Abstract: Disclosed are compositions and methods of treating cancers by constitutively activating protein phosphatase 2A (PP2A) without blocking signaling through the dopamine D2 receptor, that entail administering a therapeutically effective amount of an analog of perphenazine (PPZ) of formula (I) or (II), or a related PPZ analog lacking dopamine receptor D2 inhibitory activity, or a pharmaceutically acceptable salt thereof.
Type:
Application
Filed:
December 19, 2019
Publication date:
March 3, 2022
Applicant:
DANA-FARBER CANCER INSTITUTE, INC.
Inventors:
Alfred T. Look, Ken Morita, Eric S. Fischer, Nathanael S. Gray, Shuning He
Abstract: A biosensor for the rapid, inexpensive, quantitative, and convenient detection of SARS-CoV-2 biomarkers, methods of manufacturing, and methods of using the same, to identify a patient's prognosis and past/present SARS-CoV-2 infection status, wherein the biosensor comprises a microfluidics layer, a multimodal sensing layer comprising two or more working electrodes, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.
Type:
Application
Filed:
September 2, 2021
Publication date:
March 3, 2022
Applicant:
California Institute of Technology
Inventors:
Wei Gao, Rebeca M. Torrente-Rodriguez, Heather Lukas
Abstract: An image correction method and an image correction system based on deep learning are provided. The image correction method includes the following steps. An image containing at least one character is received by a deep learning model, and a perspective transformation matrix is generated according to the image. A perspective transformation is performed on the image according to the perspective transformation matrix to obtain a corrected image containing a front view of the at least one character. An optimized corrected image containing the front view of the at least one character is generated according to the image. An optimized perspective transformation matrix corresponding to the image and the optimized corrected image is obtained. A loss value between the optimized perspective transformation matrix and the perspective transformation matrix is calculated. The deep learning model is updated using the loss value.
Type:
Application
Filed:
November 25, 2020
Publication date:
March 3, 2022
Applicant:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Abstract: An object of the present invention is to provide an anti-human norovirus agent which can inhibit infection with and proliferation of human norovirus. The present inventors have found that the object can be attained through provision of an anti-human norovirus agent comprising, as an active ingredient, a fucose analog having an inhibitory action on glycosylation by fucosyltransferase (FUT). Examples of the active ingredient include a fucose analog represented by formula (III) or (IV) or a salt thereof. [In the formulas, each of formula (III) and formula (IV) represents an ?-anomer or a ?-anomer; each of R4, R3, and R4 is —OH or -OAc; R2 is a halogen atom, —OH, or -OAc; and R5 is —CH3, —C?CH, —C?CCH3, or —CH2C?CH.
Type:
Application
Filed:
December 27, 2019
Publication date:
March 3, 2022
Applicants:
KEIO UNIVERSITY, THE KITASATO INSTITUTE
Abstract: Compositions and methods related to multiaxially straining defect doped materials as well as their use in electrical circuits are generally described.
Type:
Application
Filed:
August 25, 2021
Publication date:
March 3, 2022
Applicants:
Massachusetts Institute of Technology, Nanyang Technological University
Abstract: The present invention relates to a light-digital PCR chamber and a light-digital PCR device. The light-digital PCR chamber comprises: a transparent substrate; a metal thin film layer formed on the transparent substrate; a light shielding layer formed on the metal thin film layer; and a microchannel structure formed on the light shielding layer. The light-digital PCR device comprises a laminate comprising a transparent substrate, a metal thin film layer formed on the transparent substrate, and a light shielding layer formed on the metal thin film layer.
Type:
Application
Filed:
November 19, 2019
Publication date:
March 3, 2022
Applicant:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY
Inventors:
Oh Seok KWON, Kyung Ho KIM, Seon Joo PARK, Seong Eun SEO, Tai Hwan HA
Abstract: An acoustic resonance diagnostic method for detecting structural degradation is provided. The method includes steps as follows: Firstly, a training model is built using a deep neural network. At least two training acoustic signals are inputted to the training model to carry a training. A diagnostic model is built according to a result of the training using a convolutional neural network. An under-test sound wave signal is captured from an under-test section of an under-test structure through direct contact, non-contact, or indirect contact. A structural degradation state of the under-test section is determined according to the under-test sound wave signal through the diagnostic model.
Type:
Application
Filed:
August 18, 2021
Publication date:
March 3, 2022
Applicant:
INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Inventors:
Hung-Chih CHANG, Yao-Long TSAI, Li-Hua WANG
Abstract: Provided is an apparatus for online action detection, the apparatus including a feature extraction unit configured to extract a chunk-level feature of a video chunk sequence of a streaming video, a filtering unit configured to perform filtering on the chunk-level feature, and an action classification unit configured to classify an action class using the filtered chunk-level feature.
Type:
Application
Filed:
August 25, 2021
Publication date:
March 3, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Jin Young MOON, Hyung Il KIM, Jong Youl PARK, Kang Min BAE, Ki Min YUN
Abstract: An electrode active material for a nonaqueous secondary battery comprising: an alkali metal-transition metal composite oxide particles, a hole-doped graphenewith an anion. The electrode active material for a nonaqueous secondary battery may be manufactured by a method which includes obtaining a hole-doped graphene by bringing a graphene raw material into contact with a two-coordinate boron cation, and bringing the hole-doped graphene into contact with an alkali metal-transition metal composite oxide particle.
Type:
Application
Filed:
November 10, 2021
Publication date:
March 3, 2022
Applicants:
TOKYO INSTITUTE OF TECHNOLOGY, NICHIA CORPORATION
Abstract: A composition for dyeing a bentonite, which includes a plant-derived polyphenol, and a method for dyeing a bentonite using the composition are provided. A composition for dyeing a bentonite, which includes a polyphenol such as lignin, pectin, tannin, and catechin, as a plant-derived material, and a method for dyeing a bentonite using the composition are provided.
Type:
Application
Filed:
June 29, 2021
Publication date:
March 3, 2022
Applicant:
Korea Institute Of Geoscience And Mineral Resources
Inventors:
Jae Hwan KIM, Chang Yun PARK, Sung Man SEO, Il Mo KANG, Ki Min ROH
Abstract: [PROBLEM TO BE SOLVED] To provide a solid heat storage material that is made of a VO2-based inorganic material, is easy to sinter, has a high latent heat storage capacity, and can be suitably used as a phase change solid heat storage material, and a method of manufacturing the same. [SOLUTION] A powder material for sintering of a first aspect of the present invention includes vanadium and oxygen and includes a vanadium oxide represented by the chemical formula VO2 and at least one other type of vanadium oxide, in which, when the molar ratio of V and O in all the powder is expressed as 1:(2+d), d is in the range of 0<d<0.5.
Type:
Application
Filed:
December 4, 2019
Publication date:
March 3, 2022
Applicant:
NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
Abstract: A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.
Type:
Application
Filed:
August 4, 2021
Publication date:
March 3, 2022
Applicants:
Massachusetts Institute of Technology, President and Fellows of Harvard College
Inventors:
Armon R. Sharei, Shirley Mao, George Hartoularos, Sophia Liu, Megan Heimann, Pamela Basto, Gregory Szeto, Siddharth Jhunjhunwala, Darrell J. Irvine, Robert S. Langer, Klavs F. Jensen, Ulrich H. Von Andrian
Abstract: Reaction schemes involving acids and bases; reactors comprising spatially varying chemical composition gradients (e.g., spatially varying pH gradients), and associated systems and methods, are generally described.
Type:
Application
Filed:
January 16, 2020
Publication date:
March 3, 2022
Applicant:
Massachusetts Institute of Technology
Inventors:
Yet-Ming Chiang, Leah Ellis, Andres Badel
Abstract: Disclosed herein is a system for recovering carbon monoxide from an industrial by-product gas, the system including a supply unit for supplying an industrial by-product gas containing carbon dioxide, nitrogen, carbon monoxide, and hydrogen, a first membrane separation unit including a separation membrane capable of allowing carbon dioxide and hydrogen to permeate, and receiving the industrial by-product gas supplied from the supply unit to allow carbon dioxide and hydrogen to permeate, and a second membrane separation unit including a polymer membrane in which a transition metal is supported, and receiving a gas remaining in the first membrane separation unit to allow carbon monoxide to permeate.
Type:
Application
Filed:
August 30, 2021
Publication date:
March 3, 2022
Applicant:
Korea Research Institute of Chemical Technology
Inventors:
Jeong Hoon Kim, Jong Yeol Jeon, Bo Ryoung Park, Ho Cheol Kang
Abstract: An image encoding/decoding method and apparatus for performing intra prediction are provided. An image decoding method of the present invention comprises deriving an intra-prediction mode for a current block, determining whether or not a left boundary or an upper boundary of the current block is a boundary of a predetermined image region, configuring a reference sample by using at least one reconstructed sample included in at least one reconstructed sample line adjacent to the current block based on the determination result, and performing intra-prediction for the current block based on the intra-prediction mode and the reference sample.
Type:
Application
Filed:
August 13, 2021
Publication date:
March 3, 2022
Applicant:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Seung Hyun CHO, Jung Won KANG, Sung Chang LIM, Hyun Suk KO, Dong San JUN, Jin Ho LEE, Ha Hyun LEE, Hui Yong KIM, Jin Soo CHOI
Abstract: The present invention provides a system for wireless power transmission, wherein the system is a system for wireless power transmission detecting a foreign object, including a power transmitting coil for transmitting AC power, a power receiving coil for receiving the AC power transmitted from the power transmitting coil wherein the power receiving coil is spaced apart from the power transmitting coil, and a detection circuit for detecting a foreign object located between the power transmitting coil and the power receiving coil wherein a first resistor and a first detection coil connected in series, and a second resistor and a second detection coil connected in series are connected in parallel, and wherein at least one of the first detection coil and the second detection coil is disposed between the power transmitting coil and the power receiving coil.
Type:
Application
Filed:
December 18, 2020
Publication date:
March 3, 2022
Applicant:
KOREA ELECTRONICS TECHNOLOGY INSTITUTE
Inventors:
Yong Seok LIM, Hae Yong JUNG, Tai Gil KWON, Yong Seong KIM, Yongju PARK
Abstract: An image encoding/decoding method and apparatus for performing intra prediction mode based intra prediction are provided. An image decoding method may comprise decoding an intra prediction mode of a current block, deriving at least one intra prediction mode from the decoded intra prediction mode of the current block, generating two or more intra prediction blocks using the intra prediction mode of the current block and the derived intra prediction mode, and generating an intra prediction block of the current block based on the two or more intra prediction blocks.
Type:
Application
Filed:
November 11, 2021
Publication date:
March 3, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Sung Chang LIM, Hyun Suk KO, Jung Won KANG, Jin Ho LEE, Ha Hyun LEE, Dong San JUN, Hui Yong KIM
Abstract: A method for detecting people entering and leaving a field is provided in an embodiment of the disclosure. The method includes the following. An event detection area corresponding to an entrance is set, and the event detection area includes an upper boundary, a lower boundary, and an internal area, and the lower boundary includes a left boundary, a right boundary, and a bottom boundary; a person image corresponding to a person in an image stream is detected and tracked; and whether the person passes through or does not pass through the entrance is determined according to a first detection result and a second detection result.
Type:
Application
Filed:
December 29, 2020
Publication date:
March 3, 2022
Applicant:
Industrial Technology Research Institute
Inventors:
Shu-Hsin Chang, Yao-Chin Yang, Yi-Yu Su, Kun-Hsien Lu
Abstract: An image encoding/decoding method and apparatus for predicting a second color component block using a first color component block are provided. An image decoding method of the present invention comprises deriving a prediction parameter using the first color component block, and predicting the second color component block using the derived prediction parameter.
Type:
Application
Filed:
November 10, 2021
Publication date:
March 3, 2022
Applicant:
Electronics and Telecommunications Research Institute
Inventors:
Jin Ho LEE, Hyun Suk KO, Jung Won KANG, Sung Chang LIM, Ha Hyun LEE, Dong San JUN, Seung Hyun CHO, Hui Yong KIM, Jin Soo CHOI