Abstract: The present invention relates to screening methods for identification of agents (e.g., small molecules) that modulate cytotoxic T lymphocyte antigen-specific target (e.g., tumor) cell killing, as well as to uses of compounds identified thereby as immunomodulatory, including use of EGFR inhibitors as immunomodulatory agents.

Abstract: A modified pigment having excellent color tone selectivity is provided by laking dye by an environmentally friendly method without using metal. A modified pigment according to the present invention is obtained by laking a dye containing at least one of an acidic group and a basic group with at least one of an amino acid and protein.

Abstract: The present disclosure discloses a citrus fruit coloring retardant, and the citrus fruit coloring retardant is a prepared indole-3-acetic acid solution with a concentration of 1,000 ?M. The citrus fruit coloring retardant is prepared by weighing 3.504 g of indole-3-acetic acid powder, dissolving the powder in 10-15 mL of absolute ethanol, adding an obtained indole-3-acetic acid absolute ethanol solution to 20 L of sterilized distilled water, and mixing evenly to obtain the retardant. In addition, the present disclosure also provides a use method of the citrus fruit coloring retardant. The method for delaying color change of citrus fruits is reliable and stable and suitable for researches on mechanism of citrus fruits ripening in laboratory in laboratory and delay of fruit ripening in production. The citrus fruit coloring retardant is a natural plant hormone, also is low cost, environmentally friendly and non-toxic.

Abstract: An the LED driving circuit, for driving an the LED load, includes: a bridge rectifier for rectifying an AC input voltage into a DC voltage; a serial capacitor voltage divider coupled to the bridge rectifier, including a plurality of serial capacitors; a half-bridge switch, coupled to the serial capacitor voltage divider; and a controller coupled to the half-bridge switch, for determining whether the DC voltage is higher than a threshold value and for controlling the half-bridge switch in a full-voltage mode or a half-voltage mode. In the full-voltage mode, the plurality of serial capacitors of the serial capacitor voltage divider synchronously supply power to the LED load. In the half-voltage mode, the plurality of serial capacitors of the serial capacitor voltage divider alternatively supply power to the LED load.

Abstract: Ion exchange membranes for use in electrochemical energy conversion and storage applications include copolymers having a backbone produced from an olefin, such as ethylene, and a cyclic olefin, such as norbornene. Haloalkyl side chains with terminal halide groups are connected to the polymer backbone via Friedel-Crafts alkylation. The halide groups are then replaced with ionic groups via substitution. The ion exchange membrane material can then be cast or impregnated into a reinforcing mesh to form cation exchange membrane or anion exchange membranes. Rigidity of the ion exchange membranes can be controlled by varying the ratio of olefin to cyclic olefin in the polymer backbone.

Abstract: Provided is a method of forming an apatite coating, the method including immersing a substrate in an apatite-forming precursor solution including Ca2+ ions and PO43? ions, emitting a laser beam onto a surface of the substrate immersed in the precursor solution, and forming an apatite coating in a region exposed to the laser beam, wherein an output power of the laser beam is set within a range enabling the surface of the substrate to be melted.

Abstract: The present invention relates to the use of an isolated Aureobasidium pullulans yeast strain YBCA5 as a biological control agent. Processes and compositions for the biological control of phytopathogenic bacteria and fungi using YBCA5 are also provided.

Abstract: According to the present invention, a TBM operation simulation equipment includes: a server 100 in which education information a is stored; and an instruction client unit 200. According to the present invention, it is possible to improve the TBM operation capability of TBM drivers and trainees by providing a TBM simulation environment in which the construction environment is realistically simulated.

Abstract: Provided are a GaN crystal used in a substrate for a nitride semiconductor device having a horizontal device structure such as GaN-HEMT, and a substrate used for production of a nitride semiconductor device having a horizontal device structure such as GaN-HEMT. The Gab crystal has a (0001) surface having an area of not less than 5 cm2, the (0001) surface having an inclination of not more than 10° with respect to the (0001) crystal plane, wherein the Fe concentration is not less than 5×1017 atoms/cm3 and less than 1×109 atoms/cm3, and wherein the total donor impurity concentration is less than 5×1016 atoms/cm3.

Abstract: Methods and alloy systems for non-Be BMG matrix composite materials that can be used to additively manufacturing parts with superior mechanical properties, especially high toughness and strength, are provided. Alloys are directed to BMGMC materials comprising a high strength BMG matrix reinforced with properly scaled, soft, crystalline metal dendrite inclusions dispersed throughout the matrix in a sufficient concentration to resist fracture.

Abstract: A method and a system for multilayer modeling are provided. The system includes a processing unit and a model building and training unit. The processing unit is configured to obtain an original data from a storage unit, obtain plural data sets of the fundamental combinations, plural data sets of the partial combinations and a data set of the full combination from the original data according to plural categorical variables of the original data, and divide the data set of each of the fundamental combinations, the data set of each of the partial combinations and the data set of the full combination into a training data set, a validation data set and a testing data set to obtain plural training data sets, plural validation data sets and plural testing data sets. The model building and training unit is configured to build plural models respectively according to the training data sets.

Abstract: The present invention provides methods of treating malaria by administration of a compound of Formula (I): or a pharmaceutically acceptable salt of said compound, to a subject in need thereof, wherein the variables X, R1, R3, R4, R5, A, B, L, m and n are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin V activity, for treating a Plasmodium infection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

Abstract: An optical beamforming device includes an RF front-end transmitting or receiving RF signals and an optical beamformer forming or compensating for a time delay for each of the plurality of channels based on the RF signals. The optical beamformer includes E/O converters converting the RF signals into optical signals, respectively, a linear modulator generating an optical modulation signal based on an RF input signal, a TTD array outputting an optical combined signal obtained by compensating for a time delay degree of the input optical signals or outputting output optical signals, in each of which a time delay is formed for each channel, by distributing the optical modulation signal, a photo detector generating an RF output signal to an RF back-end based on the optical combined signal, and O/E converters converting the output optical signals into RF signals, respectively.

Abstract: The present disclosure provides a method of separating ?-olefin by a simulated moving bed. The method comprises using a coal-based Fischer-Tropsch synthetic oil as a raw material to obtain a target olefin having a carbon number N within a range from 9 to 18, wherein the raw material is subjected to treatment steps including pretreatment, fraction cutting, alkane-alkene separation, and isomer separation, thereby obtaining a high purity ?-olefin product. As compared to conventional rectification and extraction processes, the product obtained by the method of the present disclosure has advantages of higher purity, higher yield, lower energy consumption, and significantly reduced production cost.

Abstract: Disclosed are a method and an apparatus for enhanced conditional handover (CHO). An operation method of a base station may comprise: receiving a measurement report message from a terminal; transmitting a CHO request message to one or more candidate target cells; receiving a CHO request ACK message from the one or more candidate target cells; and transmitting an RRC reconfiguration message including CHO status report configuration information to the terminal, wherein the CHO status report configuration information requests transmission of information for determining a target cell to which terminal is likely to be handed over among the one or more candidate target cells.

Abstract: Provided is a radio source position estimation system including a plurality of radio transmission devices spaced a predetermined distance apart from one another and configured to transmit radio frequency (RF) signals received from an arbitrary radio source and a central radio reception device configured to estimate a position of the radio source using the RF signals received from at least three radio transmission devices.

Abstract: A process for liquefying a process gas that includes introducing a heat transfer fluid into an active magnetic regenerative refrigerator apparatus that comprises a single stage comprising dual multilayer regenerators located axially opposite to each other.

Abstract: A method for controlling a sunshade of an autonomous vehicle is presented. The method includes determining that current conditions satisfy an activation condition. The method also includes predicting whether a driver will enable a manual mode during the current conditions. The method further includes activating a first sunshade in response to the satisfied activation condition regardless of whether the driver will enable the manual mode. The method still further includes activating a second sunshade in response to the satisfied activation condition when the driver will not enable the manual mode.

Abstract: The modification of biomolecules, small molecules, and other agents of via conjugation of excipients, tags, or labels is of great importance. For example, the modification of therapeutic agents can confer improved stability, solubility, duration of action, or pharmacological properties. Supramolecular chemistry utilizes specific, directional, reversible, non-covalent molecular recognition motifs in order to achieve organization of molecules, and can be used to complex tags to agents of interest (e.g., insulin, glucagon, antibodies). The present invention provides useful supramolecular complexes wherein an agent of interest is specifically bound to a host via non-covalent interactions, and wherein the host is conjugated to a tag. The present invention also provides methods and compounds useful in preparing supramolecular complexes, and methods of treating diseases using the supramolecular complexes.

Abstract: A vibration sensor with monitoring function is provided, which includes a substrate, a microelectromechanical vibration sensor chip and an application-specific integrated circuit chip. The microelectromechanical vibration sensor chip is disposed on the substrate and detects a vibration applied to an object to generate a plurality of vibration signals. The application-specific integrated circuit chip is disposed on the substrate and electrically connected to the microelectromechanical vibration sensor chip, which includes a sampling module, a transform module and an analysis module. The sampling module receives and converts the vibration signals into a plurality of digital signals, and filters the digital signals to generate a plurality of time-domain data. The transform module transforms the time-domain data into a frequency-domain data according to a predetermined number.