Abstract: Chromatin 3D structure modulating agents in the context of the present invention are intended to interfere or manipulate the function of loop anchor motifs, such as CTCF motifs. In certain example embodiments, the present invention may block formation of an loop anchor or chromatin domain or induce formation of a loop anchor or chromatin domain at a targeted genomic location. For instance, a loop anchor motif can be altered, such as by mutating (including inverting) a binding motif so as to remove such a motif, or by adding new binding motifs in new locations within a loop domain, so as to reduce the size of an existing loop, so as to modify the size of an existing loop, or combinations thereof. Alternatively, the chromatin 3D structure modulating agent may bind a target region and mask a loop anchor motif, thereby preventing a loop anchor or chromatin domain from forming. The chromatin 3D structure modulating agent may bind a target region and cause a loop anchor of chromatin domain to form.

Abstract: The present invention relates to the novel use of read-through compounds for use in the treatment and/or prevention of Autism Spectrum Disorder.

Abstract: An amplitude-phase correction method and system for a microwave imaging system are provided. The method comprises: carrying out data processing, in a range direction, on an echo signal reflected from a target object and acquired by a linear array antenna according to a first pre-set algorithm to obtain a compressed signal in the range direction; extracting a range value corresponding to the maximum amplitude, in the range direction, of the compressed signal in the range direction; carrying out time delay compensation on the echo signal according to the range value to obtain a time-delay-compensated signal; carrying out data processing on the time-delay-compensated signal according to a second pre-set algorithm to obtain an amplitude-phase signal; and carrying out amplitude-phase correction on the echo signal according to the time-delay-compensated signal and the amplitude-phase signal to obtain a corrected echo signal.

Abstract: Provided herein are methods for mapping antibody binding to an immunogen, comprising: immunizing a subject with an immunogen and obtaining sera from the immunized subject at multiple time intervals following immunization, wherein the sera comprises antibodies that are used to form one or more immune complexes with the immunogen; isolating the one or more immune complexes formed by the serum derived antibodies bound to the immunogen; imaging, by electron microscopy, the one or more immune complexes in each of the time intervals, to obtain structural images formed between the immunogen and serum antibodies; determining, from the plurality of structural images, immunogen-antibody binding site for each of the immune complexes obtained at the plurality of time intervals; mapping immunogen-antibody binding by measuring differences in structural images obtained at different time intervals to determine immunogen-antibody binding over multiple time intervals.

Abstract: A fast query method for a mobile network entity dynamic location information, using a distributed container hierarchical nested structure to process registration and queries for location information, includes: after a network entity connects to a network attachment point after moving and obtains a new network address assignment, determining a series of a registered container, and then registering new location information corresponding to where the network entity is currently located, the location information containing at least current network address information; when a network forwarding device learns that the network entity is currently un-reachable, querying the new location information of the network entity from the container where the network entity was located before moving; and the container where the network entity was located before moving, after receiving the query request, obtains the new location information of the network entity by searching in the container and in a peer neighboring container s

Abstract: The present disclosure relates to methods and compositions involving HCR reactions that involve initiators that are split into two or more parts. Effective HCR is dependent upon two or more of these split initiators being brought into proximity (e.g., via binding events mediated by a target) such that a full initiator is formed that is capable of triggering HCR signal amplification.

Abstract: Disclosed are a device and a method for calibrating a reference voltage. The reference voltage calibrating device includes a data signal communication unit that transmits/receives a data signal, a data strobe signal receiving unit that receives a first data strobe signal and a second data strobe signal, a voltage level of the second data strobe signal being opposite to a voltage level of the first data strobe signal, and a reference voltage generating unit that sets a reference voltage for determining a data value of the data signal, based on the first data strobe signal and the second data strobe signal, and the reference voltage generating unit adjusts the reference voltage based on the first data strobe signal and the second data strobe signal.

Abstract: A heat transfer tube includes a twisted baffle arranged in an inner wall of the tube. The twisted baffle extends spirally along an axial direction of the heat transfer tube. The twisted baffle is provided with a non-through gap extending along an axial direction of the heat transfer tube from an end to the other end of the twisted baffle. A cracking furnace uses the heat transfer tube. The heat transfer tube and cracking furnace have good heat transfer effects and small pressure loss.

Abstract: Systems and methods are disclosed for selectively reinforcing or weakening memory associations. At least one current generator provides an electrical current including a plurality of oscillating pulses with at least one predetermined frequency. A user interface includes at least one output device for delivering a sensory stimulus to a user and at least one user input device for registering a response to the stimulus. At least one processor determines from the response, based on at least one predetermined standard, whether an underlying memory association is desired or undesired and respectively sets the at least one predetermined frequency to be a beta or theta frequency. Consequently, the electrical current is generated and administered, via at least one electrode pair, thereby stimulating at least one specific portion of the user's brain so as to reinforce or weaken the underlying memory association.

Abstract: The present invention provides a factor capable of predicting an effect of a medicinal therapy on a cancer such as HER2 positive cancer. More specifically, the present invention provides a method of predicting the effect of the medicinal therapy on the cancer, comprising: (1) analyzing a methylation level of a cytosine residue in one or more CpG sites present within a nucleotide sequence in a promotor region, an untranslated region or a translated region of HSD17B4 gene in a sample taken from a human subject; and (2) predicting the effect of the medicinal therapy on the cancer based on the analyzed methylation level.

Abstract: A self-evolving agent-based simulation system generates model evolution strategy for applying a difference between real-data and a simulation resulting value to a simulation model, and reconstructing components included in the simulation module using the model evolution strategy to evolve the simulation model when the difference between the real-data and the simulation resulting value of the agent-based simulation model does not satisfy a value in a predetermined error range.

Abstract: The preset invention relates to a high resolution mass spectrometry based novel bioinformatics platform for the identification of glycation proteins and advanced glycation end-product. Particularly, the bioinformatics platform of the present invention facilitates an efficient and accurate investigation of quantitative changes of glycation proteins and advanced glycation end-products which are included in various types of samples but had not been informed yet, and uses a high resolution mass spectrometry, and thereby can be effectively used for the prediction or diagnosis of a disease including cancer by examining a disease marker in a sample.

Abstract: The present disclosure is directed to novel germanosilicate compositions and methods of producing and using the same. Included among the new materials are the new germanosilicates of CIT-5 topology having Si:Ge ratios either in a range of from 3.8 to 5.4 or from 30 to 200, with and without added metal oxides. The disclosure also describes methods of preparing and using these new germanosilicate compositions as well as the compositions themselves.

Abstract: A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.

Abstract: A light intensity fluctuation-insensitive projection objective wave aberration detection device and a detection method thereof, comprising a light source and illumination system, an object plane marking plate, an object plane displacement table, a tested projection objective, an image plane marking plate, a two-dimensional photosensor, an image plane displacement table and a control processing unit; the object plane marking plate and the image plane marking plate are provided with grating marks for shear interference test and marks for light intensity test, the shear interferograms and the light intensity information are simultaneously received through the two-dimensional photosensor, the light intensity fluctuation error corresponding to each phase-shifting interferogram is corrected through the light intensity information, improving the detection precision, reducing the complexity and the cost of the system, and improving the detection speed.

Abstract: The present disclosure is directed to novel germanosilicate compositions and methods of producing and using the same. In particular, this disclosure describes new germanosilicates of CIT-14 topology. The disclosure also describes methods of preparing and using these new germanosilicate compositions as well as the compositions themselves.

Abstract: The present invention relates to a method for decreasing the psychotomimetic side effects and enhancing the antidepressant-like effects of ketamine by the combination of ketamine with a methylglycine derivative. The present invention also relates to a method for depression treatment comprising administrating ketamine combined with a methylglycine derivative. The present invention further provides a method for preventing or treating addictive disorders of ketamine by administrating a methylglycine derivative.

Abstract: Systems and methods for storing large data sets, such as genetic sequence information. Within a “targeted subset” of positions with information, the system stores, both variant states and missing states at each position. Reference states are not stored, but are inferred within the targeted subset when neither a variant nor a missing state is stored at a given position. The absence of a variant state at a given position is assumed to be a reference state. The criteria for missing data are defined in pre-processing and are customizable based on the use case. For example, each data point may represent the genetic information of a sample at a position in the genome. The targeted subset may represent those positions that were included in a sequencing test.

Abstract: A semiconductor laser diode light source package includes: a seed light source for outputting signal beams; a pump beam source for outputting pump beams; and at least one mirror for transmitting the signal beams to a core of an output optical fiber and transmitting the pump beams to first cladding of the output optical fiber, wherein the seed light source, the pump beam source, and the at least one mirror are realized in a semiconductor chip, and the output optical fiber is connected to an end terminal of the semiconductor laser diode light source package.

Abstract: Disclosed are a perovskite compound, a method for producing the perovskite compound, a catalyst for a fuel cell including the perovskite compound, and a method for producing the catalyst. The perovskite compound overcomes the low stability of palladium due to its perovskite structural properties. Therefore, the perovskite compound can be used as a catalyst material for a fuel cell. In addition, the use of palladium in the catalyst instead of expensive platinum leads to an improvement in the price competitiveness of fuel cells. The catalyst is highly durable and catalytically active due to its perovskite structure.