Patents Assigned to INSTITUTE
  • Publication number: 20220034853
    Abstract: The present invention provides a snake venom thrombin marker peptide of Agkistrodon Halys Pallas and an application of the snake venom thrombin-like enzyme in identifying species of Hemocoagulase for Injection. The application includes the following steps of: dissolving a to-be-detected sample and a reference substance of the marker peptide respectively to prepare a test solution and a reference solution, and conducting alkylation reduction on the test solution and the reference solution with dithiothreitol and iodoacetamide; after diluting products with an ammonium bicarbonate solution, adding enzyme for hydrolysis; and after enzymolysis is finished, conducting centrifugation at a high speed, and injecting a supernatan into a liquid chromatography-mass spectrometer for analysis. This method is simple, convenient and rapid, is strong in specificity, fills the gap in identifying the source of species of the snake venom thrombin-like enzyme of Agkistrodon Halys Pallas and improves the quality control level.
    Type: Application
    Filed: July 30, 2021
    Publication date: February 3, 2022
    Applicants: Shandong Institute for Food and Drug Control, Shandong University, Avanc Pharmaceutical Co.,Ltd
    Inventors: Ruiqing Xian, Feng Shi, Liping Gong, Lianli Chi, Qunye Zhang, Weijian Wang, Hongming Du, Congcong Wang, Baojian Hang, Fengshan Wang
  • Publication number: 20220034869
    Abstract: A system and method for isolating target substrates includes a microfluidic chip, comprising a plurality of processing units, each processing unit comprising: an inlet port, a plurality of first chambers connected to the inlet port by a fluid channel, the fluid channel comprising a plurality of valves, a plurality of second chambers, each of the second chambers connected to a respective first chamber by a fluid channel, each fluid channel including a controllable blocking valve, and a plurality of respective outlet ports, each outlet port in fluid communication with a respective one of said second chambers and each outlet port including a blocking valve. A magnet is adjacent the microfluidic chip and is movable relative to the microfluidic chip. A valve control is capable of actuating certain ones of the controllable blocking valves in response to a control signal.
    Type: Application
    Filed: January 29, 2021
    Publication date: February 3, 2022
    Applicants: THE BROAD INSTITUTE, INC., MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THE GENERAL HOSPITAL CORPORATION
    Inventors: Paul Blainey, Dwayne Vickers, Nir Hacohen
  • Publication number: 20220036671
    Abstract: A rollover alarming system, a rollover risk prediction method, and a rollover alarming method. An axle housing strain measurement unit measures strain values on both sides of an axle housing of a vehicle body. A roll angle measurement unit measures a roll angle of the vehicle body. A collection control unit is configured to collect the strain values on both sides of the axle housing of the vehicle body and the roll angle of the vehicle body, calculate a strain difference between the strain values according to the strain values on both sides of the axle housing of the vehicle body, and output a corresponding alarm control signal according to the strain difference between both sides of the axle housing of the vehicle body and the roll angle of the vehicle body. An alarm unit is configured to output a corresponding alarm signal according to the received alarm control signal.
    Type: Application
    Filed: June 2, 2020
    Publication date: February 3, 2022
    Applicant: JIANGSU XCMG CONSTRUCTION MACHINERY RESEARCH INSTITUTE LTD.
    Inventors: Chunlei LIU, Yanbo GENG, Li WANG
  • Publication number: 20220032041
    Abstract: Disclosed is a muscle stimulation system, comprising a wearable garment including a plurality of electrodes, and a processor; wherein the processor is configured to define one or more regions of interest (ROI) for electrode activation via a subset of the plurality of electrodes, and provide electrical muscle stimulation, via the subset of the plurality of electrodes, to the ROI.
    Type: Application
    Filed: July 30, 2021
    Publication date: February 3, 2022
    Applicant: Battelle Memorial Institute
    Inventors: Collin F. Dunlap, Sam Colachis, Joshua R. Branch
  • Publication number: 20220031195
    Abstract: The invention provides a gait evaluating system and a gait evaluating method. The gait evaluation system includes a gait evaluating device configured to: obtain, from a pressure detection device, a plurality of pressure values of a user walking on the pressure detection device; obtain a plurality of step feature values of the user based on the pressure values; obtain a plurality of walking limb feature values when the user walks on the pressure detection device based on a sensing data provided by a limb sensing device; and evaluate a gait of the user based on the step feature values and the walking limb feature values.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 3, 2022
    Applicant: Industrial Technology Research Institute
    Inventors: Je-Ping Hu, Keng-Hsun Lin, Shih-Fang Yang Mao, Pin-Chou Li, Jian-Hong Wu, Szu-Ju Li, Hui-Yu Cho, Yu-Chang Chen, Yen-Nien Lu, Jyun-Siang Hsu, Nien-Ya Lee, Kuan-Ting Ho, Ming-Chieh Tsai, Ching-Yu Huang
  • Publication number: 20220031817
    Abstract: The use of a purine nucleoside phosphorylase or nucleoside hydrolase or a vector encoding expression of one of these enzymes is detailed along with the use of a prodrug cleaved by the purine nucleoside phosphorylase or nucleoside hydrolase for the preparation of a direct injection inhibition of replicating or non-replicating targeted cells. The targeted cells do not normally express the introduced purine nucleoside phosphorylase or nucleoside hydrolase. The enzyme and prodrug are amenable to intermixing and injection as a single dose or as separate injection or administration to the targeted cells. The substance and prodrug efficacy are enhanced through exposure of the targeted cells to X-ray radiation. Administration of a prodrug regardless of administration route to the targeted cells is effective in combination with X-ray radiation therapy to kill or inhibit function of the targeted cells.
    Type: Application
    Filed: October 15, 2021
    Publication date: February 3, 2022
    Applicants: The UAB Research Foundation, Southern Research Institute
    Inventors: William B. Parker, Eric J. Sorscher
  • Publication number: 20220038712
    Abstract: An intra prediction mode encoding and decoding method, an image decoding device, and an image encoding device operate by deriving most probable modes (MPMs) from surrounding prediction units adjacent to a current prediction unit and deriving an intra prediction mode of the current prediction unit on the basis of an MPM flag indicating whether an MPM having the same prediction mode as the intra prediction mode of the current prediction unit exists among the derived MPMs.
    Type: Application
    Filed: October 18, 2021
    Publication date: February 3, 2022
    Applicants: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE, INTELLECTUAL DISCOVERY CO., LTD.
    Inventors: Jin Ho LEE, Hui Yong KIM, Sung Chang LIM, Jin Soo CHOI, Jin woong KIM, Jae Gon KIM, Hae Chul CHOI, Sang Yong LEE
  • Publication number: 20220033830
    Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.
    Type: Application
    Filed: March 1, 2021
    Publication date: February 3, 2022
    Applicants: Trustees of Boston University, Massachusetts Institute of Technology
    Inventors: Timothy Kuan-Ta Lu, Robert James Citorik, James Collins, Russell-John Krom
  • Publication number: 20220033402
    Abstract: Disclosed are compounds that inhibit ALK, TRKA, TRKB, TRKC and ROS1. Also disclosed are pharmaceutical compositions containing the compounds and methods of using the compounds to treat disease.
    Type: Application
    Filed: September 26, 2019
    Publication date: February 3, 2022
    Applicant: DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Nathanael S. Gray, John M. Hatcher
  • Publication number: 20220033789
    Abstract: The invention relates to a GDSL lipase, genetically-engineered bacteria and an application thereof. The GDSL lipase is derived from Streptomyces diastaticus CS1801 and its amino acid sequence is as shown in SEQ ID NO.2. After construction of a genetically-engineered bacterium strain, a GDSL lipase is generated through fermentation. Through this enzyme, vitamin A and palmitic acid are converted to produce vitamin A palmitate. The content of the vitamin A palmitate obtained from the conversion is 16.35 mg/L at most. The conversion efficiency is 81.75% at most. This lipase provides a new path to synthesize vitamin A palmitate by the enzymatic method and has an important application prospect.
    Type: Application
    Filed: October 31, 2019
    Publication date: February 3, 2022
    Applicant: CHANGSHU INSTITUTE OF TECHNOLOGY
    Inventors: Limei WANG, Tiantian XU, Yamei JI, Bin QI
  • Publication number: 20220033413
    Abstract: The present invention relates to new compounds derived from marine actinomycetes Streptomyces, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.
    Type: Application
    Filed: June 3, 2019
    Publication date: February 3, 2022
    Applicant: KOREA INSTITUTE OF OCEAN SCIENCE & TECHNOLOGY
    Inventors: Hee Jae SHIN, Byeoung Kyu CHOI, Hwa Sun LEE, Hyi Seung LEE, Yeon Ju LEE, Jong Seok LEE, Ji Hoon LEE
  • Publication number: 20220034772
    Abstract: A method for analyzing stable isotopes of particulate organic carbon (POC) and nitrogen in seawater using elemental analysis-isotope ratio mass spectrometry (EA-IRMS), including: using a glass fiber filter membrane to filter a collected water sample and then filter 100 ml of distilled water; subjecting a resulting membrane sample to acidification; and subjecting an acidified membrane sample to EA-IRMS analysis on a machine, where an oxygen addition time is set to 80 s and a combustion tube temperature is set to 700° C. for an elemental analyzer, and a trap current is set to 300 ?A to 400 ?A for an isotope ratio mass spectrometer. The method of the present disclosure can reduce a detection cost and improve the data accuracy and work efficiency.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 3, 2022
    Applicant: YELLOW SEA FISHERIES RESEARCH INSTITUTE, CHINESE ACADEMY OF FISHERY SCIENCES
    Inventors: Yi LIU, Jihong ZHANG, Wenguang WU, Ke SUN
  • Publication number: 20220034990
    Abstract: A positioning method and apparatus for positioning a terminal by using various data combinations are disclosed. The present disclosure in at least one embodiment provides a positioning terminal by using data combinations, including a data collection unit for collecting n access point (AP) scan data items from each of n APs (n is a natural number), a combination generation unit for generating a plurality of data combinations by combining the n AP scan data items in units of k (k is integers from 3 up to n), a position estimation unit for estimating a plurality of preliminary positions of the terminal from the plurality of data combinations, a clustering unit configured to cluster the plurality of preliminary positions into at least one cluster according to distances or densities of the plurality of preliminary positions, and a position determination unit for determining a final position of the terminal based on at least one cluster.
    Type: Application
    Filed: October 19, 2021
    Publication date: February 3, 2022
    Applicant: Korea Railroad Research Institute
    Inventor: Seung Min YU
  • Publication number: 20220036104
    Abstract: Disclosed are a biometric device and a biometric system including the same. The device includes a hiogenic-synthesized film, a reflective layer disposed on one side of the biogenic-synthesized film, a light source disposed on the reflective layer to generate light, a beam splitter disposed between the light source and the reflective layer to provide the light to the reflective layer and another side of the biogenic-synthesized film, and a light switching layer disposed between the beam splitter and the reflective layer to switch the light provided to the reflective layer.
    Type: Application
    Filed: May 26, 2021
    Publication date: February 3, 2022
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: YOUNG SAM PARK, Seung Youl KANG, Chul Woong JOO, Jae-Eun PI
  • Publication number: 20220036776
    Abstract: A spliced display including a transparent substrate, a plurality of micro (light-emitting diodes) LEDs, and a plurality of light sensors is provided. The transparent substrate has a display surface and a back surface opposite to each other. The driving backplanes are disposed on the back surface of the transparent substrate to be spliced with each other. The micro LEDs are disposed on the driving backplanes respectively and located between the micro LEDs and the transparent substrate. Each of the driving backplanes is corresponding to parts of the micro LEDs. The light sensors are disposed on the transparent substrate and located between the driving backplanes and the transparent substrate. Each of the light sensors is adjacent to at least two of the micro LEDs, and at least one of the at least two of the micro LEDs is adjacent to two of the light sensor.
    Type: Application
    Filed: September 24, 2021
    Publication date: February 3, 2022
    Applicant: Industrial Technology Research Institute
    Inventors: Chia-Hsin Chao, Ming-Hsien Wu, Yen-Hsiang Fang, Po-Hsun Wang, Li-Chun Huang
  • Publication number: 20220038218
    Abstract: An operation method of a terminal in a communication system may comprise: receiving one or more data units from a base station; generating a HARQ codebook for at least one dada unit of the one or more data units at a reference time; and transmitting the HARQ codebook to the base station, wherein the reference time is shared by the terminal and the base station.
    Type: Application
    Filed: July 22, 2021
    Publication date: February 3, 2022
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventors: Cheul Soon KIM, Sung Hyun MOON, Jung Hoon LEE
  • Publication number: 20220034856
    Abstract: The present invention relates to the field of chemical analysis detection and application, in particular to a marker peptide of snake venom thrombin-like enzymes (SVTLEs) from Agkistrodon Halys Pallas and an application thereof. The amino acid sequence of the marker peptide of snake venom thrombin-like enzymes (SVTLEs) from Agkistrodon Halys Pallas is TLCAGVMEGGIDTCNR. Characterizing the source of species and a content of the SVTLEs in a to-be-detected sample by using the marker peptide includes the following steps of: pretreating the to-be-detected sample by trypsin through enzymolysis, and taking a supernatant of an enzymolysis liquid as a test solution; and injecting the test solution and a reference solution into a liquid chromatography-mass spectrometer, and selecting a qualitative ion pair and a quantitative ion pair for detecting the source of species and a content of the SVTLEs in the to-be-detected sample.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 3, 2022
    Applicants: Shandong Institute for Food and Drug Control, Shandong University, Avanc Pharmaceutical Co.,Ltd
    Inventors: Feng Shi, Ruiqing Xian, Liping Gong, Weijian Wang, Lianli Chi, Congcong Wang, Baojian Hang, Xunjie Zhang, Li Nie, Fengshan Wang
  • Publication number: 20220034925
    Abstract: A gene analyzer has a structure in which a metal block, a heater installed on an outer surface of the metal block, and a heat insulator applied onto an outer surface of the heater are integrally formed, thereby miniaturizing the gene analyzer. Further, parts for light measurement, such as a light source element, a light-receiving element, a light source filter, a fluorescent filter, a light source lens, a fluorescent lens, and the like, are installed in a heat insulator light source path and a heat insulator fluorescent path formed in the heat insulator, and the paths formed in the heat insulator are aligned with a block light source path and a block fluorescent path of the metal block.
    Type: Application
    Filed: August 2, 2021
    Publication date: February 3, 2022
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: Kwang Hyo CHUNG, Jin Tae KIM, Dae Heon PARK
  • Publication number: 20220038070
    Abstract: A method for preparing a film bulk acoustic wave device by using a film transfer technology includes: 1) providing an oxide monocrystal substrate; 2) implanting ions from the implantation surface into the oxide monocrystal substrate, and then forming a lower electrode on the implantation surface; or vice versa; and forming a defect layer at the preset depth; 3) providing a support substrate and bonding a structure obtained in step 2) with the support substrate; 4) removing part of the oxide monocrystal substrate along the defect layer so as to obtain an oxide monocrystal film, and transferring the obtained oxide monocrystal film and the lower electrode to the support substrate; 5) etching the support substrate from a bottom of the support substrate to form a cavity; 6) forming an upper electrode on the surface of the oxide monocrystal film.
    Type: Application
    Filed: July 10, 2017
    Publication date: February 3, 2022
    Applicant: SHANGHAI INSTITUTE OF MICROSYSTEM AND INFORMATION TECHNOLOGY, CHINESE ACADEMY OF SCIENCES
    Inventors: XIN OU, KAI HUANG, QI JIA, SHIBIN ZHANG, TIANGUI YOU, XI WANG
  • Publication number: 20220038910
    Abstract: Disclosed herein are a method for ensuring trustworthiness of a packet in a distributed synchronous wireless communication system and an apparatus using the method. The method, performed by terminals and an apparatus for checking the trustworthiness of a packet, includes: transmitting, by a first terminal, a packet including a trust field to a second terminal using distributed wireless communication; receiving, by a third terminal, the packet from the first terminal; requesting, by the third terminal, checking of trustworthiness by delivering the packet and information about the packet reception time to the apparatus; checking, by the apparatus, the trustworthiness of the packet using the trust field and the information about the packet reception time; generating, by the apparatus, a trust result notification packet when the result of checking the trustworthiness indicates that the packet is untrusted; and transmitting, by the apparatus, the trust result notification packet to the second terminal.
    Type: Application
    Filed: July 19, 2021
    Publication date: February 3, 2022
    Applicant: ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
    Inventor: Hyun-Gu HWANG