Abstract: The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.

Abstract: This disclosure provides systems, methods, and compositions for site-specific genetic engineering using Programmable Addition via Site-Specific Targeting Elements (PASTE). PASTE comprises the addition of an integration site into a target genome followed by the insertion of one or more genes of interest or one or more nucleic acid sequences of interest at the site. PASTE combines gene editing technologies and integrase technologies to achieve unidirectional incorporation of genes in a genome for the treatment of diseases and diagnosis of disease.

Abstract: Methods of manufacturing multi-material fibers having one or more electrically-connectable devices disposed therein are described. In certain instances, the methods include the steps of: positioning the electrically-connectable device(s) within a corresponding pocket provided in a preform material; positioning a first electrical conductor longitudinally within a first conduit provided in the preform material; and drawing the multi-material fiber by causing the preform material to flow, such that the first electrical conductor extends within the multi-material fiber along a longitudinal axis thereof and makes an electrical contact with a first electrode located on each electrically-connectable device. A metallurgical bond may be formed between the first electrical conductor and the first electrode while drawing the multi-material fiber and/or, after drawing the multi-material fiber, the first electrical conductor may be located substantially along a neutral axis of the multi-material fiber.

Abstract: A spectrally multiplexed quantum repeater (SMuQR) based on spatially arrayed nodes of frequency-multiplexed multi-qubit registers uses the natural inhomogeneous distribution of optical transition frequencies in solid state defect centers. This distribution enables spectrally selective, individual addressing of large numbers of defect centers within an optical diffraction limited spot along a long cavity or waveguide. The spectral selection relies on frequency shifting an incident optical field at a rate as fast as once per defect center lifetime. The defect centers are resonant at visible frequencies and emit visible single photons which are down-converted to a wavelength compatible with long-distance transmission via conventional optical fiber. The down-converted photons are all at the same telecommunications wavelength, with the different spectral bins mapped to different temporal bins to preserve the multiplexing in the time domain, for distribution to other nodes in the quantum network.

Abstract: Drug delivery articles, resident articles, and retrieval systems e.g., for gram-level dosing, are generally provided. In some embodiments, the residence articles are configured for transesophageal administration, transesophageal retrieval, and/or gastric retention to/in a subject. In certain embodiments, the residence article includes dimensions configured for transesophageal administration with a gastric resident system. In some cases, the residence article may be configured to control drug release e.g., with zero-order drug kinetics with no potential for burst release for weeks to months. In some embodiments, the residence articles described herein comprise biocompatible materials and/or are safe for gastric retention. In certain embodiments, the residence article includes dimensions configured for transesophageal retrieval. In some cases, the residence articles described herein may comprise relatively large doses of drug (e.g., greater than or equal to 1 gram).

Abstract: As described below, disclosed herein are methods of analyzing DNA methylation in cell-free DNA (cfDNA) and genomic DNA (gDNA) from sequencing data.

Abstract: An orbital tensile drive is herein disclosed, along with systems and methods associated therewith. The orbital tensile drive uses a tensile element that is conveyed around a static, fixed shaft and a rotating output shaft. This is facilitated via multiple orbiting idler pulleys that are mounted to an orbiter body. The static and rotating shafts, as well as the orbiting assembly, share a common axis. Input rotation to the orbiter body is transformed into lower-speed, higher-torque rotation at the rotating output shaft. The present invention has many potential applications including, but not limited to, robotics.

Abstract: The disclosure relates to systems and methods for noninvasively performing cardiac auscultation. In some implementations, a method includes: performing, using a BP cuff of a BP cuff system, a blood pressure measurement of a subject to obtain one or more blood pressure values corresponding to the subject; inflating, based on the one or more blood pressure values corresponding to the subject, the BP cuff to a subject specific pressure value; capturing, using the BP cuff system, while the BP cuff is inflated to the subject specific pressure value, a pulse pressure waveform signal associated with an artery of the subject; obtaining a sound waveform signal associated with a heart valve of the subject by filtering the pulse pressure waveform signal to extract sound components associated with the opening or closing of the heart valve; and analyzing the sound waveform signal to identify characteristics of the heart of the subject.

Abstract: Provided herein are compositions, devices, electrochemical systems, and methods relating to lithium-rich iron sulfide lithium-ion battery cathodes. In one embodiment, a composition may be characterized by formula FX1: Liw-?AlxFezS2. In some embodiments, w may be greater than or equal to 2 and less than or equal to 2.5. In some embodiments, x may be greater than 0 and less than or equal to 0.5. In some embodiments, z may be greater than 0 and less than or equal to 1. In some embodiments, ? may be greater than or equal to 0 and less than w. In some embodiments, the composition may have a net charge of 0.

Abstract: A thin oil film having parylene irregular dendritic-like columns extending from one side to another exhibits hydrophobic properties that can be used as a corrosion resistant coating or water-repellant, biofouling resistant surface. This parylene-in-oil layer can be paired with an adjacent layer of solid parylene that it overlays or underlays. The solid parylene cross polymerizes with the parylene dendrites, keeping them in place as well as the oil film. The parylene dendrites are fabricated by chemical vapor deposition (CVD) of parylene over the oil layer, the dendrites self-forming from the bottom to the top. Continued CVD over the dendrites can produce a top layer of solid parylene. Etching the solid parylene away can result in a water repellant, anti-biofouling surface.

Abstract: Disclosed are a method, a device, an apparatus for capturing a non-cooperative target using a space robotic arm, and a non-transitory storage medium, and relates to the technical field of on-orbit servicing. The method is applied to a space robotic arm with a magnetic capture device as an end actuator. The method includes: establishing a magnetic attractive force model for the magnetic capture device, determining a magnetic attractive force characteristic of the magnetic capture device based on the magnetic attractive force model, determining a capture strategy for the non-cooperative target based on the magnetic attractive force characteristic of the magnetic capture device, capturing the non-cooperative target according to the capture strategy, and determining whether the non-cooperative target is captured based on a preset determination condition.

Abstract: A wireless server-to-server datacenter network architecture uses wireless links to eliminate the need for power-hungry switching fabric of traditional fat-tree based datacenter networks. The server-to-server wireless datacenter network (S2S-WiDCN) requires Line-of-Sight (LoS) between servers to establish direct communication links. Utilizing this LoS links, a horizontal-first routing algorithm is developed which, will establish fast communication links between any pair of communicating servers in the data center. The wireless links can be realized in millimeter-wave (such as 30, 60, 120 GHz) or THz (such as 300 GHz) frequency bands. The use of antenna-arrays to create beam-steering towards communicating servers is necessary to establish the direct server-to-server links. In the presence of an obstruction such as an IT technician, the LoS between communicating servers may be blocked. To address this issue, an obstruction-aware adaptive routing algorithm for the S2S-WiDCN is proposed.

Abstract: Systems and methods to remediate, degrade, and/or remove pollutants within various contaminated environmental solid media that includes contaminated soils and sediments, biosolids and slurries by subjecting a mixture of the contaminated solids and a liquid to acoustic cavitation generated by more than one type of ultrasonic device. One of the ultrasonic devices operates at a low frequency and the other ultrasonic device operates at a high frequency. The system advantageously provide an efficient, sustainable, and easy to handle approach to degrade contaminant, requiring only electrical energy.

Abstract: Disclosed herein include methods, compositions, and systems suitable for use in delivering a polynucleotide to a target cell of a subject in need thereof. In some embodiments, a viral vector comprises a polynucleotide encoding nucleoprotein (N), phosphoprotein (P), matrix protein (M), RNA-dependent RNA polymerase (L), and one or more transgenes. The viral vector can comprise one or more of a conditionally stable fusion protein, a protease fusion protein, a degron fusion protein, and/or a glycoprotein derived of another species than the viral vector polynucleotide to enable control of viral vector transduction and/or replication.

Abstract: The invention relates to methods and products for generating diverse libraries of genetic material. The products include libraries and constructed nucleic acids as well as kits and databases and systems thereof.

Abstract: Various aspects described herein relate to electrochemical devices, e.g., for separation of one or more target organic or inorganic molecules (e.g., charged or neutral molecules) from solution, and methods of using the same. In particular embodiments, the electrochemical devices and methods described herein involve at least one redox-functionalized electrode, wherein the electrode comprises an immobilized redox-species that is selective toward a target molecule (e.g., charged molecule such as ion or netural molecule). The selectivity is based on a Faradaic/redox-activated chemical interaction (e.g., directional hydrogen binding) between the oxidized state of the redox species and a moiety of the target molecule (e.g., charged molecule such as ion or netural molecule).

Abstract: A method for in-vivo monitoring of a target internal volume of a mammal that includes: (a) placing the target internal volume proximal to a three-dimensional magnetic field generator; (b) generating first, second, and third magnetic field gradients along respective first, second, and third axes that are mutually orthogonal; (c) measuring first, second, and third magnetic fields with a three-dimensional magnetic sensor disposed in an ingestible capsule, the ingestible capsule disposed in the target internal volume; (d) with a controller in electrical communication with the three-dimensional magnetic sensor, generating a magnetic sensor output signal that encodes a measurement of the first, second, and third magnetic fields; (e) broadcasting the magnetic sensor output signal from an antenna disposed in the ingestible capsule, and (f) receiving the magnetic sensor output signal with a receiver. The received magnetic field data can be used to determine the three-dimensional position of the ingestible capsule.

Abstract: Techniques described herein relate to systems and methods for obtaining a high temperature superconducting (HTS) cable assembly and filling the HTS cable assembly with a molten metal, such as solder.

Abstract: Glycan-binding proteins, and compositions thereof, are generally described, including methods of making and using such proteins. The proteins may include scaffolds based on easily evolvable DNA-binding proteins, with binding sites able to specifically bind to mono- or disaccharides, such as monosaccharide-binding determinants, disaccharide-binding determinants, more complex carbohydrates, etc. In certain aspects, a protein may be generated starting from a small DNA-binding protein, such as Sso7d. Such glycan-binding proteins may have numerous applications, including in enzyme-linked immunosorbent assays (ELISAs), glycan characterization, cell selection, flow cytometry, histology, imaging, arrays, affinity purification, enzyme-linked visualization, binding to a target for pharmaceutical purposes, etc.

Abstract: A resistive random access memory (RRAM) device is provided, and includes a top electrode layer, a bottom electrode layer, and an insulating layer positioned between the top electrode layer and the bottom electrode layer. The insulating layer includes a SiNx layer.