Patents Assigned to INSTITUTE
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Patent number: 11237143Abstract: Reagents and methods are disclosed for detection of oxidizers and inorganic salts and other analytes of interest. The reagents can interact with their target analytes, especially oxidizer compositions or oxidizer-based explosives, to selectively enhance their ionization yield, interacting by chemical reaction or by forming an associative adduct which facilitates their detection. For example, the reagents can adduct with the counter-ion of the intended analyte for improved direct detection and/or react chemically via acid-base reactions to produce a new product for detection. In another aspect of the invention, reactive reagents and methods are also disclosed that facilitate indirect detection of the analyte at lower temperatures based on reduction-oxidation (redox) chemistry. These reagents are particularly useful in detecting oxidizer analytes.Type: GrantFiled: February 17, 2017Date of Patent: February 1, 2022Assignee: Massachusetts Institute Of TechnologyInventors: Kerin E. Gregory, Roderick R. Kunz, Michael Sworin
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Patent number: 11237371Abstract: A scanning microscope includes a light source for generating a light beam having a wavelength, ?, and beam-forming optics configured for receiving the light beam and generating a quasi-Bessel excitation beam that is directed into a sample. The quasi-Bessel beam has a lateral FWHM and an axial FWHM that is greater than ten times the lateral FWHM, and the beam-forming optics include an excitation objective having an axis oriented in a first direction. The microscope includes beam scanning optics configured for scanning the quasi-Bessel beam in one or more directions that are substantially perpendicular to the first direction, and a detector configured for detecting signal light received from positions within the sample that are illuminated by the quasi-Bessel beam. The signal light is generated in response to an interaction of the excitation beam with the sample, and the signal light is imaged, at least in part, by the excitation objective, onto the detector.Type: GrantFiled: October 19, 2020Date of Patent: February 1, 2022Assignee: Howard Hughes Medical InstituteInventors: Na Ji, Rongwen Lu
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Patent number: 11239878Abstract: Embodiments herein provide a transceiver system 1000a-1000f for full-duplex communication. The transceiver system 1000a-1000f includes an electrical balance based duplexer (EBD) 100 coupled with at least one transceiver 200a and 200b and at least one antenna 300a and 300b. The at least one antenna 300a and 300b is configured to transmit first signals and the at least one antennas 300a and 300b is configured to receive second signals using at least one circulators. The EBD 100 is configured to provide an isolation between the transmitting signals and the receiving signals in a same channel full duplex (SCFD) front-end circuit using the at least one circulators.Type: GrantFiled: February 13, 2019Date of Patent: February 1, 2022Assignee: INDIAN INSTITUTE OF TECHNOLOGY, MADRA (IITM)Inventors: Abhishek Kumar, Sankaran Aniruddhan, Radha Krishna Ganti
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Patent number: 11234919Abstract: The present invention relates to a novel compound represented by following formula 2 produced by means of marine-derived fungus Penicillium sp. and a composition for improving skin wrinkles, enhancing elasticity and skin whitening using excellent collagen synthesis promoting activity and melanin production inhibitory activity of the novel compound. In formula 2, R1 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms. R1 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms. R2 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms. R3 is any one selected from the group consisting of H, OH, COOH, an alkyl having 1 to 6 carbon atoms and an alkoxy having 1 to 6 carbon atoms.Type: GrantFiled: September 26, 2017Date of Patent: February 1, 2022Assignee: Korean Institute of Ocean Science & TechnologyInventors: Heejae Shin, Gambang Pil, Hyiseung Lee, Jongseok Lee, Yeonju Lee, Jihoon Lee
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Patent number: 11234608Abstract: An integrated device of a patch and sensor assembly detects extravasation or infiltration. A transmitter is positioned to direct power into a body portion. A sensor is positioned to receive the power transmitted through the body portion. A substrate is attachable to an outer surface of the body portion and supports the transmitter and the sensor. A signal processor is coupled to the transmitter and the sensor for detecting a change in a fluid level in the body portion from extravasation or infiltration based on the power received by the sensor. A power supply is coupled to the transmitter and the sensor. An indicator is responsive to the signal processor to indicate a detected change in a fluid level in the body portion from extravasation or infiltration.Type: GrantFiled: August 29, 2012Date of Patent: February 1, 2022Assignee: Battelle Memorial InstituteInventor: Chad E. Bouton
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Patent number: 11235032Abstract: The present disclosure provides a method of treating cancer with a priming dose of combination immunotherapy comprising IL-2 (e.g., extended-PK IL-2), an immune checkpoint inhibitor, a tumor targeting antibody or integrin-binding polypeptide, and optional cancer vaccine, administered prior to maintenance doses of immune checkpoint inhibitor therapy. The methods of the disclosure can be used to treat a broad range of cancer types.Type: GrantFiled: November 22, 2019Date of Patent: February 1, 2022Assignee: Massachusetts Institute of TechnologyInventors: Chensu Wang, Karl Dane Wittrup, Darrell J. Irvine
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Patent number: 11238289Abstract: An automatic lie detection method and apparatus for interactive scenarios, a device and a medium to improve the accuracy of automatic lie detection are provided. The method includes: segmenting three modalities, namely a video, an audio and a text, of a to-be-detected sample; extracting short-term features of the three modalities; integrating the short-term features of the three modalities in the to-be-detected sample to obtain long-term features of the three modalities corresponding to each dialogue; integrating the long-term features of the three modalities by a self-attention mechanism to obtain a multi-modal feature of the each dialogue; integrating the multi-modal feature of the each dialogue with interactive information by a graph neutral network to obtain a multi-modal feature integrated with the interactive information; and predicting a lie level of the each dialogue according to the multi-modal feature integrated with the interactive information.Type: GrantFiled: July 30, 2021Date of Patent: February 1, 2022Assignee: INSTITUTE OF AUTOMATION, CHINESE ACADEMY OF SCIENCESInventors: Jianhua Tao, Zheng Lian, Bin Liu, Licai Sun
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Patent number: 11239852Abstract: The present disclosure provides an error compensation correction system and method for an analog-to-digital converter with a time interleaving structure, the system includes an analog-to-digital converter with a time interleaving structure, a master clock module, a packet clock module, an error correction module, an adaptive processing module and an overall MUX circuit. Through the error compensation correction system and method for the analog-to-digital converter with a time interleaving structure according to the present disclosure, lower correction hardware implementation complexity and higher stability are ensured. The system and method according to the present disclosure are particularly suitable for interchannel mismatch error correction of dense channel time interleaving ADC, and the performance of the time interleaving ADC is improved.Type: GrantFiled: July 25, 2018Date of Patent: February 1, 2022Assignee: NO.24 RESEARCH INSTITUTE OF CHINA ELECTRONICS TECHNOLOGY GROUP CORPORATIONInventors: Jie Pu, Gangyi Hu, Jian'an Wang, Guangbing Chen, Liang Li, Ting Li, Daiguo Xu, Xingfa Huang, Xi Chen, Tiehu Li, Youhua Wang
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Patent number: 11238624Abstract: Provided are an image transform method and an image transform network. The method is for the image transform network including an image generator, a transform discriminator and a focus discriminator, and includes: generating a transformed image according to an un-transformed image and focus information by the image generator; computing a transform discrimination value according to the transformed image by the transform discriminator; computing a value of a first generator loss function and updating the image generator by the image generator; generating a focus discrimination value according to the un-transformed image, the transformed image, and the focus information by the focus discriminator; and computing a value of a second generator loss function according to the focus discrimination value and updating the image generator according to the value of the second generator loss function by the image generator.Type: GrantFiled: March 3, 2020Date of Patent: February 1, 2022Assignee: Industrial Technology Research InstituteInventors: Duan-Li Liao, Chia-Chang Li, Wen-Hung Ting, Po-Lung Chen
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Patent number: 11235054Abstract: Stable, immunogenic combination vaccine(s) comprising a mixture of antigens for prevention and prophylaxis of infections caused by Rotavirus, Poliomyelitis virus, Haemophilus influenzae, Corynebacterium diphtheriae, Clostridium tetani, Bordetella pertussis and Hepatitis B virus. A multivalent combination vaccine comprises i) significantly dose-reduced Salk-IPV or Sabin-IPV (IPV) antigens prepared by methods of formaldehyde inactivation and alum hydroxide adsorption resulting in maximum D-antigen recovery; ii) Injectable heat inactivated Rotavirus antigen(s) providing broad cross-protective immunity among human rotavirus strains; iii) Hib PRP-carrier protein conjugate having improved stability and immunogenicity; iv) whole cell pertussis antigen with improved immunogenicity and stability; and v) Homogenous fractions of Diphtheria and Tetanus toxoids.Type: GrantFiled: August 24, 2017Date of Patent: February 1, 2022Assignees: Serum Institute of India Private Limited, The United States of America, as Represented by the Secretary, Department of Health and Human ServicesInventors: Rajeev Mhalasakant Dhere, Sambhaji Shankar Pisal, Jagdish Kamalaji Zade, Rajendra Narayan Sabale, Ravindra Bapurao Kadam, Abhijeet Sanjeev Kamble, Baoming Jiang, Roger Glass
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Patent number: 11238292Abstract: In one embodiment, a system for determining the direction of objects in an image is provided. An image is received from a camera associated with a vehicle. The image is processed to identify an object, such as another vehicle. To determine the direction the object is traveling, the image is provided as input to a machine learning algorithm that outputs a direction of the detected object based at least in part on a training dataset including a plurality of images annotated to include respective direction information determined based at least in part on a plurality of 3D models set to aligned orientations that are significantly aligned with orientations of objects captured in the plurality of images. The objects and their associated directions can be provided to one or more autonomous vehicle functions, such as hazard detection or navigation.Type: GrantFiled: November 26, 2019Date of Patent: February 1, 2022Assignee: Toyota Research Institute, Inc.Inventor: Yusuke Kanzawa
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Patent number: 11235075Abstract: The present invention provides novel hydrogels through peptides, which are designed to self-assemble and produce magnetic resonance (MR) contrast through chemical exchange saturation transfer (CEST). The location and integrity of these gels could consequently be tracked using MR imaging. The self-assembly of the peptides into hydrogels can be brought about by a change in pH, ionic strength, temperature, and concentration of ions.Type: GrantFiled: April 28, 2014Date of Patent: February 1, 2022Assignees: THE JOHNS HOPKINS UNIVERSITY, KENNEDY KRIEGER INSTITUTE, INC., NATIONAL INSTITUTES OF HEALTHInventors: Michael T. McMahon, Kannie Wai-Yan Chan, Michael Christopher Giano, Nikita Oskolkov, Joel Patrick Schneider, Xiaolei Song
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Patent number: 11240081Abstract: A UE in a wireless communication system is disclosed. The UE includes a communication module and a processor for controlling the communication module. The processor determines a first cyclic shift (CS) value based on hybrid automatic repeat request acknowledgment (HARQ-ACK) information representing a response to a downlink channel having been received from a base station, determines a CS offset based on request information representing a request to be transmitted from the UE to the base station, determines a second CS value representing a degree of cyclic-shifting a base sequence to be used in a physical uplink control channel (PUCCH) based on the first CS value and the CS offset, and transmits the PUCCH for simultaneous transmission of the request information and the HARQ-ACK information using a sequence generated by cyclic-shifting the base sequence based on the second CS value.Type: GrantFiled: February 7, 2020Date of Patent: February 1, 2022Assignee: WILUS INSTITUTE OF STANDARDS AND TECHNOLOGY INC.Inventors: Minseok Noh, Jinsam Kwak, Kyungjun Choi, Hyukmin Son
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Patent number: 11239081Abstract: A method for preparing an ohmic contact electrode of a GaN-based device. Said method comprises the following steps: growing a first dielectric layer (203) on an upper surface of a device (S1); implanting silicon ions and/or indium ions in a region of the first dielectric layer (203) corresponding to an ohmic contact electrode region, and in the ohmic contact electrode region of the device (S2); growing a second dielectric layer (206) on an upper surface of the first dielectric layer (203) (S3); activating the silicon ions and/or the indium ions by means of a high temperature annealing process, so as to form an N-type heavy doping (S4); respectively removing portions, corresponding to the ohmic contact electrode region, of the first dielectric layer (203) and the second dielectric layer (206) (S5); growing a metal layer (208) on the upper surface of the ohmic contact electrode region of the device, so as to form an ohmic contact electrode (S6).Type: GrantFiled: February 27, 2019Date of Patent: February 1, 2022Assignee: THE 13TH RESEARCH INSTITUTE OF CHINA ELECTRONICSInventors: Yongliang Tan, Xingzhong Fu, Zexian Hu, Xiangwu Liu, Lijiang Zhang, Yuxing Cui, Xingchang Fu
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Patent number: 11235283Abstract: An ionic liquid and a forward osmosis process employing the same are provided. The ionic liquid has a structure represented by Formula (I) ABn??Formula (I), wherein A is n is 1 or 2; m is 0, or an integer from 1 to 7; R1 and R2 are independently methyl or ethyl; k is an integer from 3 to 8; B is i is independently 1, 2, or 3; and j is 5, 6, or 7. The forward osmosis process employing the ionic liquid is used to desalinate a brine via a forward osmosis (FO) model.Type: GrantFiled: December 30, 2019Date of Patent: February 1, 2022Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Po-I Liu, Hsin Shao, Min-Chao Chang, Yi-Chun Chen, Chiung-Hui Huang, Chia-Hua Ho, David Chiuni Wang, Ren-Yang Horng
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Patent number: 11236429Abstract: Systems and methods for electrochemically producing chemical products are provided. In certain cases, the systems and methods described herein are capable of producing chemical products such as hydrogen peroxide in solutions with relatively low concentrations of electrolyte or other dissolved species at high efficiencies and/or low energetic cost. In some cases, redox mediators are used to temporally decouple direct electrochemical processes from the production of the chemical product.Type: GrantFiled: June 24, 2019Date of Patent: February 1, 2022Assignee: Massachusetts Institute of TechnologyInventors: Sahag Voskian, Alexander Murray, Trevor Alan Hatton, Yogesh Surendranath
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Patent number: 11234995Abstract: The present invention can provide a nucleic acid medicine which has a higher effect and a more prolonged effect of inhibiting the expression of ?-synudein can be provided. Disclosed is the oligonucleotide or a pharmacologically acceptable salt thereof, the oligonucleotide containing at least one nucleoside structure represented by Formula (I): (where each of Base and A are defined substituent or structure), can bind to an ?-synudein gene, has activity for inhibiting expression of the ?-synudein gene, and is complementary to the ?-synudein gene, and the oligonucleotide has a length of twelve to twenty bases.Type: GrantFiled: January 5, 2017Date of Patent: February 1, 2022Assignees: OSAKA UNIVERSITY, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITIONInventors: Masayuki Nakamori, Hideki Mochizuki, Satoshi Obika, Takanori Yokota, Tetuya Nagata, Yuya Kasahara
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Patent number: 11239660Abstract: A demand response method, a demand response system, and a recording medium are provided. The response control method includes: determining priorities of devices to be controlled to participate in a demand response; generating respective participation profiles for the devices based on the determined priorities; and changing the priorities of the devices included in the participation profiles, based on whether participation in the demand response according to the generated participation profiles succeeds. Therefore, the user easily participates in the demand response, and thus energy can be saved.Type: GrantFiled: May 10, 2018Date of Patent: February 1, 2022Assignee: KOREA ELECTRONICS TECHNOLOGY INSTITUTEInventor: Sang Hak Lee
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Patent number: 11235278Abstract: Systems and methods for sequestering emissions from marine vessels are provided. Emissions (either flue gas from exhaust or CO2 carried on the ship under pressure in gas cylinders or CO2 obtained during the ships travel via capture) are mixed in a reactor with sea water (e.g., via gas exchange through head-space equilibration or bubbling through a diffuser) until a pH of 5.5 to 6.5 is obtained. Systems and reactors pump seawater through a reactor vessel containing a reaction medium (e.g., carbonates and silicates). The reactor produces an effluent that can be expelled into the ocean. The effluent produced from the result of a reaction according to embodiments has approximately twice the concentration of Dissolved Inorganic Carbon (DIC) and Alkalinity (Alk) as the incoming sea water and has an increased Ca+2 concentration above sea water.Type: GrantFiled: May 26, 2020Date of Patent: February 1, 2022Assignees: California Institute of Technology, University of Southern CaliforniaInventors: Jess Firey Adkins, William Max Berelson, David B. Rogers
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Patent number: 11237454Abstract: Typically, quantum systems are very sensitive to environmental fluctuations, and diagnosing errors via measurements causes unavoidable perturbations. Here, an in situ frequency-locking technique monitors and corrects frequency variations in single-photon sources based on resonators. By using the classical laser fields used for photon generation as probes to diagnose variations in the resonator frequency, the system applies feedback control to correct photon frequency errors in parallel to the optical quantum computation without disturbing the physical qubit. Our technique can be implemented on a silicon photonic device and with sub 1 pm frequency stabilization in the presence of applied environmental noise, corresponding to a fractional frequency drift of <1% of a photon linewidth. These methods can be used for feedback-controlled quantum state engineering.Type: GrantFiled: November 12, 2019Date of Patent: February 1, 2022Assignee: Massachusetts Institute of TechnologyInventors: Jacques Johannes Carolan, Uttara Chakraborty, Nicholas C. Harris, Mihir Pant, Dirk Robert Englund