nanocomposite are also provided. Embodiments of such electrodes displayed broad voltage windows. A method for producing the nanocomposites as well as other nanocomposites is also provided. The method comprises the step of electrochemically exfoliating graphite in an exfoliation electrolyte comprising an intercalant and a precursor which is an oxometallate, a polyoxometalate, a thiometallate, or metal salt together with an acid.Type: GrantFiled: November 11, 2020Date of Patent: August 22, 2023Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Benjamin Diby Ossonon, Ana Berta Lopes Correia Tavares
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Patent number: 11717543Abstract: The present invention relates to a bacterial strain of the Faecalibacterium prausnitzii species selected from a bacterial strain belonging to one of the phylogroups I, II and III, for use in the treatment and/or prevention of visceral abdominal pain in an individual. The present invention also concerns compositions comprising said bacterial strains as well as specific strains as such.Type: GrantFiled: June 22, 2020Date of Patent: August 8, 2023Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, ECOLE D'INGENIEURS DE PURPANInventors: Philippe Langella, Sylvie Miquel, Rebeca Martin Rosique, Luis Bermudez Humaran, Muriel Thomas, Harry Sokol, Frédéric Carvalho, Vassilia Theodorou
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Patent number: 11702720Abstract: The present disclosure relates to a stable copper-based core-shell nanoparticle and its process of manufacture. Further, the present disclosure relates to the use of the copper-based core-shell nanoparticles as plasmonic photocatalysts in photocalysis and hydrogen production.Type: GrantFiled: December 21, 2020Date of Patent: July 18, 2023Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Yong Wang, Dongling Ma, Mohamed Chaker
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Patent number: 11678679Abstract: A meat analogue may include a macrostructure of connected sheared fibers oriented parallel to one another and gaps positioned between the sheared fibers. The macrostructure may include meat and may include a vegetable protein. An extrusion system may include an extruder and a die. The extrusion system may produce a meat analogue. A meat analogue may include an animal protein. The extruder may be connectable to the die. The extrusion system may be configured to direct a material including an animal protein from the extruder to the die and through a fluid path extending through the die. The die may be configured to inject a fat or a fat analogue into the material such that the fat or the fat analogue is embedded but visually distinct from the material including the animal protein when the fat or the fat analogue and the material exit the die.Type: GrantFiled: April 8, 2020Date of Patent: June 20, 2023Assignees: SOCIÉTÉ DES PRODUITS NESTLÉ S.A., UNIVERSITE DE MONTPELLIER, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUEInventors: Patrick Pibarot, Christophe Joseph Etienne Schmitt, Christian Sanchez, Marie-Héléne Morel
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Patent number: 11666599Abstract: The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).Type: GrantFiled: November 28, 2017Date of Patent: June 6, 2023Assignees: INSERM, INTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE STRASBOURGInventors: Sébastien Roux, Thierry Plouvier, Julie Le Merrer, Jérôme Becker
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Patent number: 11635372Abstract: A process for detecting the sensitivity of one or more polymers and/or of one or more mixtures of polymers to a compound, including the steps of exposing a plurality of individualized micro-deposits including the polymer(s) and/or the mixture(s) of polymers to the compound, and detecting, by interferometry, a variation in appearance of an assembly of micro-deposits exposed to the compound and/or a variation in the dimensions and/or refractive index of at least one of the micro-deposits exposed to the compound, linked to an interaction between the polymer(s) and/or the mixture(s) of polymers and the compound.Type: GrantFiled: June 1, 2018Date of Patent: April 25, 2023Assignees: Universite De Lille, Centre National De La Recherche Scientifique, Institut National De La Recherche Agronomique, Institute National Des Sciences Appliquees De ToulouseInventors: Vincent Senez, Alexis Vlandas, Sebastien Lamant, Bernard Cathala, Celine Moreau, Gabrielle Veronese, Sophie Bozonnet, Elisabeth Laville, Megane Cleret
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Patent number: 11618953Abstract: A system for laser-driven propulsion, system comprising a laser source and a target comprising an accelerating part and a projectile part, the accelerating part comprising a metal layer and a porous layer pressed against the metal layer; wherein the laser source is selected to emit pulse beams directed to the metal layer at a fluence below the plasma ablation threshold of the material of the metal layer.Type: GrantFiled: June 10, 2021Date of Patent: April 4, 2023Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventor: Jean-Claude Kieffer
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Patent number: 11614401Abstract: A system for Terahertz detection of target charged cells, comprising a near-infrared femtosecond radiation source; a sensing plate, the sensing plate comprising a sensing film deposited on an insulator/semiconductor film; wherein the radiation source is configured to irradiate the sensing plate, and upon irradiation, the sensing plate emits electromagnetic pulses in a THz frequency range in a specular direction of reflection. The method for Terahertz detection of target charged cells comprises irradiating a sensing plate comprising a sensing film deposited on an insulator/semiconductor film with a near-infrared femtosecond radiation; applying a charged bias voltage to the sensing film; and monitoring variations in amplitude of THz pulses emitted by the sensing plate.Type: GrantFiled: June 24, 2020Date of Patent: March 28, 2023Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventor: Tsuneyuki Ozaki
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Patent number: 11604139Abstract: Real-time multidimensional terahertz imaging system and method, the method comprising method for imaging an object, comprising, in a laser pump line: patterning a laser pump beam with known patterns of a radiation beam and illuminating the object with the radiation beam; yielding a patterned pump beam; directing the patterned beam from the pump line and a laser probe beam from a laser probe line to a detection crystal; single-shot detection of the radiation beam waveform; and correlating the single-shot detection and the known patterns.Type: GrantFiled: October 1, 2020Date of Patent: March 14, 2023Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Riccardo Piccoli, Luca Razzari, Luca Zanotto, Junliang Dong, Roberto Morandotti
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Patent number: 11596657Abstract: The present invention relates to the preventive or curative treatment of metabolic syndrome and the associated disorders with AhR agonist or microorganism producing AhR agonist.Type: GrantFiled: July 11, 2017Date of Patent: March 7, 2023Assignees: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE, SORBONNE UNIVERSITÉ, ASSISTANCE PUBLIQUE—HÔPITAUX DE PARIS, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALEInventors: Harry Sokol, Jane Mea Natividad, Bruno Lamas, Henri Duboc, Mathias Lavie-Richard, Marie-Laure Michel, Philippe Langella
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Patent number: 11588573Abstract: A THz waveguide is described, comprising four conductive wires separated by an air gap, the THz waveguide allowing low-loss and dispersion-free propagation of a THz signal. The system for terahertz polarization-division multiplexing comprises at least two THz sources, a THz waveguide and a THz receiver, wherein said THz waveguide comprises four conductive wires separated by an air gap; THz pulses from the THz sources being coupled into the THz waveguide; the THz waveguide transmitting the THz pulses independently, the THz waveguide operating as a broadband polarization-division multiplexer. The method for terahertz polarization-division multiplexing, comprising multiplexing THz pulses from terahertz sources in free-space, coupling resulting multiplexed THz pulses into a THz waveguide comprising four conductive wires separated by an air gap; and demultiplexing the multiplexed THz pulses after propagation in the waveguide.Type: GrantFiled: July 16, 2021Date of Patent: February 21, 2023Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Junliang Dong, Alessandro Tomasino, Giacomo Balistreri, Aycan Yurtsever, José Azaña, Yoann Jestin, Roberto Morandotti
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Patent number: 11573478Abstract: A method and a system for generating intense, ultrashort pulses of XUV and soft X-ray radiation via high-order harmonic generation (HHG), the method comprising selecting a nonlinear solid target and a laser source; separating a beam from the laser source into a first laser beam and a second laser beam; focusing the first laser beam onto the nonlinear solid target, thereby generating a laser ablated plume; and compressing and frequency-doubling the second laser beam and directing a resulting second compressed and frequency-doubled laser beam to the laser ablated plume, thereby yielding high-order harmonic generation of radiation of photon energies in a range between 12 eV and 36 eV.Type: GrantFiled: December 3, 2020Date of Patent: February 7, 2023Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Mangaljit Singh, Tsuneyuki Ozaki