Abstract: The present invention relates to the field of chemical analysis detection and application, in particular to a marker peptide of snake venom thrombin-like enzymes (SVTLEs) from Agkistrodon Halys Pallas and an application thereof. The amino acid sequence of the marker peptide of snake venom thrombin-like enzymes (SVTLEs) from Agkistrodon Halys Pallas is TLCAGVMEGGIDTCNR. Characterizing the source of species and a content of the SVTLEs in a to-be-detected sample by using the marker peptide includes the following steps of: pretreating the to-be-detected sample by trypsin through enzymolysis, and taking a supernatant of an enzymolysis liquid as a test solution; and injecting the test solution and a reference solution into a liquid chromatography-mass spectrometer, and selecting a qualitative ion pair and a quantitative ion pair for detecting the source of species and a content of the SVTLEs in the to-be-detected sample.

Abstract: Provided herein are compounds useful for the treatment of diseases caused by infections of T. gondii, and closely related parasites. These compounds, as well as pharmaceutically acceptable salts thereof may be formulated in pharmaceutical compositions including veterinary compositions and may be used in methods of treatment and/or prophylaxis of disease.

Abstract: The use of a purine nucleoside phosphorylase or nucleoside hydrolase or a vector encoding expression of one of these enzymes is detailed along with the use of a prodrug cleaved by the purine nucleoside phosphorylase or nucleoside hydrolase for the preparation of a direct injection inhibition of replicating or non-replicating targeted cells. The targeted cells do not normally express the introduced purine nucleoside phosphorylase or nucleoside hydrolase. The enzyme and prodrug are amenable to intermixing and injection as a single dose or as separate injection or administration to the targeted cells. The substance and prodrug efficacy are enhanced through exposure of the targeted cells to X-ray radiation. Administration of a prodrug regardless of administration route to the targeted cells is effective in combination with X-ray radiation therapy to kill or inhibit function of the targeted cells.

Abstract: Disclosed herein are isolated follicular helper T cell (TFH) and engineered follicular helper T cell (TFH) and methods of isolating or engineering such cells. Further disclosed herein are methods of using such cells for treating diseases, such as cancer.

Abstract: The disclosure provides programmable methylation “writers” and demethylation “erasers” for editing the methylation state of RNA targets, e.g., an RNA transcriptome. In particular, the disclosure provides RNA methylation editor polynucleotide contracts and vectors comprising (i) an RNA programmable RNA binding domain (RNApRNAbd); and (ii) an effector domain, wherein the effector domain is capable of adding or removing a methyl group in an RNA. The disclosed RNA methylation editor constructs are capable of achieving limited off-target modifications in RNA molecules. Further, the disclosure provides methods for making and using the programmable methylation editors to modifying the methylation state of RNA. The disclosure further provides complexes comprising a methylation writer protein and a guide RNA molecule and complexes comprising a demethylation eraser protein and a guide RNA molecule.

Abstract: An image encoding/decoding method is disclosed. Present invention of the method of decoding an image comprises deriving motion information of a current block by using a candidate list, generating a prediction block of the current block by using the motion information of the current block and adding the motion information of the current block in the candidate list, wherein the candidate list is used for inter prediction of a block to be decoded after the current block.

Abstract: Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods include delivering to endogenous bacterial cells a recombinant bacteriophage or phagemid that is engineered to contain at least one genetic circuit.

Abstract: The present invention relates to new compounds derived from marine actinomycetes Streptomyces, and the new compound according to the present invention has an inhibitory effect of NO production on BV-2 microglia stimulated with LPS, and thus can be utilized for the prevention and treatment of neuroinflammatory diseases.

Abstract: The present invention relates to the technical field of chemical analysis and quantitative detection, in particular to a quantitative detection method for snake venom thrombin-like enzyme (SVTLE) from Agkistrodon halys pallas. The quantitative detection method for the SVTLE includes the following steps of taking a reference substance of marker peptide for the SVTLE from Agkistrodon halys pallas with an amino acid sequence of LDSPVSNSAHIAPLSLPSSAPSVGSVCR, and preparing a series of reference solutions with different concentrations; adding the reference solutions in test solutions respectively for enzymolysis, and then taking a supernatant after enzymolysis as a series of solutions to be detected; and adding the solutions to be detected in a liquid chromatogram-mass spectrometer, and then selecting a qualitative ion pair and a quantitative ion pair to detect contents of marker peptide in the solutions to be detected.

Abstract: A gene analyzer has a structure in which a metal block, a heater installed on an outer surface of the metal block, and a heat insulator applied onto an outer surface of the heater are integrally formed, thereby miniaturizing the gene analyzer. Further, parts for light measurement, such as a light source element, a light-receiving element, a light source filter, a fluorescent filter, a light source lens, a fluorescent lens, and the like, are installed in a heat insulator light source path and a heat insulator fluorescent path formed in the heat insulator, and the paths formed in the heat insulator are aligned with a block light source path and a block fluorescent path of the metal block.

Abstract: An operation method of a terminal in a communication system may comprise: receiving one or more data units from a base station; generating a HARQ codebook for at least one dada unit of the one or more data units at a reference time; and transmitting the HARQ codebook to the base station, wherein the reference time is shared by the terminal and the base station.

Abstract: In an embodiment, there is provided a three-dimensional (3-D) optic for beam shaping. The 3-D optic includes a first surface, a second surface and a beam forming feature. The first surface is configured to receive incident light. The second surface is positioned relative to the first surface and is configured to emit a light beam having a shape. The emitted beam shape is related to the beam forming feature. The beam forming feature is formed by a 3-D manufacturing process.

Abstract: Disclosed are a biometric device and a biometric system including the same. The device includes a hiogenic-synthesized film, a reflective layer disposed on one side of the biogenic-synthesized film, a light source disposed on the reflective layer to generate light, a beam splitter disposed between the light source and the reflective layer to provide the light to the reflective layer and another side of the biogenic-synthesized film, and a light switching layer disposed between the beam splitter and the reflective layer to switch the light provided to the reflective layer.

Abstract: A lead frame package including first conductive layer, first electronic component, lead frames, second conductive layer and package body. First conductive layer has conductive carriers. First electronic component has first pins. Lead frames and first pins are respectively electrically connected to conductive carriers. Second conductive layer has conductive joints respectively electrically connected to lead frames so as to be electrically connected to at least a part of conductive carriers via lead frames. Package body encapsulates first conductive layer, first electronic component, and lead frames. First conductive layer and second conductive layer are located on two opposite sides of first electronic component, respectively.

Abstract: Provided is a cooled optical transmission module device including a silicon wafer having a plurality of platform mounting grooves, each of which serves as a space for mounting in which an optical transmission platform therein, a thermoelectric cooler bonded to the platform mounting groove to transfer heat to outside, the optical transmission platform provided on the thermoelectric cooler and configured to output an optical signal by generating and reflecting the optical signal, a dielectric sub-mount bonded to the platform mounting groove of the silicon wafer and electrically connected to the mounted optical transmission platform, and a cover configured to cover the platform mounting groove of the silicon wafer and seal the platform mounting groove while providing an electric path.

Abstract: An electronic device package structure including a substrate, a first circuit layer, a second circuit layer, an electronic device and an input/output device is provided. The first circuit layer includes a first conductive portion, a second conductive portion and a first curve portion located between the first conductive portion and the second conductive portion. At least a partial thickness of the first curve portion is greater than a thickness of the first conductive portion. The electronic device disposed on the second circuit layer is electrically connected to the second conductive portion of the first circuit layer. The input/output device disposed corresponding to the first conductive portion is electrically connected to the first conductive portion of the first circuit layer.

Abstract: Embodiments of the invention relate to a novel class of polymers with superior mechanical properties and chemical stability, as compared to known polymers. These polymers are particularly well suited for use in anion exchange membranes (AEMs), including those employed in fuel cells. Novel methods for the manufacture of these polymers are also described.

Abstract: The present disclosure provides compounds of any one of Formulae (I) and (II). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1 (EZH1) and enhancer of zeste homolog 2 (EZH2)) and are useful in treating and/or preventing a broad range of diseases (e.g., proliferative diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. Further provided in the present disclosure are methods of identifying EZH1 and/or EZH2 inhibitors.

Abstract: Provided is a method of manufacturing a semiconductor device. The method includes providing a substrate, forming uneven portions in a region of the substrate in which an electrode is to be formed, forming a precursor film formed of a two-dimensional material on the substrate on which the uneven portions are formed, forming a metal chalcogen film by performing a chalcogenation process on the formed precursor film, and forming the electrode on the formed metal chalcogen film.

Abstract: An in-vessel cooling and power generation system according to the present disclosure may include a small scale reactor vessel, a heat exchange section provided inside the reactor vessel, and formed to supply supercritical fluid to receive heat from a reactor coolant system in the reactor vessel, an electric power production section comprising a supercritical turbine formed to produce electric energy using the energy of the supercritical fluid whose temperature has increased while receiving heat from the reactor coolant system, a cooling section configured to exchange heat with the supercritical fluid discharged after driving the supercritical turbine to shrink a volume of the supercritical fluid, wherein the supercritical fluid that has received heat from the reactor coolant system in the heat exchange section is formed to circulate through the electric power production section, and the cooling section.