Abstract: Lysophosphatidic acid acyltransferase-beta (LPAAT-?) catalyzes the production of phosphatidic acid (PA) from lysophosphatidic acid (LPA). The lipid cofactor PA contributes to the activation of c-Raf, BRAF, mTOR and PKC-?. LPAAT-? expression is a prognostic factor in gynecologic malignancies and is being investigated as a therapeutic target in a variety of tumor types. A class of thiosemicarbazones was identified as inhibitors of LPAAT-? from a screen of a library of small molecules. A focused library of thiosemicarbazones derivatives was prepared and led to the development of compounds which potently inhibit LPAAT-? and inhibit the growth of MiaPaCa2 human pancreatic cancer cells.

Abstract: The present invention provides a contact probe pin in which a carbon film having both of conductivity and durability is formed on a base material with a tip divided, wherein Sn adherence can be reduced as much as possible to be able to maintain stable electrical contact over a long period of time, even under such circumstances that the temperature of a usage environment becomes high. The present invention relates to a contact probe pin, including a tip divided into 2 or more projections and repeatedly coming into contact with a test surface at the projection, wherein a carbon film containing a metal element is formed at least on a surface of the projection, and a radius of curvature at an apex part of the projection is 30 ?m or more.

Abstract: A method of manufacturing a semiconductor device according to the present invention comprises: a bump forming step of forming a bump electrode 100 on a semiconductor chip 1, the bump electrode 100 protruding in a substantially conical shape; a pad forming step of forming a pad electrode 200 on a substrate 10, the pad electrode 200 having a recess 210 with inner lateral surfaces thereof defining a substantially pyramidal shape or a prism shape; a pressing step of pressing the bump electrode 100 and the pad electrode 200 in a direction which brings them closer to each other, with the bump electrode 100 being inserted in the recess 210 so that the central axis of the bump electrode 100 and the central axis of the recess 210 coincide with each other; and an ultrasonic joining step of joining the bump electrode 100 and the pad electrode 200 by vibrating at least one of the bump electrode 100 and the pad electrode 200 using ultrasonic waves.

Abstract: Mechanisms for operating a prover device and a verifier device so that the verifier device can verify the authenticity of the prover device. The prover device generates a data string by: (a) submitting a challenge to a physical unclonable function (PUF) to obtain a response string, (b) selecting a substring from the response string, (c) injecting the selected substring into the data string, and (d) injecting random bits into bit positions of the data string not assigned to the selected substring. The verifier: (e) generates an estimated response string by evaluating a computational model of the PUF based on the challenge; (f) performs a search process to identify the selected substring within the data string using the estimated response string; and (g) determines whether the prover device is authentic based on a measure of similarity between the identified substring and a corresponding substring of the estimated response string.

Abstract: The purpose of the present invention is to develop a method for amplifying in vitro to a large amount of a homogenous insoluble aggregate that is equivalent to an insoluble aggregate formed in the brain of a patient. A method of producing an insoluble aggregate including TDP-43 protein and fragments thereof according to the present invention includes the steps of: (1) introducing an insoluble fraction originated from the brain of a neurodegenerative disease patient into a cell culture in which the intact TDP-43 protein can be expressed in a constitutive manner; (2) culturing the cultured cell into which the insoluble fraction has been introduced; and (3) separating an insoluble fraction from the cultured cell. Optionally, the method may additionally include a step of amplifying the insoluble aggregate of the neurodegenerative-disease-related protein in the cultured cell.

Abstract: The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.

Abstract: A robotic zipper system for joining and separating zipper halves of a zipper tape. A chassis retains an actuator that drives a zipper slide geometry along the zipper tape to join or separate the zipper tape. A sensor can determine zipper slide position, and a control module can provide an electrical signal to the motor to move in forward or reverse. The actuator can have a motor that drives a gear system that mechanically engages zipper teeth. Teeth of the gear system can be out of phase to mesh with alternating gaps between the zipper teeth. The actuator can be removable relative to a zipper slide. Zipper slide geometry could be integrated into the chassis, such as in the form of a channel, potentially with a central post. A sensor could be positioned to detect the presence or absence of zipper teeth through an opening in a base plate.

Abstract: A resin product wherein a resin B has pillar structures or lamellar structures inside a resin A is molded by kneading the resin A and the resin B that serves as a base material in an injection molding machine while heating both of the resins to at least a temperature at which both of the resins are melted at least partially. The resin product is soaked in a solution having higher erosion capability with respect to the resin A than the resin B, thereby dissolving the resin B and forming an uneven structure on the surface. As a result, an uneven structure having various shapes, densities or depths which are precisely adjustable can be formed at low cost. And provided are a resin structure and a production method thereof that can maintain wettability control or optical property control of the molded article over a long period of time.

Abstract: The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins in mammalian host cells, for example, primate host cells and rodent host cells. The invention provides, for example but not limited to, translation systems that include host cells (e.g., primate or rodent cells), orthogonal aminoacyl-tRNA synthetases derived from eubacterial synthetases, orthogonal tRNAs, and the unnatural amino acid. The invention also relates to methods for producing proteins of interest comprising at least one unnatural amino acid in mammalian host cell systems.

Abstract: The present invention provides a SOI MOS device modeling method. The SOI MOS device is one having a source-drain injection not reaching the bottom. The method comprises: a) establishing an overall model comprising a primary MOS device model simulating an SOI MOS device having the source-drain injection reaching the bottom, a source body PN junction bottom capacitance model simulating a source body PN junction bottom capacitance, and a drain body PN junction bottom capacitance model simulating a drain body PN junction bottom capacitance; and b) extracting parameters respectively for the primary MOS device model, the source body PN junction bottom capacitance model, and the drain body PN junction bottom capacitance model in the overall model. In the prior art, the source body junction bottom capacitance and the drain body junction bottom capacitance in the SOI MOS device having a source-drain injection not reaching the bottom affect the performances of the device.

Abstract: A method and a device for encoding/decoding images are disclosed. The method for encoding images comprises the steps of: deriving a scan type of a residual signal for a current block according to whether or not the current block is a transform skip block; and applying the scan type to the residual signal for the current block, wherein the transform skip block is a block to which transform for the current block is not applied and is specified on the basis of information indicating whether or not transform for the current block is to be applied.

Abstract: The object of the present invention is to provide a novel conditionally replicating adenovirus and a reagent comprising the same for cancer cell detection or for cancer diagnosis. The present invention provides a polynucleotide, which comprises human telomerase reverse transcriptase (hTERT) promoter, E1A gene, IRES sequence and E1B gene in this order and which comprises a target sequence of a first miRNA. The present invention also provides a recombinant adenovirus, which comprises a replication cassette comprising the above polynucleotide, wherein the replication cassette is integrated into the E1 region of the adenovirus genome.

Abstract: According to one embodiment, a cross-correlator comprises a plurality of analog front ends (AFEs), a cross-correlation circuit and a data serializer. Each of the AFEs comprises a variable gain amplifier (VGA) and a corresponding analog-to-digital converter (ADC) in which the VGA receives and modifies a unique analog signal associates with a measured analog radio frequency (RF) signal and the ADC produces digital data associated with the modified analog signal. Communicatively coupled to the AFEs, the cross-correlation circuit performs a cross-correlation operation on the digital data produced from different measured analog RF signals. The data serializer is communicatively coupled to the summing and cross-correlating matrix and continuously outputs a prescribed amount of the correlated digital data.

Abstract: A method and apparatus for beamforming using a polarized antenna in a wireless communication system are disclosed. The apparatus includes a processor configured to process a signal, and a multi-polarized antenna including a plurality of antenna elements, configured to transmit the signal. The plurality of antenna elements include an electric-field dipole antenna and a magnetic-field dipole antenna, and a current is applied to the electric-field dipole antenna and the magnetic-field dipole antenna in the same direction or in opposite directions.

Abstract: A circuit for sensing an external magnetic field includes first voltage source, first magnetic sensor, second magnetic sensor, bias voltage unit, clamp voltage current mirror unit, signal transfer amplifying unit. The first voltage source provides a power voltage. The first magnetic sensor provides a reference current. The second magnetic sensor senses an external magnetic field and the conductivity of the second magnetic sensor varies in response to the external magnetic field. The bias voltage unit connected to the first magnetic sensor and the second magnetic sensor provides a bias voltage to the first magnetic sensor and the second magnetic sensor. The clamp voltage current mirror unit generates a reference current for the first magnetic sensor and mirrors the reference current to the second magnetic sensor. The signal transfer amplifying unit generates an output voltage and an additional current to compensate the change in the conductivity of the second magnetic sensor.

Abstract: The present invention relates to methods of constructing an integrated artificial immune system that comprises appropriate in vitro cellular and tissue constructs or their equivalents to mimic the normal tissues that interact with vaccines in mammals. The artificial immune system can be used to test the efficacy of vaccine candidates in vitro and thus, is useful to accelerate vaccine development and testing drug and chemical interaction with the immune system.

Abstract: The present invention addresses the problem of providing a method for synthesizing hexagonal tungsten nitride by synthesizing hexagonal tungsten nitride as a main product, and of providing the hexagonal tungsten nitride. The problem is solved through use of a method for synthesizing hexagonal tungsten nitride comprising synthesizing hexagonal tungsten nitride by heating a starting material powder containing a tungsten halide and an alkali metal nitride and/or an alkaline earth metal nitride.

Abstract: The invention provides compounds of formula I: wherein R1, R2 and R3 have values defined in the specification and a pharmaceutically acceptable salt thereof; or an optical isomer thereof; or a mixture of optical isomers, as well as compositions comprising such compounds and therapeutic methods that utilize such compounds and/or compositions.

Abstract: A cyclic azine compound represented by general formula (1): wherein each Ar1 represents an aromatic group, which is unsubstituted or substituted by a C1-4 alkyl group, a phenyl group or a pyridyl group; and A represents a group selected from those which are represented by general formulae (2) to (5), described in the description. The cyclic azine compound is useful for an organic compound layer of fluorescent or phosphorescent EL device.

Abstract: A new and distinct apricot variety is described. The variety results from selection among a population of seedlings derived from controlled crossing of the varieties ‘Bhart’ (not patented), marketed as Orangered™ and ‘Late Moorpark’ (not patented). The new variety, initially designated StB14/15 and now designated Nzsummer3, is distinguished from others by medium sized fruit with a deep red overcolour when mature accompanied by mid orange coloured firm flesh and low ethylene characteristics. Fruit of Nzsummer3 matures in early to late February in Otago, New Zealand.