Abstract: A method and device for simulating microstructure evolution of a material based on solution in an exponential time-difference format. The method includes: establishing a reaction rate theory model for substance defects, wherein the model is expressed with equations that comprise linear terms having coefficients characterized with matrixes; and iteratively solving the equations by using an exponential time-difference format, wherein during the iterative solving, the linear terms with exponential powers of the matrixes as the coefficients are integrated. Since a rate theory is not limited by spatial-temporal scales, the advantages of the rate theory can be significantly reflected when the microstructure evolution is simulated under a high damage dose condition; and then, the equations are solved by using the exponential time-difference format, with a solved result better in accuracy and higher in precision.

Abstract: The present invention discloses the use of RNA inhibitory molecules, particularly siRNA molecules silencing the expression of Voltage-Dependent Ion Chanel-1 (VDAC1) for the induction of cancer stem cell differentiation and reduction of TAMS abundance and tumor angiogenesis, thereby preventing tumor invention and recurrence.

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

Abstract: The present invention relates to novel immobilized nanoflowers made of Transglutaminase (TGase), a method for their synthesis and applications thereof. The Transglutaminase nanoflowers of the present invention are catalytically more active without mass transfer limitation, stable and reusable, wherein the overall flower is in the nano-range, is homo-dispersed and small-sized, and wherein Transglutaminase functions both as a cross-linking enzyme and as a seeding template.

Abstract: A video display method includes: acquiring at least one frame image corresponding to a current display time point in at least one source video; reading a stage configuration file, obtaining a stage modeling parameter of the stage space at the current display time point and a corresponding relationship between the at least one frame image and the stage space according to a specific stage related parameter in the stage configuration file; according to the stage modeling parameter and the corresponding relationship, processing the at least one frame image to obtain divided regions corresponding to all display screens included in the at least one stage plane; determining display contents corresponding to the divided regions, and copying the display contents to at least one target memory; and outputting a content in the at least one target memory to the at least one stage plane for display.

Abstract: Target state inference unit infers a target state of a system and a partial target state thereof between a first state of the system and the target state thereof based on the first state, inference knowledge, and quantitative knowledge, the system being configured to be operated based on a manipulation procedure. Manipulation sequence inference unit infers a manipulation for a transition to the partial target state based on a manipulation derivation rule. Learning setting generation unit generates a learning setting for the inferred manipulation based on a learning setting derivation rule. A learning agent creates information about detailed manipulations in the manipulation based on the learning setting for the manipulation.

Abstract: The image decoding method according to the present invention comprises the steps of: determining the availability of a block adjacent to a current block; configuring a merge candidate list for the current block on the basis of the result of the determined availability; and performing motion compensation for the current block on the basis of the merge candidate list, wherein the step of determining availability comprises the steps of inducing block availability information on the adjacent block and inducing the availability of motion information on the adjacent block, and the step of determining the availability of the adjacent block is such that when there is more than one adjacent block, the availability of adjacent blocks can be determined in accordance with a predetermined order restriction.

Abstract: Compositions and methods are provided comprising choline acetyltransferase (ChAT) and PEGylated ChAT for treating hypertension.

Abstract: Disclosed is an image data encoding/decoding method and apparatus. A method for decoding a 360-degree image comprises the steps of: receiving a bitstream obtained by encoding a 360-degree image; generating a prediction image by making reference to syntax information obtained from the received bitstream; combining the generated prediction image with a residual image obtained by dequantizing and inverse-transforming the bitstream, so as to obtain a decoded image; and reconstructing the decoded image into a 360-degree image according to a projection format.

Abstract: A negative electrode active material, a negative electrode and a battery are provided. The negative electrode active material includes an active particle and a modification layer. The active particle contains a silicon element, a carbon element, or a combination thereof. The modification layer covers on the surface of the active particle. The modification layer contains a reactive functional group of a coupling agent and a residual functional group of a metal compound. The reactive functional group of the coupling agent is bounded between the active particle and the residual functional group of the metal compound. The residual functional group of the metal compound contains a metal atom.

Abstract: A method of fabricating a radiation emitter including fabricating a layer stack that includes a first reflector, at least one intermediate layer, an active region and a second reflector; locally oxidizing the intermediate layer and thereby forming at least one unoxidized aperture; and locally removing the layer stack, and thereby forming a mesa that includes the first reflector, the unoxidized aperture, the active region, and the second reflector. Before or after locally removing the layer stack and forming the mesa: forming at least a first unoxidized aperture and at least a second unoxidized aperture inside the intermediate layer; etching a trench inside the layer stack, the trench defining a first portion and a second portion of the mesa, wherein the trench severs the intermediate layer(s) so that the first aperture is located in the first portion and the second aperture is located in the second portion of the mesa.

Abstract: Disclosed herein is a method of decoding an image including determining whether a current block is in a bi-directional optical flow (BIO) mode, calculating gradient information of prediction samples of the current block when the current block is in the BIO mode, and generating a prediction block of the current block using the calculated gradient information, wherein the calculating of the gradient information of the prediction samples of the current block includes calculating the gradient information using at least one neighbor sample adjacent to the prediction samples.

Abstract: Provided is a 3D printing slicing method for solving a quantization error problem. A 3D model slicing method according to an embodiment of the present invention comprises: receiving, as input, data of a 3D model to be three-dimensionally printed; calculating the height of the input 3D model; revising the height of the 3D model on the basis of a result of the calculation; and slicing the 3D model having the revised height. Accordingly, the present invention can easily and reliably solve a slicing quantization error problem even without changing the lamination thickness of a 3D printer.

Abstract: An exemplary embodiment of the invention relates to a method of fabricating a radiation emitter (100) comprising the steps of fabricating a layer stack (10) that comprises a first reflector (12), an active region (13), an oxidizable layer (21-24), and a second reflector (14); and locally removing the layer stack (10), and thereby forming a mesa (M) of the radiation emitter (100), wherein said mesa (M) comprises the first reflector (12), the active region (13), the oxidizable layer (21-24) and the second reflector (14), wherein before or after locally removing the layer stack (10) and forming said mesa (M) the following steps are carried out: vertically etching blind holes (30) inside the layer stack (10), wherein the blind holes (30) vertically extend at least to the oxidizable layer (21-24) and expose the oxidizable layer (21-24); and oxidizing the oxidizable layer (21-24) via the sidewalls (31) of the blind holes (30) in lateral direction, wherein from each hole an oxidation front (32) radially moves outwar

Abstract: Disclosed is a method of supporting wireless Internet mobility including receiving, by a mobility support server, at least one service condition selected from a service condition group consisting of mobility support target information, network information, service quality information, ubiquitous thing information, communication mode information, and access node terminal information to provide an Internet service to a mobility support target, registering, by the mobility support server, support information for the mobility support target according to the at least one service condition, providing, by the mobility support server, an Internet service for the mobility support target on the basis of the at least one service condition, and supporting, by the mobility support server, mobility for the mobility support target on the basis of the at least one service condition.

Abstract: The present disclosure relates to compositions and methods for the diagnosis and treatment or prevention of proteinopathies, particularly MUC1-associated kidney disease (ADTKD-MUC1 or MKD), Retinitis Pigmentosa (e.g., due to rhodopsin mutations), autosomal dominant tubulo-interstitial kidney disease due to UMOD mutation(s) (ADTKD-UMOD), and other forms of toxic proteinopathies resulting from mutant protein accumulation in the ER or other secretory pathway compartments and/or vesicles, among others. The disclosure also identifies and provides TMED9-binding agents as capable of treating or preventing proteinopathies of the secretory pathway, and further provides methods for identifying additional TMED9-binding agents.

Abstract: A graphene manufacturing device using Joule heating includes: a chamber having a space provided therein so as to synthesize graphene; and a first roller portion and a second roller portion disposed inside the chamber to be spaced from each other such that same support a catalyst metal penetrating the interior of the chamber and are supplied with an electric current for graphene synthesis, thereby Joule-heating the catalyst metal. In order to compensate for a temperature deviation of the catalyst metal passing between the first roller portion and the second roller portion, a first area of the catalyst metal, which is close to the first roller portion, and a second area of the catalyst metal, which is close to the second roller portion, are disposed to have movement paths facing each other.

Abstract: The present invention provides novel compounds of Formulae (I?), (I), (II?), and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, ovarian cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g.

Abstract: Disclosed herein are an apparatus and method for generating robot interaction behavior. The method for generating robot interaction behavior includes generating co-speech gesture of a robot corresponding to utterance input of a user, generating a nonverbal behavior of the robot, that is a sequence of next joint positions of the robot, which are estimated from joint positions of the user and current joint positions of the robot based on a pre-trained neural network model for robot pose estimation, and generating a final behavior using at least one of the co-speech gesture and the nonverbal behavior.

Abstract: In a plasma electrolytic oxidation apparatus and a method of plasma electrolytic oxidation using the plasma electrolytic oxidation apparatus, the plasma electrolytic oxidation apparatus includes a chamber and an electrode unit. The chamber is configured to receive an electrolyte. The electrode unit is configured to receive the electrolyte from the chamber and to treat an object with a plasma electrolytic oxidation treatment. The electrode unit includes an electrode, an enclosing part and a cover. The electrode is configured to receive a voltage from outside, and to form a receiving space in which the electrolyte is received between the electrode and the object. The enclosing part is configured to enclose a gap between the electrode and the object. The cover is configured to cover the electrode.