Patents Assigned to INSTITUTE
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Patent number: 11253367Abstract: There is provided a scaffold for bone regeneration which is adapted to be implanted at a bone defect site of a bone. The scaffold comprises a main support member configured to be fixed to the bone, and a load supporting unit configured to be installed in the bone defect site of the bone to selectively bear a load applied to the bone. The load supporting unit includes one or two supporting pieces to be installed in the bone defect site of the bone to selectively bear a load applied to the bone. The supporting piece has at one end portion a contact portion to be brought into contact with and fixed to a compact bone in the bone defect site of the bone. The other end portion of the supporting piece is selectively coupled to the main support member.Type: GrantFiled: September 9, 2019Date of Patent: February 22, 2022Assignee: Institute for Advanced EngineeringInventors: Kyoung-Don Lee, Tae-Suk Suh, Jong Won Rhie, Ki-Young Park, Jae-Sung Kim, Byeong-Ju Jin, Ki Joo Kim, Do-kun Yoon
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Patent number: 11258968Abstract: Examples of image sensors are described herein. In an example, an image sensor may comprise an array of hybrid pixels, where each hybrid pixel includes light sensing unit and a non-volatile memory component coupled to the light sensing unit. The light sensing unit comprises a light detecting element and a charge to voltage conversion unit. The charge to voltage conversion unit is to provide an output pixel signal (VPD), based on photo-electrons generated by the light detecting element. Further, the non-volatile component when calibrated to an initial resistance state is to compress the output pixel signal (VPD) during exposure.Type: GrantFiled: December 28, 2016Date of Patent: February 22, 2022Assignee: Indian Institute of Technology DelhiInventors: Manan Suri, Mukul Sarkar
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Patent number: 11253581Abstract: The present disclosure relates to a composition for preventing and treating Mycoplasma synoviae infection, the composition comprising Tuf, NOX, MS53-0285 or a combination thereof as active ingredients. The composition of the present disclosure is effective in alleviating symptoms caused by Mycoplasma synoviae infection and can be used as an effective tool in preventing or treating poultry diseases.Type: GrantFiled: November 1, 2017Date of Patent: February 22, 2022Assignee: AGRICULTURAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jiunn-Horng Lin, Ho-Yuan Chou, Jyh-Perng Wang, Zeng-Weng Chen, Weng-Zeng Huang, Hsiu-Hui Wu, Hui-Jie Lin, Sheng-Xiang Huang
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Patent number: 11257602Abstract: A new column-based purification system and approach are described for rapid separation and purification of the alpha-emitting therapeutic radioisotope 211At from dissolved cyclotron targets that provide highly reproducible product results with excellent 211At species distributions and high antibody labeling yields compared with prior art manual extraction results of the prior art that can be expected to enable enhanced production of purified 211At isotope products suitable for therapeutic medical applications such as treatment of cancer in human patients.Type: GrantFiled: March 8, 2018Date of Patent: February 22, 2022Assignee: Battelle Memorial InstituteInventor: Matthew J. O'Hara
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Patent number: 11258231Abstract: A GaN-based VCSEL chip based on porous DBR and a manufacturing method of the same, wherein the chip includes: a substrate; a buffer layer formed on the substrate; a bottom porous DBR layer formed on the buffer layer; an n-type doped GaN layer formed on the bottom porous DBR layer, which is etched downward on its periphery to form a mesa; an active layer formed on the n-type doped GaN layer; an electron blocking layer formed on the active layer; a p-type doped GaN layer formed on the electron blocking layer; a current limiting layer formed on the p-type doped GaN layer with a current window formed at a center thereof, wherein the current limiting layer covers sidewalls of the active layer, the electron blocking layer and the convex portion of the n-type doped GaN layer; a transparent electrode formed on the p-type doped GaN layer; an n-electrode formed on the mesa of the n-type doped GaN layer; a p-electrode formed on the transparent electrode with a recess formed therein; and a dielectric DBR layer formed onType: GrantFiled: June 1, 2017Date of Patent: February 22, 2022Assignee: Institute of Semiconductors, Chinese Academy of SciencesInventors: Lixia Zhao, Chao Yang, Lei Liu, Jing Li, Kaiyou Wang, Hongda Chen
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Patent number: 11254781Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.Type: GrantFiled: February 25, 2021Date of Patent: February 22, 2022Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Biocant-Center of Innovation and BiotechnologyInventors: Robert S. Langer, Jeffrey M. Karp, Maria Jose Maio Nunes-Pereira, Ben Ouyang, Lino da Silva Ferreira, Debanjan Sarkar
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Patent number: 11255220Abstract: Heat exchanger assemblies and methods for providing heat exchange as well as methods providing specific energy to predetermined materials within an assembly as well as gas turbine engines as well as methods of powering same are provided. Heating assemblies are provided that can include: a heat-sinking substrate; and a selective emitter layer in thermal communication with the substrate. These assemblies can be provided as part of heat exchanger assemblies. Methods for providing heat to a fluid are also provided that can include heating a layer upon a substrate to provide photons of a predetermined wavelength to a fluid from the layer. Turbine combustion engines are also provided that can include a turbine having at least a portion of the blades in the hot section of the turbine coated with an emissivity layer in thermal communication with the turbine blade. Methods for powering turbine combustion engines are also provided.Type: GrantFiled: October 2, 2020Date of Patent: February 22, 2022Assignee: Battelle Memorial InstituteInventors: B. Peter McGrail, Jeromy J. Jenks, Bruce E. Bernacki
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Patent number: 11255656Abstract: Our high phase sensitivity wide-field phase cancellation interferometry system allows single-shot, label-free optical sensing of neural action potentials via imaging of optical path length changes. Single-shot sensing and monitoring of single neurons within a neural network should lead to a more comprehensive understanding neural network processing, which is beneficial for the advancement in the field of neuroscience as well as its biomedical applications and impact. Our system cancels the phase profile of the resting neuron from the phase profile of the spiking neuron, improving the sensitivity by two orders of magnitude. Using a detector with an extremely large well depth and an appropriately biased interferometer increases the sensitivity by another order of magnitude, yielding a measurement that is three orders of magnitude more sensitive than those possible with other microscopes.Type: GrantFiled: January 4, 2021Date of Patent: February 22, 2022Assignee: Massachusetts Institute of TechnologyInventors: Peter T. C. So, Zahid Yaqoob, Dominika Lyzwa, Vijay Singh, Dushan N. Wadduwage
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Patent number: 11254156Abstract: An approach to printing a nickel precursor ink on a wide range of substrates for electronics and magnetic applications is disclosed. The nickel ink reduces to elemental nickel following heating. The ink was printed using an ultrasonic aerosol printing technique. By sintering the nickel precursor ink in the presence of a homogeneous magnetic field, the reduced nickel complex formed continuously aligned nickel nanofibers axially aligned with the direction of the magnetic field. The fabrication of aligned interlayered nanofiber films provides opportunities to produce structures with enhanced isotropic electrical and magnetic properties. The resistivity of the film was found to be as low as 0.56 m?·cm, and the saturation magnetization was measured to be 30 emu/g, which is comparable to bulk Ni. Magnetic anisotropy was induced with an easy axis along the direction of the applied magnetic field with soft magnetic properties.Type: GrantFiled: April 18, 2019Date of Patent: February 22, 2022Assignee: Rochester Institute of TechnologyInventors: Chaitanya G. Mahajan, Denis Cormier, Mark Irving, Scott Williams, David Borkholder, Ahmed Alfadhel
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Patent number: 11254790Abstract: The present invention discloses a silicone rubber and a method for preparing it, and a phenolic modified silicone rubber resin and a method for preparing it. The structural formula of the silicone rubber is shown as follows: Wherein x=70-80, y=10-20. The structural formula of the phenolic-modified silicone rubber resin is shown as follows: wherein n, x, y are degrees of polymerization, n=10-20, x=70-80, y=10-20. A method for preparing the phenolic-modified silicone rubber resin orderly comprises: adding 90-110 parts by mass of brominated phenolic resin and 180-220 parts of organic solvent into 100 parts by mass of silicone rubber, reacting at 70-80° C. for 24-48 h until the solution is clear and transparent; adding 9-11 parts by mass of capping agent, reacting for another 4-5 h to obtain a reaction liquid containing phenolic-modified silicone rubber resin.Type: GrantFiled: September 14, 2018Date of Patent: February 22, 2022Assignee: AEROSPACE RESEARCH INSTITUTE OF MATERIALS & PROCESSING TECHNOLOGYInventors: Chen He, Wu Lu, Boqian Li, Yibing Zeng, Junshan Wang
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Patent number: 11255276Abstract: Spark ignition engine operation at higher RPM so as to reduce alcohol requirements in high efficiency alcohol enhanced gasoline engines is disclosed. Control of engine upspeeding (use of a higher ratio of engine RPM to wheel RPM) so as to achieve an alcohol reduction objective while limiting any decrease in efficiency is described. High RPM alcohol enhanced gasoline engine operation in plug-in series hybrid powertrains for heavy duty trucks and other vehicles is also described.Type: GrantFiled: September 24, 2018Date of Patent: February 22, 2022Assignee: Massachusetts Institute of TechnologyInventors: Daniel R. Cohn, Leslie Bromberg
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Patent number: 11255740Abstract: The present invention is related to a sensor. In particular, the present invention is related to a pressure sensor die and its fabrication process. The pressure sensor comprises a chamber inside which a pressure sensor die is provided. The pressure sensor die is uniformly compressed by the external pressure to be measured and can deform freely inside the chamber. The pressure sensor die is primarily constructed of single crystalline silicon and comprises a substrate and a cap connected together. A recess is formed on the cap. The recess forms a sealed cavity with the substrate. A silicon oxide layer is formed between the substrate and the cap. The substrate further comprises a plurality of piezoresistive sensing elements which are located inside the sealed cavity. The present pressure sensor is more immune to temperature effects. It is especially suitable for operating in a high temperature, high pressure environment and is capable of delivering accurate and reliable pressure measurements at low cost.Type: GrantFiled: February 28, 2017Date of Patent: February 22, 2022Assignee: Chinese Academy of Sciences Institute of Geology and GeophysicsInventors: Kevin Chau, Man Wong
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Patent number: 11254730Abstract: The present invention provides a recombinant protein or a derivative thereof, wherein the recombinant protein has an amino acid sequence of the N-terminal portion of CC chemokine receptor 4 (CCR4). The invention also provides the use of the recombinant protein or a derivative thereof for treating or preventing a disease or condition associated with CCR4 signaling, such as an allergic disease, inflammatory enteritis, psoriasis, an inflammatory skin disease, vasculitis, spondyloarthropathy, scleroderma, asthma, a respiratory allergic disease, an autoimmune disease, graft rejection, leukemia, lymphoma, a blood-borne cancer, a disease requiring inhibition of undesirable inflammation, and a cancer.Type: GrantFiled: November 14, 2018Date of Patent: February 22, 2022Assignee: Institute of Biophysics, Chinese Academy of SciencesInventors: Pengyuan Yang, Yanan Gao, Maojun You
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Patent number: 11255025Abstract: The present invention relates to a spinning nozzle apparatus for manufacturing a high-strength fiber. The spinning nozzle apparatus for manufacturing a high-strength fiber according to the present invention is designed to optimize a heating method for the spinning region of a spinning nozzle in the melt spinning process. The heat transfer method is optimized by disposing the spinning nozzle holes of spinning nozzle commercially available on the outside of, directly under the pack body and heating the spinning nozzle holes with a heating body. In addition, an instantaneous heat treatment at high temperature is adopted to control the molecular entanglement structure in the melted polymer, which enhances the drawability of the thermoplastic resin and hence improves the mechanical properties such as strength and elongation.Type: GrantFiled: April 24, 2017Date of Patent: February 22, 2022Assignee: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGYInventors: Wan Gyu Hahm, In Woo Nam, Seung Jin Lee, Ki Sub Lim
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Patent number: 11257231Abstract: A method for monocular depth/pose estimation in a camera agnostic network is described. The method includes training a monocular depth model and a monocular pose model to learn monocular depth estimation and monocular pose estimation based on a target image and context images from monocular video captured by the camera agnostic network. The method also includes lifting 3D points from image pixels of the target image according to the context images. The method further includes projecting the lifted 3D points onto an image plane according to a predicted ray vector based on the monocular depth model, the monocular pose model, and a camera center of the camera agnostic network. The method also includes predicting a warped target image from a predicted depth map of the monocular depth model, a ray surface of the predicted ray vector, and a projection of the lifted 3D points according to the camera agnostic network.Type: GrantFiled: June 17, 2020Date of Patent: February 22, 2022Assignee: TOYOTA RESEARCH INSTITUTE, INC.Inventors: Vitor Guizilini, Sudeep Pillai, Adrien David Gaidon, Rares A. Ambrus, Igor Vasiljevic
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Patent number: 11254642Abstract: The present invention provides a method for the preparing of 2-chloro-5-trifluoromethylpyridine, comprising two steps of chlorofluorination reaction and chlorination reaction, the chlorination catalyst used in the chlorination reaction was chosen from a fluoride, an oxide, a hydroxide, a carbonate, or a chloride of magnesium, calcium and barium and a supported palladium catalyst; or under the action of at least one catalyst chosen from ZSM-5, 5A, ? and 13× molecular sieves, 3-trifluoromethylpyridine and chlorine gas phase have reaction to obtain 2-chloro-5-trifluoromethylpyridine. Or, under the action of a catalyst chosen from a fluoride, an oxide, a hydroxide, a carbonate, or a chloride of magnesium, calcium, and barium and a supported palladium catalyst, 3-trifluoromethylpyridine and chlorine gas phase have reaction to obtain 2-chloro-5-trifluoromethylpyridine.Type: GrantFiled: December 5, 2018Date of Patent: February 22, 2022Assignees: ZHEJIANG LANTIAN ENVIRONMENTAL PROTECTION HI-TECH CO., LTD., ZHEJIANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD., SINOCHEM LANTIAN CO., LTD.Inventors: Wanjin Yu, Shengda Lin, Minyang Liu, Wucan Liu, Jianjun Zhang, Xianjin Chen
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Patent number: 11255538Abstract: Methods and devices for gas mixture combustion on a surface of a permeable matrix are provided which produce or result in surface stabilized combustion (SSC) with increasing amounts of radiation energy emitted by the matrix surface and decreasing concentrations of pollutant components in the combustion products. The gas mixture is fed to a burner that includes a permeable matrix material having a first thermal conductivity and configured to preheat the combustible gas mixture as it travels through the matrix. The burner includes a plurality of thermal elements having a thermal conductivity higher than and disposed in thermal transfer communication with the matrix base material. The permeable matrix base material forms a combustion surface with at least a portion of the thermal elements exposed above the combustion surface. The gas mixture is combusted at or near exit pores and channels formed at the permeable matrix material combustion surface.Type: GrantFiled: October 18, 2018Date of Patent: February 22, 2022Assignee: GAS TECHNOLOGY INSTITUTEInventors: Aleksandr Kozlov, David Kalensky, Mark Khinkis, Vladimir Shmelev, Nikolai Vasilik
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Patent number: 11253727Abstract: Magnetic resonance (“MR”) visible markers for use in MR-guided placement of brachytherapy seeds, and for use in other MR-guided interventional procedures, are described. The MR-visible markers generally include a tube in which an absorbent thread assembly is disposed. The tube is made fluid-tight by sealing it at both ends with suitable end plugs. The absorbent thread assembly is soaked in a suitable MR-visible fluid.Type: GrantFiled: October 18, 2018Date of Patent: February 22, 2022Assignee: Sunnybrook Research InstituteInventors: Ananth Ravi, Moti Raj Paudel, Amir Owrangi, Harry Easton
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Patent number: 11254972Abstract: Provided herein, in some embodiments, are methods, compositions and kits for controlling nucleation and assembly of molecular nanostructures, microstructures and macrostructures.Type: GrantFiled: August 2, 2017Date of Patent: February 22, 2022Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.Inventors: Dionis Minev, Christopher Wintersinger, William M. Shih
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Patent number: 11258137Abstract: A metal-ion battery is provided. The metal-ion battery includes a positive electrode, a negative electrode, a separating structure, and an electrolyte, wherein the positive electrode and the negative electrode are separated by the separating structure, and the electrolyte composition is disposed between the positive electrode and the negative electrode. The separating structure includes a first separator, a second separator, and a dielectric layer, wherein the dielectric layer is disposed between the first separator and the second separator. The dielectric layer consists of a dielectric material, and the dielectric material has a dielectric constant from 10 to 200.Type: GrantFiled: September 18, 2019Date of Patent: February 22, 2022Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Mao-Chia Huang, Chien-Chih Chiang, Lu-Yu Wang, Feng-Shun Tseng, Chang-Chung Yang