Patents Assigned to Institute of Technology
  • Publication number: 20240153115
    Abstract: Retrographic sensors described herein may provide smaller sensors capable of high-resolution three-dimensional reconstruction of an object in contact with the sensor. Such sensors may be used by robots for work in narrow environments, fine manipulation tasks, and other applications. To provide a smaller sensor, a reduced number of light sources may be provided in the sensor in some embodiments. For example, three light sources, two light sources, or one light source, may be used in some sensors. When fewer light sources are provided, full color gradient information may not be provided. Instead, the missing gradients in one direction or other information related to a three-dimensional object in contact with the sensor may be determined using gradients in a different direction that were provided by the real data. This may be done using a trained statistical model, such as a neural network, in some embodiments.
    Type: Application
    Filed: January 6, 2022
    Publication date: May 9, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Shaoxiong Wang, Branden Romero, Yu She, Edward Adelson
  • Publication number: 20240153197
    Abstract: An example method includes generating embeddings of image data that includes multiple images, where each image has a different viewpoints of a scene, generating a latent space and a decoder, wherein the decoder receives embeddings as input to generate an output viewpoint, for each viewpoint in the image data, determining a volumetric rendering view synthesis loss and a multi-view photometric loss, and applying an optimization algorithm to the latent space and the decoder over a number of epochs until the volumetric rendering view synthesis loss is within a volumetric threshold and the multi-view photometric loss is within a multi-view threshold.
    Type: Application
    Filed: August 3, 2023
    Publication date: May 9, 2024
    Applicants: Toyota Research Institute, Inc., Massachusetts Institute of Technology, Toyota Jidosha Kabushiki Kaisha
    Inventors: Vitor Guizilini, Rares A. Ambrus, Jiading Fang, Sergey Zakharov, Vincent Sitzmann, Igor Vasiljevic, Adrien Gaidon
  • Publication number: 20240150413
    Abstract: In aspects, the invention provides novel compositions and methods for dominant inhibition of viral infection.
    Type: Application
    Filed: March 11, 2022
    Publication date: May 9, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Alexi G. Choueiri, Yong Qian, Bowen Li, Robert S. Langer, Daniel G. Anderson, Edward S. Boyden
  • Publication number: 20240153763
    Abstract: Systems and methods for growth of silicon carbide over a layer comprising graphene and/or hexagonal boron nitride, and related articles, are generally described. In some embodiments, a SiC film is fabricated over a layer comprising graphene and/or hexagonal boron nitride, which in turn is disposed over a substrate. The layer and/or the substrate may be lattice-matched with the SiC film to reduce defect density in the SiC film. The fabricated SiC film may then be removed from the substrate via, for example, a stressor attached to the SiC film. In certain cases, the layer serves as a reusable platform for growing SiC films and also serves a release layer that allows fast, precise, and repeatable release at the layer surface.
    Type: Application
    Filed: October 13, 2023
    Publication date: May 9, 2024
    Applicants: Massachusetts Institute of Technology, The Government of the United States of America, as Represented by the Secretary of the Navy, ROHM Co. Ltd.
    Inventors: Rachael L. Myers-Ward, Jeehwan Kim, Kuan Qiao, Wei Kong, David Kurt Gaskill, Takuji Maekawa, Noriyuki Masago
  • Publication number: 20240149036
    Abstract: Described herein is an apparatus, comprising a substrate having a top surface and a bottom surface. In an embodiment, the apparatus comprises one or more piezoelectric transducers having a diameter of about 10 mm and a thickness of about 2 mm, embedded in the substrate. In an embodiment, the apparatus comprises one or more cavitation chambers having a depth of about 1 mm, each of the one or more cavitation chambers disposed between respective ones of the one or more piezoelectric transducers and the top surface of the substrate, wherein the one or more piezoelectric transducers generate vibrations within a frequency range about 20 kHz to about 1 MHz in the cavitation chambers that cause a substance stored in the cavitation chambers to be forcibly moved through the top surface of the substrate.
    Type: Application
    Filed: November 2, 2023
    Publication date: May 9, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Canan DAGDEVIREN, Aastha SHAH
  • Patent number: 11979207
    Abstract: A wireless communication system can include an antenna and an equalization system. The antenna can be configured to wirelessly receive a data signal from a user equipment (UE). The equalization system can be configured to compensate for distortion incurred by the data signal during propagation. The equalization system can include a set of multiplier circuits. Each multiplier circuit can include a first input, a second input, a multiplier device, and a management circuit. The first input can receive a first input signal that corresponds to the data signal. The second input can receive a second input signal that corresponds to a weighting value assigned to a channel associated with the antenna. The multiplier device can be enabled or disabled. When enabled, the multiplier device can be configured to perform a multiplication operation on the first input signal and the second input signal. When disabled, the multiplier circuit may not perform the multiplication operation.
    Type: Grant
    Filed: June 2, 2022
    Date of Patent: May 7, 2024
    Assignees: Cornell University, ETH ZURICH, The Swiss Federal Institute of Technology
    Inventors: Seyed Hadi Mirfarshbafan, Christoph Studer
  • Patent number: 11977074
    Abstract: The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are described. These nanoparticles can be used to detect in vivo enzyme activity. The invention also relates to products, kits, and databases for use in the methods of the invention.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: May 7, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, David K. Wood, Gabriel A. Kwong, Andrew David Warren, Kevin Y. Lin
  • Patent number: 11977030
    Abstract: Disclosed herein are systems and methods of obtaining a derivative Raman spectrum using an excitation or Raman pump beam whose wavelength is modulated in any suitable manner such as, for example, stochastically. Shifting the wavelength of the input excitation by a small amount in approaches like SERDS can isolate the Raman scatter from other spectral artifacts and reduce the false detection rate. For example, an input excitation sequence can be correlated with the response of an individual pixel of a detector. From this, pixels that have captured Raman scattered photons can be separated from pixels capturing non-Raman photons. These techniques can be expanded to other fields and/or types of spectroscopies that utilize a dispersive element detector with time-dependent spectral features.
    Type: Grant
    Filed: January 12, 2022
    Date of Patent: May 7, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Michael Zervas, Ian W Hunter
  • Patent number: 11975824
    Abstract: A system and method for controlling a multi-rotor aircraft that implements the unconventional use of an odd number of rotors. The odd or auxiliary rotor is designed to be smaller in diameter than the remaining main rotors and accordingly generates a smaller unbalanced torque and pitch on the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque from the odd auxiliary rotor.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: May 7, 2024
    Assignees: California Institute of Technology, TooFon, Inc.
    Inventors: Morteza Gharib, Michael V. Ol, Christopher J. Dougherty
  • Patent number: 11976270
    Abstract: Provided herein, in some aspects, are methods and compositions for producing single-stranded DNA (ssDNA) having uniform length.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: May 7, 2024
    Assignee: Massachusetts Institute of Technology
    Inventors: Angela Belcher, Christopher A. Voigt, Uyanga Tsedev, Tae-Gon Cha
  • Patent number: 11977020
    Abstract: A structural electronics wireless sensor node is provided that includes layers of electronic components fabricated from patterned nanostructures embedded in an electrically conductive matrix. In some aspects, the structural electronics wireless sensor node includes a plurality of nanostructure layers that each form individual electronic components of the structural electronics wireless sensor node. In certain embodiments, the structural electronics wireless sensor node includes electronic components such as a resistor, a inductor, a capacitor, and/or an antenna.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: May 7, 2024
    Assignees: Analog Devices, Inc., Massachusetts Institute of Technology
    Inventors: Brian L. Wardle, Yosef Stein, Estelle Cohen, Michael Murray
  • Publication number: 20240144704
    Abstract: The present disclosure provides methods for identifying cells in an image. An apparatus for identifying cells in an image is also provided by the present disclosure. Further provided herein is a non-transitory computer-readable storage medium for performing the methods disclosed herein. Methods of diagnosing a disease or disorder and of treating a disease or disorder in a subject using the methods disclosed are also provided herein.
    Type: Application
    Filed: February 18, 2022
    Publication date: May 2, 2024
    Applicants: c/o The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Xiao Wang, Jia Liu, Yichun He
  • Publication number: 20240140760
    Abstract: To provide a drive device for a self-propelled elevator which is capable of moving a car in a vertical direction and a horizontal direction with a simple configuration. The drive device for a self-propelled elevator includes: a rotating body which is rotatably coupled to a back face of a cab; and wheels which are provided on the rotating body so as to sandwich guide surfaces of a rail on a back face side of the cab, which generate, by friction between the wheels and the rail, a force that moves the cab in a vertical direction when a longitudinal direction of the rail is the vertical direction, and which generate, by a friction force between the wheels and the rail, a force that moves the cab in a horizontal direction when the longitudinal direction of the rail is the horizontal direction.
    Type: Application
    Filed: March 8, 2021
    Publication date: May 2, 2024
    Applicants: Mitsubishi Electric Corporation, Tokyo Institute of Technology
    Inventors: Yusuke SUGAHARA, Yukio TAKEDA, Takahiro ISHII, Takeshi MATSUMOTO, Masayuki KAKIO
  • Publication number: 20240141324
    Abstract: The present disclosure, at least in part, provides RNA cleavage based engineered bi-stable toggle switch utilizing the Programmable Endonucleolytic Scission-Induced Stability Tuning (PERSIST) platform. Also provided herein, are vectors encoding the engineered bi-stable toggle switch, and uses thereof.
    Type: Application
    Filed: May 1, 2023
    Publication date: May 2, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Ron Weiss, Breanna E. DiAndreth, Noreen Wauford
  • Publication number: 20240141134
    Abstract: Compositions, articles, and methods related to hydrogen gas sensors are generally described.
    Type: Application
    Filed: October 18, 2023
    Publication date: May 2, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Timothy Manning Swager, Lennon Shaoxiong Luo
  • Publication number: 20240142528
    Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.
    Type: Application
    Filed: December 14, 2023
    Publication date: May 2, 2024
    Applicant: California Institute of Technology
    Inventors: Farshid ROUMI, Jamshid ROUMI
  • Publication number: 20240141309
    Abstract: Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE [SEQ ID No. 4] in position 365-379 in the ScCas9 open reading frame (Sc++). Also included are CRISPR-associated DNA endonucleases with a PAM specificity of 5?-NG-3? or 5?-NNG-3? and a method of altering expression of a gene product by utilizing the engineered ScCas9 variants.
    Type: Application
    Filed: July 11, 2023
    Publication date: May 2, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Pranam Chatterjee, Noah Michael Jakimo, Joseph M. Jacobson
  • Publication number: 20240139675
    Abstract: Methods, apparatuses, and systems related to electrochemical capture of Lewis acid gases from fluid mixtures are generally described. Certain embodiments are related to electrochemical methods involving selectively removing a first Lewis acid gas from a fluid mixture containing multiple types of Lewis acid gases (e.g., a first Lewis acid gas and a second Lewis acid gas). Certain embodiments are related to electrochemical systems comprising certain types of electroactive species having certain redox states in which the species is capable of binding a first Lewis acid gas but for which binding with a second Lewis acid gas is thermodynamically and/or kinetically unfavorable. The methods, apparatuses, and systems described herein may be useful in carbon capture and pollution mitigation applications.
    Type: Application
    Filed: November 9, 2023
    Publication date: May 2, 2024
    Applicant: Massachusetts Institute of Technology
    Inventors: Sahag Voskian, Trevor Alan Hatton, Cameron G. Halliday
  • Patent number: 11973744
    Abstract: Described in detail herein is a system for determining the validity of a transaction in a distributed network environment. The system includes a plurality of peer servers. The system elects a set of peer leaders from the plurality of peer servers. The set of peer leaders broadcast a first set of indices associated with a first subset of transactions, received from the plurality of peer servers, to one or more of the plurality of peer servers. The set of elected peer leaders execute a first instance of a binary agreement protocol based at least in part on a second subset of indices associated with a second subset of the transactions. The set of elected peer leaders output a consensus vector comprising one or more of the transactions.
    Type: Grant
    Filed: May 12, 2020
    Date of Patent: April 30, 2024
    Assignees: New Jersey Institute of Technology, Beijing Wodong Tianjun Information Technology Co., Ltd., Institute of Software, Chinese Academy of Sciences
    Inventors: Xinlei Zhai, Qiang Tang, Zhenliang Lu, Jing Xu, Zhenfeng Zhang, Bingyong Guo
  • Patent number: 11970542
    Abstract: The present disclosure provides compositions and methods for improved pre-targeted radioimmunotherapeutics (PRIT) to treat various hematological disorders, such as B cell hyperproliferative disorders and solid tumors. The disclosed compositions include bispecific antibody compositions having a first domain that specifically bind to an antigen such as CD38, BCMA, Muc1, GPRC5D, or Slam7, and a second domain that specifically binds to a radioactive ligand. Methods include administering the disclosed bispecific antibody reagent and separately administering the radioactive ligand. In some embodiments, a clearing agent is also administered. In some embodiments, the therapeutic methods comprise administering a combination of two or more bispecific antibody reagents. In some embodiments, an enhancing agent, such as ATRA, gamma secretase inhibitor, or dextramethasone, is also administered to enhance expression of the target antigen on the target cells.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: April 30, 2024
    Assignees: Fred Hutchinson Cancer Center, Massachusetts Institute of Technology
    Inventors: Damian J. Green, Yukang Lin, Oliver W. Press, Alice Tzeng, Karl Dane Wittrup