Patents Assigned to Institute of Technology
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Publication number: 20240153115Abstract: Retrographic sensors described herein may provide smaller sensors capable of high-resolution three-dimensional reconstruction of an object in contact with the sensor. Such sensors may be used by robots for work in narrow environments, fine manipulation tasks, and other applications. To provide a smaller sensor, a reduced number of light sources may be provided in the sensor in some embodiments. For example, three light sources, two light sources, or one light source, may be used in some sensors. When fewer light sources are provided, full color gradient information may not be provided. Instead, the missing gradients in one direction or other information related to a three-dimensional object in contact with the sensor may be determined using gradients in a different direction that were provided by the real data. This may be done using a trained statistical model, such as a neural network, in some embodiments.Type: ApplicationFiled: January 6, 2022Publication date: May 9, 2024Applicant: Massachusetts Institute of TechnologyInventors: Shaoxiong Wang, Branden Romero, Yu She, Edward Adelson
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Publication number: 20240153197Abstract: An example method includes generating embeddings of image data that includes multiple images, where each image has a different viewpoints of a scene, generating a latent space and a decoder, wherein the decoder receives embeddings as input to generate an output viewpoint, for each viewpoint in the image data, determining a volumetric rendering view synthesis loss and a multi-view photometric loss, and applying an optimization algorithm to the latent space and the decoder over a number of epochs until the volumetric rendering view synthesis loss is within a volumetric threshold and the multi-view photometric loss is within a multi-view threshold.Type: ApplicationFiled: August 3, 2023Publication date: May 9, 2024Applicants: Toyota Research Institute, Inc., Massachusetts Institute of Technology, Toyota Jidosha Kabushiki KaishaInventors: Vitor Guizilini, Rares A. Ambrus, Jiading Fang, Sergey Zakharov, Vincent Sitzmann, Igor Vasiljevic, Adrien Gaidon
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Publication number: 20240150413Abstract: In aspects, the invention provides novel compositions and methods for dominant inhibition of viral infection.Type: ApplicationFiled: March 11, 2022Publication date: May 9, 2024Applicant: Massachusetts Institute of TechnologyInventors: Alexi G. Choueiri, Yong Qian, Bowen Li, Robert S. Langer, Daniel G. Anderson, Edward S. Boyden
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Publication number: 20240153763Abstract: Systems and methods for growth of silicon carbide over a layer comprising graphene and/or hexagonal boron nitride, and related articles, are generally described. In some embodiments, a SiC film is fabricated over a layer comprising graphene and/or hexagonal boron nitride, which in turn is disposed over a substrate. The layer and/or the substrate may be lattice-matched with the SiC film to reduce defect density in the SiC film. The fabricated SiC film may then be removed from the substrate via, for example, a stressor attached to the SiC film. In certain cases, the layer serves as a reusable platform for growing SiC films and also serves a release layer that allows fast, precise, and repeatable release at the layer surface.Type: ApplicationFiled: October 13, 2023Publication date: May 9, 2024Applicants: Massachusetts Institute of Technology, The Government of the United States of America, as Represented by the Secretary of the Navy, ROHM Co. Ltd.Inventors: Rachael L. Myers-Ward, Jeehwan Kim, Kuan Qiao, Wei Kong, David Kurt Gaskill, Takuji Maekawa, Noriyuki Masago
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Publication number: 20240149036Abstract: Described herein is an apparatus, comprising a substrate having a top surface and a bottom surface. In an embodiment, the apparatus comprises one or more piezoelectric transducers having a diameter of about 10 mm and a thickness of about 2 mm, embedded in the substrate. In an embodiment, the apparatus comprises one or more cavitation chambers having a depth of about 1 mm, each of the one or more cavitation chambers disposed between respective ones of the one or more piezoelectric transducers and the top surface of the substrate, wherein the one or more piezoelectric transducers generate vibrations within a frequency range about 20 kHz to about 1 MHz in the cavitation chambers that cause a substance stored in the cavitation chambers to be forcibly moved through the top surface of the substrate.Type: ApplicationFiled: November 2, 2023Publication date: May 9, 2024Applicant: Massachusetts Institute of TechnologyInventors: Canan DAGDEVIREN, Aastha SHAH
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Patent number: 11979207Abstract: A wireless communication system can include an antenna and an equalization system. The antenna can be configured to wirelessly receive a data signal from a user equipment (UE). The equalization system can be configured to compensate for distortion incurred by the data signal during propagation. The equalization system can include a set of multiplier circuits. Each multiplier circuit can include a first input, a second input, a multiplier device, and a management circuit. The first input can receive a first input signal that corresponds to the data signal. The second input can receive a second input signal that corresponds to a weighting value assigned to a channel associated with the antenna. The multiplier device can be enabled or disabled. When enabled, the multiplier device can be configured to perform a multiplication operation on the first input signal and the second input signal. When disabled, the multiplier circuit may not perform the multiplication operation.Type: GrantFiled: June 2, 2022Date of Patent: May 7, 2024Assignees: Cornell University, ETH ZURICH, The Swiss Federal Institute of TechnologyInventors: Seyed Hadi Mirfarshbafan, Christoph Studer
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Patent number: 11977074Abstract: The invention relates to methods and products associated with in vivo enzyme profiling. In particular, biomarker nanoparticles capable of quantitatively detecting enzymatic activity in vivo are described. These nanoparticles can be used to detect in vivo enzyme activity. The invention also relates to products, kits, and databases for use in the methods of the invention.Type: GrantFiled: November 22, 2019Date of Patent: May 7, 2024Assignee: Massachusetts Institute of TechnologyInventors: Sangeeta N. Bhatia, David K. Wood, Gabriel A. Kwong, Andrew David Warren, Kevin Y. Lin
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Patent number: 11977030Abstract: Disclosed herein are systems and methods of obtaining a derivative Raman spectrum using an excitation or Raman pump beam whose wavelength is modulated in any suitable manner such as, for example, stochastically. Shifting the wavelength of the input excitation by a small amount in approaches like SERDS can isolate the Raman scatter from other spectral artifacts and reduce the false detection rate. For example, an input excitation sequence can be correlated with the response of an individual pixel of a detector. From this, pixels that have captured Raman scattered photons can be separated from pixels capturing non-Raman photons. These techniques can be expanded to other fields and/or types of spectroscopies that utilize a dispersive element detector with time-dependent spectral features.Type: GrantFiled: January 12, 2022Date of Patent: May 7, 2024Assignee: Massachusetts Institute of TechnologyInventors: Michael Zervas, Ian W Hunter
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Patent number: 11975824Abstract: A system and method for controlling a multi-rotor aircraft that implements the unconventional use of an odd number of rotors. The odd or auxiliary rotor is designed to be smaller in diameter than the remaining main rotors and accordingly generates a smaller unbalanced torque and pitch on the aircraft. Additional configurations implement the use of smaller thrust rotors that can be used to generate thrust as well as control yaw and thus counteract any remaining unbalanced torque from the odd auxiliary rotor.Type: GrantFiled: April 21, 2021Date of Patent: May 7, 2024Assignees: California Institute of Technology, TooFon, Inc.Inventors: Morteza Gharib, Michael V. Ol, Christopher J. Dougherty
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Patent number: 11976270Abstract: Provided herein, in some aspects, are methods and compositions for producing single-stranded DNA (ssDNA) having uniform length.Type: GrantFiled: May 14, 2020Date of Patent: May 7, 2024Assignee: Massachusetts Institute of TechnologyInventors: Angela Belcher, Christopher A. Voigt, Uyanga Tsedev, Tae-Gon Cha
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Patent number: 11977020Abstract: A structural electronics wireless sensor node is provided that includes layers of electronic components fabricated from patterned nanostructures embedded in an electrically conductive matrix. In some aspects, the structural electronics wireless sensor node includes a plurality of nanostructure layers that each form individual electronic components of the structural electronics wireless sensor node. In certain embodiments, the structural electronics wireless sensor node includes electronic components such as a resistor, a inductor, a capacitor, and/or an antenna.Type: GrantFiled: June 12, 2020Date of Patent: May 7, 2024Assignees: Analog Devices, Inc., Massachusetts Institute of TechnologyInventors: Brian L. Wardle, Yosef Stein, Estelle Cohen, Michael Murray
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Publication number: 20240144704Abstract: The present disclosure provides methods for identifying cells in an image. An apparatus for identifying cells in an image is also provided by the present disclosure. Further provided herein is a non-transitory computer-readable storage medium for performing the methods disclosed herein. Methods of diagnosing a disease or disorder and of treating a disease or disorder in a subject using the methods disclosed are also provided herein.Type: ApplicationFiled: February 18, 2022Publication date: May 2, 2024Applicants: c/o The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard CollegeInventors: Xiao Wang, Jia Liu, Yichun He
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Publication number: 20240140760Abstract: To provide a drive device for a self-propelled elevator which is capable of moving a car in a vertical direction and a horizontal direction with a simple configuration. The drive device for a self-propelled elevator includes: a rotating body which is rotatably coupled to a back face of a cab; and wheels which are provided on the rotating body so as to sandwich guide surfaces of a rail on a back face side of the cab, which generate, by friction between the wheels and the rail, a force that moves the cab in a vertical direction when a longitudinal direction of the rail is the vertical direction, and which generate, by a friction force between the wheels and the rail, a force that moves the cab in a horizontal direction when the longitudinal direction of the rail is the horizontal direction.Type: ApplicationFiled: March 8, 2021Publication date: May 2, 2024Applicants: Mitsubishi Electric Corporation, Tokyo Institute of TechnologyInventors: Yusuke SUGAHARA, Yukio TAKEDA, Takahiro ISHII, Takeshi MATSUMOTO, Masayuki KAKIO
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Publication number: 20240141324Abstract: The present disclosure, at least in part, provides RNA cleavage based engineered bi-stable toggle switch utilizing the Programmable Endonucleolytic Scission-Induced Stability Tuning (PERSIST) platform. Also provided herein, are vectors encoding the engineered bi-stable toggle switch, and uses thereof.Type: ApplicationFiled: May 1, 2023Publication date: May 2, 2024Applicant: Massachusetts Institute of TechnologyInventors: Ron Weiss, Breanna E. DiAndreth, Noreen Wauford
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Publication number: 20240141134Abstract: Compositions, articles, and methods related to hydrogen gas sensors are generally described.Type: ApplicationFiled: October 18, 2023Publication date: May 2, 2024Applicant: Massachusetts Institute of TechnologyInventors: Timothy Manning Swager, Lennon Shaoxiong Luo
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Publication number: 20240142528Abstract: A method for abnormality detection in an energy unit includes passively detecting an abnormality in an energy unit by detecting electromagnetic radiation generated by the abnormality, the energy unit comprising at least one of an electrical energy unit and an electrochemical energy unit. A method for detecting an abnormality in an energy unit includes (a) applying a signal to the energy unit, (b) performing a plurality of measurements, at a respective plurality of different locations within the energy unit, of a response of the energy unit to the signal, and (c) processing the plurality of measurements to identify the abnormality.Type: ApplicationFiled: December 14, 2023Publication date: May 2, 2024Applicant: California Institute of TechnologyInventors: Farshid ROUMI, Jamshid ROUMI
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Publication number: 20240141309Abstract: Engineered Streptococcus canis Cas9 (ScCas9) variants include an ScCas9 protein with its PID being the PID amino acid composition of Streptococcus pyogenes Cas9 (SpCas9-NG, an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 in its amino acid sequence (Sc+), and an ScCas9 protein having a threonine-to-lysine substitution mutation at position 1227 and a substitution of residues ADKKLRKRSGKLATE [SEQ ID No. 4] in position 365-379 in the ScCas9 open reading frame (Sc++). Also included are CRISPR-associated DNA endonucleases with a PAM specificity of 5?-NG-3? or 5?-NNG-3? and a method of altering expression of a gene product by utilizing the engineered ScCas9 variants.Type: ApplicationFiled: July 11, 2023Publication date: May 2, 2024Applicant: Massachusetts Institute of TechnologyInventors: Pranam Chatterjee, Noah Michael Jakimo, Joseph M. Jacobson
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Publication number: 20240139675Abstract: Methods, apparatuses, and systems related to electrochemical capture of Lewis acid gases from fluid mixtures are generally described. Certain embodiments are related to electrochemical methods involving selectively removing a first Lewis acid gas from a fluid mixture containing multiple types of Lewis acid gases (e.g., a first Lewis acid gas and a second Lewis acid gas). Certain embodiments are related to electrochemical systems comprising certain types of electroactive species having certain redox states in which the species is capable of binding a first Lewis acid gas but for which binding with a second Lewis acid gas is thermodynamically and/or kinetically unfavorable. The methods, apparatuses, and systems described herein may be useful in carbon capture and pollution mitigation applications.Type: ApplicationFiled: November 9, 2023Publication date: May 2, 2024Applicant: Massachusetts Institute of TechnologyInventors: Sahag Voskian, Trevor Alan Hatton, Cameron G. Halliday
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Patent number: 11973744Abstract: Described in detail herein is a system for determining the validity of a transaction in a distributed network environment. The system includes a plurality of peer servers. The system elects a set of peer leaders from the plurality of peer servers. The set of peer leaders broadcast a first set of indices associated with a first subset of transactions, received from the plurality of peer servers, to one or more of the plurality of peer servers. The set of elected peer leaders execute a first instance of a binary agreement protocol based at least in part on a second subset of indices associated with a second subset of the transactions. The set of elected peer leaders output a consensus vector comprising one or more of the transactions.Type: GrantFiled: May 12, 2020Date of Patent: April 30, 2024Assignees: New Jersey Institute of Technology, Beijing Wodong Tianjun Information Technology Co., Ltd., Institute of Software, Chinese Academy of SciencesInventors: Xinlei Zhai, Qiang Tang, Zhenliang Lu, Jing Xu, Zhenfeng Zhang, Bingyong Guo
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Patent number: 11970542Abstract: The present disclosure provides compositions and methods for improved pre-targeted radioimmunotherapeutics (PRIT) to treat various hematological disorders, such as B cell hyperproliferative disorders and solid tumors. The disclosed compositions include bispecific antibody compositions having a first domain that specifically bind to an antigen such as CD38, BCMA, Muc1, GPRC5D, or Slam7, and a second domain that specifically binds to a radioactive ligand. Methods include administering the disclosed bispecific antibody reagent and separately administering the radioactive ligand. In some embodiments, a clearing agent is also administered. In some embodiments, the therapeutic methods comprise administering a combination of two or more bispecific antibody reagents. In some embodiments, an enhancing agent, such as ATRA, gamma secretase inhibitor, or dextramethasone, is also administered to enhance expression of the target antigen on the target cells.Type: GrantFiled: November 8, 2018Date of Patent: April 30, 2024Assignees: Fred Hutchinson Cancer Center, Massachusetts Institute of TechnologyInventors: Damian J. Green, Yukang Lin, Oliver W. Press, Alice Tzeng, Karl Dane Wittrup