Abstract: The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating PD-1, PD-L1, and/or PD-L2 activity (e.g., persistent infections diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-PD-1, PD-L1, and PD-L2 antibodies described herein.

Abstract: The present invention relates to a process for preparing a supported catalytic material, wherein the said process comprises a step of heating a precursor of support material which has been impregnated with a mixture of chemical precursors, wherein the said mixture includes a nitrogen-containing reducing reagent as a precursor and a transition-metal-containing compound as a precursor.

Abstract: In a method for printing a three dimensional structure, a continuous length of fiber that includes, interior to a surface of the fiber, a plurality of different materials arranged as an in-fiber functional domain, with at least two electrical conductors disposed in the functional domain in electrical contact with at least one functional domain material, is dispensed through a single heated nozzle. After sections of the length of fiber are dispensed from the heated nozzle, the sections are fused together in an arrangement of a three dimensional structure. The structure can thereby include a continuous length of fiber of least three different materials arranged as an in-fiber functional device, with the continuous length of fiber disposed as a plurality of fiber sections that are each in a state of material fusion with another fiber section in a spatial arrangement of the structure.

Abstract: A system for training transfer models that includes a memory and a processor coupling to each other. The memory stores instructions. The processor accesses the instructions to retrieve raw datasets from a first-type device and train a feature extraction model, a transfer feature and a preliminary classify model based on the raw datasets. The processor further transfers the feature extraction model, the transfer feature and the preliminary classify model to a host of a manufacturer so that the host directly applies the feature extraction model and the transfer feature, and retrains the preliminary classify model as an adapted classify model based on practical datasets.

Abstract: The present invention provides a system tar wireless power transmission, wherein the system is a system for wireless power transmission detecting a foreign object, including a power transmitting coil for transmitting AC power, a power receiving coil for receiving the AC power transmitted from the power transmitting coil wherein the power receiving coil is spaced apart from the power transmitting coil, and a detection circuit for detecting a foreign object located between the power transmitting coil and the power receiving coil wherein a first resistor and a first detection coil connected in series, and a second resistor and a second detection coil connected in series are connected in parallel, and wherein at least one of the first detection coil and the second detection coil is disposed between the power transmitting coil and the power receiving coil.

Abstract: Disclosed are applications of a mussel adhesive protein or preparations thereof in suppression of skin inflammations. Specifically disclosed are applications of a mussel adhesive protein, preparations thereof and applications thereof in dermatitis, eczema, skin ulcer, technologies related to burns (comprising skin grafting), perniones, surgical incisions, herpes, abrasions, scars, psoriasis, erythema multiforme, skin damage after radiotherapy, skin cancers, folliculitis, urticaria and drug eruption, and applications in sunburn, polymorphous light eruption, pathological alopecia (comprising hair transplant), acne vulgaris, rosacea (that is, acne rosacea), and the like, and applications in the treatment of otitis externa.

Abstract: Disclosed are yeast cells expressing a polypeptide comprising a signal sequence and a human ApoE protein. In some embodiments the polypeptide comprises ApoE2. In some embodiments the polypeptide comprises ApoE3. In some embodiments the polypeptide comprises ApoE4. Also disclosed are methods of screening yeast cells to identify compounds that prevent or suppress Apo-induced toxicity. Compounds identified by such screens can be used to treat or prevent neurodegenerative disorders such as Alzheimer's disease. Also disclosed are methods of screening yeast cells to identify genetic suppressors or enhancers of ApoE-induced toxicity. Also disclosed are genetic suppressors or enhancers of ApoE-induced toxicity identified using the methods, and human homologs thereof. Also disclosed are methods of identifying compounds that modulate expression or activity of genetic modifiers of ApoE-induced toxicity.

Abstract: An impact resistant structure adapted to an electronic component. The impact resistant structure includes a resistance stack layer and a damping laminate. The resistance stack layer is disposed on a first surface of the electronic component, and the damping laminate is disposed on a second surface of the electronic component. The second surface of the electronic component is opposite to the first surface. The damping laminate includes a soft film and a support film, where the support film is disposed between the soft film and the electronic component.

Abstract: Methods and devices including implantable micro-sensors used to detect tissue-dissolved inert gas and to detect microbubble formation to avoid Caisson disease are described. The disclosed methods and devices are based on measuring the refractive index changes in hydrophobic liquids after absorbing an inert gas such as nitrogen. The changes in the refractive index are based on implementing one of an interferometry, optical microcavity resonance shift, a photonic crystal resonance, a beam deflection, a resonance tuning or detuning, an amplitude change, or an intensity change method.

Abstract: The present invention relates to a method of reducing a metal oxide comprising the steps of preparing a mixture by mixing a metal oxide and a metal hydride (step 1) and reducing the mixture by heat treatment (step 2) and a method of producing a photocatalyst using the same, and The method of reducing a metal oxide of the present invention can easily reduce such metal oxides as TiO2, ZrO2, V2O3, and Fe2O3.

Abstract: There are provided inter alia compounds capable of inhibiting retinal pigment epithelium (RPE) degeneration or geography atrophy (GA) associated with age-related macular degeneration (AMD), and methods of using the same.

Abstract: The present invention provides multispecific antibodies, and antigen binding fragments thereof, that potently neutralize a cytokine and that may thus be useful in the prevention and/or treatment of inflammatory and/or autoimmune diseases. In particular, the present invention provides a multispecific antibody, or an antigen binding fragment thereof, comprising at least two different domains specifically binding to at least two different, non-overlapping sites in a cytokine and an Fc moiety. The invention also relates to nucleic acids that encode such antibodies and antibody fragments and immortalized B cells and cultured plasma cells that produce such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments of the invention in screening methods as well as in the diagnosis, prophylaxis and treatment of inflammatory and/or autoimmune diseases.

Abstract: The present disclosure relates to a focus tracking system and method.

Abstract: The present invention relates to novel immobilized nanoflowers made of Transglutaminase (TGase), a method for their synthesis and applications thereof. The Transglutaminase nanoflowers of the present invention are catalytically more active without mass transfer limitation, stable and reusable, wherein the overall flower is in the nano-range, is homo-dispersed and small-sized, and wherein Transglutaminase functions both as a cross-linking enzyme and as a seeding template.

Abstract: The present invention relates to a method and an apparatus for binaural rendering an audio signal using variable order filtering in frequency domain. To this end, provided are a method for processing an audio signal including: receiving an input audio signal; receiving a set of truncated subband filter coefficients for filtering each subband signal of the input audio signal, the set of truncated subband filter coefficients being constituted by one or more FFT filter coefficients generated by performing FFT by a predetermined block size; generating at least one subframe for each subband; generating at least one filtered subframe for each subband; performing inverse FFT on the filtered subframe for each subband; and generating a filtered subband signal by overlap-adding the transformed subframe for each subband and an apparatus for processing an audio signal using the same.

Abstract: An exemplary embodiment of the invention relates to a method of fabricating a radiation emitter (100) comprising the steps of fabricating a layer stack (10) that comprises a first reflector (12), an active region (13), an oxidizable layer (21-24), and a second reflector (14); and locally removing the layer stack (10), and thereby forming a mesa (M) of the radiation emitter (100), wherein said mesa (M) comprises the first reflector (12), the active region (13), the oxidizable layer (21-24) and the second reflector (14), wherein before or after locally removing the layer stack (10) and forming said mesa (M) the following steps are carried out: vertically etching blind holes (30) inside the layer stack (10), wherein the blind holes (30) vertically extend at least to the oxidizable layer (21-24) and expose the oxidizable layer (21-24); and oxidizing the oxidizable layer (21-24) via the sidewalls (31) of the blind holes (30) in lateral direction, wherein from each hole an oxidation front (32) radially moves outwar

Abstract: Disclosed herein are an apparatus and method for generating robot interaction behavior. The method for generating robot interaction behavior includes generating co-speech gesture of a robot corresponding to utterance input of a user, generating a nonverbal behavior of the robot, that is a sequence of next joint positions of the robot, which are estimated from joint positions of the user and current joint positions of the robot based on a pre-trained neural network model for robot pose estimation, and generating a final behavior using at least one of the co-speech gesture and the nonverbal behavior.

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

Abstract: Methods for the fabrication of metal strain wave gear flexsplines using a specialized metal additive manufacturing technique are provided. The method allows the entire flexspline to be metal printed, including all the components: the output surface with mating features, the thin wall of the cup, and the teeth integral to the flexspline. The flexspline may be used directly upon removal from the building tray.

Abstract: A video display method includes: acquiring at least one frame image corresponding to a current display time point in at least one source video; reading a stage configuration file, obtaining a stage modeling parameter of the stage space at the current display time point and a corresponding relationship between the at least one frame image and the stage space according to a specific stage related parameter in the stage configuration file; according to the stage modeling parameter and the corresponding relationship, processing the at least one frame image to obtain divided regions corresponding to all display screens included in the at least one stage plane; determining display contents corresponding to the divided regions, and copying the display contents to at least one target memory; and outputting a content in the at least one target memory to the at least one stage plane for display.