Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.

Abstract: The present invention relates to the field of fuel cell stacks and stack tower or module, in particular to a sealing structure for stack tower and a stack tower. The sealing structure comprises a first component, a second component and a mica spacer, the first component and the second component are opposite to each other, the mica spacer is disposed between the first component and the second component, sealing part is arranged between the mica spacer and at least one of the first component and the second component, and the sealing part comprises a glass ceramic layer and an outer circumferential ceramic cement ring surrounding the glass cement layer; the sealing structure for stack tower has excellent sealing performance and service durability for a fuel cell system.

Abstract: Provided is a 3D printing slicing method for solving a quantization error problem. A 3D model slicing method according to an embodiment of the present invention comprises: receiving, as input, data of a 3D model to be three-dimensionally printed; calculating the height of the input 3D model; revising the height of the 3D model on the basis of a result of the calculation; and slicing the 3D model having the revised height. Accordingly, the present invention can easily and reliably solve a slicing quantization error problem even without changing the lamination thickness of a 3D printer.

Abstract: A nanoparticle comprises water-insoluble polymer matrix and an indicator constituent(s), wherein the indicator constituent(s) is released from the nanoparticle only when the polymer matrix is degraded or broken, and then an indicative effect is triggered or enhanced. A nanoparticle-based method for screening a bioactive substance and a microfluidic-based screening system have also been disclosed.

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

Abstract: Methods for the fabrication of metal strain wave gear flexsplines using a specialized metal additive manufacturing technique are provided. The method allows the entire flexspline to be metal printed, including all the components: the output surface with mating features, the thin wall of the cup, and the teeth integral to the flexspline. The flexspline may be used directly upon removal from the building tray.

Abstract: A video display method includes: acquiring at least one frame image corresponding to a current display time point in at least one source video; reading a stage configuration file, obtaining a stage modeling parameter of the stage space at the current display time point and a corresponding relationship between the at least one frame image and the stage space according to a specific stage related parameter in the stage configuration file; according to the stage modeling parameter and the corresponding relationship, processing the at least one frame image to obtain divided regions corresponding to all display screens included in the at least one stage plane; determining display contents corresponding to the divided regions, and copying the display contents to at least one target memory; and outputting a content in the at least one target memory to the at least one stage plane for display.

Abstract: A graphene manufacturing device using Joule heating includes: a chamber having a space provided therein so as to synthesize graphene; and a first roller portion and a second roller portion disposed inside the chamber to be spaced from each other such that same support a catalyst metal penetrating the interior of the chamber and are supplied with an electric current for graphene synthesis, thereby Joule-heating the catalyst metal. In order to compensate for a temperature deviation of the catalyst metal passing between the first roller portion and the second roller portion, a first area of the catalyst metal, which is close to the first roller portion, and a second area of the catalyst metal, which is close to the second roller portion, are disposed to have movement paths facing each other.

Abstract: A robotic welding systems and related methods are described. In some embodiments, a robotic welding system may generate a target trajectory based at least partly on a trajectory of a welding torch during manual operation of the welding torch; and operate one or more actuators of the system to control movement of the welding torch based at least partly on the target trajectory.

Abstract: The present disclosure provides a system and method for monitoring diesel vehicle emissions based on big data of remote sensing. The monitoring system includes a vehicle remote sensing data monitoring platform, a host computer, an emission remote sensing instrument, a vehicle driving state monitor, an information display screen and a license plate camera. The emission remote sensing instrument is used to acquire information of a pollutant in an exhaust plume. The vehicle driving state monitor is used to acquire a vehicle speed and acceleration. The license plate camera is used to capture license plate information. The host computer is used to process and calculate vehicle cycle and emission information. The vehicle remote sensing data monitoring platform is used to determine a high-emission vehicle, and pre-store information of all diesel vehicles, different driving cycle bins of each type of diesel vehicles and high-emission thresholds set for different bins.

Abstract: An exemplary embodiment of the invention relates to a method of fabricating a radiation emitter (100) comprising the steps of fabricating a layer stack (10) that comprises a first reflector (12), an active region (13), an oxidizable layer (21-24), and a second reflector (14); and locally removing the layer stack (10), and thereby forming a mesa (M) of the radiation emitter (100), wherein said mesa (M) comprises the first reflector (12), the active region (13), the oxidizable layer (21-24) and the second reflector (14), wherein before or after locally removing the layer stack (10) and forming said mesa (M) the following steps are carried out: vertically etching blind holes (30) inside the layer stack (10), wherein the blind holes (30) vertically extend at least to the oxidizable layer (21-24) and expose the oxidizable layer (21-24); and oxidizing the oxidizable layer (21-24) via the sidewalls (31) of the blind holes (30) in lateral direction, wherein from each hole an oxidation front (32) radially moves outwar

Abstract: An integrated optical beam steering device includes a planar Luneburg lens that collimates beams from different inputs in different directions within the lens plane. It also includes a curved (e.g., semi-circular or arced) grating coupler that diffracts the collimated beams out of the lens plane. The beams can be steered in the plane by controlling the direction along which the lens is illuminated and out of the plane by varying the beam wavelength. Unlike other beam steering devices, this device can operate over an extremely wide field of view—up to 180°—without any aberrations off boresight. In other words, the beam quality is uniform in all directions, unlike with aplanatic lenses, thanks to the circular symmetry of the planar Luneburg lens, which may be composed of subwavelength features. The lens is also robust to misalignment and fabrication imperfections and can be made using standard CMOS processes.

Abstract: A composite for sensing heat or infrared light includes a block copolymer including a first structural group represented by Chemical Formula 1, a second structural group represented by Chemical Formula 2, and a third structural group represented by Chemical Formula 3; and a polyvalent metal ion that is coordinated with a side chain group of the block copolymer.

Abstract: Provided is a dielectric thin film including a metal oxide. The metal oxide includes bismuth, sodium, barium, and titanium, at least a part of the metal oxide is a tetragonal crystal having a perovskite structure, and a (100) plane of at least a part of the tetragonal crystal is oriented in a normal direction do of a surface of the dielectric thin film 3.

Abstract: A communication device comprising: a wireless communication section; and a control section configured to correlate a first signal with a second signal from another communication device at a designated interval, convert a data matrix including an array of a plurality of correlation computation results into a format including a matrix product of an expanded modal matrix and an expanded signal matrix, estimate the expanded signal matrix that minimizes a predetermined norm, and estimate reception time of the second signal on a basis of the expanded signal matrix that minimizes the predetermined norm.

Abstract: The present invention relates to novel immobilized nanoflowers made of Transglutaminase (TGase), a method for their synthesis and applications thereof. The Transglutaminase nanoflowers of the present invention are catalytically more active without mass transfer limitation, stable and reusable, wherein the overall flower is in the nano-range, is homo-dispersed and small-sized, and wherein Transglutaminase functions both as a cross-linking enzyme and as a seeding template.

Abstract: Disclosed are a method and an apparatus for transmitting or receiving feedback information in a communication system. An operation method of a terminal comprises the steps of: receiving, from a base station, DCI #1 including scheduling information of PDSCH #1 and transmission resource information of HARQ response #1 with respect to PDSCH #1; receiving, from the base station, DCI #2 including scheduling information of PDSCH #2 and transmission resource information of HARQ response #2 with respect to PDSCH #2; and when the transmission resource information of HARQ response #1 is configured as undefined, transmitting, to the base station, HARQ response #1 and HARQ response #2 by using a resource indicated by the transmission resource information of HARQ response #2. Therefore, the performance of the communication system can be improved.

Abstract: The present invention discloses the use of RNA inhibitory molecules, particularly siRNA molecules silencing the expression of Voltage-Dependent Ion Chanel-1 (VDAC1) for the induction of cancer stem cell differentiation and reduction of TAMS abundance and tumor angiogenesis, thereby preventing tumor invention and recurrence.

Abstract: A negative electrode active material, a negative electrode and a battery are provided. The negative electrode active material includes an active particle and a modification layer. The active particle contains a silicon element, a carbon element, or a combination thereof. The modification layer covers on the surface of the active particle. The modification layer contains a reactive functional group of a coupling agent and a residual functional group of a metal compound. The reactive functional group of the coupling agent is bounded between the active particle and the residual functional group of the metal compound. The residual functional group of the metal compound contains a metal atom.