Abstract: In an effort to discover therapies for treating HSP70 related diseases, a previously unidentified hydrophobic pocket was found in the C-terminal domain of DnaK and of human HSP70. A novel chemical scaffold was also discovered for identifying compounds that treat diseases related to this hydrophobic pocket. The compounds have the structure of the formula (I), wherein L, M, and R1-R5 are defined herein and are, therefore, in these therapies, optionally with other pharmaceutical agents such as genotoxic agents. Accordingly these compounds are useful in inhibiting HSP70 or DnaK, reducing HSP70 in mitochondria of a cancer cell, treating malignant neoplastic disease, or inhibiting or reducing bacterial growth. These compounds also resulted in novel methods of screening for a HSP70 inhibitor or DnaK inhibitor by using the three-dimensional structure of the hydrophobic pocket in DnaK or HSP70.

Abstract: A nano-patterned system comprises a vacuum chamber, a sample stage and a magnetic-field applying device, which comprises a power supply, a magnetic-field generation device and a pair of magnetic poles. The magnetic-field generation device comprises a coil and a magnetic conductive soft iron core. The power supply is connected to the coil, which is wound on the soft iron core to generate a magnetic field. The soft iron core is of a semi-closed frame structure and the magnetic poles are at the ends of the frame structure. The stage is inside a vacuum chamber. The poles are oppositely arranged inside the vacuum chamber relative to the stage. The coil and the soft iron core are outside the vacuum chamber. The soft iron core leads the magnetic field generated by the coil into the vacuum chamber. The magnetic poles locate a sample on the stage and apply a local magnetic field.

Abstract: The present disclosure provides a flame-resistant electrolyte for rechargeable lithium secondary batteries, and a rechargeable lithium secondary battery including the same. The flame-resistant electrolyte for rechargeable lithium secondary batteries can reduce volatility of an organic solvent, and inhibit flammability to improve stability of a battery when a flame-resistant solvent, which includes a fluorinated phosphazene-based phosphorus compound and a phosphite-based compound for forming protective films on surfaces of negative and positive electrodes, is mixed with a lithium salt and a carbonate-based solvent, and thus has good lifespan characteristics and high battery charge/discharge efficiency even under high-temperature and high-voltage environments, and also has improved battery performance since an electrode interface is stabilized to inhibit side reaction with an electrolyte.

Abstract: The present disclosure relates to a divided-aperture laser differential confocal LIBS and Raman spectrum-mass spectrum microscopic imaging method and device.

Abstract: The present disclosure relates to a horn antenna apparatus. The horn antenna apparatus includes: a first horn antenna; and a second horn antennas provided with an input waveguide which is arranged to correspond to an output waveguide of the first horn antenna, wherein the output waveguide of the first horn antenna and the input waveguide of the second horn antenna are connected to be overlapped with each other to form a mode conversion waveguide, and higher modes of a TM11 mode and a TE12 mode are generated in an aperture of an output waveguide of the second horn antenna.

Abstract: The object of the present invention is to provide a novel functional light-transmissive material including tabular silver nanoparticles and the manufacturing of the same. According to the present invention, there is provided a functional light-transmissive material including: a transparent base material; an adsorption layer disposed on a surface of the transparent base material, wherein the adsorption layer contains a hydrophobic modified clay with organic compound; and tabular silver nanoparticles oriented and adsorbed on the adsorption layer. Furthermore, according to the present invention, there is provided a method for manufacturing a functional light-transmissive material, including: a step of forming an adsorption layer containing a hydrophobic modified clay with organic compound on a surface of a transparent base material; and a step of immersing the transparent base material provided with the adsorption layer in an aqueous dispersion of tabular silver nanoparticles.

Abstract: An optoelectronic device as well as its methods of use and manufacture are disclosed. In one embodiment, an optoelectronic device includes first and second semiconducting atomically thin layers with corresponding first and second lattice directions. The first and second semiconducting atomically thin layers are located proximate to each other, and an angular difference between the first lattice direction and the second lattice direction is between about 0.000001° and 0.5°, or about 0.000001° and 0.5° deviant from of a Vicnal angle of the first and second semiconducting atomically thin layers. Alternatively, or in addition to the above, the first and second semiconducting atomically thin layers may form a Moiré superlattice of exciton funnels with a period between about 50 nm to 3 cm. The optoelectronic device may also include charge carrier conductors in electrical communication with the semiconducting atomically thin layers to either inject or extract charge carriers.

Abstract: A method of reinforcing a metallic material includes adding graphene to an alcohol solution; subjecting the alcohol solution containing graphene to sonication; mixing a metal powder with the alcohol solution containing graphene; milling the metal powder and alcohol solution containing graphene mixture; drying the metal powder and alcohol solution containing graphene mixture to form a composite powder; subjecting the composite powder to a densification process followed by a hot isostatic pressing treatment to form a composite material; and molding the composite material by hot extrusion.

Abstract: An oil-based release agent of the present invention contains a petroleum-based hydrocarbon solvent (a) and a high temperature adhesive (b), is applied to a metal die used for die casting or casting, has high adhesion and high lubricity even with respect to a metal die at a high temperature particularly of 300° C. or higher, and can prevent seizure. In addition, the present invention provides a method for applying the oil-based release agent of the present invention by controlling an adhesion amount thereof by micronization and speed-control thereof with respect to a metal die at a high temperature, and an electrostatic application method.

Abstract: Aspects of the invention described herein, concern approaches to make genetically modified T-cells comprising a chimeric antigen receptor for human therapy. In some alternatives, the methods utilize a selection and/or isolation of CD4+ and/or CD8+ T-cells from a mixed T-cell population, such as, peripheral blood or apheresis derived mononuclear cells. Once selected/isolated, the CD4+ and/or CD8+ T-cells are then activated, genetically modified, and propagated, preferably, in separate or isolated cultures in the presence of one or more cytokines, which support survival, engraftment and/or proliferation of the cells, as well as, preferably promoting or inducing the retention of cell surface receptors, such as CD62L, CD28, and/or CD27.

Abstract: The present invention discloses a semiconductor device, comprising a plurality of fins located on a substrate and extending along a first direction; a plurality of gate stack structures extending along a second direction and across each of the fins; a plurality of stress layers located in the fins on both sides of the gate stack structures and having a plurality of source and drain regions therein; a plurality of channel regions located in the fins below the gate stack structures; characterized in that the stress layers have connected parts in the fins and that the channel regions enclose the connected parts.

Abstract: Articles and methods in which an electric field is used to actuate a material are generally described. Provided in one embodiment is a method including applying an electric field to a ceramic material. Applying the electric field to the ceramic material can transform the ceramic material from a first solid phase to a second distinct solid phase. The applied electric field is less than a breakdown electric field of the ceramic material, according to certain embodiments.

Abstract: A balancing apparatus comprises a rotating shaft (2) arranged on a transition coupler (1), a rotating rod (4) and a top seat (7). The rotating rod (4) comprises an upper and lower end plates (11,12), and a ramp protrusion (13) that is arranged between the upper and lower end plates (12), and is of a sheet protruding structure; when the upper and lower end plates serve as the reference, in the longitudinal direction, the ramp protrusion (13) outward inclines towards the rotating rod, one end of the rotating rod (4) is arranged on the rotating shaft, a pin shaft (5) is arranged at the other end of the rotating rod (4), an eyelet bolt (6) is further arranged on the pin shaft (5), and the rotating rod (4) can rotate around the rotating shaft (2) and hinged to the eyelet bolt (6) through the pin shaft (5).

Abstract: The present invention relates to a lithium recovery device and recovery method. The lithium recovery device of the present invention includes: a first electrode; a second electrode; and a power supply device. In the lithium recovery device of the present invention, since lithium is attached to an adsorbent of the first electrode by applying a current to the first and second electrodes in a state in which the first and second electrodes are immersed in a lithium-containing fluid, the first electrode including a carrier made of a stainless steel material in a form of an iron mesh or perforated sheet and having a surface coated with the adsorbent containing a manganese oxide, and the second electrode facing the first electrode, it is possible to increase a size of the device and have excellent energy efficiency and economic feasibility.

Abstract: This disclosure provides an image composition system and its method. The system includes: an image capturing unit configured for capturing at least one first image of a real object; a depth information generating unit disposed on the image capturing unit and configured for measuring a depth information between the depth information generating unit and the real object; a computing unit receiving the at least one first image and the depth information, performing the computation of removing a noise caused by a moving object other than the real object from the received depth information, and computing a moving trajectory of the image capturing unit; and a composition unit compositing the at least one first image and a second image of a virtual scene, and display the composited result on a display unit.

Abstract: This invention provides a chlorinated poly(propylene carbonate) and the preparation method thereof, the chlorinated poly(propylene carbonate) is as represented by formula (I). Compared to the prior poly(propylene carbonate)s, the chlorinated poly(propylene carbonate) has relatively stronger electronegativity due to the presence of chlorine atoms and the interaction of the chlorinated poly(propylene carbonate) with other polar materials can be enhanced, so that it can be widely used as a compatilizer, a binder, a paint, an ink, and the like. After the introduction of chlorine atoms, hydrogen bond interaction is generated within the chlorinated poly(propylene carbonate), so that its processability and mechanical properties are both improved. Furthermore, the chlorine atom may improve the flame retardancy of chlorinated poly(propylene carbonate) materials.

Abstract: A processor-implemented method for spatial sound localization and isolation is described. The method includes segmenting, via a processor, each of a plurality of source signals detected by a plurality of sensors, into a plurality of time frames. For each time frame, the method further includes obtaining, via a processor, a plurality of direction of arrival (DOA) estimates from the plurality of sensors, discretizing an area of interest into a plurality of grid points, calculating, via the processor, DOA at each of grid points, comparing, via the processor, the DOA estimates with the computed DOAs. If the number of sources is more than 1, the method includes obtaining via the processor, a plurality of combinations of DOA estimates, from amongst the plurality of combinations, estimating, via the processor, one or more initial candidate locations corresponding to each of the combinations, selecting location of the sources from amongst the initial candidate locations.

Abstract: A spin transport channel includes a dielectric layer contacting a conductive layer. The dielectric layer includes at least one of a tantalum oxide, hafnium oxide, titanium oxide, and nickel oxide. An intermediate spin layer contacts the dielectric layer. The intermediate spin layer includes at least one of copper and silver. The conductive layer is more electrochemically inert than the intermediate spin layer. A polarizer layer contacts the intermediate spin layer. The polarizer layer includes one of a nickel-iron based material, iron, and cobalt based material. The conductive layer and intermediate layer are disposed on opposite sides of the dielectric layer. The dielectric layer and the polarizer layer are disposed on opposite sides of the intermediate spin layer. The intermediate spin layer is arranged to form a conducting path through the dielectric layer configured to transport a plurality of electrons. Each of the plurality of electrons maintains a polarized electron spin.

Abstract: An electronic platform comprising a substrate made of a ABO3 crystal (2) and at least one layer of a two-dimensional conducting sheet of carbon atoms (1) of a thickness between one and four atoms, characterized in that the conducting layer(s) is (are) placed on top of a face of the crystal whose orthogonal axis is at an angle up to 35° of the crystal's spontaneous polarization or c-axis. The invention achieves a sheet resistance lower than 1 ?/square at temperatures higher than 77K.

Abstract: Disclosed herein is an apparatus and method for correcting the location of a base station. The apparatus includes a data collection unit for receiving collected data including collection places and scan data acquired from the collection places from a collection-only terminal, and receiving scan data having no collection places from a user service terminal. A determination unit obtains correlations between respective base stations based on a number of times each base station in an identical search group is found in a search using the collected data or the scan data, and determines whether a base station has been moved, deleted or added, based on the correlations between respective base stations. A location specification unit specifies a location of the corresponding base station that has changed due to any one of the movement, deletion, and addition of the base station, based on results of the determination.