Abstract: Methods for cancer immunotherapy are provided. The methods involve the use of a chimeric molecule (e.g., fusion protein) comprising an NKG2D portion and an Fc portion, which binds one or more NKG2D ligands. The methods disclosed herein are useful for the treatment of cancer that is associated with abnormal expression of one or more NKG2D ligands.
Type:
Application
Filed:
April 2, 2021
Publication date:
January 6, 2022
Applicant:
Dana-Farber Cancer Institute, Inc.
Inventors:
Glenn Dranoff, Matthew Vanneman, Gordon Freeman
Abstract: A device with integrated methods for carrying out reverse transcription polymerase chain reaction (RT-PCR) and/or array based analysis involving signal generating agents (gold nanoclusters) comprising a heating and cooling cycle based synthesis selectively with DIMA and protein as templates. The advancement is further directed to a portable device adapted for RT-PCR and array based gene and protein expression analyses based on a common detection agent involving luminescence of in-situ synthesized gold nanoclusters with adaptability for user friendly graphical user interface (GUI) for controlling, visualization and analysis of the data.
Abstract: Systems, methods, and computer-readable media for protecting distributed data are provided. The data is distributed according to a time-based shard distribution scheme that splits data into multiple pieces to prevent an attacker who successfully breaches a terminal device from reassembling the pieces.
Type:
Grant
Filed:
July 13, 2021
Date of Patent:
January 4, 2022
Assignee:
TECHNOLOGY INNOVATION INSTITUTE
Inventors:
Septimiu F. Mare, Najwa Aaraj, Marcos Manzano, Alvaro Garcia
Abstract: Through the use of a rhodamine appended chelate, a versatile strategy has been demonstrated to generate mitochondria-targeting photosensitizers via the incorporation of variety of luminescent transition metal systems. The generation of triplet excited state of rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen (1O2) for use as photodynamic therapy (PDT) agent. The combination of rhodamine organic dye and luminescent transition metal centers in such hybrid systems exhibits the synergistic merits, including low dark cytotoxicity, selective tumor cell uptake, high molar absorptivity for low-energy excitation in the visible region, and high photostability.
Type:
Grant
Filed:
August 16, 2018
Date of Patent:
January 4, 2022
Assignees:
SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY, SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
Inventors:
Keith Man Chung Wong, Chuangjun Liu, Ping Gong, Lihua Zhou, Lintao Cai
Abstract: A method of forming a functionalized device substrate is provided that includes the steps of: forming a graphene layer on a growth substrate; applying a polyimide layer to a glass, glass-ceramic or ceramic substrate, wherein a coupling agent couples the polyimide layer to the said substrate; coupling the polyimide layer to the graphene layer on the growth substrate; and peeling the growth substrate from the graphene layer.
Type:
Grant
Filed:
November 16, 2018
Date of Patent:
January 4, 2022
Assignees:
Corning Incorporated, ICFO—THE INSTITUTE OF PHOTONIC SCIENCES, INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA)
Abstract: Systems, methods, and computer-readable media for protecting distributed data are provided. The data is distributed according to a time-based shard distribution scheme that splits data into multiple pieces to prevent an attacker who successfully breaches a terminal device from reassembling the pieces.
Type:
Grant
Filed:
July 13, 2021
Date of Patent:
January 4, 2022
Assignee:
TECHNOLOGY INNOVATION INSTITUTE
Inventors:
Septimiu F. Mare, Najwa Aaraj, Marcos Manzano, Alvaro Garcia
Abstract: Provided herein are methods and kits for determining the presence or absence of certain microRNA biomarkers in a blood sample of a female patient. The microRNA biomarkers are associated with ovarian cancer. Also provided are methods for screening a female subject for the presence or absence of certain microRNA biomarkers, as well as methods for treating a female subject having an ovarian cancer.
Type:
Grant
Filed:
January 9, 2018
Date of Patent:
January 4, 2022
Assignees:
DANA-FARBER CANCER INSTITUTE, INC., THE BRIGHAM AND WOMEN'S HOSPITAL, INC., MEDICAL UNIVERSITY OF LODZ
Inventors:
Dipanjan Chowdhury, Kevin M. Elias, Wojciech Fendler, Konrad Stawiski
Abstract: An aqueous lithium-ion battery and an electrode used therein are provided, wherein the electrode includes a current collector, a coating layer, and a composite layer. The coating layer is disposed on at least one surface of the current collector, and the coating layer contains an active material. The composite layer is disposed on a surface of the coating layer. The composite layer includes a first film and a second film, wherein the first film is between the second film and the surface of the coating layer, and the water contact angle of the first film is greater than the water contact angle of the second film.
Type:
Grant
Filed:
January 24, 2019
Date of Patent:
January 4, 2022
Assignee:
Industrial Technology Research Institute
Abstract: Provided is an artificial intelligence system. The system includes a first sensor configured to generate a first sensing signal during a sensing time, a second sensor disposed adjacent to the first sensor and configured to generate a second sensing signal during the sensing time, a pre-processing unit configured to select valid data according to a magnitude of a differential signal generated based on a difference between the first sensing signal and the second sensing signal, and an artificial intelligence module configured to analyze the valid data to generate result data.
Type:
Grant
Filed:
April 9, 2019
Date of Patent:
January 4, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Sung Eun Kim, Seong Mo Park, Kwang IL Oh, Tae Wook Kang, Mi Jeong Park, Hyung-IL Park, Jae-Jin Lee, In Gi Lim
Abstract: Provided is a method of processing MPEG data, the method including: obtaining at least one access unit including media data coded through processing including an encapsulation and a packetization; generating at least one media processing unit (MPU) by grouping at least one access unit; determining a duration flag indicating whether duration information of the at least one access unit is valid, in a corresponding MPU; and inserting the duration flag into a header of the corresponding MPU.
Type:
Grant
Filed:
January 4, 2019
Date of Patent:
January 4, 2022
Assignee:
Electronics and Telecommunications Research Institute
Inventors:
Jin Young Lee, Kug Jin Yun, Won Sik Cheong, Nam Ho Hur
Abstract: A method for flue gas denotation includes the step of, in the presence of ammonia, enabling flue gas in a denitration reactor to pass through a plurality of catalyst beds from the bottom to the top to participate in a denitration reaction. Each catalyst bed contains a catalyst support component and a granular denitration catalyst stacked on the catalyst support component, and, in every single catalyst bed, the granular denitration catalyst moves along a same direction on the catalyst support component. Between every two adjacent catalyst beds, the granular denitration catalyst falls from the tail of a previous catalyst support component to the head of a next catalyst support component, making the granular denitration catalyst travel along the catalyst support components reciprocatively.
Type:
Grant
Filed:
August 31, 2017
Date of Patent:
January 4, 2022
Assignees:
China Petroleum & Chemical Corporation, Fushun Research Institute of Petroleum and Petrochemicals, SINOPEC CORP.
Inventors:
Xin Li, Shuhe Liu, Tianzhu Han, Mingxing Wang
Abstract: An implant for use in a spine includes a body and a plurality of structural members. The superior and inferior surfaces each include a ring and structural members arranged in a web-like pattern around the ring. Bone contacting members are arranged radially away from the ring and support members are arranged in a circumferential direction around the ring.
Type:
Grant
Filed:
December 23, 2019
Date of Patent:
January 4, 2022
Assignee:
Institute for Musculoskeletal Science and Education, Ltd.
Inventors:
Sean S. Bishop, Christopher J. Ryan, Edward J. McShane, III, Megan A. Stauffer, Joseph M. Nyahay
Abstract: Embodiments relate to a noise suppressor for suppressing noise of an optical signal, including a core through which the optical signal travels, a clad that is wrapped around the core and configured to expose part of the core, and a graphene layer formed on the part of the core, and a digital optical signal generation system including the same.
Type:
Grant
Filed:
April 6, 2020
Date of Patent:
January 4, 2022
Assignee:
KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Abstract: A method for obtaining a contact resistance of a planar device includes: obtaining a contact resistance of a planar device by using a potential measurement method, in the measurement of the surface potential distribution, the planar device is in a state of current flowing, a certain voltage drop is formed at a junction area of the device; extracting the voltage drop measured through the Kelvin microscope by using a linear fitting method; and dividing the measured voltage drop by the current flowing through the device, thereby accurately calculating the magnitude of the contact resistance at the junction area of the planar device. With the present invention, the contact resistance of the planar device can be precisely measured, which is suitable for the contact resistance measurement experiments of devices such as thin film transistors and diodes.
Type:
Grant
Filed:
December 25, 2015
Date of Patent:
January 4, 2022
Assignee:
INSTITUTE OF MICROELECTRONICS, CHINESE ACADEMY OF SCIENCES
Inventors:
Guangwei Xu, Zhiheng Han, Wei Wang, Congyan Lu, Lingfei Wang, Ling Li, Ming Liu
Abstract: A scanning method performed by a station (STA) in a wireless LAN system is provided. The method comprises: transmitting a probe request frame; and receiving a short probe response frame from an access point (AP) as a response to the probe request frame. The short probe response frame includes service set ID (SSID) information or compressed SSID information of the AP.
Type:
Grant
Filed:
May 19, 2020
Date of Patent:
January 4, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Jae Seung Lee, Min Ho Cheong, Hyoung Jin Kwon, Hee Jung Yu, Sok Kyu Lee
Abstract: Described are methods for providing personalized medicine for the treatment of B cell malignancies including lymphoma. The methods make use of Chimeric Antigen Receptor (CAR) technology.
Type:
Grant
Filed:
August 3, 2020
Date of Patent:
January 4, 2022
Assignees:
HESPERIX SA, The Scripps Research Institute
Inventors:
Alexey Vyacheslavovich Stepanov, Dmitry Dmitrievich Genkin, Richard A. Lerner, Alexey Anatolievich Belogurov, Alexander Gabibovich Gabibov, Jia Xie
Abstract: Provided are a compound represented by formula I that can be used in nucleic acid photoreaction techniques, and a photoreactive crosslinking agent comprising the compound.
Type:
Grant
Filed:
July 25, 2018
Date of Patent:
January 4, 2022
Assignees:
JAPAN ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, NICCA CHEMICAL CO., LTD.
Abstract: A tablet, a gas generator and a gas generating device are provided, wherein the tablet comprise a tablet body, the tablet body comprises opposite first and second sides, the tablet body is provided with a vent hole running from the first side to the second side, the first side is provided with a first positioning structure, and the second side is provided with a second positioning structure that cooperates with the first positioning structure. By the smart design of the tablet structure, the present disclosure can effectively simplify the structure of the gas generator and reduce the manufacturing cost.
Type:
Grant
Filed:
March 27, 2018
Date of Patent:
January 4, 2022
Assignee:
Hubei Institute of Aerospace Chemical Technology
Inventors:
Liu Liu, Juntao Shi, Shujuan Chen, Yinming Zhang, Jun Yao, Xingkui Wang, Fan Chen, Wei Liu, Xiaoqiang Wang
Abstract: Disclosed are a wireless communication method, and an access point and a station which perform the wireless communication method. A wireless communication method performed by an access point according to an embodiment may include performing channel sounding on a plurality of subchannels, identifying subchannels selected by stations among the subchannels, scheduling communications between the AP and the stations based on the selected subchannels, and transmitting a data frame to the stations through the subchannels based on a scheduling result.
Type:
Grant
Filed:
May 7, 2020
Date of Patent:
January 4, 2022
Assignee:
ELECTRONICS AND TELECOMMUNICATIONS RESEARCH INSTITUTE
Inventors:
Hyoung Jin Kwon, Sok Kyu Lee, Jae Seung Lee, Min ho Cheong