Abstract: An IFN-anti-PD-L1 fusion protein, a pharmaceutical composition and a kit containing the same for treating tumors are disclosed. The IFN-anti-PD-L1 fusion protein of the present invention can simultaneously target PD-L1 and IFN receptors, and the activation of IFN signals in a tumor microenvironment (TME) can enhance the PD-1/PD-L1 therapy against tumors by inducing stronger T cell activation. The anti-PD-L1 antibody can be used to specifically deliver immunomodulatory molecules to tumor tissues, and the fusion protein results in the generation of multiple feedforward responses, which can increase the targeting effect, reduce the toxicity, and enhance the response to IFN therapy, thereby maximizing the anti-tumor effect.

Abstract: Disclosed is a method for preparing a reduced graphene oxide-magnesium nanocrystal composite. The method includes contacting graphene oxide with a first reducing agent to prepare a reduced graphene oxide, and co-reducing the reduced graphene oxide and a precursor of magnesium in the presence of a second reducing agent to prepare a reduced graphene oxide-magnesium nanocrystal composite, wherein by adjusting the amount of the first reducing agent in contact with the graphene oxide, the size of the magnesium nanocrystals in the composite may be controlled.

Abstract: The present invention relates to a prebiotic composition, a composition for improving gut microorganisms, a composition for improving gut health or gut function, a composition for alleviating, preventing, or treating inflammatory bowel disease or leaky gut syndrome, or a composition for alleviating, preventing, or treating obesity or metabolic disease, which each comprise a molokhia extract or a molokhia polymer fraction as an active ingredient to induce the proliferation of beneficial intestinal bacteria and to improve, prevent, or treat gut heath or gut function. In addition, the composition comprising a molokhia extract or a molokhia polymer fraction as an active ingredient can alleviate, prevent, or treat bowel disease or leaky gut syndrome.

Abstract: An agent for inhibiting binding of transferrin receptor to SARS-CoV-2 spike protein or an anti-SARS-CoV-2 medicament is provided, where active pharmaceutical ingredients of the agent or the medicament include interference peptides, and the interference peptides include: SL8, FG8, DL12, RK4, SD6, HF7, and/or QK8.

Abstract: The presently disclosed subject matter provides novel T cell receptors (TCRs) that target a mutated RAS protooncogene. The presently disclosed subject matter further provides cells comprising such TCRs. and methods of using such cells for treating cancers associated with RAS.

Abstract: The present invention relates to a single atom catalyst and, more particularly, to a single atom catalyst having double active sites which improves the activity of an electrochemical reaction through the development of high-dispersion and high-support synthesis technology.

Abstract: The present invention relates to an anti-TM4SF4 (TransMembrane 4 Superfamily Member 4) humanized antibody and use thereof. The anti-TM4SF4 humanized antibody of present invention has high affinity for binding specifically to TM4SF4 while exhibiting low immunogenicity in humans, and thus can be advantageously used to detect TM4SF4 or to target cancer cells and cancer stem cells that overexpress TM4SF4.

Abstract: The present invention is to provide a carbon dioxide adsorbent that can collect carbon dioxide generated during a natural gas reforming process at a high concentration and has an excellent adsorption working capacity, a manufacturing method of the same, and a device and process using the same. The carbon dioxide adsorbent according to various examples of the present invention is characterized by including X-type or Y-type zeolite in which at least a part of alkali metal cations or alkali earth metal cations is replaced with H+ ions.

Abstract: An anion exchange membrane is composed of a copolymer of 1,1-diphenylethylene and one or more styrene monomers, such as 4-tert-butylstyrene. The copolymer includes a backbone substituted with a plurality of ionic groups coupled to phenyl groups on the backbone via hydrocarbyl tethers between about 1 and about 7 carbons in length. High-temperature conditions enabled by these copolymers enhance conductivity performance, making them particularly suitable for use in anion exchange membranes in fuel cells, electrolyzers employing hydrogen, ion separations, etc. The properties of the membranes can be tuned via the degree of functionalization of the phenyl groups and selection of the functional groups, such as quaternary ammonium groups. Several processes can be used to incorporate the desired ionic functional groups into the polymers, such as chloromethylation, radical bromination, Friedel-Crafts acylation and alkylation, sulfonation followed by amination, or combinations thereof.

Abstract: The present invention relates to oligonucleotides that maintain a Toll-Like Receptor 7 (TLR7) response and/or which potentiate Toll-Like Receptor 8 (TLR8) sensinq.

Abstract: An oil-soluble conductive agent and a preparation method therefor. Raw materials for preparing the oil-soluble conductive agent comprise the following components: 20 parts by weight of ethyl caprate or bis(2-ethylhexyl) sebacate, 1.8-2.2 parts by weight of ethyl methyl carbonate, and 2-8 parts by weight of fluorine-containing ion salt; and the fluorine-containing ion salt is selected from one or more of lithium bis(trifluoromethanesulfonyl)imide, lithium trifluoromethanesulfonate, and lithium tetrafluoroborate. The oil-soluble conductive agent is apparently a colorless transparent liquid at 25° C. or higher, and the conductivity at 25° C. reaches 1×10?4 S/cm. The oil-soluble conductive agent can be completely dissolved in a base oil and improve the conductivity thereof, so as to have the effects of arc suppression, being anti-static, cooling, heat transfer, and conduction.

Abstract: A method for correcting an analog-to-digital converter includes the following steps: extracting gain errors and weight errors of all conversion stages of an analog-to-digital converter; performing first correction on the analog-to-digital converter based on the gain errors and the weight errors; extracting jitter errors of all conversion stages of the analog-to-digital converter after the first correction; and performing a second correction on the analog-to-digital converter based on the jitter errors. According to the disclosure, the gain errors, the weight errors, and the jitter errors of all conversion stages are successively extracted, and then the analog-to-digital converter is corrected. Precision after the corrections is higher.

Abstract: An objective of the present invention is to provide a method for manufacturing a soft ocular lens in which the surface of the lens is hydrophilized by means of plasma processing, wherein a substrate surface can be sufficiently hydrophilized by performing, once, a reaction between the substrate and a hydrophilic polymer. Another object of the present invention is to provide a soft ocular lens with sufficient hydrophilicity which comprises only one layer comprising a hydrophilic polymer on a substrate surface. A substrate comprising a hydrocarbon group-containing polysiloxane is subjected to plasma processing with an inert gas such as nitrogen, to form a radical including Si—CH2 on the substrate surface, and produce radical rearrangement with a hydrophilic polymer, thereby causing the hydrophilic polymer to bind to the substrate surface by recombination of a radical generated in the hydrophilic polymer with the substrate.

Abstract: The present invention relates to a composition for the prevention or treatment of a muscle disease, comprising an extract of Ponciri Fructus. The extract of the present invention has the effect of increasing the expression of genes related to myotube cell differentiation and/or athletic performance, increasing muscle weight, and/or improving athletic performance.

Abstract: A method for sequential point cloud forecasting is described. The method includes training a vector-quantized conditional variational autoencoder (VQ-CVAE) framework to map an output to a closest vector in a discrete latent space to obtain a future latent space. The method also includes outputting, by a trained VQ-CVAE, a categorical distribution of a probability of V vectors in a discrete latent space in response to an input previously sampled latent space and past point cloud sequences. The method further includes sampling an inferred future latent space from the categorical distribution of the probability of the V vectors in the discrete latent space. The method also includes predicting a future point cloud sequence according to the inferred future latent space and the past point cloud sequences. The method further includes denoising, by a denoising diffusion probabilistic model (DDPM), the predicted future point cloud sequences according to an added noise.

Abstract: Provided are a method of and apparatus for evaluating immune cells using magnetic particles. According to an aspect of the method, magnetic particles may be used to measure interaction of the magnetic particles with immune cells, thereby diagnosing or evaluating a degree of activation of immune cells of a subject or immune-related diseases of the subject. Further, according to an aspect of the apparatus, a phenomenon of interaction of magnetic particles and activated immune cells via endocytosis may be used to collect magnetic particle-immune cell complexes resulting from the interaction with the magnetic particles by applying a magnetic field, thereby effectively isolating the activated immune cells in a short period of time.

Abstract: The technology described herein is directed to compositions and cell culture media for increasing the lifespan of neutrophils. Also described are methods and kits for culturing neutrophils using the compositions or cell culture media. Such cultured neutrophils can be used to treat disorders such as neutropenia or microbial infections.

Abstract: Disclosed embodiments aim to provide an apparatus and method for three-dimensional navigation of a medical tool that enables identifying the three-dimensional shape and position of the medical tool within a human body. To achieve the above object, the disclosed embodiment includes a three-dimensional high-resolution image acquisition unit configured to acquire a three-dimensional high-resolution image of a human organ that is targeted for a medical procedure; a three-dimensional shape data acquisition unit configured to acquire three-dimensional shape data of a medical tool of a flexible material in real time; a registration unit configured to register the three-dimensional high-resolution image and the three-dimensional shape data with a reference point; and a display unit configured to display an image registered by the registration unit.

Abstract: Proposed are a personal mobility device system and a control method of a personal mobility device system. The personal mobility device system includes a boarding body having a seat that a user is capable of sitting on, and includes a moving body which is coupled to the boarding body and which has a driving force based on an electric power.

Abstract: The present disclosure relates to relates to an industrial premixed gas combustor using internal exhaust gas recirculation and an operating method thereof.