Abstract: Provided is a DC-DC converter including an inductor configured to store input energy, a ground switch configured to provide a ground path of the inductor in response to a first signal, an inductor switch connected in parallel to the inductor so as to maintain the energy stored in the inductor in response to a second signal, output switches configured to output the energy stored in the inductor as multi-output voltages in response to third signals, and a switch controller including a switch controller configured to determine cross regulation between the multi-outputs and generate the first to third signals for decreasing the cross regulation.

Abstract: The present invention provides a human Tim-3-Ig fusion protein which can block Tim-3 signal pathway, and said Ig fusion protein comprises Tim-3 protein, human Ig fragment, and the linking sequence therebetween. In the present invention, a human Tim-3-Ig gene is obtained by an artificial synthesis process; an expression vector containing the Tim-3-Ig gene is constructed; and the prepared Ig fusion protein is tested in an expression verification experiment, a binding activity experiment, a blocking activity experiment in different cell lines, and in vivo experiments in mice. The human Tim-3-Ig fusion protein prepared in the present invention can be used to treat immunological diseases caused by high expression of Tim-3.

Abstract: Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject.

Abstract: A method for treating water using a salt desorption process of gas hydrates according to the present invention includes: (a) introducing water containing impurities and a plurality of guest gases into a reactor; (b) forming gas hydrates by causing the water and the plurality of guest gases to react under a first condition; and (c) dissociating a gas hydrate of one guest gas from among the plurality of guest gases by changing the first condition to a second condition, wherein the first condition refers to temperature and pressure conditions under which all of the plurality of guest gases form gas hydrates and the second condition refers to temperature and pressure conditions under which the gas hydrate of the one guest gas from the mixed gas hydrates is dissociated.

Abstract: A method for differentiating stem cells into vascular cells, including adhering the stem cells to a culture plate with a surface having a hydrophobic property or on which a growth factor is immobilized, and culturing the cells. The cultured stem cells later detach from the culture plate as their density increases to form a three-dimensional cell cluster and differentiate into vascular cells. The cell cluster can be used as a cell therapy agent for angiogenesis.

Abstract: A cold-adapted protease derived from Pseudoalteromonas arctica PAMC 21717 or a recombinant cold-adapted protease obtained by expressing a gene encoding the cold-adapted protease in E. coli is described, and more particularly, a crystal of a protease exhibiting activity at low temperatures, a method for crystallizing the protease, a method for preparing the protease, a recombinant microorganism that expresses the protease, a method for preparing the recombinant microorganism, a method for preparing the recombinant protease and the use of the cold-adapted protease. The cold-adapted protease exhibits high activity at low temperatures, and securely maintains its enzymatic activity even in the presence of high pH, various metal ions and surfactants. Thus, it is useful in various industrial applications.

Abstract: A method for manufacturing a quantum dot thin film includes applying a tensile force to a substrate to elongate the substrate, coating a quantum dot particle on the substrate to form a quantum dot thin film, replacing a ligand of the quantum dot particle, and removing the tensile force from the substrate. The method may reduce a crack in a quantum dot thin film.

Abstract: A data access control method includes requesting, by the data owner unit, the generation of a data encryption key (DEK) from the manager unit, generating, by the manager unit, the DEK, generating, by the manager unit, the result of the Ciphertext Policy-Attribute Based Encryption (CP-ABE) of the DEK and a secret key used to decrypt the result of the CP-ABE encryption, and then responding, by the manager unit, to the data owner unit, obtaining, by the data owner unit, the DEK by performing the CP-ABE decryption of the result of the CP-ABE encryption using the secret key, encrypting, by the data owner unit, data with the obtained DEK, and uploading, by the data owner unit, the encrypted data and DEK information to the cloud.

Abstract: A population of nanowires can be prepared by a method involving electric field catalyzed growth and alteration based on surface charge density.

Abstract: A welding wire is formed from a hoop having an inner surface and formed from a metal material, a core wire having a surface and formed from a metal material, and an alkaline metal compound. The hoop metal material and the core wire metal material are different from each other. A composition of the welding wire is divided into the hoop metal material and the core wire metal material. The alkaline metal compound is disposed between the inner face of the hoop and the surface of the core wire. An amount of the alkaline metal compound is from more than 10 ppm to 1000 ppm based on a weight of the welding wire.

Abstract: The invention provides compositions and methods for the breeding, production, processing and use of specialty cannabis.

Abstract: The present disclosure provides methods of determining the levels of BRCA1 in a cell, altering the levels of BRCA1 in a cell, determining the likelihood of developing cancer, and determining the prognosis of a patient with cancer using miR-182 and analogs thereof. Importantly, the invention also provides methods of determining whether a patient should be treated with PARP inhibitors, improving PARP therapy in cancer, as well as methods for selecting and improving genotoxic therapies. Also featured are methods of treating patients with cancers based on the expression levels of miR-182. The invention also features compositions comprising miR-182 and analogs thereof, antagomirs of mIR-182 and analogs thereof, in combination with PARP inhibitors and genotoxic agents.

Abstract: Bias-switchable dual-band infrared detectors and methods of manufacturing such detectors are provided. The infrared detectors are based on a back-to-back heterojunction diode design, where the detector structure consists of, sequentially, a top contact layer, a unipolar hole barrier layer, an absorber layer, a unipolar electron barrier, a second absorber, a second unipolar hole barrier, and a bottom contact layer. In addition, by substantially reducing the width of one of the absorber layers, a single-band infrared detector can also be formed.

Abstract: Thin parylene C membranes having smooth front sides and ultrathin regions (e.g., 0.01 ?m to 5 ?m thick) interspersed with thicker regions are disclosed. The back sides of the membranes can be rough compared with the smooth front sides. The membranes can be used in vitro to grow monolayers of cells in a laboratory or in vivo as surgically implantable growth layers, such as to replace the Bruch's membrane in the eye. The application further provides an implantable cage-like apparatus for culturing cells comprising the parylene membrane.

Abstract: Techniques to generate custom electronic forms are described. An apparatus may comprise a logic device and an application having a form manager component. The form manager component may be operative on the logic device to manage one or more forms for a user interface of the application during a run-time mode of the application. The form manager component may have a custom prompt module operative to determine whether an application context interface is available for a dynamic form prompt of a form. The form manager component may determine whether a custom language interface is available for the dynamic form prompt when the application context interface is available. The form manager component may retrieve custom content in a custom presentation language for the dynamic form prompt when the custom language interface is available. Other embodiments are described and claimed.

Abstract: The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.

Abstract: A back-up roll device and method for conducting corner deformation on a chamfered continuous casting slab. The back-up roll device includes back-up rolls with ?-angle bevels, movable bearing seats, bearing seat moving rails, bearing seat motion holding mechanisms and inner arc or outer arc frames of a casting machine. The back-up rolls are arranged on the inner and/or outer arc frames of the horizontal segment of the casting machine. Support surfaces of the back-up rolls make contact with and squeeze smaller obtuse angles adjacent to the wide face of the inner or outer arc on the chamfered continuous casting slab, and therefore each smaller obtuse angle is squeezed into two larger obtuse angles. The back-up roll device and method for conducting corner deformation on the chamfered casting slab can achieve the purposes of eliminating edge slivers.

Abstract: The present invention relates to a thiazole-based compound, a preparation method therefor, and a use thereof. More specifically, the present invention relates to a 2,2?-bis-thiazole-based compound, a preparation method therefor, and a use of 2,2?-bis-thiazole-based compound a histone deacetylase inhibitor in the preparation of an antitumor medicament, a medicament for treating autoimmune diseases, a medicament for treating type II diabetes mellitus and complication thereof, or a medicament for treating neurodegenerative diseases.

Abstract: An equalizer provided in a digital transmitter compensates for attenuation in a signal channel to a digital receiver. The equalizer generates signal levels as a logical function of bit history to emphasize transition signal levels relative to repeated signal levels. The preferred equalizer includes an FIR transition filter using a look-up table. Parallel circuits including FIR filters and digital-to-analog converters provide a high speed equalizer with lower speed circuitry. The equalizer is particularly suited to in-cabinet and local area network transmissions where feedback circuitry facilitates adaptive training of the equalizer.

Abstract: A metal loaded catalyst comprises a support and main active metal components and optional auxiliary active metal components, wherein the main active metal components are elementary substances and obtained by ionizing radiation reducing precursors of main active metal components. The catalyst can be widely used in the catalytic reactions of petrochemistry industry with high activity and selectivity. The catalyst can be used directly without being reduced preliminarily by hydrogen.